{"id":"https://openalex.org/W7225095161","doi":"https://doi.org/10.1186/s12891-026-10654-x","title":"A novel minimally invasive metabolomic strategy for differential diagnosis of spinal infections: blood-derived metabolic signatures as candidate biomarkers distinguishing tuberculous spondylitis from brucellar spondylitis","display_name":"A novel minimally invasive metabolomic strategy for differential diagnosis of spinal infections: blood-derived metabolic signatures as candidate biomarkers distinguishing tuberculous spondylitis from brucellar spondylitis","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225095161","doi":"https://doi.org/10.1186/s12891-026-10654-x"},"language":"en","primary_location":{"id":"doi:10.1186/s12891-026-10654-x","doi":"https://doi.org/10.1186/s12891-026-10654-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12891-026-10654-x","pdf_url":null,"source":{"id":"https://openalex.org/S35439863","display_name":"BMC Musculoskeletal Disorders","issn_l":"1471-2474","issn":["1471-2474"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskeletal Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12891-026-10654-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023853696","display_name":"Parhat Yasin","orcid":"https://orcid.org/0000-0002-9202-5795","observed_orcids":["https://orcid.org/0000-0002-9202-5795"]},"institutions":[{"id":"https://openalex.org/I4210151285","display_name":"Sixth Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/03r4az639","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151285"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Parhat Yasin","raw_affiliation_strings":["Department of Spine Surgery, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-9202-5795","affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160342519","display_name":"Hongwei Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongwei Ye","raw_affiliation_strings":["Department of Pathology, the Sixth People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, the Sixth People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, People\u2019s Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048838651","display_name":"Xinghua Song","orcid":"https://orcid.org/0000-0001-6208-4156","observed_orcids":["https://orcid.org/0000-0001-6208-4156"]},"institutions":[{"id":"https://openalex.org/I4210151285","display_name":"Sixth Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/03r4az639","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151285"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinghua Song","raw_affiliation_strings":["Department of Spine Surgery, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, People\u2019s Republic of China","Xinjiang Key Laboratory of Artificial Intelligence Assisted Imaging Diagnosis, Kashi, 844000, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-6208-4156","affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210151285"]},{"raw_affiliation_string":"Xinjiang Key Laboratory of Artificial Intelligence Assisted Imaging Diagnosis, Kashi, 844000, People\u2019s Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124066794","display_name":"Jie Sheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jie Sheng","raw_affiliation_strings":["The Second Department of General Surgery, The Sixth People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of General Surgery, The Sixth People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, People\u2019s Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048838651","https://openalex.org/A5124066794"],"corresponding_institution_ids":["https://openalex.org/I4210151285"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88504402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-tuberculosis","display_name":"spinal tuberculosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/brucellar-spondylitis","display_name":"brucellar spondylitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/spinal-infection","display_name":"spinal infection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.777999997138977},{"id":"https://openalex.org/keywords/plasma-metabolomics","display_name":"plasma metabolomics","score":0.8370000123977661},{"id":"https://openalex.org/keywords/blood-derived-biomarkers","display_name":"blood-derived biomarkers","score":0.7879999876022339},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6230000257492065},{"id":"https://openalex.org/keywords/linoleic-acid-metabolism","display_name":"linoleic acid metabolism","score":0.9729999899864197},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8812999725341797},{"id":"https://openalex.org/C2779650986","wikidata":"https://www.wikidata.org/wiki/Q2165411","display_name":"Spondylitis","level":3,"score":0.7419000267982483},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6071000099182129},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.5224000215530396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5072000026702881},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.5016999840736389},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4546999931335449},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4059999883174896},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.38960000872612},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38199999928474426},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.3781000077724457},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34850001335144043},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2937000095844269},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.27390000224113464}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12891-026-10654-x","doi":"https://doi.org/10.1186/s12891-026-10654-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12891-026-10654-x","pdf_url":null,"source":{"id":"https://openalex.org/S35439863","display_name":"BMC Musculoskeletal Disorders","issn_l":"1471-2474","issn":["1471-2474"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskeletal Disorders","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12891-026-10654-x","doi":"https://doi.org/10.1186/s12891-026-10654-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12891-026-10654-x","pdf_url":null,"source":{"id":"https://openalex.org/S35439863","display_name":"BMC Musculoskeletal Disorders","issn_l":"1471-2474","issn":["1471-2474"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskeletal Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393244188","https://openalex.org/W2570996357","https://openalex.org/W4394774368","https://openalex.org/W1995886408","https://openalex.org/W4411841911","https://openalex.org/W7171966193","https://openalex.org/W2339197350","https://openalex.org/W1466493721","https://openalex.org/W4405828035","https://openalex.org/W4313640393"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Tuberculous":[2],"spondylitis":[3,7],"(TS)":[4],"and":[5,38,46,60,77,87,112,122,198,213],"brucellar":[6],"(BS)":[8],"can":[9],"present":[10],"with":[11,36,40,63,110,114],"overlapping":[12],"manifestations.":[13],"This":[14],"study":[15,31],"assessed":[16],"plasma":[17],"metabolic":[18],"differences":[19],"between":[20,43],"the":[21,91,105,152,163,170,180,210],"two":[22],"diagnostic":[23,227],"groups.":[24,215],"Methods":[25],"We":[26],"conducted":[27],"a":[28,53],"retrospective":[29],"case-control":[30],"of":[32,101,128,179,190],"53":[33],"patients":[34],"(36":[35],"TS":[37,212],"17":[39],"BS)":[41],"enrolled":[42],"January":[44],"2021":[45],"December":[47],"2024.":[48],"Diagnoses":[49],"were":[50,83,135],"established":[51],"using":[52],"composite":[54],"reference":[55],"standard":[56],"integrating":[57],"compatible":[58],"clinical":[59,230],"radiological":[61],"findings":[62],"microbiological":[64],"and/or":[65],"histopathological":[66],"evidence.":[67],"Untargeted":[68],"ultra-high-performance":[69],"liquid":[70],"chromatography-tandem":[71],"mass":[72],"spectrometry":[73],"(UHPLC-MS/MS),":[74],"multivariate":[75],"analyses":[76,82],"receiver":[78],"operating":[79],"characteristic":[80],"(ROC)":[81],"used.":[84],"Candidate":[85],"selection":[86],"ROC":[88,164],"assessment":[89],"used":[90],"same":[92],"participants.":[93],"Results":[94],"The":[95,157,203],"processed":[96],"dataset":[97],"contained":[98],"1060":[99],"features,":[100],"which":[102],"190":[103],"met":[104],"nominal":[106,140],"differential-screening":[107],"criteria":[108],"(56":[109],"higher":[111],"134":[113],"lower":[115],"relative":[116,183],"peak":[117,184],"areas":[118,185],"in":[119],"TS).":[120],"Lipids":[121],"lipid-like":[123],"molecules":[124],"accounted":[125],"for":[126,169,208],"390":[127],"1058":[129],"classified":[130],"features":[131,134,207],"(36.86%);":[132],"2":[133],"unclassified.":[136],"No":[137],"pathway":[138],"reached":[139],"P":[141,154],"<":[142],"0.05":[143],"among":[144],"27":[145],"tested":[146],"pathways;":[147],"linoleic":[148],"acid":[149],"metabolism":[150],"had":[151,186],"lowest":[153],"value":[155],"(0.0767).":[156],"highest":[158],"individual":[159],"apparent":[160,188,195,199],"area":[161],"under":[162],"curve":[165],"(AUC)":[166],"was":[167],"0.922":[168],"feature":[171],"annotated":[172],"as":[173],"12-hydroxyjasmonic":[174],"acid.":[175],"An":[176],"unweighted":[177],"sum":[178],"top":[181],"nine":[182],"an":[187],"AUC":[189],"0.904":[191],"(95%":[192],"CI":[193],"0.825-0.983),":[194],"sensitivity":[196],"0.806":[197],"specificity":[200,222],"0.882.":[201],"Conclusion":[202],"results":[204],"identify":[205],"candidate":[206],"distinguishing":[209],"sampled":[211],"BS":[214],"They":[216],"do":[217],"not":[218],"establish":[219],"independent":[220],"associations,":[221],"against":[223],"other":[224],"pathogens,":[225],"validated":[226],"accuracy":[228],"or":[229],"utility.":[231]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}