{"id":"https://openalex.org/W7225040964","doi":"https://doi.org/10.21203/rs.3.rs-10631076/v1","title":"Older Adults With Cardiovascular-Kidney-Metabolic Stage 2: Six-Year Risk Stratification Using NT-proBNP and TNFR1","display_name":"Older Adults With Cardiovascular-Kidney-Metabolic Stage 2: Six-Year Risk Stratification Using NT-proBNP and TNFR1","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225040964","doi":"https://doi.org/10.21203/rs.3.rs-10631076/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10631076/v1","doi":"https://doi.org/10.21203/rs.3.rs-10631076/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10631076/v1","pdf_url":"https://www.researchsquare.com/article/rs-10631076/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10631076/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160302818","display_name":"Sirui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sirui Sun","raw_affiliation_strings":["Tongji University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160321995","display_name":"Jie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Tongji University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongji University","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I116953780"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-kidney-metabolic-syndrome","display_name":"cardiovascular-kidney-metabolic syndrome","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tnfr1","display_name":"TNFR1","score":0.7670000195503235},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mortality-risk","display_name":"mortality risk","score":0.9490000009536743},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9319999814033508},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7964000105857849},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5738999843597412},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.5471000075340271},{"id":"https://openalex.org/C3018284874","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Cardiovascular health","level":3,"score":0.46540001034736633},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.45829999446868896},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4325999915599823},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.4131999909877777},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39329999685287476},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3499000072479248},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3456999957561493},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32089999318122864},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2777999937534332},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2655999958515167},{"id":"https://openalex.org/C192943249","wikidata":"https://www.wikidata.org/wiki/Q1893382","display_name":"Stratification (seeds)","level":5,"score":0.26080000400543213},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2547999918460846},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10631076/v1","doi":"https://doi.org/10.21203/rs.3.rs-10631076/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10631076/v1","pdf_url":"https://www.researchsquare.com/article/rs-10631076/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10631076/v1","doi":"https://doi.org/10.21203/rs.3.rs-10631076/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10631076/v1","pdf_url":"https://www.researchsquare.com/article/rs-10631076/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225040964.pdf","grobid_xml":"https://content.openalex.org/works/W7225040964.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1966714873","https://openalex.org/W1986122868","https://openalex.org/W1995023972","https://openalex.org/W2038981426","https://openalex.org/W2045030989","https://openalex.org/W2078271269","https://openalex.org/W2113454700","https://openalex.org/W2129155846","https://openalex.org/W2129675891","https://openalex.org/W2133593325","https://openalex.org/W2160272053","https://openalex.org/W2172227211","https://openalex.org/W2275737843","https://openalex.org/W2556674574","https://openalex.org/W2580830941","https://openalex.org/W2779292813","https://openalex.org/W2802253155","https://openalex.org/W2885738092","https://openalex.org/W3012467235","https://openalex.org/W4200550972","https://openalex.org/W4387435427","https://openalex.org/W4387439311","https://openalex.org/W4388025459","https://openalex.org/W4388569456","https://openalex.org/W4388573970","https://openalex.org/W4388924599","https://openalex.org/W4396733463","https://openalex.org/W4405183946","https://openalex.org/W4411639134","https://openalex.org/W7117756052","https://openalex.org/W7131649709","https://openalex.org/W7162787684","https://openalex.org/W7162998969","https://openalex.org/W7164022603"],"related_works":["https://openalex.org/W2105468970","https://openalex.org/W2017202756","https://openalex.org/W160629405","https://openalex.org/W2068798989","https://openalex.org/W7108074132","https://openalex.org/W4292822033","https://openalex.org/W2911294889","https://openalex.org/W72264384","https://openalex.org/W2101204929","https://openalex.org/W4411940111"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Many":[2],"older":[3,63,204],"adults":[4,58,205],"without":[5],"cardiovascular":[6,30,71,153,218],"disease":[7,72,154],"meet":[8],"criteria":[9],"for":[10],"CKM":[11,35,66,83,136,207,230],"stage":[12,36,67,84,137,208,231],"2,":[13,209],"but":[14],"their":[15],"near-term":[16],"risk":[17,33,151,182,227],"may":[18,224],"differ":[19],"substantially.":[20],"We":[21,39],"examined":[22],"whether":[23],"NT-proBNP":[24,86,101,144,160,171,210],"and":[25,31,46,69,122,196,211,219],"TNFR1":[26,105,176,212],"could":[27],"distinguish":[28],"six-year":[29,150,217],"mortality":[32,220],"within":[34,229],"2.":[37,85,138,232],"Methods":[38],"used":[40,92],"data":[41],"from":[42],"the":[43,90],"2016":[44],"Health":[45],"Retirement":[47],"Study":[48,51],"Venous":[49],"Blood":[50],"with":[52,64,81,100,143,159,170,180,206],"follow-up":[53],"through":[54],"2022.":[55],"Participants":[56],"were":[57,132],"aged":[59],"50":[60],"years":[61],"or":[62,155],"measured":[65,82,135],"0\u20132":[68],"no":[70],"at":[73],"baseline.":[74],"The":[75],"main":[76],"analysis":[77],"focused":[78],"on":[79],"participants":[80,99,142,169],"was":[87,106],"evaluated":[88],"using":[89,109],"commonly":[91],"clinical":[93],"cutoff":[94],"of":[95,152],"125":[96,103,146,163,173],"pg/mL.":[97],"Among":[98,126,168],"<":[102,145,172],"pg/mL,":[104,174],"further":[107],"assessed":[108],"threshold":[110],"analysis,":[111,119],"restricted":[112],"cubic":[113],"splines,":[114],"bootstrap":[115],"validation,":[116],"decision":[117],"curve":[118],"survey-weighted":[120],"models,":[121],"competing-risk":[123],"analysis.":[124],"Results":[125],"6,488":[127],"eligible":[128],"participants,":[129],"6,205":[130],"(95.6%)":[131],"classified":[133],"as":[134],"Within":[139],"this":[140],"group,":[141],"pg/mL":[147,164],"had":[148],"lower":[149],"death":[156],"than":[157],"those":[158],">":[161],"=":[162],"(15.9%":[165],"vs":[166,184],"44.0%).":[167],"higher":[175],"identified":[177,213],"a":[178],"subgroup":[179],"greater":[181],"(27.5%":[183],"13.5%;":[185],"adjusted":[186],"HR":[187],"1.68":[188],"(1.37\u20132.05)).":[189],"Risk":[190],"increased":[191],"stepwise":[192],"across":[193],"biomarker-defined":[194],"groups,":[195],"sensitivity":[197],"analyses":[198],"showed":[199],"similar":[200],"patterns.":[201],"Conclusions":[202],"In":[203],"marked":[214],"differences":[215],"in":[216],"risk.":[221],"These":[222],"biomarkers":[223],"help":[225],"refine":[226],"assessment":[228]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-11-02T00:00:00"}
