{"id":"https://openalex.org/W7225037600","doi":"https://doi.org/10.1016/j.phrs.2026.109726","title":"Ubiquitination of retinoic acid receptor alpha promotes severe acute pancreatitis-associated acute lung injury by releasing hexokinase 3 transcriptional repression","display_name":"Ubiquitination of retinoic acid receptor alpha promotes severe acute pancreatitis-associated acute lung injury by releasing hexokinase 3 transcriptional repression","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225037600","doi":"https://doi.org/10.1016/j.phrs.2026.109726","pmid":"https://pubmed.ncbi.nlm.nih.gov/42967531"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2026.109726","doi":"https://doi.org/10.1016/j.phrs.2026.109726","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2026.109726","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.phrs.2026.109726","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089454469","display_name":"\u9f99\u5efa\u6b66","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwu Long","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148561443","display_name":"Jinli Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinli Zheng","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003021181","display_name":"\u5218\u9f99\u98de","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longfei Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160289595","display_name":"Xianrong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianrong Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148074119","display_name":"Shiyi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyi Chen","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160294712","display_name":"Chen Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Xu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148550415","display_name":"Lang Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lang Ou","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032244938","display_name":"\u5468\u6653\u541b","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Zhou","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016286470","display_name":"\u5362\u5148\u5dde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianzhou Lu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China. Electronic address: 1998030003@usc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, PR China. Electronic address: 1998030003@usc.edu.cn","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160308473","display_name":"Jing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Endocrinology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, P.R. China, Hengyang 421010, Hunan, PR China. Electronic address: 2010030011@usc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan, P.R. China, Hengyang 421010, Hunan, PR China. Electronic address: 2010030011@usc.edu.cn","institution_ids":["https://openalex.org/I91935597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016286470","https://openalex.org/A5160308473"],"corresponding_institution_ids":["https://openalex.org/I91935597"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":{"value":4130,"currency":"USD","value_usd":4130},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87222034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"109726","last_page":"109726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-acute-pancreatitis","display_name":"severe acute pancreatitis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9729999899864197},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-alpha","display_name":"retinoic acid receptor alpha","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hexokinase-3","display_name":"HK3","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nedd4l","display_name":"NEDD4L","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9150000214576721},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.824999988079071},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9010000228881836},{"id":"https://openalex.org/keywords/macrophage-glycolysis","display_name":"macrophage glycolysis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lung-macrophages","display_name":"lung macrophages","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cd14-monocytes","display_name":"CD14+ monocytes","score":0.7630000114440918},{"id":"https://openalex.org/keywords/apache-ii","display_name":"APACHE II score","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6215000152587891},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5339000225067139},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5171999931335449},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5109999775886536},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44749999046325684},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4226999878883362},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.41269999742507935},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.37940001487731934},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.3702999949455261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36820000410079956},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.3659999966621399},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.3296000063419342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3294999897480011},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3046000003814697},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.28850001096725464},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2806999981403351},{"id":"https://openalex.org/C119775778","wikidata":"https://www.wikidata.org/wiki/Q18031040","display_name":"Retinoic acid receptor alpha","level":5,"score":0.27619999647140503},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2524999976158142}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2026.109726","doi":"https://doi.org/10.1016/j.phrs.2026.109726","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2026.109726","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:42967531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42967531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phrs.2026.109726","doi":"https://doi.org/10.1016/j.phrs.2026.109726","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2026.109726","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1997653917","https://openalex.org/W2067786443","https://openalex.org/W2077852247","https://openalex.org/W2145758369","https://openalex.org/W2164603756","https://openalex.org/W2544533001","https://openalex.org/W2556363128","https://openalex.org/W2905877938","https://openalex.org/W2960378113","https://openalex.org/W2988457676","https://openalex.org/W3000045791","https://openalex.org/W3111442780","https://openalex.org/W3130683230","https://openalex.org/W3194808817","https://openalex.org/W3200175180","https://openalex.org/W3205926919","https://openalex.org/W3209792871","https://openalex.org/W3216898179","https://openalex.org/W4205742853","https://openalex.org/W4220682170","https://openalex.org/W4225534586","https://openalex.org/W4304185595","https://openalex.org/W4306377293","https://openalex.org/W4311479728","https://openalex.org/W4362658337","https://openalex.org/W4376119951","https://openalex.org/W4377042029","https://openalex.org/W4381548584","https://openalex.org/W4382727674","https://openalex.org/W4384926988","https://openalex.org/W4385216881","https://openalex.org/W4388416326","https://openalex.org/W4396920963","https://openalex.org/W4401107802","https://openalex.org/W4412809657","https://openalex.org/W7123595445"],"related_works":["https://openalex.org/W2057330616","https://openalex.org/W7202073224","https://openalex.org/W2052656468","https://openalex.org/W2015097836","https://openalex.org/W2486396895","https://openalex.org/W1719765306","https://openalex.org/W2993844712","https://openalex.org/W3030396886","https://openalex.org/W2371037664","https://openalex.org/W4381252685"],"abstract_inverted_index":{"Lung":[0],"macrophages":[1,53,63,90],"constitute":[2],"the":[3,14,28,33,83,92,106,114,172],"first":[4],"line":[5],"of":[6,16,30,35,54,60,80,86,108,111,130,179,185],"defense":[7],"against":[8],"environmental":[9],"attack":[10],"and":[11,58,71,121,128,132,142,153,163,191],"participate":[12],"in":[13,38,51,62,76,139,194],"pathogenesis":[15],"acute":[17,40,43],"lung":[18,44,52,77],"injury":[19,45],"(ALI).":[20],"In":[21,146,175],"this":[22],"study,":[23],"we":[24],"sought":[25],"to":[26,105,187],"elucidate":[27],"impact":[29],"HK3":[31,47,61,81,101,112,154,186],"on":[32],"regulation":[34],"macrophage":[36,73,115,136,189],"phenotype":[37],"severe":[39],"pancreatitis":[41],"(SAP)-associated":[42],"(PALI).":[46],"expression":[48,156,170],"was":[49],"enhanced":[50,82],"mice":[55],"with":[56,159,165],"SAP,":[57],"overexpression":[59,134],"using":[64],"adeno-associated":[65],"viral":[66],"vectors":[67],"exacerbated":[68],"PALI":[69,123,195],"progression":[70],"increased":[72],"M1":[74,93,140,192],"polarization":[75,141,193],"tissues.":[78],"Overexpression":[79],"glycolytic":[84],"activity":[85],"macrophages,":[87],"thereby":[88],"polarizing":[89],"toward":[91],"phenotype.":[94],"Retinoic":[95],"acid":[96],"receptor":[97],"alpha":[98],"(RARA)":[99],"repressed":[100],"transcription":[102],"by":[103,118],"binding":[104],"promoter":[107],"HK3.":[109],"Knockdown":[110],"inhibited":[113,143],"glycolysis":[116,190],"induced":[117],"RARA":[119,168,180],"knockdown":[120],"alleviated":[122],"development.":[124,196],"NEDD4L":[125,133,152],"mediated":[126],"ubiquitination":[127],"degradation":[129,178],"RARA,":[131],"promoted":[135],"glycolysis-induced":[137],"increase":[138],"M2":[144],"polarization.":[145],"peripheral":[147],"blood":[148],"CD14":[149],"+":[150],"monocytes,":[151],"mRNA":[155,169],"correlated":[157],"positively":[158],"APACHE":[160],"II":[161],"scores":[162],"negatively":[164],"PaO\u2082/FiO\u2082,":[166],"whereas":[167],"showed":[171],"opposite":[173],"associations.":[174],"conclusion,":[176],"NEDD4L-mediated":[177],"hinders":[181],"its":[182],"transcriptional":[183],"repression":[184],"activate":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-02T00:00:00"}
