{"id":"https://openalex.org/W7225106510","doi":"https://doi.org/10.1016/j.jfma.2026.10.041","title":"Dexmedetomidine and transversus abdominis plane block in multimodal general anesthesia for postoperative patient-controlled analgesia after uterine surgery: a propensity-score-matched cohort study","display_name":"Dexmedetomidine and transversus abdominis plane block in multimodal general anesthesia for postoperative patient-controlled analgesia after uterine surgery: a propensity-score-matched cohort study","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225106510","doi":"https://doi.org/10.1016/j.jfma.2026.10.041","pmid":"https://pubmed.ncbi.nlm.nih.gov/42967844"},"language":"en","primary_location":{"id":"doi:10.1016/j.jfma.2026.10.041","doi":"https://doi.org/10.1016/j.jfma.2026.10.041","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jfma.2026.10.041","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0929664626009770/pdf","source":{"id":"https://openalex.org/S2755764997","display_name":"Journal of the Formosan Medical Association","issn_l":"0929-6646","issn":["0929-6646","1876-0821"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Formosan Medical Association","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0929664626009770/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058724025","display_name":"Feng-Sheng Lin","orcid":"https://orcid.org/0000-0001-7798-9716","observed_orcids":["https://orcid.org/0000-0001-7798-9716"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Feng-Sheng Lin","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058579232","display_name":"Wei\u2010Han Chou","orcid":"https://orcid.org/0000-0001-6868-3985","observed_orcids":["https://orcid.org/0000-0001-6868-3985"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Han Chou","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160364171","display_name":"Yi-Hsin Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Hsin Chiu","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147342430","display_name":"I-Ling Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Ling Hsu","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160343479","display_name":"Hui-Min Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Min Kao","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039930231","display_name":"Ping-Ju Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ping-Ju Chen","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan. Electronic address: pjchen1991@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan. Electronic address: pjchen1991@gmail.com","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160380510","display_name":"Chun-Yu Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Yu Wu","raw_affiliation_strings":["Department of Anesthesiology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan; College of Medicine, National Taiwan University, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan; College of Medicine, National Taiwan University, Taiwan","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039930231"],"corresponding_institution_ids":["https://openalex.org/I4210131804"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89610314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transversus-abdominis-plane-block","display_name":"transversus abdominis plane block","score":0.9980000257492065},{"id":"https://openalex.org/keywords/patient-controlled-analgesia","display_name":"patient-controlled analgesia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/uterine-surgery","display_name":"uterine surgery","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hysterectomy","display_name":"hysterectomy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/myomectomy","display_name":"myomectomy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/morphine-consumption","display_name":"morphine consumption","score":0.9020000100135803},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.7749999761581421},{"id":"https://openalex.org/keywords/regional-analgesia","display_name":"regional analgesia","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9706000089645386},{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.9258999824523926},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7764000296592712},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.7400000095367432},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5838000178337097},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5379999876022339},{"id":"https://openalex.org/C2779494336","wikidata":"https://www.wikidata.org/wiki/Q550675","display_name":"Hysterectomy","level":2,"score":0.4433000087738037},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.44200000166893005},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41850000619888306},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4124000072479248},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.367900013923645},{"id":"https://openalex.org/C2776045914","wikidata":"https://www.wikidata.org/wiki/Q1382057","display_name":"Patient-controlled analgesia","level":3,"score":0.33709999918937683},{"id":"https://openalex.org/C2994102832","wikidata":"https://www.wikidata.org/wiki/Q81938","display_name":"Postoperative pain","level":2,"score":0.31450000405311584},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.296999990940094},{"id":"https://openalex.org/C2776572635","wikidata":"https://www.wikidata.org/wiki/Q3272027","display_name":"Levobupivacaine","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C2776983577","wikidata":"https://www.wikidata.org/wiki/Q166543","display_name":"General anaesthesia","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C2777704003","wikidata":"https://www.wikidata.org/wiki/Q4959802","display_name":"Breast surgery","level":4,"score":0.25040000677108765}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jfma.2026.10.041","doi":"https://doi.org/10.1016/j.jfma.2026.10.041","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jfma.2026.10.041","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0929664626009770/pdf","source":{"id":"https://openalex.org/S2755764997","display_name":"Journal of the Formosan Medical Association","issn_l":"0929-6646","issn":["0929-6646","1876-0821"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Formosan Medical Association","raw_type":"journal-article"},{"id":"pmid:42967844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42967844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Formosan Medical Association = Taiwan yi zhi","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jfma.2026.10.041","doi":"https://doi.org/10.1016/j.jfma.2026.10.041","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jfma.2026.10.041","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0929664626009770/pdf","source":{"id":"https://openalex.org/S2755764997","display_name":"Journal of the Formosan Medical Association","issn_l":"0929-6646","issn":["0929-6646","1876-0821"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Formosan Medical Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225106510.pdf","grobid_xml":"https://content.openalex.org/works/W7225106510.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W2018628127","https://openalex.org/W2040880477","https://openalex.org/W2065506323","https://openalex.org/W2066946879","https://openalex.org/W2067445466","https://openalex.org/W2111635289","https://openalex.org/W2126049444","https://openalex.org/W2136860059","https://openalex.org/W2141857327","https://openalex.org/W2315213761","https://openalex.org/W2465129494","https://openalex.org/W2560115237","https://openalex.org/W2573324045","https://openalex.org/W2595548800","https://openalex.org/W2789554341","https://openalex.org/W2902566073","https://openalex.org/W2918317484","https://openalex.org/W2961010871","https://openalex.org/W2964791155","https://openalex.org/W2980177983","https://openalex.org/W3033225790","https://openalex.org/W3048426041","https://openalex.org/W3121724601","https://openalex.org/W3211963545","https://openalex.org/W4210687445","https://openalex.org/W4224115577","https://openalex.org/W4377221438","https://openalex.org/W4386845947","https://openalex.org/W4400748040","https://openalex.org/W4401200001","https://openalex.org/W4412002296","https://openalex.org/W7118181039","https://openalex.org/W7127328527"],"related_works":["https://openalex.org/W2808348503","https://openalex.org/W2414384010","https://openalex.org/W2972864192","https://openalex.org/W6892933894","https://openalex.org/W7125812183","https://openalex.org/W4206363959","https://openalex.org/W2901727583","https://openalex.org/W4315651798","https://openalex.org/W2069578957","https://openalex.org/W7125526763"],"abstract_inverted_index":{"BACKGROUND:":[0],"Multimodal":[1],"general":[2,84],"anesthesia":[3,85],"(MGA)":[4],"combines":[5],"hypnotic":[6],"adjuvants":[7],"and":[8,29,62,81,106,135,143,166,178,189,195],"regional":[9],"analgesia,":[10],"but":[11],"their":[12],"individual":[13],"contributions":[14],"to":[15],"postoperative":[16,220],"patient-controlled":[17],"analgesia":[18],"(PCA)":[19],"remain":[20],"unclear.":[21],"This":[22,43],"study":[23,47],"evaluated":[24],"the":[25,91,126,133,214],"effects":[26],"of":[27],"dexmedetomidine":[28,73],"transversus":[30],"abdominis":[31],"plane":[32],"(TAP)":[33],"block":[34,78,168,212],"on":[35],"PCA-derived":[36],"analgesic":[37],"outcomes":[38,97],"after":[39,208],"uterine":[40,209],"surgery.":[41],"METHODS:":[42],"single-center":[44],"retrospective":[45],"propensity-score-matched":[46],"included":[48,98],"adult":[49],"women":[50,204],"undergoing":[51],"elective":[52],"hysterectomy":[53],"or":[54],"myomectomy":[55],"with":[56,72,116,132,219,228],"morphine-based":[57],"intravenous":[58],"PCA":[59,93,207,231],"between":[60,164,187],"2021":[61],"2024.":[63],"Patients":[64],"were":[65,114,198],"matched":[66],"1:1:1":[67],"into":[68],"three":[69],"groups:":[70],"MGA":[71,123,165,171,188,225],"plus":[74],"TAP":[75,77,167,211],"block,":[76],"without":[79,234],"dexmedetomidine,":[80],"conventional":[82],"balanced":[83],"alone.":[86,169],"The":[87,122,170],"primary":[88],"outcome":[89],"was":[90,213,226],"48-h":[92,128],"demand/delivery":[94,129,232],"ratio.":[95],"Secondary":[96],"morphine":[99,155,159,206,221],"consumption,":[100],"pain":[101,181],"scores,":[102],"PCA-related":[103,192],"adverse":[104,193,236],"events,":[105],"prescription":[107],"re-adjustment.":[108],"RESULTS:":[109],"After":[110],"matching,":[111],"192":[112],"patients":[113,118],"analyzed,":[115],"64":[117],"in":[119],"each":[120],"group.":[121],"group":[124,172],"had":[125,173],"lowest":[127],"ratio":[130,233],"compared":[131],"TAP-block":[134,190],"control":[136],"groups":[137,152],"(1.00":[138],"[1.00-1.13]":[139],"vs.":[140],"1.06":[141],"[1.00-1.35]":[142],"1.09":[144],"[1.00-1.40],":[145],"respectively;":[146],"p":[147],"=":[148],"0.013).":[149],"Both":[150],"TAP-containing":[151],"consumed":[153],"less":[154],"than":[156,182],"controls,":[157],"whereas":[158,223],"consumption":[160],"did":[161],"not":[162],"differ":[163],"lower":[174,230],"intraoperative":[175],"fentanyl":[176],"requirement":[177],"postoperative-day-1":[179],"dynamic":[180],"controls;":[183],"neither":[184],"differed":[185],"significantly":[186],"groups.":[191,201],"events":[194],"re-adjustment":[196],"rates":[197],"comparable":[199],"among":[200],"CONCLUSION:":[202],"In":[203],"receiving":[205],"surgery,":[210],"component":[215],"most":[216],"consistently":[217],"associated":[218,227],"sparing,":[222],"dexmedetomidine-containing":[224],"a":[229],"increased":[235],"events.":[237]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}