{"id":"https://openalex.org/W7225110431","doi":"https://doi.org/10.1007/s10157-026-02976-w","title":"Long-term outcomes of a quadruple calcineurin inhibitor-minimization regimen with everolimus introduced 3\u20136 months after kidney transplantation","display_name":"Long-term outcomes of a quadruple calcineurin inhibitor-minimization regimen with everolimus introduced 3\u20136 months after kidney transplantation","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225110431","doi":"https://doi.org/10.1007/s10157-026-02976-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42970195"},"language":"en","primary_location":{"id":"doi:10.1007/s10157-026-02976-w","doi":"https://doi.org/10.1007/s10157-026-02976-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10157-026-02976-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10157-026-02976-w.pdf","source":{"id":"https://openalex.org/S53361855","display_name":"Clinical and Experimental Nephrology","issn_l":"1342-1751","issn":["1342-1751","1437-7799"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10157-026-02976-w.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109793393","display_name":"Satoshi Kitamura","orcid":"https://orcid.org/0009-0008-1464-4364","observed_orcids":["https://orcid.org/0009-0008-1464-4364"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kitamura","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059978896","display_name":"Yoji Hyodo","orcid":"https://orcid.org/0000-0002-9553-0981","observed_orcids":["https://orcid.org/0000-0002-9553-0981"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoji Hyodo","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan. yhyodo@med.kobe-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-9553-0981","affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan. yhyodo@med.kobe-u.ac.jp","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082515762","display_name":"Yuki Tashiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Tashiro","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000051416","display_name":"Takahito Endo","orcid":"https://orcid.org/0000-0003-2338-6711","observed_orcids":["https://orcid.org/0000-0003-2338-6711"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahito Endo","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160386547","display_name":"Naoki Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Yokoyama","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032900550","display_name":"Takuto Hara","orcid":"https://orcid.org/0000-0003-4524-2815","observed_orcids":["https://orcid.org/0000-0003-4524-2815"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuto Hara","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067691014","display_name":"Koji Chiba","orcid":"https://orcid.org/0000-0001-5575-0667","observed_orcids":["https://orcid.org/0000-0001-5575-0667"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Chiba","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101684236","display_name":"Hideaki Miyake","orcid":"https://orcid.org/0000-0003-0563-4160","observed_orcids":["https://orcid.org/0000-0003-0563-4160"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Miyake","raw_affiliation_strings":["Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, 650-0017, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059978896"],"corresponding_institution_ids":["https://openalex.org/I65837984"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8972722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/calcineurin-inhibitor-minimization","display_name":"calcineurin inhibitor minimization","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.925000011920929},{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":0.9660000205039978},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.968999981880188},{"id":"https://openalex.org/keywords/quadruple-immunosuppression","display_name":"quadruple immunosuppression","score":0.8270000219345093},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.9309999942779541},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.964900016784668},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.7955999970436096},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.7062000036239624},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6376000046730042},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.6190000176429749},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5922999978065491},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5867999792098999},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.5285999774932861},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5278000235557556},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.511900007724762},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45410001277923584},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C2778033501","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolic acid","level":3,"score":0.44999998807907104},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42640000581741333},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.41690000891685486},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.3953000009059906},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.35030001401901245},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.32030001282691956},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.3181000053882599},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2781307858","wikidata":"https://www.wikidata.org/wiki/Q418702","display_name":"Basiliximab","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.26030001044273376}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s10157-026-02976-w","doi":"https://doi.org/10.1007/s10157-026-02976-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10157-026-02976-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10157-026-02976-w.pdf","source":{"id":"https://openalex.org/S53361855","display_name":"Clinical and Experimental Nephrology","issn_l":"1342-1751","issn":["1342-1751","1437-7799"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Nephrology","raw_type":"journal-article"},{"id":"pmid:42970195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42970195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental nephrology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10157-026-02976-w","doi":"https://doi.org/10.1007/s10157-026-02976-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10157-026-02976-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10157-026-02976-w.pdf","source":{"id":"https://openalex.org/S53361855","display_name":"Clinical and Experimental Nephrology","issn_l":"1342-1751","issn":["1342-1751","1437-7799"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Nephrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320318705","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225110431.pdf","grobid_xml":"https://content.openalex.org/works/W7225110431.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W138823017","https://openalex.org/W1480181413","https://openalex.org/W1597697188","https://openalex.org/W1600996638","https://openalex.org/W1688730716","https://openalex.org/W1969510397","https://openalex.org/W1984110560","https://openalex.org/W1987234463","https://openalex.org/W1990018039","https://openalex.org/W2044600432","https://openalex.org/W2045028110","https://openalex.org/W2071302339","https://openalex.org/W2074433596","https://openalex.org/W2088411775","https://openalex.org/W2101302191","https://openalex.org/W2299019178","https://openalex.org/W2313107754","https://openalex.org/W2400889191","https://openalex.org/W2561091271","https://openalex.org/W2625903344","https://openalex.org/W2799859234","https://openalex.org/W2801490541","https://openalex.org/W2891183647","https://openalex.org/W3009348385","https://openalex.org/W4206156186","https://openalex.org/W4409527019"],"related_works":["https://openalex.org/W2991530110","https://openalex.org/W2575825528","https://openalex.org/W4412882741","https://openalex.org/W2616025232","https://openalex.org/W3134991919","https://openalex.org/W3021012257","https://openalex.org/W2754475484","https://openalex.org/W2400889191","https://openalex.org/W3128618311","https://openalex.org/W4205869896"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quadruple":[1],"maintenance":[2],"immunosuppression":[3],"with":[4,48,97,159,173,209],"everolimus":[5],"(EVR),":[6],"low-dose":[7,210],"tacrolimus":[8],"(TAC),":[9],"mycophenolate":[10],"mofetil,":[11],"and":[12,59,64,82,113,118,121,127,180,217,228],"methylprednisolone":[13],"may":[14,225],"improve":[15],"allograft":[16],"survival":[17,109,123,187,219],"by":[18,200],"reducing":[19],"calcineurin":[20],"inhibitor":[21],"exposure;":[22],"however,":[23],"real-world":[24],"long-term":[25],"data":[26],"on":[27,100,161],"delayed":[28],"EVR":[29,49,74,153,204],"introduction":[30,205],"remain":[31],"limited.":[32],"METHODS:":[33],"We":[34],"retrospectively":[35],"analyzed":[36],"186":[37],"adult":[38],"primary":[39],"kidney":[40],"transplant":[41],"recipients":[42,99],"who":[43],"received":[44],"this":[45],"quadruple":[46],"regimen":[47],"introduced":[50],"3-6":[51,207],"months":[52,208],"post-transplantation":[53],"in":[54,132,141,148],"2013-2023.":[55],"Outcomes":[56],"included":[57],"graft":[58,108,176,216],"patient":[60,122,186,218,223],"survival,":[61,177],"post-transplant":[62],"complications,":[63],"EVR-related":[65,138],"adverse":[66],"events":[67],"(AEs).":[68],"The":[69],"association":[70],"between":[71],"the":[72,135,170],"initial":[73,152],"dose":[75,154],"adjusted":[76],"for":[77],"body":[78],"surface":[79],"area":[80],"(BSA)":[81],"AEs":[83,139,160],"was":[84,110,124,157,188,212],"evaluated.":[85],"In":[86,169],"a":[87,195],"secondary":[88],"landmark":[89],"analysis":[90,163],"from":[91],"1":[92],"year,":[93],"outcomes":[94],"were":[95,220],"compared":[96],"contemporaneous":[98],"triple":[101,174],"therapy":[102],"using":[103],"overlap":[104],"weighting.":[105],"RESULTS:":[106],"Death-censored":[107],"99.5%,":[111,112],"97.0%":[114],"at":[115,206],"3,":[116],"5,":[117],"10":[119],"years,":[120],"98.9%,":[125],"98.2%,":[126],"97.4%.":[128],"Clinical":[129],"rejection":[130],"occurred":[131,140],"4.8%":[133],"within":[134],"first":[136],"year.":[137],"28.0%":[142],"of":[143],"patients,":[144],"leading":[145],"to":[146],"discontinuation":[147],"9.1%.":[149],"A":[150],"higher":[151,189],"per":[155],"BSA":[156],"associated":[158],"univariate":[162],"but":[164,222],"not":[165,183],"after":[166],"multivariable":[167],"adjustment.":[168],"weighted":[171],"comparison":[172],"therapy,":[175],"renal":[178],"function,":[179],"proteinuria":[181],"did":[182],"differ,":[184],"whereas":[185],"(HR":[190],"0.17,":[191],"95%":[192],"CI":[193],"0.03-0.82),":[194],"difference":[196],"possibly":[197],"reflecting":[198],"confounding":[199],"indication.":[201],"CONCLUSIONS:":[202],"Delayed":[203],"TAC":[211],"well":[213],"tolerated.":[214],"Long-term":[215],"favorable,":[221],"selection":[224],"have":[226],"contributed,":[227],"prospective":[229],"evaluation":[230],"is":[231],"needed.":[232]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}