{"id":"https://openalex.org/W7225088341","doi":"https://doi.org/10.4239/wjd.125608","title":"Once-weekly basal insulin analogs in type 2 diabetes: Pharmacological rationale, clinical evidence, and practical considerations for implementation","display_name":"Once-weekly basal insulin analogs in type 2 diabetes: Pharmacological rationale, clinical evidence, and practical considerations for implementation","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225088341","doi":"https://doi.org/10.4239/wjd.125608"},"language":"en","primary_location":{"id":"doi:10.4239/wjd.125608","doi":"https://doi.org/10.4239/wjd.125608","is_oa":true,"landing_page_url":"https://doi.org/10.4239/wjd.125608","pdf_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=125608&filepath=8E31D0401EB18CD6271A9142AB7E05E35D8B424385E526E595C1A7E70FA2E40D3EA6153556EAC0AE","source":{"id":"https://openalex.org/S9864596","display_name":"World Journal of Diabetes","issn_l":"1948-9358","issn":["1948-9358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=125608&filepath=8E31D0401EB18CD6271A9142AB7E05E35D8B424385E526E595C1A7E70FA2E40D3EA6153556EAC0AE","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119625108","display_name":"Melike Yakut","orcid":"https://orcid.org/0000-0002-8198-8588","observed_orcids":["https://orcid.org/0000-0002-8198-8588"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melike Yakut","raw_affiliation_strings":["Department of Internal Medicine , Eskisehir Cifteler State Hospital , Eskisehir 26700 , T\u00fcrkiye","Department of Internal Medicine , Eskisehir Cifteler State Hospital , No. 2 \u0130brahim Dede Caddesi , Eskisehir 26700 , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine , Eskisehir Cifteler State Hospital , Eskisehir 26700 , T\u00fcrkiye","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine , Eskisehir Cifteler State Hospital , No. 2 \u0130brahim Dede Caddesi , Eskisehir 26700 , T\u00fcrkiye","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5119625108"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87273743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.6948000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9020000100135803},{"id":"https://openalex.org/keywords/insulin-icodec","display_name":"insulin icodec","score":0.9440000057220459},{"id":"https://openalex.org/keywords/insulin-analogs","display_name":"insulin analogues","score":0.5989999771118164},{"id":"https://openalex.org/keywords/insulin-adherence","display_name":"insulin adherence","score":0.4320000112056732},{"id":"https://openalex.org/keywords/injection-burden","display_name":"injection burden","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.7599999904632568},{"id":"https://openalex.org/keywords/insulin-dose-adjustment","display_name":"insulin dose adjustment","score":0.5490000247955322},{"id":"https://openalex.org/keywords/insulin-naive-patients","display_name":"insulin-naive patients","score":0.5590000152587891},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.7369999885559082},{"id":"https://openalex.org/keywords/insulin-dose-reduction","display_name":"insulin dose reduction","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9550999999046326},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.6284000277519226},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6133999824523926},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.5271999835968018},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.5256999731063843},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.515999972820282},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5095999836921692},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.44339999556541443},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44040000438690186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43779999017715454},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4244000017642975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3880000114440918},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3871999979019165},{"id":"https://openalex.org/C2776486108","wikidata":"https://www.wikidata.org/wiki/Q3492616","display_name":"Insulin lispro","level":4,"score":0.34360000491142273},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.32440000772476196},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C185280430","wikidata":"https://www.wikidata.org/wiki/Q14909910","display_name":"Glucagon-like peptide 1 receptor","level":4,"score":0.3167000114917755},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C2909524832","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Basal insulin","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C2776246316","wikidata":"https://www.wikidata.org/wiki/Q421937","display_name":"Hydroxyzine","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C72092618","wikidata":"https://www.wikidata.org/wiki/Q894640","display_name":"Vial","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4239/wjd.125608","doi":"https://doi.org/10.4239/wjd.125608","is_oa":true,"landing_page_url":"https://doi.org/10.4239/wjd.125608","pdf_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=125608&filepath=8E31D0401EB18CD6271A9142AB7E05E35D8B424385E526E595C1A7E70FA2E40D3EA6153556EAC0AE","source":{"id":"https://openalex.org/S9864596","display_name":"World Journal of Diabetes","issn_l":"1948-9358","issn":["1948-9358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Diabetes","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4239/wjd.125608","doi":"https://doi.org/10.4239/wjd.125608","is_oa":true,"landing_page_url":"https://doi.org/10.4239/wjd.125608","pdf_url":"https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=125608&filepath=8E31D0401EB18CD6271A9142AB7E05E35D8B424385E526E595C1A7E70FA2E40D3EA6153556EAC0AE","source":{"id":"https://openalex.org/S9864596","display_name":"World Journal of Diabetes","issn_l":"1948-9358","issn":["1948-9358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225088341.pdf","grobid_xml":"https://content.openalex.org/works/W7225088341.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1975663485","https://openalex.org/W3159368726","https://openalex.org/W3196288505","https://openalex.org/W4312066873","https://openalex.org/W4367837000","https://openalex.org/W4372214904","https://openalex.org/W4381852469","https://openalex.org/W4381887577","https://openalex.org/W4387008366","https://openalex.org/W4387710695","https://openalex.org/W4396229456","https://openalex.org/W4396760455","https://openalex.org/W4400842693","https://openalex.org/W4402390799","https://openalex.org/W4402406906","https://openalex.org/W4411010628","https://openalex.org/W4411010725","https://openalex.org/W4411523952","https://openalex.org/W4411523963","https://openalex.org/W4411524025","https://openalex.org/W4417017774"],"related_works":["https://openalex.org/W7164333391","https://openalex.org/W4413735055","https://openalex.org/W7202179770","https://openalex.org/W4390919591","https://openalex.org/W7162963334","https://openalex.org/W7160603355","https://openalex.org/W3210022710","https://openalex.org/W4411801394","https://openalex.org/W4396225068","https://openalex.org/W7157654804"],"abstract_inverted_index":{"Many":[0],"patients":[1],"with":[2,63,158],"type":[3,82,124],"2":[4,83],"diabetes":[5],"require":[6],"insulin,":[7],"but":[8],"adherence":[9],"to":[10,74,118,131],"daily":[11,75,105],"basal":[12,29],"regimens":[13],"is":[14],"frequently":[15],"suboptimal":[16],"because":[17],"of":[18,113,148,176],"injection":[19],"burden,":[20],"needle":[21],"anxiety,":[22],"and":[23,77,137,143,160,165,179,182],"lifestyle":[24],"disruption.Two":[25],"molecularly":[26],"distinct":[27],"once-weekly":[28],"insulin":[30,51,141],"analogs":[31],"have":[32],"completed":[33],"phase":[34],"3":[35],"evaluation.Insulin":[36],"icodec":[37,71,157],"achieves":[38],"prolonged":[39],"action":[40],"through":[41],"fatty":[42],"diacid-mediated":[43],"albumin":[44],"binding":[45],"(half-life":[46,54],"approximately":[47],"196":[48],"hours),":[49],"whereas":[50],"efsitora":[52,89],"alfa":[53],"10-14":[55],"days)":[56],"uses":[57],"immunoglobulin":[58],"fragment":[59],"crystallizable-domain":[60],"(Fc-domain)":[61],"fusion":[62],"neonatal":[64],"Fc-receptor":[65],"recycling.Across":[66],"the":[67,85,110,146],"six":[68],"ONWARDS":[69],"trials,":[70,88],"was":[72,90,129],"noninferior":[73],"comparators":[76],"additionally":[78],"superior":[79,138],"in":[80,123],"insulin-na\u00efve":[81],"diabetes.Across":[84],"five":[86],"QWINT":[87],"non-inferior":[91,130],"without":[92],"demonstrating":[93],"superiority;":[94],"QWINT-1":[95],"showed":[96],"that":[97],"a":[98,171],"simplified":[99],"fixed-step":[100],"regimen":[101],"can":[102],"match":[103],"titrated":[104],"glargine":[106],"U100":[107],"while":[108],"reducing":[109],"median":[111],"number":[112],"dose":[114],"adjustments":[115],"from":[116],"eight":[117],"two.Both":[119],"agents":[120],"increased":[121],"hypoglycemia":[122],"1":[125],"diabetes.The":[126],"IcoSema":[127],"coformulation":[128],"basal-bolus":[132],"therapy":[133],"for":[134,139],"glycated":[135],"hemoglobin":[136],"weight,":[140],"dose,":[142],"hypoglycemia,":[144],"at":[145],"cost":[147],"more":[149],"gastrointestinal":[150],"adverse":[151],"events.No":[152],"head-to-head":[153],"trial":[154],"has":[155],"compared":[156],"efsitora,":[159],"long-term":[161],"cardiovascular,":[162],"real-world":[163],"adherence,":[164],"cost-effectiveness":[166],"data":[167],"are":[168],"unavailable.Implementation":[169],"requires":[170],"modified":[172],"titration":[173],"cadence,":[174],"awareness":[175],"loading-dose":[177],"effects,":[178],"structured":[180],"sickday":[181],"perioperative":[183],"planning.":[184]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}
