{"id":"https://openalex.org/W7225082473","doi":"https://doi.org/10.1073/pnas.2602240123","title":"Kinome profiling enabled development of a LATS1/2 inhibitor with wound healing potential","display_name":"Kinome profiling enabled development of a LATS1/2 inhibitor with wound healing potential","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225082473","doi":"https://doi.org/10.1073/pnas.2602240123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42970682"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2602240123","doi":"https://doi.org/10.1073/pnas.2602240123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2602240123","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2602240123","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2602240123","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014960774","display_name":"Frances Anne Tosto","orcid":"https://orcid.org/0000-0003-1109-7103","observed_orcids":["https://orcid.org/0000-0003-1109-7103"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances A. Tosto","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0003-1109-7103","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085899840","display_name":"Patrick J. Morris","orcid":"https://orcid.org/0000-0003-2380-4178","observed_orcids":["https://orcid.org/0000-0003-2380-4178"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick J. Morris","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0003-2380-4178","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112954881","display_name":"Yanyan Qu","orcid":"https://orcid.org/0009-0005-3094-3098","observed_orcids":["https://orcid.org/0009-0005-3094-3098"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yanyan Qu","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0009-0005-3094-3098","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046691637","display_name":"Lale Evsen","orcid":"https://orcid.org/0009-0003-2417-3598","observed_orcids":["https://orcid.org/0009-0003-2417-3598"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lale Evsen","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0009-0003-2417-3598","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070884494","display_name":"Gregory J. Tawa","orcid":"https://orcid.org/0000-0002-5573-308X","observed_orcids":["https://orcid.org/0000-0002-5573-308X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory J. Tawa","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007577603","display_name":"Ravi Tharakan","orcid":"https://orcid.org/0000-0001-5895-9271","observed_orcids":["https://orcid.org/0000-0001-5895-9271"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Tharakan","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-5895-9271","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141177748","display_name":"Bridget S. Scherer","orcid":"https://orcid.org/0009-0000-5668-9247","observed_orcids":["https://orcid.org/0009-0000-5668-9247"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bridget S. Scherer","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0009-0000-5668-9247","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010552508","display_name":"Damien Y. Duveau","orcid":"https://orcid.org/0000-0001-9954-7126","observed_orcids":["https://orcid.org/0000-0001-9954-7126"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damien Y. Duveau","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090967616","display_name":"Dvir Blivis","orcid":"https://orcid.org/0000-0001-6203-7325","observed_orcids":["https://orcid.org/0000-0001-6203-7325"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dvir Blivis","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-6203-7325","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107771287","display_name":"Ty C. Voss","orcid":"https://orcid.org/0009-0002-8750-2478","observed_orcids":["https://orcid.org/0009-0002-8750-2478"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ty Voss","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056377642","display_name":"Ganesha Rai","orcid":"https://orcid.org/0000-0001-9763-9641","observed_orcids":["https://orcid.org/0000-0001-9763-9641"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganesha Rai","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-9763-9641","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113826906","display_name":"Mahfuza Sharmin","orcid":"https://orcid.org/0000-0003-2059-0549","observed_orcids":["https://orcid.org/0000-0003-2059-0549"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahfuza Sharmin","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0003-2059-0549","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039590396","display_name":"Dingyin Tao","orcid":"https://orcid.org/0000-0001-6531-2740","observed_orcids":["https://orcid.org/0000-0001-6531-2740"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dingyin Tao","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-6531-2740","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048143682","display_name":"Christopher A. LeClair","orcid":"https://orcid.org/0000-0002-2746-5938","observed_orcids":["https://orcid.org/0000-0002-2746-5938"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. LeClair","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0002-2746-5938","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091208273","display_name":"Leonid Peshkin","orcid":"https://orcid.org/0000-0002-6420-848X","observed_orcids":["https://orcid.org/0000-0002-6420-848X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonid Peshkin","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School"],"raw_orcid":"https://orcid.org/0000-0002-6420-848X","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022390160","display_name":"Taranjit S. Gujral","orcid":"https://orcid.org/0000-0002-4453-3031","observed_orcids":["https://orcid.org/0000-0002-4453-3031"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taranjit S. Gujral","raw_affiliation_strings":["Human Biology Division, Fred Hutchinson Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-4453-3031","affiliations":[{"raw_affiliation_string":"Human Biology Division, Fred Hutchinson Cancer Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030915433","display_name":"Ana Corrionero","orcid":"https://orcid.org/0009-0002-9990-1214","observed_orcids":["https://orcid.org/0009-0002-9990-1214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Corrionero","raw_affiliation_strings":["Enzymlogic S.L"],"raw_orcid":"https://orcid.org/0009-0002-9990-1214","affiliations":[{"raw_affiliation_string":"Enzymlogic S.L","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112269074","display_name":"Scott B. Hoyt","orcid":"https://orcid.org/0009-0009-9788-1935","observed_orcids":["https://orcid.org/0009-0009-9788-1935"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott B. Hoyt","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0009-0009-9788-1935","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015176214","display_name":"Marc W. Kirschner","orcid":"https://orcid.org/0000-0001-6540-6130","observed_orcids":["https://orcid.org/0000-0001-6540-6130"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc W. Kirschner","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School"],"raw_orcid":"https://orcid.org/0000-0001-6540-6130","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014278257","display_name":"Craig J. Thomas","orcid":"https://orcid.org/0000-0001-9386-9001","observed_orcids":["https://orcid.org/0000-0001-9386-9001"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig J. Thomas","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-9386-9001","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045917555","display_name":"Michele Ceribelli","orcid":"https://orcid.org/0000-0001-9857-9521","observed_orcids":["https://orcid.org/0000-0001-9857-9521"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michele Ceribelli","raw_affiliation_strings":["Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0001-9857-9521","affiliations":[{"raw_affiliation_string":"Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014278257","https://openalex.org/A5045917555","https://openalex.org/A5085899840","https://openalex.org/A5112954881"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75525876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"45","first_page":"e2602240123","last_page":"e2602240123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinome-profiling","display_name":"kinome profiling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/yap-phosphorylation","display_name":"YAP phosphorylation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/yap-nuclear-translocation","display_name":"YAP nuclear translocation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6890000104904175},{"id":"https://openalex.org/keywords/scaffold-hopping","display_name":"scaffold hopping","score":0.6539999842643738},{"id":"https://openalex.org/keywords/agc-kinases","display_name":"AGC kinases","score":0.7179999947547913},{"id":"https://openalex.org/keywords/chemoproteomics","display_name":"chemoproteomics","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8629999756813049},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-cycle-activation","display_name":"cell cycle activation","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.8920999765396118},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.7263000011444092},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6362000107765198},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.6205000281333923},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5758000016212463},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5213000178337097},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.49950000643730164},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4740000069141388},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.45399999618530273},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43529999256134033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.428600013256073},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42489999532699585},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.41769999265670776},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4153999984264374},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41519999504089355},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4025999903678894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3874000012874603},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3614000082015991},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35269999504089355},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33709999918937683},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.29919999837875366},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2847000062465668},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.2770000100135803},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.257999986410141},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25189998745918274},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1073/pnas.2602240123","doi":"https://doi.org/10.1073/pnas.2602240123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2602240123","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2602240123","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:42970682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42970682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2602240123","doi":"https://doi.org/10.1073/pnas.2602240123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2602240123","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2602240123","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000195628","display_name":null,"funder_award_id":"AG073341","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225082473.pdf","grobid_xml":"https://content.openalex.org/works/W7225082473.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1912766252","https://openalex.org/W1918079945","https://openalex.org/W1972724690","https://openalex.org/W1996435746","https://openalex.org/W1996690536","https://openalex.org/W2002143632","https://openalex.org/W2040430549","https://openalex.org/W2084966484","https://openalex.org/W2086286404","https://openalex.org/W2088593944","https://openalex.org/W2099072529","https://openalex.org/W2099709490","https://openalex.org/W2109838283","https://openalex.org/W2112933956","https://openalex.org/W2121072573","https://openalex.org/W2125539642","https://openalex.org/W2130410032","https://openalex.org/W2134937820","https://openalex.org/W2148056172","https://openalex.org/W2152265294","https://openalex.org/W2179438025","https://openalex.org/W2265398540","https://openalex.org/W2512544075","https://openalex.org/W2741274392","https://openalex.org/W2760084386","https://openalex.org/W2764199374","https://openalex.org/W2773242491","https://openalex.org/W2898701745","https://openalex.org/W2941492678","https://openalex.org/W2951428751","https://openalex.org/W2963554762","https://openalex.org/W2994464657","https://openalex.org/W3014692852","https://openalex.org/W3027748790","https://openalex.org/W3044562385","https://openalex.org/W3165505877","https://openalex.org/W3177828909","https://openalex.org/W3183475563","https://openalex.org/W3197240335","https://openalex.org/W4200603327","https://openalex.org/W4210412137","https://openalex.org/W4210647789","https://openalex.org/W4224285025","https://openalex.org/W4284883844","https://openalex.org/W4315642941","https://openalex.org/W4327951657","https://openalex.org/W4388020043","https://openalex.org/W4388539829","https://openalex.org/W4390755179","https://openalex.org/W4391953879","https://openalex.org/W4393950523","https://openalex.org/W4396721179","https://openalex.org/W4404046121","https://openalex.org/W4412726340","https://openalex.org/W4413013196"],"related_works":["https://openalex.org/W3047038545","https://openalex.org/W4413013196","https://openalex.org/W4402547107","https://openalex.org/W7154998031","https://openalex.org/W2883818766","https://openalex.org/W1967676836","https://openalex.org/W2060290661","https://openalex.org/W2163840470","https://openalex.org/W4389937847","https://openalex.org/W7139091095"],"abstract_inverted_index":{"System-level":[0],"mapping":[1],"of":[2,30,37,42,48,109,146,159,167,187,198,226],"kinase":[3,32,210],"inhibitors'":[4],"polypharmacology":[5],"can":[6],"uncover":[7],"opportunities":[8],"for":[9,16,55,219],"drug":[10],"repurposing":[11],"and":[12,45,59,76,91,101,107,119,122,153,181,207,216],"identify":[13],"starting":[14,70],"points":[15],"medicinal":[17],"chemistry":[18],"campaigns":[19],"aimed":[20],"at":[21],"novel":[22],"targets.":[23],"Here,":[24],"we":[25,72,202],"describe":[26,203],"a":[27,39,52,69,82],"large-scale":[28],"profiling":[29],"257":[31],"inhibitors":[33],"that":[34],"revealed":[35,157],"domains":[36],"promiscuity,":[38],"broad":[40,217],"region":[41],"uninhibited":[43],"targets":[44],"discrete":[46],"pockets":[47],"selectivity.":[49,124],"Focusing":[50],"on":[51],"subcluster":[53],"enriched":[54],"AGC":[56],"group":[57],"kinases":[58],"using":[60],"the":[61],"AKT":[62],"inhibitor":[63,84,211],"AT-7867":[64],"(an":[65],"antiproliferative":[66],"agent)":[67],"as":[68],"point,":[71],"employed":[73],"scaffold":[74],"hopping":[75],"property-based":[77],"optimization":[78],"to":[79,143],"discover":[80],"NCGC-6782,":[81],"LATS1/2":[83,96,209],"with":[85,212],"robust":[86],"proproliferative":[87],"activity.":[88],"In":[89,125],"biochemical":[90],"cell-based":[92,180],"assays,":[93],"NCGC-6782":[94,127,156,174],"inhibited":[95],"activity,":[97],"reduced":[98],"YAP":[99,104],"phosphorylation,":[100],"promoted":[102],"rapid":[103,144],"nuclear":[105],"translocation":[106],"transactivation":[108],"YAP-target":[110],"genes.":[111],"Kinome-wide":[112],"profilings":[113],"demonstrated":[114],"good":[115],"in":[116,148,178,182],"vitro":[117],"selectivity":[118],"exquisite":[120],"chemoproteomic":[121],"kinetic":[123],"vivo,":[126],"exhibited":[128],"favorable":[129],"pharmacokinetic":[130],"(PK)":[131],"profiles":[132],"following":[133,155,223],"intraperitoneal":[134],"(IP),":[135],"intravenous":[136],"(IV),":[137],"or":[138],"oral":[139],"(PO)":[140],"dosing,":[141],"leading":[142],"inhibition":[145],"YAP-phosphorylation":[147],"murine":[149],"liver":[150],"samples.":[151],"Transcriptomics":[152],"proteomics":[154],"upregulation":[158],"YAP-dependent":[160],"genes":[161],"(4":[162],"h)":[163],"followed":[164],"by":[165],"activation":[166],"cell":[168],"cycle":[169],"programs":[170],"(24":[171],"h).":[172],"Consistently,":[173],"accelerated":[175],"proliferative":[176],"regeneration":[177],"both":[179],"vivo":[183],"wound":[184],"healing":[185],"models":[186],"full-thickness":[188],"excisional":[189],"skin":[190],"injury,":[191],"significantly":[192],"shortening":[193],"wound-closure":[194],"time":[195],"without":[196],"evidence":[197],"systemic":[199],"toxicity.":[200],"Altogether,":[201],"an":[204],"optimized,":[205],"potent,":[206],"selective":[208],"desirable":[213],"drug-like":[214],"properties":[215],"potential":[218],"regenerative":[220],"medicine":[221],"applications":[222],"acute":[224],"injury":[225],"nonproliferative,":[227],"postmitotic":[228],"tissues.":[229]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-03T00:00:00"}