{"id":"https://openalex.org/W7225094599","doi":"https://doi.org/10.66224/jcbior.7.3.380","title":"Immunosenescence in lung cancer: Linking aging, chronic inflammation, and tumor immune dysfunction","display_name":"Immunosenescence in lung cancer: Linking aging, chronic inflammation, and tumor immune dysfunction","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225094599","doi":"https://doi.org/10.66224/jcbior.7.3.380"},"language":"en","primary_location":{"id":"pmh:oai:jcbior.com:article/380","doi":"https://doi.org/10.66224/jcbior.7.3.380","is_oa":true,"landing_page_url":"https://jcbior.com/index.php/JCBioR/article/view/380","pdf_url":"https://jcbior.com/index.php/JCBioR/article/download/380/653","source":{"id":"https://openalex.org/S4210240050","display_name":"Journal of Current Biomedical Reports","issn_l":"2717-1906","issn":["2717-1906"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2717-1906","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jcbior.com/index.php/JCBioR/article/download/380/653","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006427690","display_name":"Maryam Falahatzadeh","orcid":"https://orcid.org/0009-0005-8139-8392","observed_orcids":["https://orcid.org/0009-0005-8139-8392"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Falahatzadeh, Maryam","raw_affiliation_strings":["Department of Biotechnology, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119377293","display_name":"Maryam Alsadat Baniaghil","orcid":"https://orcid.org/0000-0001-8948-9313","observed_orcids":["https://orcid.org/0000-0001-8948-9313"]},"institutions":[{"id":"https://openalex.org/I61554058","display_name":"Qom University of Medical Science and Health Services","ror":"https://ror.org/00y2dy597","country_code":"IR","type":"education","lineage":["https://openalex.org/I61554058"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Baniaghil, Maryam Alsadat","raw_affiliation_strings":["Department of Internal Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, School of Medicine, Qom University of Medical Sciences, Qom, Iran","institution_ids":["https://openalex.org/I61554058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160338358","display_name":"Seyedeh Hatameh Asadinejad Tahergourabi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asadinejad Tahergourabi, Seyedeh Hatameh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119920153","display_name":"Niloofar Keikhaei","orcid":"https://orcid.org/0000-0002-7292-8639","observed_orcids":["https://orcid.org/0000-0002-7292-8639"]},"institutions":[{"id":"https://openalex.org/I4210127922","display_name":"Golestan University of Medical Sciences","ror":"https://ror.org/03mcx2558","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210127922"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Keikhaei, Niloofar","raw_affiliation_strings":["Sayad Shirazi Hospital, Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sayad Shirazi Hospital, Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran","institution_ids":["https://openalex.org/I4210127922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070557401","display_name":"Mohsen Farrokhpour","orcid":"https://orcid.org/0000-0001-6057-5437","observed_orcids":["https://orcid.org/0000-0001-6057-5437"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210097843","display_name":"Firoozgar General Hospital","ror":"https://ror.org/014hy9c40","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210097843"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farrokhpour, Mohsen","raw_affiliation_strings":["Firouzgar Hospital, Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firouzgar Hospital, Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210097843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160385984","display_name":"Hamed Hekmat Nejad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184896493","display_name":"Sari Agricultural Sciences and Natural Resources University","ror":"https://ror.org/0284vkq26","country_code":"IR","type":"education","lineage":["https://openalex.org/I184896493"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hekmat Nejad, Hamed","raw_affiliation_strings":["Department of Basic Sciences , Sari Agricultural Sciences and Natural Resources University , Sari , Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences , Sari Agricultural Sciences and Natural Resources University , Sari , Iran","institution_ids":["https://openalex.org/I184896493"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":10000000,"currency":"IRR","value_usd":null},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82884835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.32670000195503235,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6650000214576721},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9020000100135803},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7170000076293945},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.6299999952316284},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.5889999866485596},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8682000041007996},{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.6931999921798706},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6255000233650208},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6015999913215637},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4733000099658966},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43959999084472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4348999857902527},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3961000144481659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3862000107765198},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3815999925136566},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3573000133037567},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30169999599456787},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.2818000018596649},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2815999984741211},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.2806999981403351},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.2766000032424927},{"id":"https://openalex.org/C157081693","wikidata":"https://www.wikidata.org/wiki/Q21113934","display_name":"CCL18","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:jcbior.com:article/380","doi":"https://doi.org/10.66224/jcbior.7.3.380","is_oa":true,"landing_page_url":"https://jcbior.com/index.php/JCBioR/article/view/380","pdf_url":"https://jcbior.com/index.php/JCBioR/article/download/380/653","source":{"id":"https://openalex.org/S4210240050","display_name":"Journal of Current Biomedical Reports","issn_l":"2717-1906","issn":["2717-1906"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2717-1906","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:jcbior.com:article/380","doi":"https://doi.org/10.66224/jcbior.7.3.380","is_oa":true,"landing_page_url":"https://jcbior.com/index.php/JCBioR/article/view/380","pdf_url":"https://jcbior.com/index.php/JCBioR/article/download/380/653","source":{"id":"https://openalex.org/S4210240050","display_name":"Journal of Current Biomedical Reports","issn_l":"2717-1906","issn":["2717-1906"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2717-1906","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225094599.pdf","grobid_xml":"https://content.openalex.org/works/W7225094599.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379877682","https://openalex.org/W4413428153","https://openalex.org/W4412832146","https://openalex.org/W7221636227","https://openalex.org/W7134934773","https://openalex.org/W7161947396","https://openalex.org/W4404451236","https://openalex.org/W4394766602","https://openalex.org/W7218402227","https://openalex.org/W4406230041"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,117,244],"is":[2,25,141],"predominantly":[3],"diagnosed":[4],"in":[5,45,89,115,121,159,175],"older":[6,96],"adults,":[7],"raising":[8],"important":[9],"questions":[10],"regarding":[11],"the":[12,31,49,63,77,84,108,132,136,169,197,236],"contribution":[13],"of":[14,30,80,111,126,135,212,239,259],"age-related":[15],"biological":[16,85,122],"changes":[17,44],"to":[18,51,57,153,177,229,243],"tumor":[19,64,154,199],"development":[20],"and":[21,33,43,61,83,92,118,123,138,151,168,185,194,201,234,246,262],"immune":[22,32,90,112,139,155,179,183,213,232,260],"regulation.":[23],"Aging":[24],"accompanied":[26],"by":[27],"progressive":[28],"remodeling":[29,134],"pulmonary":[34,137],"systems,":[35],"including":[36],"immunosenescence,":[37,148],"cellular":[38,149],"senescence,":[39,150],"inflammaging,":[40],"metabolic":[41,193],"alterations,":[42],"tissue":[46],"homeostasis.":[47],"However,":[48],"extent":[50],"which":[52],"these":[53,209],"interconnected":[54,210],"processes":[55],"contribute":[56],"impaired":[58,178],"antitumor":[59,81,231],"immunity":[60],"shape":[62],"microenvironment":[65],"remains":[66],"incompletely":[67],"understood.":[68],"In":[69,128],"particular,":[70],"chronological":[71,223],"age":[72,224],"does":[73],"not":[74],"necessarily":[75],"reflect":[76],"functional":[78],"state":[79],"immunity,":[82],"basis":[86],"for":[87,220],"heterogeneity":[88],"function":[91,203],"immunotherapy":[93],"response":[94],"among":[95],"individuals":[97],"requires":[98],"further":[99],"clarification.":[100],"This":[101,248],"issue":[102],"has":[103],"become":[104],"increasingly":[105],"relevant":[106],"with":[107],"expanding":[109],"use":[110],"checkpoint":[113],"inhibitors":[114],"lung":[116],"growing":[119],"interest":[120],"immunological":[124],"measures":[125],"aging.":[127],"this":[129,215],"narrative":[130],"review,":[131],"age-associated":[133],"systems":[140],"examined":[142],"through":[143],"an":[144],"integrated":[145],"perspective":[146,249],"linking":[147],"inflammaging":[152],"dysfunction.":[156],"Age-related":[157],"alterations":[158],"T":[160],"cells,":[161,164,166,192],"natural":[162],"killer":[163],"antigen-presenting":[165],"macrophages,":[167],"senescent-cell":[170],"secretory":[171],"environment":[172],"are":[173,204],"considered":[174],"relation":[176],"surveillance,":[180],"chronic":[181],"inflammation,":[182],"escape,":[184],"therapeutic":[186,264],"response.":[187],"Emerging":[188],"approaches":[189,242],"targeting":[190],"senescent":[191],"mitochondrial":[195],"dysfunction,":[196],"aging":[198,261],"microenvironment,":[200],"immune-cell":[202],"also":[205],"discussed.":[206],"By":[207],"integrating":[208],"dimensions":[211],"aging,":[214],"review":[216],"provides":[217],"a":[218],"framework":[219],"understanding":[221],"why":[222],"alone":[225],"may":[226,250],"be":[227],"insufficient":[228],"characterize":[230],"competence":[233],"highlights":[235],"potential":[237],"value":[238],"biologically":[240],"informed":[241],"prevention":[245],"treatment.":[247],"help":[251],"guide":[252],"future":[253],"research":[254],"toward":[255],"more":[256],"precise":[257],"assessment":[258],"individualized":[263],"strategies.":[265]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}
