{"id":"https://openalex.org/W7225040385","doi":"https://doi.org/10.17605/osf.io/z2q8e","title":"Five-layer in-silico validation of the CA9\u2013histone-lactylation\u2013drug-efflux axis in osteosarcoma, with read-level cfDNA fragmentomics as a relapse-monitoring feasibility endpoin","display_name":"Five-layer in-silico validation of the CA9\u2013histone-lactylation\u2013drug-efflux axis in osteosarcoma, with read-level cfDNA fragmentomics as a relapse-monitoring feasibility endpoin","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225040385","doi":"https://doi.org/10.17605/osf.io/z2q8e"},"language":"en","primary_location":{"id":"doi:10.17605/osf.io/z2q8e","doi":"https://doi.org/10.17605/osf.io/z2q8e","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/z2q8e","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},"volume":null,"type":"study-registration","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17605/osf.io/z2q8e","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103146328","display_name":"Ke Zeng","orcid":"https://orcid.org/0000-0001-8876-6665","observed_orcids":["https://orcid.org/0000-0001-8876-6665"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ke Zeng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8876-6665","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103146328"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.37059998512268066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.9330000281333923},{"id":"https://openalex.org/keywords/histone-lactylation","display_name":"histone lactylation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.8700000047683716},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9750000238418579},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cfdna-fragmentomics","display_name":"cfDNA fragmentomics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/relapse-monitoring","display_name":"relapse monitoring","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.578000009059906},{"id":"https://openalex.org/keywords/regulatory-networks","display_name":"regulatory networks","score":0.4830000102519989},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6776999831199646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6194999814033508},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5180000066757202},{"id":"https://openalex.org/C106347477","wikidata":"https://www.wikidata.org/wiki/Q5384228","display_name":"Equating","level":3,"score":0.4433000087738037},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.37940001487731934},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.35249999165534973},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.31859999895095825},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3154999911785126},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3050000071525574},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2953999936580658},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29190000891685486},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.29159998893737793},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.26910001039505005},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2655999958515167},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25540000200271606},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17605/osf.io/z2q8e","doi":"https://doi.org/10.17605/osf.io/z2q8e","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/z2q8e","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"}],"best_oa_location":{"id":"doi:10.17605/osf.io/z2q8e","doi":"https://doi.org/10.17605/osf.io/z2q8e","is_oa":true,"landing_page_url":"https://doi.org/10.17605/osf.io/z2q8e","pdf_url":null,"source":{"id":"https://openalex.org/S7407050956","display_name":"Open Science Framework","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"StudyRegistration"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311067930","https://openalex.org/W4393633425","https://openalex.org/W4409628314","https://openalex.org/W7128587489","https://openalex.org/W6929011075","https://openalex.org/W4385827290","https://openalex.org/W7148787453","https://openalex.org/W4319063059","https://openalex.org/W4401505905","https://openalex.org/W4408244537"],"abstract_inverted_index":{"Five-layer":[0],"in-silico":[1],"validation":[2],"of":[3,33,53,58,137,143],"the":[4,80,138,144,148],"CA9-histone-lactylation-drug-efflux":[5],"axis":[6,29,102],"in":[7,109,121,151],"osteosarcoma":[8],"(OS),":[9],"plus":[10],"a":[11],"read-level":[12],"cfDNA":[13,112,145],"fragmentomics":[14],"feasibility":[15,107],"endpoint.":[16],"Orthogonal":[17],"public-data":[18],"layers":[19],"with":[20,35,129],"different":[21],"confounders":[22],"are":[23,156],"pre-specified":[24,130],"to":[25],"converge":[26],"on":[27],"one":[28],"reading:":[30],"(i)":[31],"association":[32],"CA9":[34],"lactylation/glycolysis":[36],"module":[37],"scores":[38],"across":[39],"three":[40],"OS":[41],"cohorts":[42],"(TARGET,":[43],"GSE21257,":[44],"SGH":[45],"n=87);":[46],"(ii)":[47],"direction":[48],"via":[49,88],"graph-regulatory-network":[50],"virtual":[51],"knockdown":[52],"CA9;":[54],"(iii)":[55],"cellular":[56],"localisation":[57],"ABCB1/ABCG2":[59],"within":[60],"CA9+":[61],"malignant":[62],"cells":[63],"(17,465":[64],"single":[65],"cells);":[66],"(iv)":[67],"confounding":[68],"control":[69],"using":[70],"stroma-free":[71],"CCLE":[72],"cell":[73],"lines":[74],"(1,019":[75],"lines;":[76],"EBI":[77],"E-MTAB-2770)":[78],"against":[79],"patient-bulk":[81],"CA9-ABCG2":[82],"negative":[83],"association;":[84],"(v)":[85],"clinical":[86],"context":[87],"pathological":[89],"necrosis-response":[90],"strata":[91],"(TARGET":[92],"n=21).":[93],"A":[94],"LINCS":[95],"L1000":[96],"signature-matching":[97],"intervention":[98],"preview":[99],"ranks":[100],"candidate":[101],"inducers":[103],"and":[104,141],"reversers.":[105],"Secondary":[106],"endpoint:":[108],"perioperative":[110],"plasma":[111],"(n=11,":[113],"RRBS/Bismark":[114],"BAMs),":[115],"median":[116],"fragment":[117],"length":[118],"is":[119],"shorter":[120],"relapse/metastasis":[122],"event":[123],"patients,":[124],"tested":[125],"by":[126],"exact":[127],"permutation":[128],"direction.":[131],"Pre-registered":[132],"decision":[133],"rules":[134],"govern":[135],"acceptance":[136],"stromal-confounding":[139],"interpretation":[140],"downgrading":[142],"endpoint":[146],"if":[147],"signal":[149],"fails":[150],"expanded":[152],"samples.":[153],"All":[154],"data":[155],"public":[157],"or":[158],"de-identified;":[159],"analysis":[160],"code":[161],"will":[162],"be":[163],"released":[164],"under":[165],"MIT.":[166]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-02T00:00:00"}
