{"id":"https://openalex.org/W7225100982","doi":"https://doi.org/10.1590/1984-0462/2026/44/2026053","title":"NT-proBNP levels and arrhythmias in adolescents with chronic upper gastrointestinal diseases","display_name":"NT-proBNP levels and arrhythmias in adolescents with chronic upper gastrointestinal diseases","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7225100982","doi":"https://doi.org/10.1590/1984-0462/2026/44/2026053","pmid":"https://pubmed.ncbi.nlm.nih.gov/42987088","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13730238"},"language":"en","primary_location":{"id":"doi:10.1590/1984-0462/2026/44/2026053","doi":"https://doi.org/10.1590/1984-0462/2026/44/2026053","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1984-0462/2026/44/2026053","pdf_url":"https://www.scielo.br/j/rpp/a/wVmjcKHkPBbLCcsDk5DprzG/?lang=en&format=pdf","source":{"id":"https://openalex.org/S123735288","display_name":"Revista Paulista de Pediatria","issn_l":"0103-0582","issn":["0103-0582","1984-0462"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Paulista de Pediatria","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/rpp/a/wVmjcKHkPBbLCcsDk5DprzG/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029602003","display_name":"\u041d.\u0421. \u0428\u0435\u0432\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-4407-6050","observed_orcids":["https://orcid.org/0000-0003-4407-6050"]},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Natalia Shevchenko","raw_affiliation_strings":["V. N. Karazin Kharkiv National University"],"raw_orcid":"https://orcid.org/0000-0003-4407-6050","affiliations":[{"raw_affiliation_string":"V. N. Karazin Kharkiv National University","institution_ids":["https://openalex.org/I8765205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010039325","display_name":"N. V. \u041arutenko","orcid":"https://orcid.org/0000-0002-3236-0057","observed_orcids":["https://orcid.org/0000-0002-3236-0057"]},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nataliia Krutenko","raw_affiliation_strings":["V. N. Karazin Kharkiv National University"],"raw_orcid":"https://orcid.org/0000-0002-3236-0057","affiliations":[{"raw_affiliation_string":"V. N. Karazin Kharkiv National University","institution_ids":["https://openalex.org/I8765205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034661142","display_name":"T.V. Zimnytska","orcid":"https://orcid.org/0000-0002-9381-4075","observed_orcids":["https://orcid.org/0000-0002-9381-4075"]},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Tetiana Zimnytska","raw_affiliation_strings":["V. N. Karazin Kharkiv National University"],"raw_orcid":"https://orcid.org/0000-0002-9381-4075","affiliations":[{"raw_affiliation_string":"V. N. Karazin Kharkiv National University","institution_ids":["https://openalex.org/I8765205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021722261","display_name":"\u0412\u043e\u043b\u043e\u0448\u0438\u043d \u041a\u043e\u0441\u0442\u044f\u043d\u0442\u0438\u043d \u0412\u0456\u043a\u0442\u043e\u0440\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-8262-5159","observed_orcids":["https://orcid.org/0000-0001-8262-5159"]},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Kostiantyn Voloshyn","raw_affiliation_strings":["V. N. Karazin Kharkiv National University"],"raw_orcid":"https://orcid.org/0000-0001-8262-5159","affiliations":[{"raw_affiliation_string":"V. N. Karazin Kharkiv National University","institution_ids":["https://openalex.org/I8765205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111148950","display_name":"T. O. Holovko","orcid":"https://orcid.org/0000-0003-3815-7874","observed_orcids":["https://orcid.org/0000-0003-3815-7874"]},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Tetiana Holovko","raw_affiliation_strings":["V. N. Karazin Kharkiv National University"],"raw_orcid":"https://orcid.org/0000-0003-3815-7874","affiliations":[{"raw_affiliation_string":"V. N. Karazin Kharkiv National University","institution_ids":["https://openalex.org/I8765205"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8765205"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86156884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":null,"first_page":"e2026053","last_page":"e2026053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.25,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.25,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.13850000500679016,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9950000047683716},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.7549999952316284},{"id":"https://openalex.org/keywords/24-hour-holter-monitoring","display_name":"24-hour Holter monitoring","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/electrocardiographic-abnormalities","display_name":"electrocardiographic abnormalities","score":0.7580000162124634},{"id":"https://openalex.org/keywords/diagnostic-cut-off-values","display_name":"diagnostic thresholds","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9210000038146973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6456999778747559},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6330999732017517},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5837000012397766},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5633000135421753},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5110999941825867},{"id":"https://openalex.org/C2779812945","wikidata":"https://www.wikidata.org/wiki/Q1162673","display_name":"Holter monitor","level":3,"score":0.4690000116825104},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.46560001373291016},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.4059000015258789},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33739998936653137},{"id":"https://openalex.org/C14865658","wikidata":"https://www.wikidata.org/wiki/Q17003004","display_name":"Benign early repolarization","level":4,"score":0.30809998512268066},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.2946999967098236},{"id":"https://openalex.org/C2775846464","wikidata":"https://www.wikidata.org/wiki/Q66360952","display_name":"Brain natriuretic peptide","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.25429999828338623}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015716","descriptor_name":"Electrocardiography, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1590/1984-0462/2026/44/2026053","doi":"https://doi.org/10.1590/1984-0462/2026/44/2026053","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1984-0462/2026/44/2026053","pdf_url":"https://www.scielo.br/j/rpp/a/wVmjcKHkPBbLCcsDk5DprzG/?lang=en&format=pdf","source":{"id":"https://openalex.org/S123735288","display_name":"Revista Paulista de Pediatria","issn_l":"0103-0582","issn":["0103-0582","1984-0462"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Paulista de Pediatria","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13730238","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730238/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730238/pdf/1984-0462-rpp-44-e2026053.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rev Paul Pediatr","raw_type":"Text"},{"id":"pmid:42987088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42987088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:28ebd31a189c4e08afb92f5ec21150ce","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/28ebd31a189c4e08afb92f5ec21150ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Paulista de Pediatria, Vol 44 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/1984-0462/2026/44/2026053","doi":"https://doi.org/10.1590/1984-0462/2026/44/2026053","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1984-0462/2026/44/2026053","pdf_url":"https://www.scielo.br/j/rpp/a/wVmjcKHkPBbLCcsDk5DprzG/?lang=en&format=pdf","source":{"id":"https://openalex.org/S123735288","display_name":"Revista Paulista de Pediatria","issn_l":"0103-0582","issn":["0103-0582","1984-0462"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-70","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Paulista de Pediatria","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225100982.pdf","grobid_xml":"https://content.openalex.org/works/W7225100982.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1122574352","https://openalex.org/W1558479246","https://openalex.org/W1993306770","https://openalex.org/W2139811249","https://openalex.org/W2411036069","https://openalex.org/W2613494736","https://openalex.org/W2776010931","https://openalex.org/W2779306471","https://openalex.org/W2787161171","https://openalex.org/W3045734853","https://openalex.org/W3111424608","https://openalex.org/W3118924431","https://openalex.org/W3126167614","https://openalex.org/W3140856198","https://openalex.org/W3204130127","https://openalex.org/W4226154835","https://openalex.org/W4295484284","https://openalex.org/W4312127472","https://openalex.org/W4321513970","https://openalex.org/W4361221098","https://openalex.org/W4381716105","https://openalex.org/W4387229194","https://openalex.org/W4390267849","https://openalex.org/W4399202131","https://openalex.org/W4404833372","https://openalex.org/W4406778666"],"related_works":["https://openalex.org/W1975845967","https://openalex.org/W1558479246","https://openalex.org/W4396834429","https://openalex.org/W7214181296","https://openalex.org/W2946577182","https://openalex.org/W3173083026","https://openalex.org/W2379409123","https://openalex.org/W7125753580","https://openalex.org/W4389200749","https://openalex.org/W2922206990"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"plasma":[3],"N-terminal":[4],"pro-B-type":[5],"natriuretic":[6],"peptide":[7],"(NT-proBNP)":[8],"levels":[9,136,219],"in":[10,64,107,120,148],"adolescents":[11,32,42],"with":[12,21,33,130,150,222],"chronic":[13,35,45],"upper":[14,36],"gastrointestinal":[15,37,46],"diseases":[16,38],"and":[17,39,67,143,160,208,230],"investigate":[18],"their":[19],"association":[20,235],"24-hour":[22,53],"Holter":[23,54,83,103,132,162,181,214,224],"electrocardiographic":[24,55],"findings.":[25,215,225],"METHODS:":[26],"This":[27],"cross-sectional":[28,228],"study":[29],"included":[30],"104":[31],"endoscopically-verified":[34],"58":[40],"comparison":[41],"without":[43],"clinically-documented":[44],"or":[47,89,96],"cardiovascular":[48,151],"disease.":[49],"Both":[50],"groups":[51],"underwent":[52],"monitoring.":[56],"NT-proBNP":[57,135,199,218],"was":[58],"measured":[59],"by":[60],"enzyme-linked":[61],"immunosorbent":[62],"assay":[63],"60":[65],"patients":[66,109,122,142,149],"28":[68],"controls.":[69],"Receiver":[70],"operating":[71,175],"characteristic":[72,176],"analysis":[73,177],"explored":[74],"the":[75,173,188,227],"ability":[76],"of":[77,124,128,190,202],"this":[78,234],"biomarker":[79],"to":[80,172],"identify":[81],"positive":[82,131,161,180,213,223],"findings,":[84,182],"defined":[85],"as":[86],"rhythm,":[87],"conduction,":[88],"repolarization":[90],"abnormalities":[91,118],"exceeding":[92],"age-related":[93],"physiological":[94],"limits":[95],"requiring":[97],"further":[98],"cardiological":[99],"evaluation.":[100],"RESULTS:":[101],"Positive":[102],"findings":[104,112,163],"were":[105,113,146,220],"observed":[106,184],"71":[108],"(68.3%).":[110],"Most":[111],"benign;":[114],"potentially":[115],"clinically":[116],"significant":[117],"occurred":[119],"11":[121],"(10.6%":[123],"all":[125],"patients;":[126],"15.5%":[127],"those":[129],"findings).":[133],"Median":[134],"did":[137],"not":[138],"significantly":[139],"differ":[140],"between":[141],"controls":[144],"but":[145],"higher":[147],"complaints":[152],"(53.0":[153],"42.5-85.0":[154],"versus":[155,166],"22.6":[156],"12.4-41.4":[157],"pg/mL;":[158,169],"p=0.001)":[159],"(50.0":[164],"32.2-70.5":[165],"27.8":[167],"10.7-41.4":[168],"p<0.05).":[170],"According":[171],"receiver":[174],"for":[178,211],"identifying":[179,212],"we":[183],"an":[185],"area":[186],"under":[187],"curve":[189],"0.779":[191],"(95%":[192],"confidence":[193],"interval":[194],"95%CI:":[195],"0.726-0.833;":[196],"p<0.001).":[197],"An":[198],"cutoff":[200],"value":[201],"\u226543.2":[203],"pg/mL":[204],"showed":[205],"66.7%":[206],"sensitivity":[207],"90.9%":[209],"specificity":[210],"CONCLUSIONS:":[216],"Higher":[217],"associated":[221],"Given":[226],"design":[229],"limited":[231],"monitoring":[232],"period,":[233],"requires":[236],"prospective":[237],"validation.":[238]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-03T00:00:00"}