{"id":"https://openalex.org/W7225047576","doi":"https://doi.org/10.29244/jji.v11i6.594","title":"Effectiveness of Ethanol Extract of Kluwih (Artocarpus camansi) Leaves on Total Cholesterol in Rats Given a High-Fat Diet and Streptozotocin","display_name":"Effectiveness of Ethanol Extract of Kluwih (Artocarpus camansi) Leaves on Total Cholesterol in Rats Given a High-Fat Diet and Streptozotocin","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225047576","doi":"https://doi.org/10.29244/jji.v11i6.594"},"language":"en","primary_location":{"id":"doi:10.29244/jji.v11i6.594","doi":"https://doi.org/10.29244/jji.v11i6.594","is_oa":true,"landing_page_url":"https://doi.org/10.29244/jji.v11i6.594","pdf_url":"https://jamu-journal.ipb.ac.id/index.php/JJI/article/download/594/286","source":{"id":"https://openalex.org/S4210181251","display_name":"Jurnal Jamu Indonesia","issn_l":"2407-7178","issn":["2407-7178","2407-7763"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Jamu Indonesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jamu-journal.ipb.ac.id/index.php/JJI/article/download/594/286","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075606622","display_name":"Syafika Alaydrus","orcid":"https://orcid.org/0000-0001-9728-9354","observed_orcids":["https://orcid.org/0000-0001-9728-9354"]},"institutions":[{"id":"https://openalex.org/I4405274178","display_name":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","ror":"https://ror.org/017szad60","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274178"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Syafika Alaydrus","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu"],"raw_orcid":"https://orcid.org/0000-0001-9728-9354","affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","institution_ids":["https://openalex.org/I4405274178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078407926","display_name":"Niluh Puspita Dewi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274178","display_name":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","ror":"https://ror.org/017szad60","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274178"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Niluh Puspita Dewi","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","institution_ids":["https://openalex.org/I4405274178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024747130","display_name":"Leonov Rianto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonov Rianto","raw_affiliation_strings":["Sekolah Tinggi Ilmu Kesehatan IKIFA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Kesehatan IKIFA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160293899","display_name":"Charles Charles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Charles","raw_affiliation_strings":["Sekolah Tinggi Ilmu Kesehatan IKIFA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Kesehatan IKIFA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039310118","display_name":"Yanthy Susanti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanthy Susanti","raw_affiliation_strings":["Sekolah Tinggi Ilmu Kesehatan IKIFA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Kesehatan IKIFA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012484262","display_name":"Indah Kurnia Utami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274178","display_name":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","ror":"https://ror.org/017szad60","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274178"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Indah Kurnia Utami","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","institution_ids":["https://openalex.org/I4405274178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160321849","display_name":"Fina Mei Liya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274178","display_name":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","ror":"https://ror.org/017szad60","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274178"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Fina Mei Liya","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","institution_ids":["https://openalex.org/I4405274178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076998620","display_name":"Faikah Dyah Utami","orcid":"https://orcid.org/0009-0004-5382-3411","observed_orcids":["https://orcid.org/0009-0004-5382-3411"]},"institutions":[{"id":"https://openalex.org/I4405274178","display_name":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","ror":"https://ror.org/017szad60","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274178"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Faikah Dyah Utami","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu"],"raw_orcid":"https://orcid.org/0009-0004-5382-3411","affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","institution_ids":["https://openalex.org/I4405274178"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5116434862","display_name":"Matra Novalia Palipadang","orcid":"https://orcid.org/0009-0008-7034-7591","observed_orcids":["https://orcid.org/0009-0008-7034-7591"]},"institutions":[{"id":"https://openalex.org/I4405274178","display_name":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","ror":"https://ror.org/017szad60","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274178"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Matra Novalia Palipadang","raw_affiliation_strings":["Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu"],"raw_orcid":"https://orcid.org/0009-0008-7034-7591","affiliations":[{"raw_affiliation_string":"Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu","institution_ids":["https://openalex.org/I4405274178"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83046575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"6","first_page":"525","last_page":"531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artocarpus-camansi","display_name":"Artocarpus camansi","score":1.0},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.8550000190734863},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.953000009059906},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9160000085830688},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/simvastatin-comparison","display_name":"simvastatin comparison","score":0.8550000190734863},{"id":"https://openalex.org/keywords/medicinal-plant-extracts","display_name":"medicinal plant extracts","score":0.3199999928474426},{"id":"https://openalex.org/keywords/lipid-lowering-effect","display_name":"hypolipidemic effect","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6140999794006348},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.588699996471405},{"id":"https://openalex.org/C2994423189","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Total cholesterol","level":3,"score":0.5692999958992004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5353999733924866},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.5142999887466431},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.47189998626708984},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4291999936103821},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3490999937057495},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C2778951191","wikidata":"https://www.wikidata.org/wiki/Q211420","display_name":"Aphrodisiac","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29244/jji.v11i6.594","doi":"https://doi.org/10.29244/jji.v11i6.594","is_oa":true,"landing_page_url":"https://doi.org/10.29244/jji.v11i6.594","pdf_url":"https://jamu-journal.ipb.ac.id/index.php/JJI/article/download/594/286","source":{"id":"https://openalex.org/S4210181251","display_name":"Jurnal Jamu Indonesia","issn_l":"2407-7178","issn":["2407-7178","2407-7763"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Jamu Indonesia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29244/jji.v11i6.594","doi":"https://doi.org/10.29244/jji.v11i6.594","is_oa":true,"landing_page_url":"https://doi.org/10.29244/jji.v11i6.594","pdf_url":"https://jamu-journal.ipb.ac.id/index.php/JJI/article/download/594/286","source":{"id":"https://openalex.org/S4210181251","display_name":"Jurnal Jamu Indonesia","issn_l":"2407-7178","issn":["2407-7178","2407-7763"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Jamu Indonesia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225047576.pdf","grobid_xml":"https://content.openalex.org/works/W7225047576.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2039762060","https://openalex.org/W2290466312","https://openalex.org/W2532850922","https://openalex.org/W2606264400","https://openalex.org/W2769588514","https://openalex.org/W2776116431","https://openalex.org/W2820707192","https://openalex.org/W2905331745","https://openalex.org/W2914567765","https://openalex.org/W2981499784","https://openalex.org/W3010072417","https://openalex.org/W3012530939","https://openalex.org/W3092533065","https://openalex.org/W3111930466","https://openalex.org/W3134008195","https://openalex.org/W3142840603","https://openalex.org/W4206276470","https://openalex.org/W4210969963","https://openalex.org/W4236357753","https://openalex.org/W4280568227","https://openalex.org/W4281613480","https://openalex.org/W4288467522","https://openalex.org/W4306399013","https://openalex.org/W4391929297","https://openalex.org/W4400799887","https://openalex.org/W4404727693","https://openalex.org/W4405971624","https://openalex.org/W4410231591","https://openalex.org/W4412632241","https://openalex.org/W7172514316","https://openalex.org/W7211865413"],"related_works":["https://openalex.org/W255916219","https://openalex.org/W7217702862","https://openalex.org/W7089298215","https://openalex.org/W7126038710","https://openalex.org/W2626360423","https://openalex.org/W2064341442","https://openalex.org/W3005475438","https://openalex.org/W2981057856","https://openalex.org/W3204163762","https://openalex.org/W3129660410"],"abstract_inverted_index":{"Leaves":[0],"of":[1,35,100],"Artocarpus":[2],"camansi":[3,37],"(kluwih)":[4],"are":[5,18],"used":[6],"in":[7,21,27,39],"Indonesian":[8],"folk":[9],"medicine,":[10],"but":[11],"their":[12],"effect":[13],"on":[14,76],"blood":[15],"lipids,":[16],"which":[17],"often":[19],"disturbed":[20],"type":[22],"2":[23],"diabetes,":[24],"is":[25],"untested":[26],"vivo.":[28],"This":[29],"study":[30],"evaluated":[31],"an":[32],"ethanol":[33],"extract":[34,62,93],"A.":[36],"leaves":[38],"rats":[40,51,115],"given":[41],"a":[42,98],"high-fat":[43],"diet":[44],"followed":[45],"by":[46,97],"low-dose":[47],"streptozotocin.":[48],"Thirty":[49],"male":[50],"formed":[52],"six":[53],"groups":[54],"(n":[55],"=":[56],"5):":[57],"normal,":[58],"vehicle,":[59],"simvastatin,":[60,112],"and":[61,82,103],"at":[63,105],"300,":[64],"350":[65],"or":[66,141],"400":[67],"mg/kg":[68],"daily":[69],"for":[70,111],"14":[71],"days.":[72],"Total":[73],"cholesterol,":[74],"measured":[75],"days":[77],"0,":[78],"14,":[79],"21,":[80],"28":[81],"35,":[83],"rose":[84],"from":[85,138],"43\u201348":[86],"to":[87],"127\u2013141":[88],"mg/dL":[89],"after":[90],"induction.":[91],"The":[92],"then":[94],"lowered":[95],"it":[96],"mean":[99],"57.2%,":[101],"48.0%":[102],"43.5%":[104],"the":[106,139],"three":[107],"doses,":[108],"against":[109],"64.9%":[110],"while":[113],"vehicle":[114],"kept":[116],"rising":[117],"(group":[118],"\u00d7":[119],"time":[120],"interaction,":[121],"p":[122],"<":[123],"0.001).":[124],"At":[125],"300":[126],"mg/kg,":[127],"final":[128],"total":[129],"cholesterol":[130],"(53.4":[131],"\u00b1":[132],"5.1":[133],"mg/dL)":[134],"did":[135],"not":[136],"differ":[137],"normal":[140],"simvastatin":[142],"groups.":[143],"Its":[144],"active":[145],"constituents":[146],"remain":[147],"unquantified.":[148]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-02T00:00:00"}