{"id":"https://openalex.org/W7225086786","doi":"https://doi.org/10.3390/biology15211982","title":"Genomic Differentiation Along an Altitudinal\u2013Longitudinal Gradient in Yarlung Zangbo Rock Agamas (Laudakia)","display_name":"Genomic Differentiation Along an Altitudinal\u2013Longitudinal Gradient in Yarlung Zangbo Rock Agamas (Laudakia)","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225086786","doi":"https://doi.org/10.3390/biology15211982"},"language":"en","primary_location":{"id":"doi:10.3390/biology15211982","doi":"https://doi.org/10.3390/biology15211982","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15211982","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology15211982","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112417500","display_name":"Cong Wei","orcid":"https://orcid.org/0009-0002-7847-3337","observed_orcids":["https://orcid.org/0009-0002-7847-3337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cong Wei","raw_affiliation_strings":["Institute of Plateau Biology of Xizang Autonomous Region, Lhasa 850001, China"],"raw_orcid":"https://orcid.org/0009-0002-7847-3337","affiliations":[{"raw_affiliation_string":"Institute of Plateau Biology of Xizang Autonomous Region, Lhasa 850001, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160383558","display_name":"Jianchuan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianchuan Li","raw_affiliation_strings":["Natural Science Museum of Xizang, Lhasa 850001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Science Museum of Xizang, Lhasa 850001, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083546821","display_name":"Lifang Peng","orcid":"https://orcid.org/0000-0001-9325-7048","observed_orcids":["https://orcid.org/0000-0001-9325-7048"]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]},{"id":"https://openalex.org/I4387155391","display_name":"State Key Laboratory of Plateau Ecology and Agriculture","ror":"https://ror.org/03va7tm69","country_code":"CN","type":"facility","lineage":["https://openalex.org/I116265982","https://openalex.org/I4387155391"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifang Peng","raw_affiliation_strings":["State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China"],"raw_orcid":"https://orcid.org/0000-0001-9325-7048","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China","institution_ids":["https://openalex.org/I116265982","https://openalex.org/I4387155391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066240136","display_name":"Shiyang Weng","orcid":"https://orcid.org/0009-0005-5322-9671","observed_orcids":["https://orcid.org/0009-0005-5322-9671"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shiyang Weng","raw_affiliation_strings":["Institute of Plateau Biology of Xizang Autonomous Region, Lhasa 850001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Plateau Biology of Xizang Autonomous Region, Lhasa 850001, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066240136"],"corresponding_institution_ids":[],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7848746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"21","first_page":"1982","last_page":"1982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elevation-gradient","display_name":"elevation gradient","score":0.9190000295639038},{"id":"https://openalex.org/keywords/genomic-differentiation","display_name":"genomic differentiation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8489999771118164},{"id":"https://openalex.org/keywords/inbreeding","display_name":"inbreeding","score":0.9390000104904175},{"id":"https://openalex.org/keywords/effective-population-size","display_name":"effective population size","score":0.9300000071525574},{"id":"https://openalex.org/keywords/selective-sweeps","display_name":"selective sweeps","score":0.5950000286102295},{"id":"https://openalex.org/keywords/local-adaptation","display_name":"local adaptation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/climate-change-vulnerability","display_name":"climate change vulnerability","score":0.6119999885559082},{"id":"https://openalex.org/keywords/conservation-genetics","display_name":"conservation genetics","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tibetan-plateau","display_name":"Tibetan Plateau","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8784999847412109},{"id":"https://openalex.org/C67205732","wikidata":"https://www.wikidata.org/wiki/Q966735","display_name":"Cline (biology)","level":3,"score":0.8191999793052673},{"id":"https://openalex.org/C49735019","wikidata":"https://www.wikidata.org/wiki/Q4115005","display_name":"Selective sweep","level":5,"score":0.5791000127792358},{"id":"https://openalex.org/C2780354846","wikidata":"https://www.wikidata.org/wiki/Q24962946","display_name":"Local adaptation","level":3,"score":0.5482000112533569},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5379999876022339},{"id":"https://openalex.org/C137848329","wikidata":"https://www.wikidata.org/wiki/Q804635","display_name":"Balancing selection","level":4,"score":0.534600019454956},{"id":"https://openalex.org/C3641667","wikidata":"https://www.wikidata.org/wiki/Q1295959","display_name":"Effective population size","level":4,"score":0.4390000104904175},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.43639999628067017},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42910000681877136},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.35440000891685486},{"id":"https://openalex.org/C517289559","wikidata":"https://www.wikidata.org/wiki/Q10297573","display_name":"Demographic history","level":4,"score":0.3481999933719635},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3402000069618225},{"id":"https://openalex.org/C85721925","wikidata":"https://www.wikidata.org/wiki/Q31151","display_name":"Population genetics","level":3,"score":0.3398999869823456},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.3314000070095062},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3278999924659729},{"id":"https://openalex.org/C2779040068","wikidata":"https://www.wikidata.org/wiki/Q7229807","display_name":"Population genomics","level":5,"score":0.3183000087738037},{"id":"https://openalex.org/C2777782036","wikidata":"https://www.wikidata.org/wiki/Q38978","display_name":"Inbreeding","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C26589402","wikidata":"https://www.wikidata.org/wiki/Q7068267","display_name":"Nucleotide diversity","level":5,"score":0.31349998712539673},{"id":"https://openalex.org/C80990810","wikidata":"https://www.wikidata.org/wiki/Q486420","display_name":"Genetic drift","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C6350597","wikidata":"https://www.wikidata.org/wiki/Q339495","display_name":"Altitude (triangle)","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2778146401","wikidata":"https://www.wikidata.org/wiki/Q10916362","display_name":"Disequilibrium","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C33511622","wikidata":"https://www.wikidata.org/wiki/Q1851434","display_name":"Morphometrics","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C112133119","wikidata":"https://www.wikidata.org/wiki/Q7543566","display_name":"Small population size","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C169733012","wikidata":"https://www.wikidata.org/wiki/Q1613416","display_name":"Population size","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C7649158","wikidata":"https://www.wikidata.org/wiki/Q10395284","display_name":"Hybrid zone","level":5,"score":0.25940001010894775},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/biology15211982","doi":"https://doi.org/10.3390/biology15211982","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15211982","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/biology15211982","doi":"https://doi.org/10.3390/biology15211982","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15211982","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life on land","score":0.7605999708175659,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1538931861","https://openalex.org/W1772281102","https://openalex.org/W1793793548","https://openalex.org/W1908810753","https://openalex.org/W1982518595","https://openalex.org/W1984068087","https://openalex.org/W2037412015","https://openalex.org/W2050340111","https://openalex.org/W2087377825","https://openalex.org/W2110065044","https://openalex.org/W2111647009","https://openalex.org/W2119180969","https://openalex.org/W2119444539","https://openalex.org/W2122403114","https://openalex.org/W2149992227","https://openalex.org/W2161633633","https://openalex.org/W2162348455","https://openalex.org/W2171932688","https://openalex.org/W2181045166","https://openalex.org/W2186562439","https://openalex.org/W2495190760","https://openalex.org/W2537045088","https://openalex.org/W2564456678","https://openalex.org/W2736436381","https://openalex.org/W2797449804","https://openalex.org/W2885671209","https://openalex.org/W2897268704","https://openalex.org/W2951912016","https://openalex.org/W2962767035","https://openalex.org/W3199637732","https://openalex.org/W4225113132","https://openalex.org/W4229812736","https://openalex.org/W4294733854","https://openalex.org/W4318587449","https://openalex.org/W4319982309","https://openalex.org/W4321019193","https://openalex.org/W4321370611","https://openalex.org/W4396541716","https://openalex.org/W4401321093","https://openalex.org/W4402750214","https://openalex.org/W4405627455","https://openalex.org/W4406104714","https://openalex.org/W4411967890","https://openalex.org/W4412124367","https://openalex.org/W4413113045","https://openalex.org/W4413527251","https://openalex.org/W7124675345","https://openalex.org/W7131129463"],"related_works":["https://openalex.org/W2951526603","https://openalex.org/W4392593779","https://openalex.org/W2411509391","https://openalex.org/W6948702614","https://openalex.org/W6948650057","https://openalex.org/W4387115901","https://openalex.org/W7213942757","https://openalex.org/W2943318011","https://openalex.org/W2997643550","https://openalex.org/W7153157128"],"abstract_inverted_index":{"Extreme":[0],"altitudinal":[1,56],"gradients":[2,10],"are":[3],"natural":[4],"experiments":[5],"for":[6,196],"testing":[7],"how":[8],"environmental":[9],"shape":[11],"genomic":[12,180],"variation,":[13],"yet":[14],"remain":[15],"poorly":[16],"characterised":[17],"in":[18,42],"high-altitude":[19,197],"reptiles.":[20,198],"We":[21],"analysed":[22],"whole-genome":[23],"resequencing":[24],"data":[25],"(~17\u00d7)":[26],"from":[27,36],"44":[28],"rock":[29],"agamas":[30],"(Laudakia":[31],"sacra":[32,52],"and":[33,88,123,148,158,174,192],"L.":[34,51],"wui)":[35],"five":[37],"populations":[38],"spanning":[39,144],"2311\u20133758":[40],"m":[41],"the":[43,64,72,89,101,132,137,165,170,183],"Yarlung":[44],"Zangbo":[45],"valley,":[46],"Qinghai\u2013Tibet":[47],"Plateau.":[48],"Variation":[49],"within":[50],"formed":[53],"a":[54,115],"continuous":[55],"cline":[57,117],"rather":[58],"than":[59],"four":[60],"discrete":[61],"units,":[62],"with":[63,77,95,106,136,187],"first":[65],"principal":[66],"component":[67],"(PC1)":[68],"explaining":[69],"41.29%":[70],"of":[71],"variance;":[73],"diversity":[74],"declined":[75],"monotonically":[76],"altitude":[78],"(\u03c0":[79],"fell":[80],"~9-fold),":[81],"linkage":[82],"disequilibrium":[83],"(LD)":[84],"half-decay":[85],"lengthened":[86],"27-fold":[87],"inbreeding":[90],"coefficient":[91],"(FROH)":[92],"reached":[93],"0.155":[94],"effective":[96,156],"population":[97],"size":[98,157],"lowest":[99],"at":[100,164],"valley":[102,166],"head.":[103],"Redundancy":[104],"analysis":[105,126],"permutation":[107],"identified":[108],"593":[109],"altitude-associated":[110],"SNPs,":[111],"jointly":[112],"supported":[113],"by":[114],"rank-based":[116],"screen":[118],"(6.1-fold":[119],"enrichment":[120],"over":[121],"independence),":[122],"selective":[124],"sweep":[125],"detected":[127],"4573":[128],"candidate":[129],"genes":[130],"across":[131],"ten":[133],"pairwise":[134],"comparisons,":[135],"extreme":[138],"interspecific":[139],"contrast":[140],"(C1":[141],"vs.":[142],"C5)":[143],"cytoskeletal,":[145],"epigenetic,":[146],"glycolytic":[147],"oxygen-sensing":[149],"functions.":[150],"Low":[151],"diversity,":[152],"high":[153],"inbreeding,":[154],"small":[155],"large":[159],"projected":[160],"genetic":[161],"offset":[162],"coincided":[163],"head,":[167],"making":[168],"it":[169],"most":[171],"genetically":[172],"depauperate":[173],"climate-vulnerable":[175],"population.":[176],"These":[177],"results":[178],"reveal":[179],"differentiation":[181],"along":[182],"altitudinal\u2013longitudinal":[184],"gradient":[185],"consistent":[186],"putative":[188],"incipient":[189],"local":[190],"adaptation":[191],"identify":[193],"conservation":[194],"priorities":[195]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}