{"id":"https://openalex.org/W7225040586","doi":"https://doi.org/10.1002/advs.78442","title":"Cross\u2010Organ Multi\u2010Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment","display_name":"Cross\u2010Organ Multi\u2010Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225040586","doi":"https://doi.org/10.1002/advs.78442","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723713"},"language":"en","primary_location":{"id":"doi:10.1002/advs.78442","doi":"https://doi.org/10.1002/advs.78442","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78442","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.78442","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076211418","display_name":"Wenya Gao","orcid":"https://orcid.org/0000-0002-7324-8723","observed_orcids":["https://orcid.org/0000-0002-7324-8723"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenya Gao","raw_affiliation_strings":["Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China","Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":"https://orcid.org/0000-0002-7324-8723","affiliations":[{"raw_affiliation_string":"Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160294997","display_name":"Jing Gao","orcid":"https://orcid.org/0009-0002-7165-9710","observed_orcids":["https://orcid.org/0009-0002-7165-9710"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Gao","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":"https://orcid.org/0009-0002-7165-9710","affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160291683","display_name":"Xiaohui Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Su","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111407906","display_name":"Xiangying Kong","orcid":"https://orcid.org/0000-0003-3769-3368","observed_orcids":["https://orcid.org/0000-0003-3769-3368"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangying Kong","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":"https://orcid.org/0000-0003-3769-3368","affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127942609","display_name":"Xiaolu Wei","orcid":"https://orcid.org/0000-0002-2337-2208","observed_orcids":["https://orcid.org/0000-0002-2337-2208"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolu Wei","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":"https://orcid.org/0000-0002-2337-2208","affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121329679","display_name":"Tunan Ding","orcid":"https://orcid.org/0009-0000-1460-0603","observed_orcids":["https://orcid.org/0009-0000-1460-0603"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tunan Ding","raw_affiliation_strings":["Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160316004","display_name":"Tiantian Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiantian Guo","raw_affiliation_strings":["Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Academy of Traditional Chinese Medicine Beijing University of Chinese Medicine  Beijing China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160320391","display_name":"Shuangrong Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangrong Gao","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060166451","display_name":"Yanyan Zhou","orcid":"https://orcid.org/0000-0002-9891-1966","observed_orcids":["https://orcid.org/0000-0002-9891-1966"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Zhou","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":"https://orcid.org/0000-0002-9891-1966","affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160290533","display_name":"Junyi Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junyi Zhou","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076824143","display_name":"Haiyu Zhao","orcid":"https://orcid.org/0000-0003-0035-1874","observed_orcids":["https://orcid.org/0000-0003-0035-1874"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyu Zhao","raw_affiliation_strings":["Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China"],"raw_orcid":"https://orcid.org/0000-0003-0035-1874","affiliations":[{"raw_affiliation_string":"Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076824143","https://openalex.org/A5160290533"],"corresponding_institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73188462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9390000104904175},{"id":"https://openalex.org/keywords/huanglian-jiedu-decoction","display_name":"Huanglian Jiedu Decoction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tca-cycle-metabolites","display_name":"TCA cycle metabolites","score":0.8949999809265137},{"id":"https://openalex.org/keywords/prooxidant-antioxidant-balance","display_name":"prooxidant-antioxidant balance","score":0.8379999995231628},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.718999981880188},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.48100000619888306},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5270000100135803},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.843500018119812},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.698199987411499},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5465999841690063},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5205000042915344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5159000158309937},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.49939998984336853},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49230000376701355},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4417000114917755},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3783000111579895},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.36160001158714294},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.3481999933719635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3264000117778778},{"id":"https://openalex.org/C2777735490","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disorder","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.3003000020980835},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.2897999882698059},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2808000147342682},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26649999618530273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26589998602867126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25600001215934753}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.78442","doi":"https://doi.org/10.1002/advs.78442","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78442","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:42966893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723713","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723713/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/advs.78442","doi":"https://doi.org/10.1002/advs.78442","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.78442","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1982795519","https://openalex.org/W2013881792","https://openalex.org/W2067267561","https://openalex.org/W2089532303","https://openalex.org/W2092356280","https://openalex.org/W2117317220","https://openalex.org/W2178866977","https://openalex.org/W2297007897","https://openalex.org/W2312933856","https://openalex.org/W2787666045","https://openalex.org/W2808548053","https://openalex.org/W2895618137","https://openalex.org/W2959600071","https://openalex.org/W2966029669","https://openalex.org/W2984955289","https://openalex.org/W3044114834","https://openalex.org/W3045828365","https://openalex.org/W3046745046","https://openalex.org/W3048549881","https://openalex.org/W3126337434","https://openalex.org/W3139177424","https://openalex.org/W3178416121","https://openalex.org/W4200300845","https://openalex.org/W4212911584","https://openalex.org/W4220860947","https://openalex.org/W4226064241","https://openalex.org/W4292379491","https://openalex.org/W4307265309","https://openalex.org/W4308510589","https://openalex.org/W4323542992","https://openalex.org/W4367839822","https://openalex.org/W4381887391","https://openalex.org/W4382987966","https://openalex.org/W4383823386","https://openalex.org/W4389427726","https://openalex.org/W4394852695","https://openalex.org/W4402646187","https://openalex.org/W4403703331","https://openalex.org/W4403778026","https://openalex.org/W4407094370","https://openalex.org/W4407842359","https://openalex.org/W4408266534"],"related_works":["https://openalex.org/W4409442959","https://openalex.org/W3126337434","https://openalex.org/W2989330157","https://openalex.org/W7160959416","https://openalex.org/W2998179695","https://openalex.org/W4386759985","https://openalex.org/W7123362243","https://openalex.org/W6958257853","https://openalex.org/W4403887738","https://openalex.org/W4220892095"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3],"increasingly":[4],"recognized":[5],"as":[6],"a":[7,179],"systemic":[8],"disorder":[9],"involving":[10],"metabolic":[11,97],"abnormalities":[12,125],"beyond":[13],"the":[14,83,115],"brain,":[15],"but":[16],"links":[17],"between":[18],"hepatic":[19,96,190],"alterations":[20,100],"and":[21,32,58,64,77,91,99,104,109,120,123,132,186],"neuroinflammation":[22,92],"remain":[23],"unclear.":[24],"We":[25],"integrated":[26],"behavioral,":[27],"histopathological,":[28],"transcriptomic,":[29],"proteomic,":[30],"phosphoproteomic,":[31],"metabolomic":[33],"analyses":[34],"in":[35,101,126,165,192],"male":[36],"mice":[37],"assigned":[38],"to":[39,142,183],"WT":[40,136],"(n":[41,45,50,55,60],"=":[42,46,51,56,61],"15),":[43],"AD":[44],"16),":[47,52],"high-dose":[48],"HLJDD":[49,54],"low-dose":[53],"11),":[57],"donepezil":[59],"10)":[62],"groups":[63],"treated":[65],"for":[66],"10":[67],"weeks.":[68],"Longitudinal":[69],"behavioral":[70,119],"data":[71],"were":[72,80,93],"analyzed":[73],"using":[74,82],"repeated-measures":[75],"models,":[76],"omics":[78],"p-values":[79],"adjusted":[81],"Benjamini-Hochberg":[84],"FDR":[85],"procedure.":[86],"Cognitive":[87],"impairment,":[88],"glial":[89],"activation,":[90],"accompanied":[94],"by":[95],"disturbances":[98],"insulin":[102],"signaling":[103],"energy":[105],"metabolism,":[106],"implicating":[107],"PPAR":[108],"PI3K/Akt-related":[110],"processes.":[111],"HLJDD,":[112],"particularly":[113],"at":[114],"high":[116],"dose,":[117],"improved":[118],"neuropathological":[121],"outcomes":[122],"shifted":[124],"TCA-cycle":[127],"metabolites,":[128],"amino":[129],"acid":[130],"neurotransmitters,":[131],"oxidative":[133],"balance":[134],"toward":[135],"levels.":[137],"To":[138],"assess":[139],"hepatocyte":[140,152,180],"contributions":[141],"microglial":[143,184],"inflammation,":[144],"we":[145],"established":[146],"an":[147],"AML12-BV2":[148],"conditioned-medium":[149],"model":[150],"with":[151],"PPAR-\u03b3":[153,173],"knockdown.":[154],"Conditioned":[155],"medium":[156,169],"from":[157,170],"LPS/HLJDD-cotreated":[158],"AML12":[159],"cells":[160,167],"elicited":[161],"lower":[162],"inflammatory":[163],"responses":[164],"BV2":[166],"than":[168],"LPS-treated":[171],"hepatocytes.":[172],"knockdown":[174],"attenuated":[175],"this":[176],"effect,":[177],"supporting":[178],"PPAR-\u03b3-dependent":[181],"contribution":[182],"regulation":[185],"further":[187],"investigation":[188],"of":[189],"involvement":[191],"HLJDD-associated":[193],"neuroprotection.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-02T00:00:00"}
