{"id":"https://openalex.org/W7225106484","doi":"https://doi.org/10.2196/91035","title":"Topical Esomeprazole for the Prevention and Treatment of Radiation Dermatitis in Patients With Head and Neck Cancer: Protocol for a Phase 2 Randomized Controlled Trial","display_name":"Topical Esomeprazole for the Prevention and Treatment of Radiation Dermatitis in Patients With Head and Neck Cancer: Protocol for a Phase 2 Randomized Controlled Trial","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225106484","doi":"https://doi.org/10.2196/91035","pmid":"https://pubmed.ncbi.nlm.nih.gov/42970785"},"language":"en","primary_location":{"id":"doi:10.2196/91035","doi":"https://doi.org/10.2196/91035","is_oa":true,"landing_page_url":"https://doi.org/10.2196/91035","pdf_url":null,"source":{"id":"https://openalex.org/S2739058702","display_name":"JMIR Research Protocols","issn_l":"1929-0748","issn":["1929-0748"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Research Protocols","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2196/91035","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025418255","display_name":"Aaron T. Cheng","orcid":"https://orcid.org/0000-0002-5791-4896","observed_orcids":["https://orcid.org/0000-0002-5791-4896"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Cheng","raw_affiliation_strings":["Long School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0000-0002-5791-4896","affiliations":[{"raw_affiliation_string":"Long School of Medicine, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160336563","display_name":"Pavela Bambekova","orcid":"https://orcid.org/0009-0000-7498-9198","observed_orcids":["https://orcid.org/0009-0000-7498-9198"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavela Bambekova","raw_affiliation_strings":["Division of Dermatology, University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0009-0000-7498-9198","affiliations":[{"raw_affiliation_string":"Division of Dermatology, University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048885679","display_name":"Yohannes T. Ghebre","orcid":"https://orcid.org/0000-0002-2144-8600","observed_orcids":["https://orcid.org/0000-0002-2144-8600"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yohannes T Ghebre","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":"https://orcid.org/0000-0002-2144-8600","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]},{"raw_affiliation_string":"School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063417154","display_name":"Mark Bonnen","orcid":"https://orcid.org/0009-0000-6389-3182","observed_orcids":["https://orcid.org/0009-0000-6389-3182"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D Bonnen","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0009-0000-6389-3182","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012351961","display_name":"Timothy J. Wagner","orcid":"https://orcid.org/0000-0002-3958-212X","observed_orcids":["https://orcid.org/0000-0002-3958-212X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Wagner","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0000-0002-3958-212X","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160350469","display_name":"Sandra Osswald","orcid":"https://orcid.org/0009-0007-1635-9295","observed_orcids":["https://orcid.org/0009-0007-1635-9295"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Osswald","raw_affiliation_strings":["Division of Dermatology, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0009-0007-1635-9295","affiliations":[{"raw_affiliation_string":"Division of Dermatology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160339863","display_name":"Carol Jenkins","orcid":"https://orcid.org/0009-0009-5777-9725","observed_orcids":["https://orcid.org/0009-0009-5777-9725"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Jenkins","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0009-0009-5777-9725","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160388308","display_name":"Pia Roperes","orcid":"https://orcid.org/0009-0003-0765-3530","observed_orcids":["https://orcid.org/0009-0003-0765-3530"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pia Roperes","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0009-0003-0765-3530","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031717800","display_name":"Shraddha Mahesh Dalwadi","orcid":"https://orcid.org/0000-0003-1971-0523","observed_orcids":["https://orcid.org/0000-0003-1971-0523"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039360","display_name":"Mays Cancer Center at UT Health San Antonio","ror":"https://ror.org/04aysmc18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I165951966","https://openalex.org/I4390039360","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shraddha Dalwadi","raw_affiliation_strings":["Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States"],"raw_orcid":"https://orcid.org/0000-0003-1971-0523","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Health at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4390039360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88085938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":"e91035","last_page":"e91035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-dermatitis","display_name":"radiation dermatitis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/esomeprazole","display_name":"esomeprazole","score":0.9490000009536743},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7919999957084656},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dose-volume-parameters","display_name":"dose-volume parameters","score":0.7509999871253967},{"id":"https://openalex.org/keywords/antifibrotic-effect","display_name":"antifibrotic effect","score":0.6690000295639038},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.32600000500679016},{"id":"https://openalex.org/keywords/skindex-16","display_name":"Skindex-16","score":0.7020000219345093},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7900000214576721},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9492999911308289},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7700999975204468},{"id":"https://openalex.org/C2778204628","wikidata":"https://www.wikidata.org/wiki/Q553223","display_name":"Esomeprazole","level":2,"score":0.6546000242233276},{"id":"https://openalex.org/C2777793932","wikidata":"https://www.wikidata.org/wiki/Q1116229","display_name":"Common Terminology Criteria for Adverse Events","level":3,"score":0.6377999782562256},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48919999599456787},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.47440001368522644},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43560001254081726},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.42800000309944153},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3783999979496002},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.3610000014305115},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.35359999537467957},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.35120001435279846},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C2779517570","wikidata":"https://www.wikidata.org/wiki/Q7144954","display_name":"Patient-reported outcome","level":3,"score":0.32109999656677246},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31630000472068787},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011855","descriptor_name":"Radiodermatitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064098","descriptor_name":"Esomeprazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D064098","descriptor_name":"Esomeprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2196/91035","doi":"https://doi.org/10.2196/91035","is_oa":true,"landing_page_url":"https://doi.org/10.2196/91035","pdf_url":null,"source":{"id":"https://openalex.org/S2739058702","display_name":"JMIR Research Protocols","issn_l":"1929-0748","issn":["1929-0748"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Research Protocols","raw_type":"journal-article"},{"id":"doi:10.2196/preprints.91035","doi":"https://doi.org/10.2196/preprints.91035","is_oa":false,"landing_page_url":"https://doi.org/10.2196/preprints.91035","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42970785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42970785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR research protocols","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2196/91035","doi":"https://doi.org/10.2196/91035","is_oa":true,"landing_page_url":"https://doi.org/10.2196/91035","pdf_url":null,"source":{"id":"https://openalex.org/S2739058702","display_name":"JMIR Research Protocols","issn_l":"1929-0748","issn":["1929-0748"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Research Protocols","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2001009396","https://openalex.org/W2001738446","https://openalex.org/W2004020565","https://openalex.org/W2025605750","https://openalex.org/W2034192147","https://openalex.org/W2043945205","https://openalex.org/W2050150145","https://openalex.org/W2092803489","https://openalex.org/W2093485019","https://openalex.org/W2093672204","https://openalex.org/W2148907713","https://openalex.org/W2155817714","https://openalex.org/W2171811563","https://openalex.org/W2443565029","https://openalex.org/W2760357872","https://openalex.org/W2765574040","https://openalex.org/W2765631041","https://openalex.org/W2919724920","https://openalex.org/W2968793187","https://openalex.org/W3020342575","https://openalex.org/W3036562742","https://openalex.org/W3090392120","https://openalex.org/W3100165832","https://openalex.org/W3127854198","https://openalex.org/W3208871130","https://openalex.org/W3215209645","https://openalex.org/W4225087946","https://openalex.org/W4248690752","https://openalex.org/W4379513321","https://openalex.org/W4415421909"],"related_works":["https://openalex.org/W7163175794","https://openalex.org/W2891753617","https://openalex.org/W3088647995","https://openalex.org/W4402106746","https://openalex.org/W3167374765","https://openalex.org/W3081458909","https://openalex.org/W2407447915","https://openalex.org/W4387160290","https://openalex.org/W2968793187","https://openalex.org/W2759580121"],"abstract_inverted_index":{"BACKGROUND:":[0],"Radiation":[1],"dermatitis":[2,310],"(RD)":[3],"is":[4,45,124,192],"a":[5,58,125,132],"common":[6],"and":[7,26,39,70,93,109,146,179,195,239,249,269,281,298,312,320,330,376,384],"clinically":[8,112],"significant":[9,113],"toxicity":[10],"affecting":[11],"the":[12,89,107,193,204,219,260,374],"majority":[13],"of":[14,34,95,111,138,154,186,197,251,256,304,340,378,388],"patients":[15,116,360],"undergoing":[16,361],"external":[17],"beam":[18],"radiation":[19,187,221,263,306,362],"therapy,":[20,363],"particularly":[21],"those":[22],"treated":[23],"for":[24,49,212,296,302,309,373],"head":[25,145],"neck":[27,147],"cancer":[28],"(HNC).":[29],"RD":[30,114,358],"can":[31],"impair":[32],"quality":[33,255,303,387],"life,":[35,305],"limit":[36],"treatment":[37,202,237,371],"intensity,":[38],"compromise":[40],"oncologic":[41],"outcomes;":[42],"yet,":[43],"there":[44],"no":[46],"established":[47],"standard-of-care":[48],"its":[50],"prevention":[51,375],"or":[52,171,369],"management.":[53],"Preclinical":[54],"studies":[55],"suggest":[56],"that":[57,73],"topically":[59],"reformulated":[60],"proton":[61],"pump":[62],"inhibitor":[63],"(PPI),":[64],"esomeprazole":[65],"(Dermaprazole),":[66],"has":[67,331],"antioxidant,":[68],"anti-inflammatory,":[69],"antifibrotic":[71],"properties":[72],"may":[74,365],"mitigate":[75],"radiation-induced":[76],"skin":[77],"injury.":[78],"OBJECTIVE:":[79],"This":[80,123],"phase":[81],"2":[82,182],"randomized":[83,128,165],"controlled":[84,129],"trial":[85,130],"aims":[86],"to":[87,150,166,247,346],"evaluate":[88],"potential":[90],"safety,":[91],"feasibility,":[92],"efficacy":[94,355],"prophylactic":[96],"topical":[97,169],"Dermaprazole":[98,170,353],"compared":[99],"with":[100,117,131,143,223,267,343],"standard":[101],"supportive":[102],"care":[103],"(Aquaphor)":[104],"in":[105,115,271,327,356,359],"reducing":[106,357,381],"incidence":[108],"severity":[110,196],"HNC":[118],"receiving":[119],"definitive":[120,152],"chemoradiation.":[121],"METHODS:":[122],"prospective,":[126],"single-center,":[127],"2:1":[133],"allocation":[134],"ratio.":[135],"A":[136],"total":[137],"45":[139],"adults":[140],"(\u226518":[141],"y)":[142],"biopsy-confirmed":[144],"malignancy":[148],"planned":[149],"receive":[151,167],"chemoradiation":[153],"at":[155,174],"least":[156],"66":[157],"Gy":[158],"will":[159,163,287,336],"be":[160,164,288,347],"enrolled.":[161],"Participants":[162],"twice-daily":[168],"Aquaphor":[172],"beginning":[173],"computed":[175],"tomography":[176],"(CT)":[177],"simulation":[178],"continuing":[180],"through":[181,290],"weeks":[183],"after":[184,321],"completion":[185,241,339],"therapy.":[188],"The":[189,324],"primary":[190],"outcome":[191],"rate":[194],"RD,":[198,254,379],"assessed":[199,258,289],"weekly":[200],"during":[201,390],"using":[203,259],"National":[205],"Cancer":[206],"Institute":[207],"(NCI)":[208],"Common":[209],"Terminology":[210],"Criteria":[211],"Adverse":[213],"Events":[214],"(CTCAE)":[215],"version":[216,293],"5":[217,294],"by":[218,349],"treating":[220],"oncologist,":[222],"blinded":[224],"dermatologic":[225],"assessment":[226],"based":[227],"on":[228],"standardized":[229],"medical":[230],"photography.":[231],"Feasibility":[232],"outcomes":[233,244,286],"include":[234,245],"accrual":[235],"rate,":[236],"compliance,":[238],"questionnaire":[240],"rates.":[242],"Secondary":[243],"time":[246],"onset":[248,297],"healing":[250],"grade":[252],"\u22652":[253],"life":[257,389],"Skindex-16":[261],"instrument,":[262],"dose":[264],"thresholds":[265],"associated":[266],"dermatitis,":[268],"changes":[270],"inflammatory":[272,314],"biomarkers":[273],"(C-reactive":[274],"protein,":[275],"tumor":[276],"necrosis":[277],"factor-\u03b1,":[278],"interleukin":[279],"[IL]-1\u03b2,":[280],"IL-6).":[282],"More":[283],"specifically,":[284],"secondary":[285],"serial":[291],"CTCAE":[292],"evaluations":[295],"healing,":[299],"Skindex16":[300],"questionnaires":[301],"dose-volume":[307],"parameters":[308],"thresholds,":[311],"serum":[313],"marker":[315],"concentration":[316],"measurements":[317],"before,":[318],"during,":[319],"treatment.":[322],"RESULTS:":[323],"study":[325],"began":[326],"June":[328],"2022":[329],"completed":[332],"enrollment.":[333],"Data":[334],"analysis":[335],"commence":[337],"following":[338],"data":[341],"collection,":[342],"results":[344],"expected":[345],"published":[348],"2027.":[350],"CONCLUSIONS:":[351],"Should":[352],"demonstrate":[354],"it":[364],"offer":[366],"an":[367],"alternative":[368],"adjunctive":[370],"option":[372],"management":[377],"potentially":[380],"treatment-related":[382],"morbidity":[383],"improving":[385],"patients'":[386],"radiotherapy.":[391],"TRIAL":[392],"REGISTRATION:":[393],"ClinicalTrials.gov":[394],"NCT04865731;":[395],"https://clinicaltrials.gov/study/NCT04865731.":[396],"INTERNATIONAL":[397],"REGISTERED":[398],"REPORT":[399],"IDENTIFIER":[400],"(IRRID):":[401],"DERR1-10.2196/91035.":[402]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}