{"id":"https://openalex.org/W7225101614","doi":"https://doi.org/10.3389/fmed.2026.2011703","title":"The dual role of small EVs in asthma and chronic obstructive pulmonary disease: from pathogenesis to clinical translation","display_name":"The dual role of small EVs in asthma and chronic obstructive pulmonary disease: from pathogenesis to clinical translation","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225101614","doi":"https://doi.org/10.3389/fmed.2026.2011703"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.2011703","doi":"https://doi.org/10.3389/fmed.2026.2011703","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.2011703","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.2011703/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.2011703/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160334523","display_name":"Jun Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160359202","display_name":"Zhouqiang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhouqiang Li","raw_affiliation_strings":["Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160332087","display_name":"Haining Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haining Hu","raw_affiliation_strings":["Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160333595","display_name":"Guanzhu Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanzhu Wu","raw_affiliation_strings":["Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122809755","display_name":"Peng Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ye Peng","raw_affiliation_strings":["Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160371099","display_name":"Hualing Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hualing Zhang","raw_affiliation_strings":["Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ward II, Department of Respiratory and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital (Liuzhou Zhuang Medical Hospital)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160371099"],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74741129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-extracellular-vesicles","display_name":"small extracellular vesicles","score":0.996999979019165},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":1.0},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.949999988079071},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.9369999766349792},{"id":"https://openalex.org/keywords/liquid-biopsy-biomarkers","display_name":"liquid biopsy biomarkers","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lung-repair","display_name":"lung repair","score":0.5059999823570251},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.695900022983551},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6620000004768372},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6525999903678894},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6190999746322632},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5810999870300293},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5730000138282776},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5289000272750854},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4474000036716461},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.41519999504089355},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4101000130176544},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.40070000290870667},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.3917999863624573},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.39089998602867126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3885999917984009},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3853999972343445},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.34850001335144043},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3160000145435333},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.31209999322891235},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C2910285276","wikidata":"https://www.wikidata.org/wiki/Q395788","display_name":"Small airways","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C3019440502","wikidata":"https://www.wikidata.org/wiki/Q500430","display_name":"Dual role","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.2563000023365021}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmed.2026.2011703","doi":"https://doi.org/10.3389/fmed.2026.2011703","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.2011703","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.2011703/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:05130f2e725747d3a3b143d30460afcc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/05130f2e725747d3a3b143d30460afcc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.2011703","doi":"https://doi.org/10.3389/fmed.2026.2011703","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.2011703","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.2011703/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327522","display_name":"Guangxi University","ror":"https://ror.org/02c9qn167"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225101614.pdf","grobid_xml":"https://content.openalex.org/works/W7225101614.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W2207291742","https://openalex.org/W2237376052","https://openalex.org/W2608201389","https://openalex.org/W2735330142","https://openalex.org/W2768241957","https://openalex.org/W2896616277","https://openalex.org/W2898749924","https://openalex.org/W2922418593","https://openalex.org/W2966670499","https://openalex.org/W2980563089","https://openalex.org/W2981683125","https://openalex.org/W2984026219","https://openalex.org/W2984418064","https://openalex.org/W3005104290","https://openalex.org/W3044261814","https://openalex.org/W3112741558","https://openalex.org/W3118504473","https://openalex.org/W3118516145","https://openalex.org/W3137097754","https://openalex.org/W3154309549","https://openalex.org/W3157459040","https://openalex.org/W3158284748","https://openalex.org/W3160157164","https://openalex.org/W3161635549","https://openalex.org/W3161861684","https://openalex.org/W3188331302","https://openalex.org/W3196266381","https://openalex.org/W3207987303","https://openalex.org/W3217044600","https://openalex.org/W4205542544","https://openalex.org/W4206445785","https://openalex.org/W4210441610","https://openalex.org/W4220703150","https://openalex.org/W4225286519","https://openalex.org/W4226293947","https://openalex.org/W4281767471","https://openalex.org/W4288038420","https://openalex.org/W4292599047","https://openalex.org/W4292882166","https://openalex.org/W4294843261","https://openalex.org/W4306411818","https://openalex.org/W4327811717","https://openalex.org/W4365509230","https://openalex.org/W4376131095","https://openalex.org/W4385597198","https://openalex.org/W4387958254","https://openalex.org/W4388982310","https://openalex.org/W4391649568","https://openalex.org/W4391687140","https://openalex.org/W4392016425","https://openalex.org/W4392165337","https://openalex.org/W4392729420","https://openalex.org/W4395695798","https://openalex.org/W4396495744","https://openalex.org/W4399095933","https://openalex.org/W4399651313","https://openalex.org/W4399789295","https://openalex.org/W4400560746","https://openalex.org/W4400981524","https://openalex.org/W4401993181","https://openalex.org/W4402962854","https://openalex.org/W4406939251","https://openalex.org/W4407002118","https://openalex.org/W4408380425","https://openalex.org/W4409737667","https://openalex.org/W4409839586","https://openalex.org/W4411100385","https://openalex.org/W4411897754","https://openalex.org/W4412557893","https://openalex.org/W4412618790","https://openalex.org/W4413930130","https://openalex.org/W4414095797","https://openalex.org/W4415615498","https://openalex.org/W7113895293","https://openalex.org/W7125775108","https://openalex.org/W7128505483","https://openalex.org/W7128518324","https://openalex.org/W7128585927","https://openalex.org/W7130569817","https://openalex.org/W7130942376","https://openalex.org/W7133507874","https://openalex.org/W7134914537","https://openalex.org/W7135401402","https://openalex.org/W7138913449","https://openalex.org/W7138940823","https://openalex.org/W7140225297","https://openalex.org/W7153615968","https://openalex.org/W7154479696","https://openalex.org/W7161257516","https://openalex.org/W7161559494","https://openalex.org/W7161985375","https://openalex.org/W7163873008","https://openalex.org/W7165950383","https://openalex.org/W7166874884","https://openalex.org/W7168239215","https://openalex.org/W7169801868","https://openalex.org/W7203909173","https://openalex.org/W7211916089"],"related_works":["https://openalex.org/W4416072294","https://openalex.org/W3128805692","https://openalex.org/W1986182160","https://openalex.org/W4408772645","https://openalex.org/W3041084658","https://openalex.org/W3160512018","https://openalex.org/W2981900708","https://openalex.org/W3119319695","https://openalex.org/W2543963901","https://openalex.org/W3135318173"],"abstract_inverted_index":{"Asthma":[0],"and":[1,53,60,69,81,93,99,105,126,133,144],"chronic":[2,11],"obstructive":[3],"pulmonary":[4],"disease":[5,23],"(COPD)":[6],"are":[7],"leading":[8],"causes":[9],"of":[10,33,44,114],"respiratory":[12],"morbidity,":[13],"yet":[14],"current":[15],"therapies":[16],"fail":[17],"to":[18,56],"halt":[19],"airway":[20,97],"remodeling":[21,100],"or":[22,101],"progression.":[24],"Small":[25],"extracellular":[26,34],"vesicles":[27,35],"(small":[28],"EVs),":[29],"a":[30],"nanoscale":[31],"subset":[32],"that":[36],"includes":[37],"exosomes,":[38],"have":[39],"emerged":[40],"as":[41,78,131],"key":[42],"mediators":[43],"intercellular":[45],"communication":[46],"in":[47,91,117,141],"the":[48,111],"lung,":[49],"transferring":[50],"proteins,":[51],"lipids":[52],"nucleic":[54],"acids":[55],"modulate":[57],"inflammation,":[58],"immunity":[59],"tissue":[61],"repair.":[62,107],"Their":[63],"cargo":[64],"reflects":[65],"donor":[66],"cell":[67],"state":[68],"can":[70],"be":[71],"sampled":[72],"from":[73],"biofluids,":[74],"suggesting":[75],"their":[76,123,128],"potential":[77,130],"liquid-biopsy":[79],"biomarkers":[80,132],"therapeutic":[82,135],"vehicles.":[83],"Notably,":[84],"small":[85,115],"EVs":[86,116],"exert":[87],"context-dependent":[88],"bidirectional":[89],"effects":[90],"asthma":[92],"COPD,":[94],"either":[95],"exacerbating":[96],"inflammation":[98],"suppressing":[102],"immune":[103],"responses":[104],"promoting":[106],"This":[108],"review":[109],"synthesizes":[110],"biological":[112],"functions":[113],"these":[118],"diseases,":[119],"dissects":[120],"mechanisms":[121],"underlying":[122],"dual":[124],"roles,":[125],"evaluates":[127],"translational":[129],"candidate":[134],"strategies,":[136],"while":[137],"outlining":[138],"critical":[139],"challenges":[140],"isolation,":[142],"standardization":[143],"clinical":[145],"validation.":[146]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}
