{"id":"https://openalex.org/W7225104102","doi":"https://doi.org/10.1177/0271678x261505273","title":"EXPRESS: Distinct pressure- and flow-driven propagation pathways of low-frequency oscillations in the human brain","display_name":"EXPRESS: Distinct pressure- and flow-driven propagation pathways of low-frequency oscillations in the human brain","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225104102","doi":"https://doi.org/10.1177/0271678x261505273","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968203"},"language":"en","primary_location":{"id":"doi:10.1177/0271678x261505273","doi":"https://doi.org/10.1177/0271678x261505273","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0271678x261505273","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046196906","display_name":"Adam M. Wright","orcid":"https://orcid.org/0000-0001-9524-2210","observed_orcids":["https://orcid.org/0000-0001-9524-2210"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam M Wright","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":"https://orcid.org/0000-0001-9524-2210","affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160382820","display_name":"Dennis Kountouris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Kountouris","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057996182","display_name":"Vidhya Vijayakrishnan Nair","orcid":"https://orcid.org/0000-0002-9454-8645","observed_orcids":["https://orcid.org/0000-0002-9454-8645"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidhya V Nair","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":"https://orcid.org/0000-0002-9454-8645","affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012404873","display_name":"Brianna R. Kish","orcid":"https://orcid.org/0000-0001-5906-1295","observed_orcids":["https://orcid.org/0000-0001-5906-1295"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brianna R Kish","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States"],"raw_orcid":"https://orcid.org/0000-0001-5906-1295","affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000988295","display_name":"Qiuting Wen","orcid":"https://orcid.org/0000-0002-7885-4036","observed_orcids":["https://orcid.org/0000-0002-7885-4036"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiuting Wen","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":"https://orcid.org/0000-0002-7885-4036","affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005065459","display_name":"Yunjie Tong","orcid":"https://orcid.org/0000-0001-6052-8913","observed_orcids":["https://orcid.org/0000-0001-6052-8913"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yunjie Tong","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States"],"raw_orcid":"https://orcid.org/0000-0001-6052-8913","affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005065459"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85469608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"271678X261505273","last_page":"271678X261505273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-frequency-oscillations","display_name":"low-frequency oscillations","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pressure-transmission","display_name":"pressure transmission","score":0.6370000243186951},{"id":"https://openalex.org/keywords/superior-sagittal-sinus","display_name":"superior sagittal sinus","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cerebral-arteries","display_name":"cerebral arteries","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bold-signal","display_name":"BOLD signal","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cerebrovascular-physiology","display_name":"cerebrovascular physiology","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.7681999802589417},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6676999926567078},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.526199996471405},{"id":"https://openalex.org/C2776620988","wikidata":"https://www.wikidata.org/wiki/Q4115976","display_name":"Superior sagittal sinus","level":3,"score":0.4544999897480011},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4528999924659729},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4099999964237213},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.4041000008583069},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3971000015735626},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.39010000228881836},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.3671000003814697},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.34549999237060547},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3391000032424927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33640000224113464},{"id":"https://openalex.org/C171614378","wikidata":"https://www.wikidata.org/wiki/Q5064093","display_name":"Cerebral arteries","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C2982720008","wikidata":"https://www.wikidata.org/wiki/Q70680914","display_name":"Cerebral blood volume","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C3020437955","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Human blood","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.2913999855518341},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C2776407911","wikidata":"https://www.wikidata.org/wiki/Q7525187","display_name":"Sinus (botany)","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2743000090122223},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.27149999141693115},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.2549999952316284},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.25279998779296875},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/0271678x261505273","doi":"https://doi.org/10.1177/0271678x261505273","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0271678x261505273","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},{"id":"pmid:42968203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2784286959","https://openalex.org/W2029995174","https://openalex.org/W2774829721","https://openalex.org/W4411980008","https://openalex.org/W4417116460","https://openalex.org/W4383566720","https://openalex.org/W4414236137","https://openalex.org/W2271529269","https://openalex.org/W1977244523","https://openalex.org/W2976406642"],"abstract_inverted_index":{"IntroductionLow-frequency":[0],"oscillations":[1],"(LFOs)":[2],"are":[3],"emerging":[4],"as":[5,24,41],"key":[6],"drivers":[7],"of":[8,65,156,169],"brain":[9],"fluid":[10],"dynamics,":[11],"and":[12,73,81,85,97,109,136,153],"through":[13],"functional":[14],"MRI":[15],"(fMRI)":[16],"studies,":[17],"systemic":[18],"LFOs":[19],"(sLFOs)":[20],"have":[21],"been":[22,39],"identified":[23],"endogenous":[25],"contrast":[26],"agents":[27],"that":[28],"track":[29],"cerebral":[30,35,66],"blood":[31,44,144],"flow.":[32],"However,":[33],"their":[34,106,170],"propagation":[36,64,160],"has":[37],"largely":[38],"interpreted":[40],"reflecting":[42,130],"slow":[43],"flow,":[45],"potentially":[46],"overlooking":[47],"a":[48,58,124,137,166],"faster":[49],"pressure":[50,127],"transmission":[51,110,128,133],"mechanism.":[52],"In":[53],"this":[54],"work,":[55],"we":[56],"propose":[57],"comprehensive":[59,167],"physiological":[60],"framework":[61],"for":[62],"the":[63,151],"vascular":[67],"sLFOs,":[68,157],"leveraging":[69],"both":[70],"blood-oxygen-level-dependent":[71],"(BOLD)":[72],"non-BOLD":[74],"fMRI":[75,96],"signal":[76],"components":[77,155],"to":[78,99,104,176],"capture":[79],"flow-":[80],"velocity-driven":[82],"dynamics.MethodsCerebral":[83],"artery":[84],"superior":[86],"sagittal":[87],"sinus":[88],"(SSS)":[89],"sLFOs":[90,103,115],"(0.01-0.15":[91],"Hz)":[92],"were":[93],"extracted":[94],"from":[95],"time-locked":[98],"gray":[100],"matter":[101],"(GM)":[102],"characterize":[105],"temporal":[107,118],"coupling":[108],"patterns.ResultsIn":[111],"605":[112],"subjects,":[113],"artery-GM-SSS":[114],"exhibited":[116],"strong":[117],"coupling,":[119],"revealing":[120,158],"two":[121],"distinct":[122,159],"pathways:":[123],"rapid,":[125],"millisecond-scale":[126],"route":[129,140],"intracranial":[131],"pulse":[132],"(~100":[134],"milliseconds),":[135],"slower,":[138],"second-scale":[139],"consistent":[141],"with":[142,162],"artery-to-capillary-to-venous":[143],"flow":[145],"transit":[146],"(~5":[147],"seconds).DiscussionThese":[148],"findings":[149],"distinguish":[150],"pressure-":[152],"flow-driven":[154],"pathways":[161],"different":[163],"timescales,":[164],"providing":[165],"characterization":[168],"underlying":[171],"physiology,":[172],"enabling":[173],"new":[174],"approaches":[175],"investigate":[177],"cerebrovascular":[178],"health":[179],"using":[180],"fMRI.":[181]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}