{"id":"https://openalex.org/W7225034896","doi":"https://doi.org/10.2147/ccid.s650250","title":"Integrated Transcriptomic and DNA Methylation Analysis Identifies KRT6B and CHI3L2 as Candidate Shared Biomarkers of Psoriasis and Cutaneous Melanoma","display_name":"Integrated Transcriptomic and DNA Methylation Analysis Identifies KRT6B and CHI3L2 as Candidate Shared Biomarkers of Psoriasis and Cutaneous Melanoma","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225034896","doi":"https://doi.org/10.2147/ccid.s650250"},"language":"en","primary_location":{"id":"doi:10.2147/ccid.s650250","doi":"https://doi.org/10.2147/ccid.s650250","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s650250","pdf_url":"https://www.dovepress.com/article/download/121727","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121727","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058558910","display_name":"\u9ad8\u51cc\u5cf0","orcid":"https://orcid.org/0009-0003-7945-4725","observed_orcids":["https://orcid.org/0009-0003-7945-4725"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingfeng Gao","raw_affiliation_strings":["Department of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, People\u2019s Republic of China;"],"raw_orcid":"https://orcid.org/0009-0003-7945-4725","affiliations":[{"raw_affiliation_string":"Department of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, People\u2019s Republic of China;","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093105564","display_name":"Xiaotian RenChen","orcid":"https://orcid.org/0009-0001-5820-1097","observed_orcids":["https://orcid.org/0009-0001-5820-1097"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotian RenChen","raw_affiliation_strings":["School of Public Health, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160300855","display_name":"Huaqiang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huaqiang Li","raw_affiliation_strings":["Department of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, People\u2019s Republic of China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, People\u2019s Republic of China;","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160322845","display_name":"Biqiang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biqiang Li","raw_affiliation_strings":["Department of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, People\u2019s Republic of China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, People\u2019s Republic of China;","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79199645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":1.0},{"id":"https://openalex.org/keywords/krt6b","display_name":"KRT6B","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chi3l2","display_name":"CHI3L2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/shared-biomarkers","display_name":"shared biomarkers","score":0.8140000104904175},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.8205000162124634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7509999871253967},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7376999855041504},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6565999984741211},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4553999900817871},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.45239999890327454},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3864000141620636},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.26579999923706055}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2147/ccid.s650250","doi":"https://doi.org/10.2147/ccid.s650250","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s650250","pdf_url":"https://www.dovepress.com/article/download/121727","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},{"id":"pmh:oai:dovepress.com/121727","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/integrated-transcriptomic-and-dna-methylation-analysis-identifies-krt6-peer-reviewed-fulltext-article-CCID","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ccid.s650250","doi":"https://doi.org/10.2147/ccid.s650250","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ccid.s650250","pdf_url":"https://www.dovepress.com/article/download/121727","source":{"id":"https://openalex.org/S73516063","display_name":"Clinical Cosmetic and Investigational Dermatology","issn_l":"1178-7015","issn":["1178-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225034896.pdf","grobid_xml":"https://content.openalex.org/works/W7225034896.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1581115144","https://openalex.org/W1985987855","https://openalex.org/W1987430117","https://openalex.org/W2006617902","https://openalex.org/W2015699418","https://openalex.org/W2035618305","https://openalex.org/W2048845953","https://openalex.org/W2107940314","https://openalex.org/W2114104545","https://openalex.org/W2123929789","https://openalex.org/W2146512944","https://openalex.org/W2159675211","https://openalex.org/W2159707944","https://openalex.org/W2169353806","https://openalex.org/W2170032191","https://openalex.org/W2584999205","https://openalex.org/W2769832991","https://openalex.org/W2886996640","https://openalex.org/W2965238520","https://openalex.org/W3003649269","https://openalex.org/W3014808271","https://openalex.org/W3015610507","https://openalex.org/W3027121332","https://openalex.org/W3118521605","https://openalex.org/W3152808396","https://openalex.org/W3154037490","https://openalex.org/W3204540059","https://openalex.org/W4214825548","https://openalex.org/W4220856798","https://openalex.org/W4281984246","https://openalex.org/W4285390698","https://openalex.org/W4297184212","https://openalex.org/W4310045651","https://openalex.org/W4311784417","https://openalex.org/W4324274083","https://openalex.org/W4366450537","https://openalex.org/W4384828860","https://openalex.org/W4390050935","https://openalex.org/W4391482840","https://openalex.org/W4402125637","https://openalex.org/W4404468662","https://openalex.org/W4408838944","https://openalex.org/W4410019298","https://openalex.org/W4410547912","https://openalex.org/W4410630441","https://openalex.org/W4411569372","https://openalex.org/W4412451957","https://openalex.org/W4412665203","https://openalex.org/W4412864864","https://openalex.org/W4412901708","https://openalex.org/W4415043831","https://openalex.org/W4415604780","https://openalex.org/W4416656791","https://openalex.org/W7160836147","https://openalex.org/W7162759401"],"related_works":["https://openalex.org/W4412515729","https://openalex.org/W2044738765","https://openalex.org/W7151533835","https://openalex.org/W7213928253","https://openalex.org/W4240309000","https://openalex.org/W7156197470","https://openalex.org/W2595981051","https://openalex.org/W4409670706","https://openalex.org/W7169850816","https://openalex.org/W4375952194"],"abstract_inverted_index":{"Background:":[0],"Different":[1],"studies":[2],"have":[3,28],"drawn":[4],"inconsistent":[5],"conclusions":[6],"on":[7,108,150,161,170],"whether":[8,40],"psoriasis":[9,68,78,190,269,276],"increases":[10],"the":[11,25,65,97,109,131,137,141,151,162,171],"risk":[12],"of":[13,77,140,241],"cutaneous":[14,293],"melanoma":[15],"(CM).":[16],"Although":[17],"shared":[18,265],"gene":[19],"expression":[20,41,101,138,230,240],"or":[21],"methylation":[22,43,75,104],"pathways":[23],"between":[24,67,268],"two":[26,250],"diseases":[27],"been":[29],"independently":[30],"reported,":[31],"suggesting":[32],"a":[33,264],"potential":[34,62],"molecular":[35,266],"basis":[36],"for":[37,64,263],"their":[38,47],"comorbidity,":[39],"and":[42,69,73,79,84,92,102,114,125,156,165,181,200,205,243,257,270,277,285],"synergistically":[44],"contribute":[45],"to":[46,55,135],"pathogenesis":[48],"remains":[49],"unclear.":[50],"Therefore,":[51],"this":[52],"study":[53,248],"aimed":[54],"identify":[56],"common":[57],"methylation-regulated":[58],"genes":[59],"(co-MRGs)":[60],"as":[61,96,130,275],"biomarkers":[63],"association":[66],"CM.":[70,145,271],"Methods:":[71],"Transcriptomic":[72],"DNA":[74],"data":[76,121,279],"CM,":[80,194],"comprising":[81],"53":[82],"cases":[83,124],"55":[85],"normal":[86,127],"controls":[87],"in":[88,144,189,193,197,207,219],"total,":[89],"from":[90,282],"GEO":[91],"ArrayExpress":[93],"were":[94,106,117,148,159,168,184,280],"used":[95],"main":[98,110,152],"dataset.":[99],"Differential":[100],"differential":[103,239],"analyses":[105,147,158,167],"performed":[107],"dataset":[111,134],"using":[112],"limma":[113],"DMRcate;":[115],"co-MRGs":[116,143,176],"further":[118,286],"identified.":[119,185],"TCGA-GTEx":[120],"(472":[122],"CM":[123,225,278],"326":[126],"controls)":[128],"served":[129],"external":[132],"validation":[133,163,237,288],"validate":[136],"regulation":[139],"identified":[142,249],"Network":[146],"based":[149,160,169],"dataset;":[153,164],"immune":[154],"infiltration":[155],"survival":[157],"IHC":[166,236],"HPA":[172],"database.":[173],"Results:":[174],"Three":[175],"(":[177],"KRT6B,":[178],"CHI3L2":[179,202,228,244,258],",":[180,259],"TSPAN8":[182,216],")":[183],"KRT6B":[186,221,242,256],"was":[187,203,217],"hypomethylated/upregulated":[188],"but":[191],"hypermethylated/downregulated":[192,218],"with":[195,232],"enrichment":[196],"epidermal":[198],"development":[199],"keratinization.":[201],"hypomethylated":[204],"upregulated":[206],"both,":[208],"exhibiting":[209],"superior":[210],"diagnostic":[211],"performance":[212],"(AUC":[213],"=":[214],"0.867).":[215],"both.":[220],"trended":[222],"toward":[223],"poor":[224],"prognosis,":[226],"whereas":[227],"high":[229],"correlated":[231],"better":[233],"survival.":[234],"HPA-based":[235],"confirmed":[238],".":[245],"Conclusion:":[246],"This":[247],"novel":[251],"promising":[252],"candidate":[253],"co-MRG":[254],"biomarkers,":[255],"providing":[260],"preliminary":[261],"evidence":[262],"link":[267],"However,":[272],"limitations":[273],"remain,":[274],"derived":[281],"separate":[283],"datasets,":[284],"experimental":[287],"is":[289],"required.":[290],"Keywords:":[291],"psoriasis,":[292],"melanoma,":[294],"transcriptomic,":[295],"methylation,":[296],"multi-omics":[297]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-02T00:00:00"}