{"id":"https://openalex.org/W7225080893","doi":"https://doi.org/10.1007/s10238-026-02313-1","title":"Transcriptomic profiling of severe acute pancreatitis reveals neutrophil-driven inflammatory signatures and a five-gene diagnostic panel","display_name":"Transcriptomic profiling of severe acute pancreatitis reveals neutrophil-driven inflammatory signatures and a five-gene diagnostic panel","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225080893","doi":"https://doi.org/10.1007/s10238-026-02313-1"},"language":"en","primary_location":{"id":"doi:10.1007/s10238-026-02313-1","doi":"https://doi.org/10.1007/s10238-026-02313-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10238-026-02313-1","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s10238-026-02313-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115590906","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-0423-4157","observed_orcids":["https://orcid.org/0000-0003-0423-4157","https://orcid.org/0009-0008-6594-7111","https://orcid.org/0000-0001-8394-4303"]},"institutions":[{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160365113","display_name":"Junda Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junda Li","raw_affiliation_strings":["Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160382784","display_name":"Yuqi Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Han","raw_affiliation_strings":["Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I2802734952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160366122","display_name":"Peipei Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peipei Duan","raw_affiliation_strings":["Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I2802734952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111211116","display_name":"Xinwen Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinwen Yang","raw_affiliation_strings":["Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I2802734952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111211116"],"corresponding_institution_ids":["https://openalex.org/I2802734952"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.88831719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-acute-pancreatitis","display_name":"severe acute pancreatitis","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.6909999847412109},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7440000176429749},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.593999981880188},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.6880000233650208},{"id":"https://openalex.org/keywords/immune-cell-deconvolution","display_name":"immune cell deconvolution","score":0.7360000014305115},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9430000185966492},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/myc-target-genes","display_name":"MYC target genes","score":0.5569999814033508},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/disease-severity-classification","display_name":"disease severity classification","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.42500001192092896},{"id":"https://openalex.org/keywords/neutrophil-granule-proteins","display_name":"neutrophil granule proteins","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.7663999795913696},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.758400022983551},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6439999938011169},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.544700026512146},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5306000113487244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4779999852180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47699999809265137},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4684999883174896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41110000014305115},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3831000030040741},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37959998846054077},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.37869998812675476},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3684999942779541},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3659999966621399},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3416000008583069},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.32739999890327454},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.296099990606308},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2874999940395355},{"id":"https://openalex.org/C2778963024","wikidata":"https://www.wikidata.org/wiki/Q17132454","display_name":"Neutrophil to lymphocyte ratio","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C2781397275","wikidata":"https://www.wikidata.org/wiki/Q1996053","display_name":"Pancreatitis, chronic","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.2727999985218048},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C171196145","wikidata":"https://www.wikidata.org/wiki/Q4774577","display_name":"Antibody microarray","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s10238-026-02313-1","doi":"https://doi.org/10.1007/s10238-026-02313-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10238-026-02313-1","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s10238-026-02313-1","doi":"https://doi.org/10.1007/s10238-026-02313-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10238-026-02313-1","pdf_url":null,"source":{"id":"https://openalex.org/S1255940","display_name":"Clinical and Experimental Medicine","issn_l":"1591-8890","issn":["1591-8890","1591-9528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214388277","https://openalex.org/W4295168502","https://openalex.org/W7204853216","https://openalex.org/W4414187821","https://openalex.org/W4399755691","https://openalex.org/W4223903024","https://openalex.org/W4390976695","https://openalex.org/W7154708704","https://openalex.org/W4409319357","https://openalex.org/W4402694214"],"abstract_inverted_index":{"Severe":[0],"acute":[1,31],"pancreatitis":[2,32],"(SAP)":[3],"is":[4,458,514,528,553],"a":[5,35,43,228,316,365,487,556,575,581,588],"life-threatening":[6],"condition":[7],"associated":[8],"with":[9,105,129,141,195,233,241,320,561],"systemic":[10],"inflammatory":[11,612],"response":[12],"syndrome,":[13],"multi-organ":[14],"failure,":[15],"and":[16,22,84,108,145,179,186,205,211,248,256,273,287,335,407,418,565,594,617],"mortality":[17],"rates":[18],"of":[19,25,30,377,433,470,518,534,610],"20\u201340%.":[20],"Early":[21],"accurate":[23],"stratification":[24],"SAP":[26,72,309,337,415,474,530,552],"from":[27,63,283,338],"milder":[28,339],"forms":[29,341],"(AP)":[33],"remains":[34,546],"critical":[36],"clinical":[37,550],"challenge.":[38],"Blood-based":[39],"transcriptomic":[40,559],"signatures":[41],"offer":[42],"promising":[44],"avenue":[45],"for":[46,116,461],"non-invasive":[47],"biomarker":[48],"discovery.":[49],"We":[50],"analyzed":[51],"the":[52,306,343,359,374,452,473,497,500,511,519,522,529,603],"publicly":[53],"available":[54],"dataset":[55],"GSE194331,":[56],"comprising":[57],"human":[58,414],"whole":[59],"blood":[60,119,558],"bulk":[61],"RNA-seq":[62,157],"119":[64],"samples:":[65],"healthy":[66],"controls":[67],"(HC,":[68],"n":[69,74,81,88,480],"=":[70,75,82,89,203,209,220,238,245,251,263,270,278,303,325,328,351,371,481],"32),":[71],"(":[73,261,268,276,479],"10),":[76],"moderately":[77],"severe":[78],"AP":[79,86,321,340,344,405,605],"(MSAP,":[80],"20),":[83],"mild":[85],"(MildAP,":[87],"57).":[90],"Differential":[91],"expression":[92],"analysis":[93,103],"was":[94,123,136,151,362],"performed":[95,124],"using":[96,125,138,153],"DESeq2,":[97],"followed":[98],"by":[99,182,391,555],"gene":[100,110,457],"set":[101],"enrichment":[102,128],"(GSEA)":[104],"MSigDB":[106],"Hallmark":[107],"KEGG":[109],"sets.":[111],"Single-sample":[112,223],"immune":[113,120,224,567,571],"cell":[114,121,225,409,425],"deconvolution":[115,226],"12":[117],"peripheral":[118],"types":[122,426],"ssGSEA-like":[126],"rank-weighted":[127],"curated":[130],"marker":[131],"panels.":[132],"A":[133,291],"diagnostic":[134,293,600],"panel":[135,294,313,369,379,586],"developed":[137],"elastic":[139],"net/LASSO":[140],"leave-one-out":[142],"cross-validation":[143,495],"(LOO-CV)":[144],"bootstrap":[146],"stability":[147],"selection.":[148],"Cross-species":[149,608],"validation":[150,540],"conducted":[152],"mouse":[154,396,424],"pancreatic":[155],"single-cell":[156],"data":[158],"(GSE188819;":[159],"25,870":[160],"cells,":[161],"10x":[162],"Genomics).":[163],"DESeq2":[164],"identified":[165],"472":[166],"differentially":[167],"expressed":[168],"genes":[169,613],"(DEGs;":[170],"367":[171],"upregulated,":[172],"105":[173],"downregulated)":[174],"at":[175],"padj":[176],"<":[177],"0.01":[178],"|log2FC|\u22652,":[180],"dominated":[181],"neutrophil":[183,442],"granule":[184],"proteins":[185],"lymphocyte":[187],"depletion":[188,410],"markers.":[189,394],"GSEA":[190],"revealed":[191,227],"67":[192],"significant":[193],"pathways,":[194],"top":[196,212],"activated":[197],"pathways":[198,214],"including":[199,215],"Oxidative":[200],"Phosphorylation":[201],"(NES":[202,208,219],"2.71)":[204],"Inflammatory":[206],"Response":[207],"2.13),":[210],"suppressed":[213],"MYC":[216],"Targets":[217],"V2":[218],"\u2212":[221,264,271,279,332],"2.19).":[222],"continuous,":[229,576],"severity-graded":[230,577],"innate\u2013adaptive":[231,570],"imbalance,":[232],"M2":[234],"macrophages":[235],"(Spearman":[236,323],"r":[237,262,269,277,324],"+":[239,246,252,258],"0.66":[240],"severity),":[242],"neutrophils":[243],"(r":[244,250],"0.51),":[247],"monocytes":[249],"0.46)":[253],"progressively":[254,281],"expanding,":[255],"CD4":[257],"T":[259],"cells":[260,267,275,438],"0.61),":[265],"B":[266],"0.47),":[272],"NK":[274],"0.40)":[280],"contracting":[282],"HC":[284,307,476],"through":[285],"MildAP":[286],"MSAP":[288],"to":[289,364],"SAP.":[290],"five-gene":[292,585],"(CAMP,":[295],"LIPN,":[296],"RAB13,":[297],"SERPINB10,":[298],"LILRA4)":[299],"achieved":[300],"LOO-CV":[301,468],"AUC":[302,350,469,502,533],"1.000":[304,471,504],"in":[305,358,427,435,472,541],"vs.":[308,348,475,531],"discovery":[310,360,477],"comparison.":[311],"The":[312,467,569,584],"score":[314],"showed":[315],"strong":[317],"monotonic":[318],"relationship":[319],"severity":[322,606],"0.672,":[326],"P":[327],"5.8":[329],"\u00d7":[330],"10":[331],"17":[333],")":[334],"discriminated":[336],"within":[342],"cohort":[345,499,545],"itself":[346],"(SAP":[347],"Mild+MSAP":[349,532],"0.890,":[352],"95%":[353],"CI":[354,507,537],"0.756\u20130.982).":[355],"Diagnostic":[356],"performance":[357,601],"comparison":[361,478],"comparable":[363],"previously":[366],"published":[367],"S100A8/S100A9/S100A12":[368],"(AUC":[370],"0.997),":[372],"while":[373],"dual-axis":[375,589],"composition":[376],"our":[378],"(innate-myeloid":[380],"activation":[381,592],"plus":[382],"adaptive-compartment":[383,595],"integrity)":[384],"provided":[385],"complementary":[386],"biological":[387],"information":[388],"not":[389,515],"captured":[390],"single-axis":[392],"innate-immune":[393,462],"In":[395,429],"scRNA-seq,":[397],"massive":[398],"macrophage":[399],"expansion":[400],"(546":[401],"WT":[402],"\u2192":[403],"8,976":[404],"cells)":[406],"T/NK":[408],"were":[411],"observed.":[412],"Key":[413],"genes\u2014Anxa3,":[416],"S100a9,":[417],"Rab13\u2014were":[419],"consistently":[420],"upregulated":[421],"across":[422,602],"multiple":[423],"AP.":[428],"vitro,":[430],"siRNA-mediated":[431],"knockdown":[432],"CAMP":[434],"ATRA-differentiated":[436],"HL-60":[437],"markedly":[439],"attenuated":[440],"LPS-induced":[441],"extracellular":[443],"trap":[444],"(NET)":[445],"formation,":[446],"providing":[447],"direct":[448],"functional":[449],"evidence":[450],"that":[451,510],"panel\u2019s":[453],"most":[454],"stably":[455],"selected":[456],"mechanistically":[459],"required":[460],"effector":[463],"responses.":[464],"[Revision":[465],"note:":[466],"42)":[482],"should":[483],"be":[484],"interpreted":[485],"as":[486,574],"discovery-cohort":[488],"upper":[489],"bound.":[490],"Under":[491],"200-repeat":[492],"stratified":[493],"5-fold":[494],"on":[496],"same":[498],"mean":[501],"remained":[503],"[95%":[505,536],"percentile":[506],"1.000\u20131.000],":[508],"confirming":[509],"perfect":[512],"value":[513],"an":[516,542],"artefact":[517],"LOO":[520],"scheme;":[521],"clinically":[523],"more":[524],"informative":[525],"primary":[526],"read-out":[527],"0.906":[535],"0.815\u20130.971].":[538],"External":[539],"independent":[543],"prospective":[544],"mandatory":[547],"before":[548],"any":[549],"use.]":[551],"characterized":[554],"neutrophil-driven":[557],"signature":[560],"concurrent":[562],"metabolic":[563],"reprogramming":[564],"adaptive":[566],"suppression.":[568],"imbalance":[572],"unfolds":[573],"process":[578],"rather":[579],"than":[580],"binary":[582],"switch.":[583],"encodes":[587],"molecular":[590],"fingerprint\u2014innate-myeloid":[591],"(CAMP/LIPN/RAB13/SERPINB10)":[593],"integrity":[596],"(LILRA4)\u2014translating":[597],"into":[598],"superior":[599],"full":[604],"spectrum.":[607],"conservation":[609],"key":[611],"supports":[614],"their":[615],"mechanistic":[616],"translational":[618],"relevance.":[619]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-03T00:00:00"}