{"id":"https://openalex.org/W7225087693","doi":"https://doi.org/10.1002/cap.70121","title":"Guided bone regeneration using CAD\u2010CAM zirconia barriers: A case series with digital evaluation of bone changes","display_name":"Guided bone regeneration using CAD\u2010CAM zirconia barriers: A case series with digital evaluation of bone changes","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225087693","doi":"https://doi.org/10.1002/cap.70121","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968394"},"language":"en","primary_location":{"id":"doi:10.1002/cap.70121","doi":"https://doi.org/10.1002/cap.70121","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cap.70121","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cap.70121","source":{"id":"https://openalex.org/S2764953765","display_name":"Clinical Advances in Periodontics","issn_l":"2163-0097","issn":["2163-0097","2573-8046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Advances in Periodontics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cap.70121","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159351236","display_name":"Roberto Ledergerber","orcid":"https://orcid.org/0009-0001-9507-8040","observed_orcids":["https://orcid.org/0009-0001-9507-8040"]},"institutions":[{"id":"https://openalex.org/I3132284232","display_name":"Universidad Esp\u00edritu Santo","ror":"https://ror.org/00b210x50","country_code":"EC","type":"education","lineage":["https://openalex.org/I3132284232"]}],"countries":["EC"],"is_corresponding":false,"raw_author_name":"Roberto Ledergerber","raw_affiliation_strings":["School of Dentistry Universidad de Especialidades Esp\u00edritu Santo  Samborond\u00f3n Ecuador"],"raw_orcid":"https://orcid.org/0009-0001-9507-8040","affiliations":[{"raw_affiliation_string":"School of Dentistry Universidad de Especialidades Esp\u00edritu Santo  Samborond\u00f3n Ecuador","institution_ids":["https://openalex.org/I3132284232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012559922","display_name":"Javier Flores Fraile","orcid":"https://orcid.org/0000-0003-1338-0551","observed_orcids":["https://orcid.org/0000-0003-1338-0551"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Flores\u2010Fraile","raw_affiliation_strings":["Department of Surgery Faculty of Medicine Dental Clinic University of Salamanca Campus Miguel de Unamuno  Salamanca Spain"],"raw_orcid":"https://orcid.org/0000-0003-1338-0551","affiliations":[{"raw_affiliation_string":"Department of Surgery Faculty of Medicine Dental Clinic University of Salamanca Campus Miguel de Unamuno  Salamanca Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031221554","display_name":"Tiago Marques","orcid":"https://orcid.org/0000-0003-2474-4613","observed_orcids":["https://orcid.org/0000-0003-2474-4613"]},"institutions":[{"id":"https://openalex.org/I25169866","display_name":"Universidade Cat\u00f3lica Portuguesa","ror":"https://ror.org/03b9snr86","country_code":"PT","type":"education","lineage":["https://openalex.org/I25169866"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Tiago Marques","raw_affiliation_strings":["Faculty of Dental Medicine The Catholic University of Portugal (UCP)  Viseu Portugal"],"raw_orcid":"https://orcid.org/0000-0003-2474-4613","affiliations":[{"raw_affiliation_string":"Faculty of Dental Medicine The Catholic University of Portugal (UCP)  Viseu Portugal","institution_ids":["https://openalex.org/I25169866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160364899","display_name":"Javier Soldevila","orcid":"https://orcid.org/0009-0009-0264-230X","observed_orcids":["https://orcid.org/0009-0009-0264-230X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Soldevila","raw_affiliation_strings":["Department of Periodontics and Implant Dentistry Institucion Mississippi Madrid Spain"],"raw_orcid":"https://orcid.org/0009-0009-0264-230X","affiliations":[{"raw_affiliation_string":"Department of Periodontics and Implant Dentistry Institucion Mississippi Madrid Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160365130","display_name":"Martin Lindstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Lindstr\u00f6m","raw_affiliation_strings":["Private Practice Limhamns Tandl\u00e4kargrupp  Malm\u00f6 Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice Limhamns Tandl\u00e4kargrupp  Malm\u00f6 Sweden","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024836718","display_name":"Norberto Quispe\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0002-8835-2427","observed_orcids":["https://orcid.org/0000-0002-8835-2427"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Norberto Quispe\u2010L\u00f3pez","raw_affiliation_strings":["Department of Surgery Faculty of Medicine Dental Clinic University of Salamanca Campus Miguel de Unamuno  Salamanca Spain"],"raw_orcid":"https://orcid.org/0000-0002-8835-2427","affiliations":[{"raw_affiliation_string":"Department of Surgery Faculty of Medicine Dental Clinic University of Salamanca Campus Miguel de Unamuno  Salamanca Spain","institution_ids":["https://openalex.org/I184999862"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024836718"],"corresponding_institution_ids":["https://openalex.org/I184999862"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87686592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11363","display_name":"Dental Radiography and Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guided-bone-regeneration","display_name":"guided bone regeneration","score":0.9559999704360962},{"id":"https://openalex.org/keywords/alveolar-ridge-reconstruction","display_name":"alveolar ridge reconstruction","score":0.6959999799728394},{"id":"https://openalex.org/keywords/dental-implants","display_name":"dental implants","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cone-beam-computed-tomography","display_name":"cone-beam computed tomography","score":0.8149999976158142},{"id":"https://openalex.org/keywords/intraoral-scanning","display_name":"intraoral scanning","score":0.800000011920929},{"id":"https://openalex.org/keywords/guided-surgery","display_name":"guided surgery","score":0.5080000162124634},{"id":"https://openalex.org/keywords/digital-surgical-planning","display_name":"digital surgical planning","score":0.5929999947547913},{"id":"https://openalex.org/keywords/peri-implant-soft-tissue-management","display_name":"peri-implant soft tissue management","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6644999980926514},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5708000063896179},{"id":"https://openalex.org/C2779813781","wikidata":"https://www.wikidata.org/wiki/Q1224951","display_name":"Cone beam computed tomography","level":3,"score":0.49970000982284546},{"id":"https://openalex.org/C123609680","wikidata":"https://www.wikidata.org/wiki/Q225666","display_name":"Cubic zirconia","level":3,"score":0.4611000120639801},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43709999322891235},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.3441999852657318},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.3154999911785126},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.31310001015663147},{"id":"https://openalex.org/C2780338112","wikidata":"https://www.wikidata.org/wiki/Q143680","display_name":"Dental implant","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2732999920845032}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/cap.70121","doi":"https://doi.org/10.1002/cap.70121","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cap.70121","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cap.70121","source":{"id":"https://openalex.org/S2764953765","display_name":"Clinical Advances in Periodontics","issn_l":"2163-0097","issn":["2163-0097","2573-8046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Advances in Periodontics","raw_type":"journal-article"},{"id":"pmid:42968394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in periodontics","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1002/cap.70121","doi":"https://doi.org/10.1002/cap.70121","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cap.70121","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cap.70121","source":{"id":"https://openalex.org/S2764953765","display_name":"Clinical Advances in Periodontics","issn_l":"2163-0097","issn":["2163-0097","2573-8046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Advances in Periodontics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225087693.pdf","grobid_xml":"https://content.openalex.org/works/W7225087693.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W2021256968","https://openalex.org/W2023503504","https://openalex.org/W2036438966","https://openalex.org/W2040212992","https://openalex.org/W2126497169","https://openalex.org/W2165946230","https://openalex.org/W2166703442","https://openalex.org/W2563572680","https://openalex.org/W2746568420","https://openalex.org/W2905006116","https://openalex.org/W2945453675","https://openalex.org/W2961474915","https://openalex.org/W3093022214","https://openalex.org/W3114416202","https://openalex.org/W3142297395","https://openalex.org/W3167076116","https://openalex.org/W3193446603","https://openalex.org/W4220781737","https://openalex.org/W4239557900","https://openalex.org/W4318754648","https://openalex.org/W4324129638","https://openalex.org/W4385256222","https://openalex.org/W4385476945","https://openalex.org/W4385680773","https://openalex.org/W4387077788","https://openalex.org/W4387765761","https://openalex.org/W4390706818","https://openalex.org/W4392771431","https://openalex.org/W4399326137","https://openalex.org/W4401396594","https://openalex.org/W4401851403","https://openalex.org/W4402068535","https://openalex.org/W4406736638","https://openalex.org/W4407590734","https://openalex.org/W4411187187","https://openalex.org/W4413434543","https://openalex.org/W4415644375","https://openalex.org/W7155001930","https://openalex.org/W7169759508"],"related_works":["https://openalex.org/W3193446603","https://openalex.org/W4399326137","https://openalex.org/W3043944647","https://openalex.org/W7129407000","https://openalex.org/W4403046469","https://openalex.org/W7116673960","https://openalex.org/W3168878525","https://openalex.org/W4408227704","https://openalex.org/W4304480613","https://openalex.org/W2738758116"],"abstract_inverted_index":{"Background":[0],"CAD/CAM":[1,44,84],"zirconia":[2,40,67,223,265,360,426],"barriers":[3,41,224,361,427],"represent":[4,429],"an":[5,303,409],"advanced":[6],"option":[7],"for":[8,118,151,259,297,433],"guided":[9,111,260],"bone":[10,57,100,114,157,186,212,247,261,320,343,366,370,381,416,438],"regeneration":[11,262],"(GBR)":[12],"in":[13,46,145,231,312,322,333],"three\u2010dimensional":[14,133,238],"defects,":[15,439],"integrating":[16],"mechanical":[17],"stability,":[18,276],"biocompatibility,":[19],"and":[20,34,50,61,79,86,101,113,127,166,199,228,243,277,299,306,368,411],"digital":[21,129,234,295,405],"precision.":[22],"The":[23,91,233,290],"objectives":[24],"of":[25,38,88,98,159,170,178,188,219,246,286,292,309,358,399,414,436,445],"this":[26],"case":[27,252,353],"series":[28,253,354],"were":[29,59,93,108,116,123,138,173],"to":[30,180,346,363,383,388,449],"evaluate,":[31],"clinically,":[32],"histologically,":[33],"three\u2010dimensionally,":[35],"the":[36,89,104,149,163,287,313,323,334,341,356,373,389,397,415,434],"use":[37,357],"customized":[39,66,264,359,425],"designed":[42,362],"using":[43,65,95,110,263],"technology":[45],"GBR":[47,64],"procedures.":[48,154],"Methods":[49],"Results":[51],"Three":[52],"patients":[53,446],"with":[54,63,175,216,237],"severe":[55],"maxillary":[56],"atrophy":[58],"included":[60],"treated":[62,377],"barriers.":[68,90],"Digital":[69],"planning":[70],"was":[71],"performed":[72],"based":[73,131,267],"on":[74,132,268],"cone":[75],"beam":[76],"computed":[77],"tomography":[78],"intraoral":[80],"scanning,":[81],"followed":[82],"by":[83],"design":[85],"fabrication":[87],"defects":[92,378],"regenerated":[94,288],"a":[96,241,255,293,348,403,430],"mixture":[97],"autogenous":[99],"xenograft.":[102],"After":[103,372],"healing":[105,374],"period,":[106,375],"implants":[107,329],"placed":[109,332],"surgery,":[112],"biopsies":[115],"obtained":[117],"histological":[119,229,284],"analysis.":[120],"Bone":[121],"gains":[122,158,169,187],"evaluated":[124],"through":[125],"linear":[126,298],"volumetric":[128,300],"analysis":[130,184,206,285,301,395],"model":[134],"superimposition.":[135],"All":[136],"surgeries":[137],"completed":[139],"without":[140,148],"complications,":[141],"allowing":[142],"implant":[143,385],"placement":[144,386],"all":[146,376],"cases":[147],"need":[150],"additional":[152],"augmentation":[153],"Mean":[155],"horizontal":[156],"6.17":[160],"mm":[161,172,190,195,201],"at":[162],"crestal":[164],"level":[165],"mean":[167],"vertical":[168],"2.62":[171],"recorded,":[174],"maximum":[176],"values":[177],"up":[179],"5.11":[181],"mm.":[182],"Volumetric":[183],"revealed":[185],"797.158":[189],"3":[191,196,202],"(case":[192,197,203],"1),":[193],"459.718":[194],"2),":[198],"1416.870":[200],"3).":[204],"Histological":[205,394],"demonstrated":[207,225],"vital,":[208],"well\u2010vascularized":[209],"newly":[210],"formed":[211],"undergoing":[213],"active":[214],"remodeling,":[215],"no":[217],"evidence":[218],"inflammation.":[220],"Conclusions":[221],"Customized":[222],"favorable":[226],"clinical":[227,257],"outcomes":[230],"GBR.":[232],"workflow,":[235],"combined":[236],"analysis,":[239],"allowed":[240],"precise":[242,307],"reproducible":[244,412],"evaluation":[245,308],"changes.":[248],"KEY":[249],"POINTS":[250],"This":[251,352],"presents":[254],"comprehensive":[256],"protocol":[258,296,407],"barriers,":[266],"prosthetically":[269],"driven":[270],"planning,":[271],"individualized":[272],"barrier":[273],"design,":[274],"graft":[275],"meticulous":[278],"peri\u2010implant":[279],"soft":[280],"tissue":[281],"management,":[282],"including":[283],"tissue.":[289],"incorporation":[291],"standardized":[294,404],"enabled":[302],"objective,":[304],"reproducible,":[305],"dimensional":[310],"changes":[311,417],"alveolar":[314],"ridge.":[315],"Plain":[316],"language":[317],"summary":[318],"Significant":[319],"loss":[321],"upper":[324],"jaw":[325],"can":[326],"prevent":[327],"dental":[328],"from":[330],"being":[331],"correct":[335],"position.":[336],"In":[337],"these":[338,451],"situations,":[339],"rebuilding":[340],"lost":[342],"is":[344],"necessary":[345],"achieve":[347],"stable":[349],"long\u2010term":[350],"outcome.":[351],"describes":[355],"fit":[364],"each":[365],"defect":[367],"support":[369],"regeneration.":[371],"showed":[379],"sufficient":[380],"gain":[382],"allow":[384],"according":[387],"original":[390],"prosthetic":[391],"treatment":[392],"plan.":[393],"confirmed":[396],"formation":[398],"new":[400],"bone,":[401],"while":[402],"measurement":[406],"provided":[408],"objective":[410],"assessment":[413],"achieved":[418],"after":[419],"treatment.":[420],"These":[421],"findings":[422],"suggest":[423],"that":[424],"may":[428],"promising":[431],"alternative":[432],"management":[435],"complex":[437],"although":[440],"studies":[441],"involving":[442],"larger":[443],"numbers":[444],"are":[447],"needed":[448],"confirm":[450],"results.":[452]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}