{"id":"https://openalex.org/W7225047008","doi":"https://doi.org/10.1007/s43939-026-01064-w","title":"Chitosan and aloe vera-based biomaterials for wound healing applications","display_name":"Chitosan and aloe vera-based biomaterials for wound healing applications","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225047008","doi":"https://doi.org/10.1007/s43939-026-01064-w"},"language":"en","primary_location":{"id":"doi:10.1007/s43939-026-01064-w","doi":"https://doi.org/10.1007/s43939-026-01064-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43939-026-01064-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210203817","display_name":"Discover Materials","issn_l":"2730-7727","issn":["2730-7727"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s43939-026-01064-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160318007","display_name":"Yasir Qasim Almajidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Yasir Qasim Almajidi","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, Alnahrain University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, Alnahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069740458","display_name":"Maher Abdulrazzaq Al-hakeem","orcid":"https://orcid.org/0000-0001-9525-8896","observed_orcids":["https://orcid.org/0000-0001-9525-8896"]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Maher Abdulrazzaq Al-hakeem","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, Alnahrain University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, Alnahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064540201","display_name":"Abdullah Ali Alzahrani","orcid":"https://orcid.org/0009-0000-4633-1276","observed_orcids":["https://orcid.org/0009-0000-4633-1276"]},"institutions":[{"id":"https://openalex.org/I179331831","display_name":"Taif University","ror":"https://ror.org/014g1a453","country_code":"SA","type":"education","lineage":["https://openalex.org/I179331831"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah Ali Alzahrani","raw_affiliation_strings":["Taif University, Taif, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taif University, Taif, Saudi Arabia","institution_ids":["https://openalex.org/I179331831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119180600","display_name":"Jawad Mahmood","orcid":"https://orcid.org/0009-0004-7318-4960","observed_orcids":["https://orcid.org/0009-0004-7318-4960"]},"institutions":[{"id":"https://openalex.org/I4405253933","display_name":"Al-Zahrawi University","ror":"https://ror.org/017jj3e32","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405253933"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mahmood Jawad","raw_affiliation_strings":["Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq","institution_ids":["https://openalex.org/I4405253933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111097717","display_name":"Zahir Al-Khafaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166455938","display_name":"University of Babylon","ror":"https://ror.org/0170edc15","country_code":"IQ","type":"education","lineage":["https://openalex.org/I166455938"]},{"id":"https://openalex.org/I3131779051","display_name":"Iraqi University","ror":"https://ror.org/01wfhkb67","country_code":"IQ","type":"education","lineage":["https://openalex.org/I3131779051"]},{"id":"https://openalex.org/I4405259362","display_name":"Islamic University of Najaf","ror":"https://ror.org/024dzaa63","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405259362"]},{"id":"https://openalex.org/I4405260788","display_name":"Islamic University Babylon Campus","ror":"https://ror.org/0498zzm94","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405260788"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Zahraa Abbas Al-Khafaji","raw_affiliation_strings":["College of pharmacy, the Islamic University, Najaf, Iraq","Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq","Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of pharmacy, the Islamic University, Najaf, Iraq","institution_ids":["https://openalex.org/I4405259362"]},{"raw_affiliation_string":"Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq","institution_ids":["https://openalex.org/I3131779051"]},{"raw_affiliation_string":"Department of Medical Analysis, Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq","institution_ids":["https://openalex.org/I166455938","https://openalex.org/I4405260788"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113313383","display_name":"Zainab Sadeq Yousif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156470","display_name":"Mazaya University College","ror":"https://ror.org/058arh533","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4387156470"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Zainab Sadeq Yousif","raw_affiliation_strings":["Mazaya University College, Dhiqar, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazaya University College, Dhiqar, Iraq","institution_ids":["https://openalex.org/I4387156470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128285458","display_name":"Shahabe Saquib Abullais","orcid":"https://orcid.org/0000-0002-5223-2167","observed_orcids":["https://orcid.org/0000-0002-5223-2167"]},"institutions":[{"id":"https://openalex.org/I4210103194","display_name":"Dr. D.Y. Patil Vidyapeeth, Pune","ror":"https://ror.org/00s2qq515","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210103194"]},{"id":"https://openalex.org/I4210130476","display_name":"Datta Meghe Institute of Higher Education and Research","ror":"https://ror.org/02w7k5y22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210130476"]},{"id":"https://openalex.org/I4210162544","display_name":"Dr D Y Patil Dental College & Hospital","ror":"https://ror.org/05watjs66","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210162544"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shahabe Saquib Abullais","raw_affiliation_strings":["Department of Dental Research Cell, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, 411018, India","Department of Periodontology and Implantology, Sharad Pawar Dental College, Research DMIHER, Sawangi, Wardha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Research Cell, Dr. D. Y. Patil Dental College & Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, 411018, India","institution_ids":["https://openalex.org/I4210103194","https://openalex.org/I4210162544"]},{"raw_affiliation_string":"Department of Periodontology and Implantology, Sharad Pawar Dental College, Research DMIHER, Sawangi, Wardha, India","institution_ids":["https://openalex.org/I4210130476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078255846","display_name":"Shakeel Ahmed Ansari","orcid":"https://orcid.org/0000-0002-5630-8034","observed_orcids":["https://orcid.org/0000-0002-5630-8034"]},"institutions":[{"id":"https://openalex.org/I4400600919","display_name":"Batterjee Medical College","ror":"https://ror.org/00dqry546","country_code":"SA","type":"education","lineage":["https://openalex.org/I4400600919"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Shakeel Ahmed Ansari","raw_affiliation_strings":["Department of Biochemistry, General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia","institution_ids":["https://openalex.org/I4400600919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019817672","display_name":"Yasser Fakri Mustafa","orcid":"https://orcid.org/0000-0002-0926-7428","observed_orcids":["https://orcid.org/0000-0002-0926-7428"]},"institutions":[{"id":"https://openalex.org/I12150220","display_name":"University of Mosul","ror":"https://ror.org/039cf4q47","country_code":"IQ","type":"education","lineage":["https://openalex.org/I12150220"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Yasser Fakri Mustafa","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq","institution_ids":["https://openalex.org/I12150220"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077372817","display_name":"Mohammad Ehsan Taghavizadeh Yazdi","orcid":"https://orcid.org/0000-0003-0086-8005","observed_orcids":["https://orcid.org/0000-0003-0086-8005"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Ehsan Taghavizadeh Yazdi","raw_affiliation_strings":["Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":"https://orcid.org/0000-0003-0086-8005","affiliations":[{"raw_affiliation_string":"Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5077372817"],"corresponding_institution_ids":["https://openalex.org/I165560825"],"apc_list":{"value":1590,"currency":"USD","value_usd":1590},"apc_paid":{"value":1590,"currency":"USD","value_usd":1590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8725245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":1.0},{"id":"https://openalex.org/keywords/aloe-vera","display_name":"Aloe vera","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.902999997138977},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nanofibers","display_name":"nanofibers","score":0.9900000095367432},{"id":"https://openalex.org/keywords/3d-printed-scaffolds","display_name":"3D-printed scaffolds","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.7770000100135803},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/re-epithelialization","display_name":"re-epithelialization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9729999899864197},{"id":"https://openalex.org/keywords/scar-reduction","display_name":"scar reduction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5820000171661377},{"id":"https://openalex.org/keywords/degree-of-deacetylation","display_name":"degree of deacetylation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/acemannan","display_name":"acemannan","score":0.6850000023841858},{"id":"https://openalex.org/keywords/toxicological-profiling","display_name":"toxicological profiling","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2779404486","wikidata":"https://www.wikidata.org/wiki/Q80079","display_name":"Aloe vera","level":2,"score":0.7383000254631042},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7207000255584717},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.5633000135421753},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4749000072479248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4300999939441681},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3889999985694885},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3447999954223633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33880001306533813},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C2781051411","wikidata":"https://www.wikidata.org/wiki/Q2078852","display_name":"Chronic wound","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C2993807428","wikidata":"https://www.wikidata.org/wiki/Q25324087","display_name":"Wound care","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s43939-026-01064-w","doi":"https://doi.org/10.1007/s43939-026-01064-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43939-026-01064-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210203817","display_name":"Discover Materials","issn_l":"2730-7727","issn":["2730-7727"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Materials","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s43939-026-01064-w","doi":"https://doi.org/10.1007/s43939-026-01064-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s43939-026-01064-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210203817","display_name":"Discover Materials","issn_l":"2730-7727","issn":["2730-7727"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411189668","https://openalex.org/W7128223658","https://openalex.org/W4411627054","https://openalex.org/W6893226067","https://openalex.org/W4288925643","https://openalex.org/W7134126975","https://openalex.org/W4224443314","https://openalex.org/W7129314356","https://openalex.org/W7141177571","https://openalex.org/W7138866196"],"abstract_inverted_index":{"Abstract":[0],"The":[1,86],"complexity":[2],"of":[3,26,83,127,134,197,209],"wound":[4,17,35,160],"healing,":[5],"particularly":[6],"for":[7,223],"chronic":[8],"wounds,":[9],"necessitates":[10],"advanced":[11,34],"dressings":[12],"that":[13],"actively":[14],"modulate":[15],"the":[16,23,205,213],"microenvironment.":[18],"This":[19,201],"work":[20],"critically":[21,203],"evaluates":[22],"synergistic":[24,78],"integration":[25],"chitosan":[27],"(CS)":[28],"and":[29,43,54,97,109,122,130,137,141,166,187,194,219],"aloe":[30],"vera":[31,48],"(AV)":[32],"into":[33],"dressings.":[36],"Chitosan":[37],"offers":[38],"a":[39,195],"biocompatible,":[40],"biodegradable,":[41],"antimicrobial,":[42],"hemostatic":[44],"scaffold,":[45],"while":[46],"Aloe":[47],"contributes":[49],"potent":[50,120],"anti-inflammatory,":[51],"antioxidant,":[52],"moisturizing,":[53],"pro-regenerative":[55],"biomaterials.":[56],"While":[57],"single-component":[58],"products":[59],"based":[60],"on":[61,144],"CS":[62],"(e.g.,":[63,67,105],"MaxioCel\u00ae)":[64],"or":[65],"AV":[66,188],"Acemannan":[68],"hydrogel)":[69],"are":[70],"clinically":[71],"established,":[72],"hybrid":[73],"CS\u2013AV":[74,210],"systems":[75],"present":[76],"distinct":[77],"advantages":[79],"across":[80],"multiple":[81],"phases":[82],"tissue":[84,168],"repair.":[85],"review":[87,202],"details":[88],"innovative":[89],"formulations,":[90],"including":[91],"hydrogels,":[92],"nanofibers,":[93],"3D-printed":[94],"structures,":[95],"films,":[96],"sponges,":[98],"highlighting":[99],"advancements":[100],"in":[101,170],"crosslinking,":[102],"functional":[103],"additives":[104],"antimicrobials,":[106],"growth":[107],"factors),":[108],"fabrication":[110],"techniques.":[111],"Mechanistically,":[112],"CS-AV":[113],"synergy":[114],"manifests":[115],"through":[116],"enhanced":[117,164],"antimicrobial":[118],"efficacy,":[119],"anti-inflammatory":[121],"antioxidant":[123],"effects":[124],"via":[125],"modulation":[126],"cytokine":[128],"profiles":[129],"ROS":[131],"scavenging,":[132],"stimulation":[133],"cellular":[135],"proliferation":[136],"migration":[138],"(fibroblasts,":[139],"keratinocytes),":[140],"positive":[142],"influence":[143],"extracellular":[145],"matrix":[146],"(ECM)":[147],"remodeling,":[148],"potentially":[149],"leading":[150],"to":[151],"reduced":[152],"scar":[153],"formation.":[154],"Preclinical":[155],"evidence":[156],"consistently":[157],"demonstrates":[158],"accelerated":[159],"closure,":[161],"improved":[162],"re-epithelialization,":[163],"angiogenesis,":[165],"superior":[167],"quality":[169],"various":[171],"animal":[172],"models.":[173],"However,":[174],"substantial":[175],"translational":[176],"challenges":[177],"remain":[178],"regarding":[179],"raw":[180],"material":[181],"standardization":[182],"(CS":[183],"molecular":[184],"weight/deacetylation":[185],"degree":[186],"acemannan":[189],"quantification),":[190],"residual":[191],"crosslinker":[192],"safety,":[193],"lack":[196],"randomized":[198],"clinical":[199,220],"trials.":[200],"balances":[204],"promising":[206],"preclinical":[207],"efficacy":[208],"composites":[211],"with":[212],"rigorous":[214],"standardization,":[215],"GLP":[216],"toxicological":[217],"profiling,":[218],"frameworks":[221],"required":[222],"bench-to-bedside":[224],"translation.":[225]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-11-02T00:00:00"}
