{"id":"https://openalex.org/W7225110828","doi":"https://doi.org/10.6084/m9.figshare.34886005","title":"Efinaconazole-Loaded Liposomal Nanocarriers: A Box-Behnken Design Approach in Formulation Designing and Optimization for Onychomycosis","display_name":"Efinaconazole-Loaded Liposomal Nanocarriers: A Box-Behnken Design Approach in Formulation Designing and Optimization for Onychomycosis","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225110828","doi":"https://doi.org/10.6084/m9.figshare.34886005"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.34886005","doi":"https://doi.org/10.6084/m9.figshare.34886005","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34886005","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34886005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160343468","display_name":"Mahima Singh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahima Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158731165","display_name":"Prakash K. Soni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prakash K. Soni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108845135","display_name":"REENA SONI","orcid":"https://orcid.org/0009-0006-0971-7560","observed_orcids":["https://orcid.org/0009-0006-0971-7560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reena Soni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82760619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11253","display_name":"Nail Diseases and Treatments","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/efinaconazole","display_name":"efinaconazole","score":1.0},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8119999766349792},{"id":"https://openalex.org/keywords/onychomycosis","display_name":"onychomycosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/transungual-drug-delivery","display_name":"transungual drug delivery","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9890000224113464},{"id":"https://openalex.org/keywords/box-behnken-design","display_name":"Box-Behnken design","score":0.8610000014305115},{"id":"https://openalex.org/keywords/formulation-optimization","display_name":"formulation optimization","score":0.7080000042915344},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.656000018119812},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ethanol-injection","display_name":"ethanol injection","score":0.6869999766349792},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8600000143051147},{"id":"https://openalex.org/keywords/korsmeyer-peppas-kinetics","display_name":"Korsmeyer-Peppas kinetics","score":0.9010000228881836},{"id":"https://openalex.org/keywords/topical-antifungal-therapy","display_name":"topical antifungal therapy","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7616000175476074},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6855000257492065},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6401000022888184},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.5788999795913696},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.5683000087738037},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.4896000027656555},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.48399999737739563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47519999742507935},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.41339999437332153},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4097999930381775},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.4009999930858612},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.39329999685287476},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3903000056743622},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.352400004863739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3483000099658966},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.3393999934196472},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.31859999895095825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27799999713897705},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2549999952316284},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.34886005","doi":"https://doi.org/10.6084/m9.figshare.34886005","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34886005","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34886005.v1","doi":"https://doi.org/10.6084/m9.figshare.34886005.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34886005.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34886005","doi":"https://doi.org/10.6084/m9.figshare.34886005","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34886005","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313593512","https://openalex.org/W3049173605","https://openalex.org/W2989255575","https://openalex.org/W3131718577","https://openalex.org/W6949667084","https://openalex.org/W7163755280","https://openalex.org/W2730792302","https://openalex.org/W4283462139","https://openalex.org/W3204493257","https://openalex.org/W4400429595"],"abstract_inverted_index":{"To":[0],"design,":[1],"optimize,":[2],"and":[3,16,35,58,89,103,126,152,181,219,228],"evaluate":[4],"efinaconazole-loaded":[5],"liposomal":[6,41,203,212],"formulation":[7,131,204,213],"with":[8,48,133,162],"sustained":[9,159,225],"drug":[10,14,18,37,46,56,105,116,165,186,191,208,223,226,238],"release,":[11,117,227],"enhanced":[12,221],"trans-ungual":[13,45,222],"penetration,":[15,224],"improved":[17],"retention":[19],"for":[20,27,54,76],"treatment":[21],"of":[22,141,145,149,155,202],"onychomycosis.":[23],"Conventional":[24],"topical":[25],"therapies":[26],"onychomycosis":[28],"are":[29],"limited":[30],"by":[31],"poor":[32],"nail":[33,124,195],"permeability":[34],"low":[36],"retention.":[38],"The":[39,82,107,129,188,210],"optimized":[40,108,130,211],"nanocarrier":[42],"system":[43],"enhances":[44],"penetration":[47],"sustains":[49],"release":[50,120,160,166],"kinetics":[51],"showing":[52],"potential":[53,148],"effective":[55],"delivery":[57,239],"patient":[59],"compliance.":[60],"Liposomes":[61],"encapsulating":[62],"efinaconazole":[63],"were":[64,95],"synthesized":[65],"via":[66],"the":[67,182,216],"ethanol":[68],"injection":[69],"technique.":[70],"A":[71],"Box-Behnken":[72],"design":[73],"was":[74],"employed":[75],"optimization":[77],"using":[78],"Design":[79],"Expert\u00ae":[80],"software.":[81],"independent":[83],"variables":[84,94],"included":[85],"phospholipid":[86],"(HSPC),":[87],"cholesterol,":[88],"stirring":[90],"speed,":[91],"while":[92],"dependent":[93],"particle":[96,139],"size,":[97],"PDI,":[98],"zeta":[99,147],"potential,":[100],"entrapment":[101,153],"efficiency,":[102],"cumulative":[104,164],"release.":[106],"liposomes":[109],"underwent":[110],"comprehensive":[111],"characterization":[112],"including":[113],"in":[114],"vitro":[115],"TEM,":[118],"DSC,":[119],"kinetics,":[121],"ex":[122,189],"vivo":[123,190],"permeation,":[125],"physical":[127,230],"stability.":[128],"prepared":[132],"HSPC:cholesterol":[134],"(4.83:1":[135],"w/w":[136],"ratio)":[137],"exhibited":[138],"size":[140],"190":[142],"nm,":[143],"PDI":[144],"0.187,":[146],"-28.20":[150],"mV,":[151],"efficiency":[154],"47.80%.":[156],"It":[157],"showed":[158,197],"profile":[161],"75.41%":[163],"at":[167],"12":[168],"h":[169],"following":[170],"Korsmeyer-Peppas":[171],"kinetic":[172],"model.":[173],"TEM":[174],"analysis":[175],"confirmed":[176],"spherical,":[177],"nanosized,":[178],"unilamellar":[179],"vesicles,":[180],"DSC":[183],"indicated":[184],"successful":[185],"encapsulation.":[187],"permeation":[192,201],"across":[193],"human":[194],"plate":[196],"approximately":[198],"1.7-fold":[199],"higher":[200],"compared":[205],"to":[206],"pure":[207],"solution.":[209],"closely":[214],"matched":[215],"software-predicted":[217],"values":[218],"demonstrated":[220],"satisfactory":[229],"stability,":[231],"indicating":[232],"its":[233],"promising":[234],"prospects":[235],"as":[236],"transungual":[237],"system.":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}
