{"id":"https://openalex.org/W7225058675","doi":"https://doi.org/10.21203/rs.3.rs-11024297/v1","title":"Association Between Lesion-Directed Positioning Management and Early Functional Recovery Following PRP-Augmented Meniscal Repair: A Retrospective Cohort Study","display_name":"Association Between Lesion-Directed Positioning Management and Early Functional Recovery Following PRP-Augmented Meniscal Repair: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225058675","doi":"https://doi.org/10.21203/rs.3.rs-11024297/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11024297/v1","doi":"https://doi.org/10.21203/rs.3.rs-11024297/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11024297/v1","pdf_url":"https://www.researchsquare.com/article/rs-11024297/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11024297/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160323855","display_name":"Xinxin Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Cheng","raw_affiliation_strings":["Fujian Medical University Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080033175","display_name":"Shixin Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shixin Nie","raw_affiliation_strings":["Fujian Medical University Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160286461","display_name":"Biwen Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biwen Lu","raw_affiliation_strings":["Fujian Medical University Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160290137","display_name":"Hua Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":["Fujian Medical University Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital","institution_ids":["https://openalex.org/I4210163933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210163933"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/meniscal-repair","display_name":"meniscal repair","score":0.9279999732971191},{"id":"https://openalex.org/keywords/arthroscopic-surgery","display_name":"arthroscopic surgery","score":0.7409999966621399},{"id":"https://openalex.org/keywords/postoperative-positioning","display_name":"postoperative positioning","score":0.9390000104904175},{"id":"https://openalex.org/keywords/meniscus-tear","display_name":"meniscal tears","score":0.6380000114440918},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.7210000157356262},{"id":"https://openalex.org/keywords/knee-function","display_name":"knee function","score":0.6100000143051147},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.8930000066757202},{"id":"https://openalex.org/keywords/early-functional-recovery","display_name":"early functional recovery","score":0.6209999918937683},{"id":"https://openalex.org/keywords/ikdc-score","display_name":"IKDC score","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lysholm-score","display_name":"Lysholm score","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tegner-score","display_name":"Tegner score","score":0.8640000224113464},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.6299999952316284},{"id":"https://openalex.org/keywords/reoperation","display_name":"reoperation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/arthrofibrosis","display_name":"arthrofibrosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9301999807357788},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7178000211715698},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5480999946594238},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4641999900341034},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44440001249313354},{"id":"https://openalex.org/C2779162959","wikidata":"https://www.wikidata.org/wiki/Q708232","display_name":"Arthroscopy","level":2,"score":0.4025000035762787},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29179999232292175},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C60465272","wikidata":"https://www.wikidata.org/wiki/Q494478","display_name":"Range of motion","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11024297/v1","doi":"https://doi.org/10.21203/rs.3.rs-11024297/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11024297/v1","pdf_url":"https://www.researchsquare.com/article/rs-11024297/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11024297/v1","doi":"https://doi.org/10.21203/rs.3.rs-11024297/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11024297/v1","pdf_url":"https://www.researchsquare.com/article/rs-11024297/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225058675.pdf","grobid_xml":"https://content.openalex.org/works/W7225058675.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2043737316","https://openalex.org/W2113761408","https://openalex.org/W2292613647","https://openalex.org/W2510968112","https://openalex.org/W3163565119","https://openalex.org/W3169010754","https://openalex.org/W3216037414","https://openalex.org/W4309676974","https://openalex.org/W4375954882","https://openalex.org/W4392561042","https://openalex.org/W4392895569","https://openalex.org/W4401427783","https://openalex.org/W4401614939","https://openalex.org/W4403344917","https://openalex.org/W4408260921","https://openalex.org/W4410243296","https://openalex.org/W4410284165","https://openalex.org/W4412001459","https://openalex.org/W4414794047","https://openalex.org/W4415989556","https://openalex.org/W4416917899","https://openalex.org/W7134163226","https://openalex.org/W7134285179","https://openalex.org/W7166813537"],"related_works":["https://openalex.org/W1997844772","https://openalex.org/W7165564298","https://openalex.org/W3035865024","https://openalex.org/W7163030848","https://openalex.org/W7202194880","https://openalex.org/W2794121651","https://openalex.org/W1968201611","https://openalex.org/W3169010754","https://openalex.org/W3088484146","https://openalex.org/W7171250312"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Platelet-rich":[2],"plasma":[3],"(PRP)":[4],"serves":[5],"as":[6],"a":[7,123,131,141,252,260],"biological":[8],"augment":[9],"for":[10],"meniscal":[11,86,101,202,323],"repair;":[12],"however,":[13],"evidence":[14],"regarding":[15],"strategies":[16],"to":[17,70],"optimize":[18],"the":[19,27,31,45,51,72,109,152,195,235,246,284,337],"local":[20],"retention":[21],"and":[22,54,79,116,166,177,183,205,207,224,229,259,312,342,355],"distribution":[23,47],"of":[24,48,111,283,293,305,353,357],"PRP":[25,49,106],"at":[26,50,108,174,227,345],"repair":[28,52,102],"site":[29,53,295],"in":[30,192,281,309],"postoperative":[32,340],"period":[33],"remains":[34],"scarce.":[35],"Postoperative":[36,181],"positioning":[37,78,125,133,144,218,237,248,328,364],"protocols":[38],"administered":[39],"by":[40,360],"nursing":[41,361,370],"personnel":[42],"may":[43],"modulate":[44],"gravitational":[46],"consequently":[55],"influence":[56],"early":[57,80],"functional":[58,334],"recovery,":[59],"yet":[60],"this":[61,363],"hypothesis":[62],"has":[63],"not":[64],"been":[65],"investigated.":[66],"This":[67,89,188],"study":[68,93,189],"aimed":[69],"evaluate":[71],"association":[73],"between":[74,113,214],"nurse-led,":[75],"lesion":[76,142,326],"site\u2013directed":[77,143,327],"patient-reported":[81,209,333],"outcomes":[82,150,335],"following":[83],"PRP-augmented":[84,321],"arthroscopic":[85,100,303,322],"repair.":[87],"Methods":[88],"single-center":[90],"retrospective":[91],"cohort":[92],"included":[94,151],"53":[95],"consecutive":[96],"patients":[97,319],"who":[98],"underwent":[99,315],"supplemented":[103],"with":[104,194,234,331],"intra-articular":[105],"injection":[107],"conclusion":[110],"surgery":[112],"April":[114],"2024":[115],"January":[117],"2025.":[118],"Patients":[119],"were":[120,185,212,279,307],"stratified":[121],"into":[122,368],"directed":[124,217,247],"group":[126,134,219,238,249],"(n":[127,135],"=":[128,136],"23)":[129],"or":[130,300],"conventional":[132,236],"30)":[137],"based":[138],"on":[139],"whether":[140],"protocol":[145],"was":[146,190,329],"implemented":[147],"postoperatively.":[148,180],"Primary":[149],"International":[153],"Knee":[154],"Documentation":[155],"Committee":[156],"(IKDC)":[157],"subjective":[158],"score,":[159,161,165],"Lysholm":[160,225],"Tegner":[162,255],"activity":[163,256],"level":[164,257],"Numeric":[167],"Rating":[168],"Scale":[169],"(NRS)":[170],"pain":[171,264,344],"score":[172,258,265],"assessed":[173],"1,":[175],"3,":[176],"12":[178,271],"months":[179,231,272,341],"complications":[182],"reoperations":[184],"also":[186,250],"documented.":[187],"reported":[191],"accordance":[193],"STROBE":[196],"guidelines.":[197],"Results":[198],"Baseline":[199],"demographic":[200],"characteristics,":[201],"tear":[203],"morphology":[204],"location,":[206],"preoperative":[208],"outcome":[210,285],"measures":[211,286],"comparable":[213],"groups.":[215],"The":[216],"exhibited":[220],"significantly":[221,253,261],"superior":[222],"IKDC":[223],"scores":[226],"1":[228],"3":[230,244,339,346],"postoperatively":[232],"compared":[233],"(both":[239,266],"P":[240,267,288],"<":[241,268],"0.05).":[242,269,290],"At":[243],"months,":[245],"demonstrated":[251],"higher":[254],"lower":[262],"NRS":[263],"By":[270],"postoperatively,":[273],"no":[274,313],"statistically":[275],"significant":[276],"between-group":[277],"differences":[278],"detected":[280],"any":[282],"(all":[287],">":[289],"No":[291],"cases":[292],"surgical":[294],"infection,":[296],"deep":[297],"vein":[298],"thrombosis,":[299],"arthrofibrosis":[301],"necessitating":[302],"lysis":[304],"adhesions":[306],"recorded":[308],"either":[310],"group,":[311],"patient":[314],"reoperation.":[316],"Conclusions":[317],"In":[318],"undergoing":[320],"repair,":[324],"nurse-led":[325],"associated":[330],"improved":[332],"during":[336],"first":[338],"reduced":[343],"months.":[347],"Given":[348],"its":[349,373],"low":[350],"cost,":[351],"ease":[352],"implementation,":[354],"feasibility":[356],"independent":[358],"execution":[359],"staff,":[362],"strategy":[365],"warrants":[366],"integration":[367],"orthopedic":[369],"practice;":[371],"nevertheless,":[372],"clinical":[374],"efficacy":[375],"necessitates":[376],"confirmation":[377],"through":[378],"well-designed":[379],"prospective":[380],"trials.":[381]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-11-02T00:00:00"}