{"id":"https://openalex.org/W7225083111","doi":"https://doi.org/10.5530/jppcm.20270753","title":"Prevalence of Serious Adverse Drug Reactions: Is India Vigilant Enough?","display_name":"Prevalence of Serious Adverse Drug Reactions: Is India Vigilant Enough?","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225083111","doi":"https://doi.org/10.5530/jppcm.20270753"},"language":"en","primary_location":{"id":"doi:10.5530/jppcm.20270753","doi":"https://doi.org/10.5530/jppcm.20270753","is_oa":true,"landing_page_url":"https://doi.org/10.5530/jppcm.20270753","pdf_url":"https://www.jppcm.org/article/13/1/60.pdf","source":{"id":"https://openalex.org/S4210195304","display_name":"Journal of Pharmacy Practice and Community Medicine","issn_l":"2455-3255","issn":["2455-3255"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy Practice and Community Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jppcm.org/article/13/1/60.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119683732","display_name":"Pravartika Gandhi","orcid":"https://orcid.org/0009-0009-7407-2246","observed_orcids":["https://orcid.org/0009-0009-7407-2246"]},"institutions":[{"id":"https://openalex.org/I1312996466","display_name":"Safdarjang Hospital","ror":"https://ror.org/0267zkr58","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1312996466"]},{"id":"https://openalex.org/I17972996","display_name":"Vardhman Mahavir Medical College & Safdarjung Hospital","ror":"https://ror.org/03zj0ps89","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I17972996"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pravartika Gandhi","raw_affiliation_strings":["Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar West, New Delhi, Delhi, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar West, New Delhi, Delhi, INDIA","institution_ids":["https://openalex.org/I1312996466","https://openalex.org/I17972996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160343736","display_name":"Ranveer Sahrawat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312996466","display_name":"Safdarjang Hospital","ror":"https://ror.org/0267zkr58","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1312996466"]},{"id":"https://openalex.org/I17972996","display_name":"Vardhman Mahavir Medical College & Safdarjung Hospital","ror":"https://ror.org/03zj0ps89","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I17972996"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ranveer Sahrawat","raw_affiliation_strings":["Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar West, New Delhi, Delhi, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar West, New Delhi, Delhi, INDIA","institution_ids":["https://openalex.org/I1312996466","https://openalex.org/I17972996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080942991","display_name":"Preeta Kaur Chugh","orcid":"https://orcid.org/0000-0003-0331-2600","observed_orcids":["https://orcid.org/0000-0003-0331-2600"]},"institutions":[{"id":"https://openalex.org/I1312996466","display_name":"Safdarjang Hospital","ror":"https://ror.org/0267zkr58","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1312996466"]},{"id":"https://openalex.org/I17972996","display_name":"Vardhman Mahavir Medical College & Safdarjung Hospital","ror":"https://ror.org/03zj0ps89","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I17972996"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Preeta Kaur Chugh","raw_affiliation_strings":["Department of Pharmacology , Vardhman Mahavir Medical College and Safdarjung Hospital , Ansari Nagar West , New Delhi , Delhi , INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Vardhman Mahavir Medical College and Safdarjung Hospital , Ansari Nagar West , New Delhi , Delhi , INDIA","institution_ids":["https://openalex.org/I1312996466","https://openalex.org/I17972996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83868052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"1","first_page":"60","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serious-adverse-drug-reactions","display_name":"serious adverse drug reactions","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6150000095367432},{"id":"https://openalex.org/keywords/nsaid-nephrotoxicity","display_name":"NSAID nephrotoxicity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/india","display_name":"India","score":0.31700000166893005},{"id":"https://openalex.org/keywords/cross-national-comparison","display_name":"cross-national comparison","score":0.5580000281333923},{"id":"https://openalex.org/keywords/patient-safety","display_name":"patient safety","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8988000154495239},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.7609999775886536},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4772000014781952},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4174000024795532},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3783999979496002},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3781000077724457},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.34610000252723694},{"id":"https://openalex.org/C2781342390","wikidata":"https://www.wikidata.org/wiki/Q17146321","display_name":"Under-reporting","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C23276603","wikidata":"https://www.wikidata.org/wiki/Q158230","display_name":"Pharmacoepidemiology","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.30970001220703125},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.29820001125335693},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.27639999985694885},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C3017566137","wikidata":"https://www.wikidata.org/wiki/Q5308929","display_name":"Drug usage","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C2776034101","wikidata":"https://www.wikidata.org/wiki/Q1509347","display_name":"Commission","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C186079640","wikidata":"https://www.wikidata.org/wiki/Q719602","display_name":"Prevalence","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C83864248","wikidata":"https://www.wikidata.org/wiki/Q177323","display_name":"Developing country","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C70917649","wikidata":"https://www.wikidata.org/wiki/Q94307","display_name":"Thiopurine methyltransferase","level":4,"score":0.2540999948978424},{"id":"https://openalex.org/C3020169349","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug event","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C160050368","wikidata":"https://www.wikidata.org/wiki/Q132453","display_name":"Developed country","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5530/jppcm.20270753","doi":"https://doi.org/10.5530/jppcm.20270753","is_oa":true,"landing_page_url":"https://doi.org/10.5530/jppcm.20270753","pdf_url":"https://www.jppcm.org/article/13/1/60.pdf","source":{"id":"https://openalex.org/S4210195304","display_name":"Journal of Pharmacy Practice and Community Medicine","issn_l":"2455-3255","issn":["2455-3255"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy Practice and Community Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5530/jppcm.20270753","doi":"https://doi.org/10.5530/jppcm.20270753","is_oa":true,"landing_page_url":"https://doi.org/10.5530/jppcm.20270753","pdf_url":"https://www.jppcm.org/article/13/1/60.pdf","source":{"id":"https://openalex.org/S4210195304","display_name":"Journal of Pharmacy Practice and Community Medicine","issn_l":"2455-3255","issn":["2455-3255"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy Practice and Community Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225083111.pdf","grobid_xml":"https://content.openalex.org/works/W7225083111.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1986876983","https://openalex.org/W2007817717","https://openalex.org/W2107273840","https://openalex.org/W2108032385","https://openalex.org/W2133104620","https://openalex.org/W2140475238","https://openalex.org/W2149015305","https://openalex.org/W2149191413","https://openalex.org/W2739417088","https://openalex.org/W2807432002","https://openalex.org/W2899577938","https://openalex.org/W2974811933","https://openalex.org/W3158213549","https://openalex.org/W3165433365","https://openalex.org/W4200569966","https://openalex.org/W4210342792","https://openalex.org/W4363650187","https://openalex.org/W4390610989","https://openalex.org/W4391880004"],"related_works":["https://openalex.org/W2338541698","https://openalex.org/W4385559171","https://openalex.org/W2792564858","https://openalex.org/W4407480038","https://openalex.org/W2099498081","https://openalex.org/W3094099345","https://openalex.org/W7162559648","https://openalex.org/W2473827101","https://openalex.org/W7108473053","https://openalex.org/W7206208645"],"abstract_inverted_index":{"**Background:**":[0],"Serious":[1],"Adverse":[2,117],"Drug":[3],"Reactions":[4],"(sADRs)":[5],"are":[6,20],"one":[7],"of":[8,12,56,80,98,155,188,199],"the":[9,54,72,96,101,136,197,207],"important":[10],"causes":[11],"morbidity":[13],"and":[14,47,66,69,76,114,125,139,167,180,203,215,220],"mortality.":[15],"In":[16],"India,":[17],"pharmacovigilance":[18],"practices":[19],"evolving":[21],"but":[22],"comprehensive":[23],"regional":[24],"data":[25,106],"on":[26],"sADRs":[27,58,99,144,189,200],"is":[28,40],"lacking.":[29],"Understanding":[30],"how":[31],"sADR":[32],"prevalence":[33,55,97,154,198],"in":[34,64,100,162,190,196,218],"India":[35,65,163,202],"compares":[36],"with":[37,60,142],"global":[38],"patterns":[39],"essential":[41],"to":[42,52,70,94,212],"improve":[43],"patient":[44,103,221],"safety.":[45],"**Aims":[46],"Objectives:**":[48],"This":[49],"study":[50],"aimed":[51],"compare":[53],"selected":[57,146],"associated":[59,216],"commonly":[61],"used":[62],"drugs":[63,81,141],"other":[67,204],"countries,":[68],"examine":[71],"contributing":[73],"factors.":[74],"**Materials":[75],"Methods:**":[77],"A":[78,89],"list":[79],"was":[82,92,123],"compiled":[83],"using":[84],"a":[85,152],"generic":[86],"drug":[87],"index.":[88],"PubMed":[90],"search":[91],"conducted":[93],"estimate":[95],"Indian":[102,110,149,191],"population.":[104],"Additional":[105],"were":[107,145],"obtained":[108],"from":[109],"Pharmacopoeia":[111],"Commission":[112],"publications":[113],"FAERS":[115,133],"(FDA":[116],"Event":[118],"Reporting":[119],"System)":[120],"database.":[121],"Data":[122],"extracted":[124],"tabulated":[126],"for":[127,147,209],"comparison.":[128,148],"**Results:**":[129],"Twenty-two":[130],"studies":[131],"(including":[132],"data)":[134],"met":[135],"inclusion":[137],"criteria,":[138],"ten":[140],"their":[143],"patients":[150],"exhibited":[151],"higher":[153],"several":[156],"sADRs-for":[157],"example,":[158],"Linezolid-induced":[159],"neuropathy":[160],"(93.3%":[161],"vs.":[164,175],"1.6%":[165],"globally)":[166],"Non":[168],"Steroidal":[169],"Anti-Inflammatory":[170],"Drugs":[171],"(NSAID)-induced":[172],"nephrotoxicity":[173],"(27.88%":[174],"13%).":[176],"Lamivudine-induced":[177],"hearing":[178],"loss":[179],"Pioglitazone-induced":[181],"bladder":[182],"cancer":[183],"showed":[184],"significantly":[185],"lower":[186],"rates":[187],"studies.":[192],"**Conclusion:**":[193],"Marked":[194],"differences":[195,214],"between":[201],"countries":[205],"highlight":[206],"need":[208],"sensitising":[210],"physicians":[211],"these":[213],"implications":[217],"prescribing":[219],"management.":[222]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}