{"id":"https://openalex.org/W7225100748","doi":"https://doi.org/10.4103/ijp.ijp_141_26","title":"Aromadendrin attenuates dexamethasone-induced osteoporosis in rats by modulating oxidative stress, inflammation, and bone remodeling","display_name":"Aromadendrin attenuates dexamethasone-induced osteoporosis in rats by modulating oxidative stress, inflammation, and bone remodeling","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225100748","doi":"https://doi.org/10.4103/ijp.ijp_141_26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42969984"},"language":"en","primary_location":{"id":"doi:10.4103/ijp.ijp_141_26","doi":"https://doi.org/10.4103/ijp.ijp_141_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijp.ijp_141_26","pdf_url":null,"source":{"id":"https://openalex.org/S112348374","display_name":"Indian Journal of Pharmacology","issn_l":"0253-7613","issn":["0253-7613","1998-3751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/ijp.ijp_141_26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160344872","display_name":"Ru Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ru Ma","raw_affiliation_strings":["Department of Geriatric Hospitals, Xi \u2018an International Medical Center Hospital, Xi \u2018an 710000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Hospitals, Xi \u2018an International Medical Center Hospital, Xi \u2018an 710000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160345417","display_name":"Xia Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Li","raw_affiliation_strings":["Department of Geriatric Hospitals, Xi \u2018an International Medical Center Hospital, Xi \u2018an 710000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Hospitals, Xi \u2018an International Medical Center Hospital, Xi \u2018an 710000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112583156","display_name":"Md. Nafis Fuad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohd Afiq Muhamed Fuad","raw_affiliation_strings":["Department Orthopaedic, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Orthopaedic, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160364518","display_name":"Shuang Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuang Lu","raw_affiliation_strings":["Department of Geriatric Hospitals, Xi \u2018an International Medical Center Hospital, Xi \u2018an 710000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Hospitals, Xi \u2018an International Medical Center Hospital, Xi \u2018an 710000, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75269438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":"6","first_page":"652","last_page":"664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.20679999887943268,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromadendrin","display_name":"aromadendrin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteoporosis","display_name":"glucocorticoid-induced osteoporosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7229999899864197},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.6290000081062317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.890999972820282},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/rankl-opg-ratio","display_name":"RANKL/OPG ratio","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.847000002861023},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.6899999976158142},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.6800000071525574},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8899999856948853},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.8169999718666077},{"id":"https://openalex.org/keywords/anti-osteoporosis-agents","display_name":"anti-osteoporosis agents","score":0.6970000267028809},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.33399999141693115},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.7802000045776367},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.746999979019165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7342000007629395},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7074999809265137},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6865000128746033},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6588000059127808},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5252000093460083},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.5090000033378601},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.47859999537467957},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4756999909877777},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.47350001335144043},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.462799996137619},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.41510000824928284},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4122999906539917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39719998836517334},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.38940000534057617},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3847000002861023},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.3662000000476837},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31949999928474426},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.25440001487731934}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4103/ijp.ijp_141_26","doi":"https://doi.org/10.4103/ijp.ijp_141_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijp.ijp_141_26","pdf_url":null,"source":{"id":"https://openalex.org/S112348374","display_name":"Indian Journal of Pharmacology","issn_l":"0253-7613","issn":["0253-7613","1998-3751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:42969984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42969984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/ijp.ijp_141_26","doi":"https://doi.org/10.4103/ijp.ijp_141_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijp.ijp_141_26","pdf_url":null,"source":{"id":"https://openalex.org/S112348374","display_name":"Indian Journal of Pharmacology","issn_l":"0253-7613","issn":["0253-7613","1998-3751"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1761584390","https://openalex.org/W1876124517","https://openalex.org/W1978750436","https://openalex.org/W2019554446","https://openalex.org/W2038682678","https://openalex.org/W2069811152","https://openalex.org/W2413425742","https://openalex.org/W2560615458","https://openalex.org/W2560774896","https://openalex.org/W2593841410","https://openalex.org/W2599490889","https://openalex.org/W2765900805","https://openalex.org/W2911958614","https://openalex.org/W2971703125","https://openalex.org/W2980786252","https://openalex.org/W2992593546","https://openalex.org/W2995163384","https://openalex.org/W2999569987","https://openalex.org/W3021982027","https://openalex.org/W3027056905","https://openalex.org/W3084229226","https://openalex.org/W3084286686","https://openalex.org/W4205184981","https://openalex.org/W4292372224","https://openalex.org/W4303473189","https://openalex.org/W4323318740","https://openalex.org/W4323322209","https://openalex.org/W4390658755","https://openalex.org/W4407782362"],"related_works":["https://openalex.org/W4413109180","https://openalex.org/W4297404757","https://openalex.org/W4292372224","https://openalex.org/W6989280477","https://openalex.org/W7138850975","https://openalex.org/W2024164431","https://openalex.org/W4323322209","https://openalex.org/W7136091372","https://openalex.org/W4414521318","https://openalex.org/W2019487776"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glucocorticoids":[1],"(GCs)":[2],"are":[3],"used":[4,75,87],"in":[5,64,76,93,263],"the":[6,19,35,47,53,65,89,94,100,149,154,178,246],"treatment":[7,147,244],"of":[8,46,56,82,91,103,180,231,249,267],"asthma,":[9],"autoimmune":[10],"and":[11,25,41,79,107,110,137,152,159,171,239,269],"allergic":[12],"disease,":[13],"but":[14],"long-term":[15],"GC":[16],"therapy":[17],"increased":[18],"bone":[20,27,122,162,168,172,183],"resorption,":[21],"oxidative":[22,39,128,210],"stress,":[23,211],"inflammation,":[24],"impaired":[26],"formation.":[28],"Aromadendrin":[29,146,176,243,255],"is":[30],"a":[31],"flavonol":[32],"(flavonoid)":[33],"exhibited":[34],"potent":[36],"effect":[37,55,259],"against":[38,58,260],"stress":[40,129],"inflammatory":[42,131,135,212,214],"disease.":[43],"The":[44,96,115],"aim":[45],"experimental":[48],"study":[49,78],"was":[50,86],"to":[51],"investigate":[52],"antiosteoporosis":[54],"aromadendrin":[57,104],"dexamethasone":[59],"(DEX)":[60],"induced":[61],"osteoporosis":[62],"(OS)":[63],"rats.":[66,95],"MATERIALS":[67],"AND":[68],"METHODS:":[69],"Female":[70],"Sprague":[71],"Dawley":[72],"rats":[73,97,264],"were":[74,98,143],"this":[77],"subcutaneous":[80],"administration":[81,102],"DEX":[83],"(2.5":[84],"mg/kg/day)":[85],"for":[88,112],"induction":[90],"OS":[92,262],"received":[99],"oral":[101],"(2.5,":[105],"5":[106],"10":[108],"mg/kg)":[109],"alendronate":[111],"20":[113],"weeks.":[114],"body":[116,150],"weight,":[117,119,163],"organ":[118,155],"transverse":[120,164],"diameter,":[121,165],"length,":[123,167],"microcomputed":[124],"tomography":[125],"(MicroCT)":[126],"parameters,":[127,130,134,182],"cytokines,":[132,213],"caspase":[133,224],"parameters":[136,184,215,225],"messenger":[138],"ribonucleic":[139],"acid":[140,191,196],"(mRNA)":[141],"expression":[142,248],"estimated.":[144],"RESULTS:":[145],"improved":[148],"weight":[151,156],"altered":[153,177,245],"(vagina,":[157],"uterus,":[158],"femoral":[160],"weight);":[161],"bine":[166],"mineral":[169,173],"density":[170],"content":[174],"level.":[175],"level":[179,205],"MicroCT":[181],"(osteocalcin":[185],"[OC],":[186],"border":[187],"gateway":[188],"protocol,":[189],"tartrate-resistant":[190],"phosphatase,":[192,195],"beta-CrossLaps,":[193],"alkaline":[194],"phosphatase);":[197],"nutrient":[198],"(phosphorus,":[199],"magnesium,":[200],"calcium,":[201],"1,25(OH)2-vitamin":[202],"D3);":[203],"hormone":[204],"(calcitonin,":[206],"parathyroid":[207],"hormone,":[208],"E2),":[209],"(nuclear":[216],"factor-\u03baB":[217],"[NF-\u03baB],":[218],"C-reactive":[219],"protein,":[220],"monocyte":[221],"chemoattractant":[222],"protein-1);":[223],"(caspase-3,":[226],"caspase-8,":[227],"caspase-9),":[228],"receptor":[229],"activator":[230],"nuclear":[232],"factor":[233],"B":[234],"ligand":[235],"(RANKL),":[236],"Osteoprotegerin":[237],"(OPG),":[238],"OPG/RANKL":[240,252],"ratio,":[241],"respectively.":[242],"mRNA":[247],"RANKL,":[250],"OPG,":[251],"ratio.":[253],"CONCLUSION:":[254],"exerts":[256],"an":[257],"anti-OS":[258],"DEX-induced":[261],"via":[265],"alteration":[266],"NF-\u03baB":[268],"RANKL/OPG":[270],"signaling":[271],"pathway.":[272]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}