{"id":"https://openalex.org/W7225083381","doi":"https://doi.org/10.1002/inm3.70097","title":"Hepatocyte\u2010Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies","display_name":"Hepatocyte\u2010Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225083381","doi":"https://doi.org/10.1002/inm3.70097"},"language":"en","primary_location":{"id":"doi:10.1002/inm3.70097","doi":"https://doi.org/10.1002/inm3.70097","is_oa":true,"landing_page_url":"https://doi.org/10.1002/inm3.70097","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inm3.70097","source":{"id":"https://openalex.org/S5407053375","display_name":"iNew Medicine","issn_l":"3067-2767","issn":["3067-2767","3067-2775"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iNew Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inm3.70097","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003541822","display_name":"Eui Jung Jung","orcid":"https://orcid.org/0009-0002-5190-3747","observed_orcids":["https://orcid.org/0009-0002-5190-3747"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eui Jung Jung","raw_affiliation_strings":["Department of Medicine Columbia University Irving Medical Center  New York New York USA"],"raw_orcid":"https://orcid.org/0009-0002-5190-3747","affiliations":[{"raw_affiliation_string":"Department of Medicine Columbia University Irving Medical Center  New York New York USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100410379","display_name":"Xiaobo Wang","orcid":"https://orcid.org/0000-0001-6044-914X","observed_orcids":["https://orcid.org/0000-0001-6044-914X","https://orcid.org/0000-0003-3632-6347","https://orcid.org/0009-0001-5123-1664"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaobo Wang","raw_affiliation_strings":["Columbia University Digestive and Liver Disease Research Center  New York New York USA","Department of Medicine Columbia University Irving Medical Center  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0001-6044-914X","affiliations":[{"raw_affiliation_string":"Columbia University Digestive and Liver Disease Research Center  New York New York USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Medicine Columbia University Irving Medical Center  New York New York USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100410379"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84198151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.32519999146461487,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hepatic-stellate-cell-activation","display_name":"hepatic stellate cell activation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/indian-hedgehog","display_name":"Indian hedgehog","score":0.9380000233650208},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/jagged1","display_name":"Jagged1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/orotic-acid","display_name":"orotic acid","score":0.9089999794960022},{"id":"https://openalex.org/keywords/small-extracellular-vesicles","display_name":"small extracellular vesicles","score":0.9610000252723694},{"id":"https://openalex.org/keywords/alpha-1-antichymotrypsin","display_name":"alpha-1-antichymotrypsin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/angptl6","display_name":"ANGPTL6","score":1.0},{"id":"https://openalex.org/keywords/trkb-signaling","display_name":"TrkB signaling","score":0.9620000123977661},{"id":"https://openalex.org/keywords/galnac-conjugated-sirna","display_name":"GalNAc-conjugated siRNA","score":0.9570000171661377},{"id":"https://openalex.org/keywords/taz","display_name":"TAZ","score":0.6980000138282776},{"id":"https://openalex.org/keywords/jag1","display_name":"JAG1","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5667999982833862},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.5536999702453613},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5497000217437744},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5102999806404114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4000000059604645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39309999346733093},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3677999973297119},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.36230000853538513},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3562000095844269},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33739998936653137},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.3328000009059906},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3091999888420105},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.30809998512268066},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2903999984264374},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.29010000824928284},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/inm3.70097","doi":"https://doi.org/10.1002/inm3.70097","is_oa":true,"landing_page_url":"https://doi.org/10.1002/inm3.70097","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inm3.70097","source":{"id":"https://openalex.org/S5407053375","display_name":"iNew Medicine","issn_l":"3067-2767","issn":["3067-2767","3067-2775"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iNew Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/inm3.70097","doi":"https://doi.org/10.1002/inm3.70097","is_oa":true,"landing_page_url":"https://doi.org/10.1002/inm3.70097","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/inm3.70097","source":{"id":"https://openalex.org/S5407053375","display_name":"iNew Medicine","issn_l":"3067-2767","issn":["3067-2767","3067-2775"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iNew Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225083381.pdf","grobid_xml":"https://content.openalex.org/works/W7225083381.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1957489287","https://openalex.org/W1965588383","https://openalex.org/W1968393209","https://openalex.org/W1985333297","https://openalex.org/W2006241936","https://openalex.org/W2007873310","https://openalex.org/W2014718725","https://openalex.org/W2020433001","https://openalex.org/W2031293873","https://openalex.org/W2035030361","https://openalex.org/W2046127837","https://openalex.org/W2067042708","https://openalex.org/W2082179247","https://openalex.org/W2089055027","https://openalex.org/W2098202805","https://openalex.org/W2100538674","https://openalex.org/W2105231460","https://openalex.org/W2106069121","https://openalex.org/W2112944592","https://openalex.org/W2129125398","https://openalex.org/W2132916165","https://openalex.org/W2164556013","https://openalex.org/W2164567049","https://openalex.org/W2205982384","https://openalex.org/W2207469885","https://openalex.org/W2259003342","https://openalex.org/W2321179708","https://openalex.org/W2415876542","https://openalex.org/W2522516051","https://openalex.org/W2541359632","https://openalex.org/W2605897013","https://openalex.org/W2901663946","https://openalex.org/W2914978609","https://openalex.org/W2934235733","https://openalex.org/W2945289743","https://openalex.org/W2945824290","https://openalex.org/W2963050675","https://openalex.org/W2971782246","https://openalex.org/W2972904585","https://openalex.org/W2977959633","https://openalex.org/W3005214954","https://openalex.org/W3015115032","https://openalex.org/W3085137158","https://openalex.org/W3094558588","https://openalex.org/W3120402636","https://openalex.org/W3173162204","https://openalex.org/W3216127697","https://openalex.org/W4289527021","https://openalex.org/W4322154784","https://openalex.org/W4385336685","https://openalex.org/W4387893128","https://openalex.org/W4388948539","https://openalex.org/W4391592880","https://openalex.org/W4393058007","https://openalex.org/W4393356717","https://openalex.org/W4393357046","https://openalex.org/W4396894700","https://openalex.org/W4398202580","https://openalex.org/W4400080172","https://openalex.org/W4401191303","https://openalex.org/W4403902513","https://openalex.org/W4404933387","https://openalex.org/W4407957920","https://openalex.org/W4409353958","https://openalex.org/W4409963211","https://openalex.org/W4413101427","https://openalex.org/W4414113946","https://openalex.org/W4415503139","https://openalex.org/W4416083516","https://openalex.org/W4416505972","https://openalex.org/W4417535020","https://openalex.org/W7117145643","https://openalex.org/W7125837068","https://openalex.org/W7127633106","https://openalex.org/W7128785329","https://openalex.org/W7134182409","https://openalex.org/W7134934687","https://openalex.org/W7135086886","https://openalex.org/W7139132625","https://openalex.org/W7149608627","https://openalex.org/W7153520981","https://openalex.org/W7154397030"],"related_works":["https://openalex.org/W4393357046","https://openalex.org/W7165489242","https://openalex.org/W4404172212","https://openalex.org/W7208805009","https://openalex.org/W4387330412","https://openalex.org/W4414195829","https://openalex.org/W4409353958","https://openalex.org/W4414554746","https://openalex.org/W7215125666","https://openalex.org/W4400386436"],"abstract_inverted_index":{"ABSTRACT":[0],"Metabolic":[1],"dysfunction\u2010associated":[2],"steatohepatitis":[3],"(MASH)":[4],"is":[5],"a":[6,29,182],"major":[7],"driver":[8],"of":[9,19],"liver":[10],"fibrosis,":[11],"with":[12,43,112],"fibrosis":[13,187],"stage":[14],"being":[15],"the":[16,58,117],"strongest":[17],"predictor":[18],"clinical":[20],"outcomes.":[21],"Recent":[22],"advances":[23],"have":[24,168],"redefined":[25],"MASH":[26,186],"pathogenesis":[27],"as":[28,88,90,96,116,121,164,193],"hepatocyte\u2010centered":[30,183],"process":[31],"in":[32,62,173],"which":[33,137],"metabolically":[34,53],"stressed":[35],"hepatocytes":[36,72,126],"actively":[37],"regulate":[38],"fibrogenesis":[39],"through":[40],"direct":[41],"communication":[42],"hepatic":[44],"stellate":[45],"cells":[46],"(HSCs).":[47],"This":[48],"review":[49,180],"integrates":[50],"findings":[51],"from":[52],"relevant":[54],"animal":[55],"models,":[56],"particularly":[57,157],"fructose\u2013palmitate\u2013cholesterol":[59],"model,":[60],"and":[61,86,92,99,109,134,166,175,188,202],"vitro":[63],"systems":[64],"to":[65,73,197],"highlight":[66],"how":[67],"distinct":[68],"metabolic":[69],"insults":[70],"reprogram":[71],"secrete":[74],"profibrotic":[75],"mediators,":[76],"including":[77,131],"Indian":[78],"hedgehog,":[79],"osteopontin,":[80],"meteorin,":[81],"bone":[82],"morphogenetic":[83],"protein":[84],"8B,":[85],"Jagged1,":[87],"well":[89],"metabolite\u2010":[91],"vesicle\u2010mediated":[93],"signals":[94],"such":[95,115,163],"orotic":[97],"acid":[98],"small":[100,153],"extracellular":[101],"vesicles.":[102],"These":[103],"hepatocyte\u2010derived":[104],"factors":[105],"directly":[106],"activate":[107],"HSCs":[108],"sustain":[110],"fibrogenesis,":[111],"convergent":[113],"pathways":[114],"cholesterol\u2013TAZ\u2013IHH":[118],"axis":[119],"emerging":[120],"central":[122],"drivers.":[123],"In":[124],"parallel,":[125],"also":[127],"produce":[128],"antifibrotic":[129,171],"signals,":[130],"SERPINA3,":[132],"ANGPTL6,":[133],"TrkB\u2010dependent":[135],"pathways,":[136],"counterbalance":[138],"HSC":[139,200],"activation":[140,201],"but":[141],"are":[142],"diminished":[143],"during":[144],"disease":[145],"progression.":[146],"Building":[147],"on":[148],"these":[149],"mechanistic":[150],"insights,":[151],"hepatocyte\u2010targeted":[152],"interfering":[154],"RNA":[155],"therapies,":[156],"GalNAc\u2010conjugated":[158],"approaches":[159],"targeting":[160],"key":[161],"regulators":[162],"TAZ":[165],"JAG1,":[167],"demonstrated":[169],"robust":[170],"efficacy":[172],"preclinical":[174],"humanized":[176],"models.":[177],"Together,":[178],"this":[179],"establishes":[181],"framework":[184],"for":[185],"highlights":[189],"precision":[190],"gene\u2010silencing":[191],"strategies":[192],"promising":[194],"therapeutic":[195],"avenues":[196],"disrupt":[198],"hepatocyte\u2010driven":[199],"fibrotic":[203],"remodeling.":[204]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}
