{"id":"https://openalex.org/W7225019584","doi":"https://doi.org/10.1186/s42466-026-00545-w","title":"Diffusion-weighted imaging reversal after reperfusion therapy in acute ischemic stroke: associations with white matter hyperintensities and cerebral microbleeds","display_name":"Diffusion-weighted imaging reversal after reperfusion therapy in acute ischemic stroke: associations with white matter hyperintensities and cerebral microbleeds","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7225019584","doi":"https://doi.org/10.1186/s42466-026-00545-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966855","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723929"},"language":"en","primary_location":{"id":"doi:10.1186/s42466-026-00545-w","doi":"https://doi.org/10.1186/s42466-026-00545-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s42466-026-00545-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s42466-026-00545-w.pdf","source":{"id":"https://openalex.org/S4210211355","display_name":"Neurological Research and Practice","issn_l":"2524-3489","issn":["2524-3489"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research and Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s42466-026-00545-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135531500","display_name":"Nora Bannert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nora Bannert","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025693415","display_name":"Paula C. Klassen","orcid":"https://orcid.org/0009-0005-5244-9576","observed_orcids":["https://orcid.org/0009-0005-5244-9576"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paula Klassen","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160249576","display_name":"Regina Krijatov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Regina Krijatov","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135478502","display_name":"Amir Dooat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amir Dooat","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074279174","display_name":"Anastasia Nosanova","orcid":"https://orcid.org/0009-0001-2994-3278","observed_orcids":["https://orcid.org/0009-0001-2994-3278"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anastasia Nosanova","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","Institute for Anatomy and Cell Biology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Institute for Anatomy and Cell Biology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031960482","display_name":"Jens Dreyhaupt","orcid":"https://orcid.org/0000-0001-8057-161X","observed_orcids":["https://orcid.org/0000-0001-8057-161X"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Dreyhaupt","raw_affiliation_strings":["Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112565224","display_name":"Hans-Peter M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter M\u00fcller","raw_affiliation_strings":["Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany","Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","Department of Nuclear Medicine, School of Medicine, University Hospital Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Department of Nuclear Medicine, School of Medicine, University Hospital Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006938674","display_name":"Karl Georg H\u00e6usler","orcid":"https://orcid.org/0000-0002-6389-5054","observed_orcids":["https://orcid.org/0000-0002-6389-5054"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Georg Haeusler","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008553447","display_name":"Mona Laible","orcid":"https://orcid.org/0000-0002-2836-096X","observed_orcids":["https://orcid.org/0000-0002-2836-096X"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mona Laible","raw_affiliation_strings":["Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany. mona.laible@uniklinik-ulm.de","German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany. mona.laible@uniklinik-ulm.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany. mona.laible@uniklinik-ulm.de","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany. mona.laible@uniklinik-ulm.de","institution_ids":["https://openalex.org/I2801533059"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008553447"],"corresponding_institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210155144"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":3.8991,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95280971,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"8","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9419999718666077},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.953000009059906},{"id":"https://openalex.org/keywords/cerebral-microbleeds","display_name":"cerebral microbleeds","score":1.0},{"id":"https://openalex.org/keywords/reperfusion-therapy","display_name":"reperfusion therapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mechanical-thrombectomy","display_name":"mechanical thrombectomy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.9129999876022339},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.7509999871253967},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9386000037193298},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.6974999904632568},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.6941999793052673},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.656000018119812},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.6365000009536743},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6136999726295471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5705000162124634},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5367000102996826},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.49720001220703125},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4948999881744385},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.48899999260902405},{"id":"https://openalex.org/C2780387585","wikidata":"https://www.wikidata.org/wiki/Q4816772","display_name":"Reperfusion therapy","level":3,"score":0.45559999346733093},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.39719998836517334},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3650999963283539},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3646000027656555},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.361299991607666},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.3531000018119812},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C16246696","wikidata":"https://www.wikidata.org/wiki/Q15282184","display_name":"Susceptibility weighted imaging","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2517000138759613},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s42466-026-00545-w","doi":"https://doi.org/10.1186/s42466-026-00545-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s42466-026-00545-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s42466-026-00545-w.pdf","source":{"id":"https://openalex.org/S4210211355","display_name":"Neurological Research and Practice","issn_l":"2524-3489","issn":["2524-3489"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research and Practice","raw_type":"journal-article"},{"id":"pmid:42966855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological research and practice","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723929","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723929/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurol Res Pract","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fa419fd9b80c470494c58bbcef0e5389","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fa419fd9b80c470494c58bbcef0e5389","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurological Research and Practice, Vol 8, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s42466-026-00545-w","doi":"https://doi.org/10.1186/s42466-026-00545-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s42466-026-00545-w","pdf_url":"https://link.springer.com/content/pdf/10.1186/s42466-026-00545-w.pdf","source":{"id":"https://openalex.org/S4210211355","display_name":"Neurological Research and Practice","issn_l":"2524-3489","issn":["2524-3489"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225019584.pdf","grobid_xml":"https://content.openalex.org/works/W7225019584.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1020976502","https://openalex.org/W1565215438","https://openalex.org/W1895270397","https://openalex.org/W1901234763","https://openalex.org/W1966862723","https://openalex.org/W2000111801","https://openalex.org/W2013830574","https://openalex.org/W2038145343","https://openalex.org/W2045836414","https://openalex.org/W2091741867","https://openalex.org/W2103368759","https://openalex.org/W2117855158","https://openalex.org/W2121854361","https://openalex.org/W2127272421","https://openalex.org/W2132587494","https://openalex.org/W2148972503","https://openalex.org/W2154350726","https://openalex.org/W2157338473","https://openalex.org/W2158742097","https://openalex.org/W2159233098","https://openalex.org/W2292308933","https://openalex.org/W2327037637","https://openalex.org/W2341400080","https://openalex.org/W2498985254","https://openalex.org/W2569936885","https://openalex.org/W2801199684","https://openalex.org/W2803802119","https://openalex.org/W2893296071","https://openalex.org/W2894632880","https://openalex.org/W2912604046","https://openalex.org/W2944491145","https://openalex.org/W2945290291","https://openalex.org/W2947924379","https://openalex.org/W2982303713","https://openalex.org/W3026427942","https://openalex.org/W3082248399","https://openalex.org/W3187004150","https://openalex.org/W4307337219","https://openalex.org/W4375955674","https://openalex.org/W4377695790","https://openalex.org/W4385068505","https://openalex.org/W4388423103","https://openalex.org/W4389804620","https://openalex.org/W4404660093","https://openalex.org/W4413326434"],"related_works":["https://openalex.org/W7160437524","https://openalex.org/W4375955674","https://openalex.org/W4411105663","https://openalex.org/W2123591668","https://openalex.org/W2089526904","https://openalex.org/W2942940375","https://openalex.org/W2132587494","https://openalex.org/W3026427942","https://openalex.org/W7100550908","https://openalex.org/W4413881076"],"abstract_inverted_index":{"BACKGROUND:":[0],"White":[1],"matter":[2],"hyperintensities":[3],"(WMH)":[4],"and":[5,18,55,109,139,170,191,263,304],"cerebral":[6],"microbleeds":[7],"(CMBs)":[8],"are":[9,288,307],"common":[10],"MRI":[11,93,286],"markers":[12,31,287],"of":[13,118,134,201,212,219,222,232,253,291],"chronic":[14,285],"small-vessel":[15,301],"brain":[16],"injury":[17],"have":[19],"been":[20],"associated":[21,173,197,208],"with":[22,47,71,79,174,198,209,228,236],"adverse":[23],"outcomes":[24],"after":[25,59,100],"ischemic":[26,34,73],"stroke.":[27],"However,":[28],"whether":[29],"these":[30,283],"influence":[32],"early":[33,264,292],"tissue":[35,294],"reversibility":[36],"following":[37,271],"reperfusion":[38,61,272],"therapy":[39,273],"remains":[40],"unclear.":[41],"We":[42,215,249],"therefore":[43],"investigated":[44],"their":[45],"associations":[46],"diffusion-weighted":[48],"imaging":[49],"(DWI)":[50],"lesion":[51,105,124,266],"reversal,":[52,136,203],"hemorrhagic":[53,269],"complications,":[54],"short-term":[56],"functional":[57,140,237],"outcome":[58,141],"MRI-guided":[60,76],"therapy.":[62],"METHODS:":[63],"In":[64],"this":[65,275],"retrospective":[66],"single-center":[67],"study,":[68],"consecutive":[69],"patients":[70,148,168,240],"acute":[72],"stroke":[74],"undergoing":[75],"intravenous":[77],"thrombolysis,":[78],"or":[80,184,225,231,260,268],"without":[81],"additional":[82],"mechanical":[83,161],"thrombectomy,":[84],"were":[85,129,196],"included.":[86],"According":[87],"to":[88,102,131],"the":[89],"institutional":[90],"protocol,":[91],"follow-up":[92,246,306],"was":[94,113,171,206],"planned":[95],"24":[96],"\u00b1":[97],"6":[98],"h":[99],"treatment":[101,182],"assess":[103],"DWI":[104,111,123,135,163,202,213,265],"evolution,":[106],"WMH":[107,176,223,258],"volume,":[108,177,181],"CMBs.":[110],"reversal":[112,164,267],"defined":[114],"as":[115],"a":[116],"reduction":[117],"\u2265":[119],"25%":[120],"in":[121,166,274],"baseline":[122,175,189,257],"volume.":[125],"Multivariable":[126],"regression":[127],"analyses":[128],"performed":[130],"identify":[132],"predictors":[133],"intracerebral":[137,229],"hemorrhage,":[138],"at":[142],"hospital":[143],"discharge.":[144],"RESULTS:":[145],"Among":[146],"345":[147],"(median":[149],"age":[150],"74":[151],"years":[152],"[IQR":[153],"63-82],":[154],"48.1%":[155],"female),":[156],"45":[157],"(13%)":[158],"additionally":[159],"underwent":[160],"thrombectomy.":[162],"occurred":[165],"76":[167],"(22.0%)":[169],"not":[172],"CMBs,":[178],"initial":[179],"infarct":[180,293],"modality,":[183],"thrombolysis":[185],"time":[186],"window.":[187],"Higher":[188],"NIHSS":[190],"modified":[192],"Rankin":[193],"Scale":[194],"scores":[195],"lower":[199],"odds":[200,211],"whereas":[204],"hypercholesterolemia":[205],"independently":[207],"increased":[210],"reversal.":[214],"found":[216,250],"no":[217,251,280],"evidence":[218,252,281],"an":[220,233,254],"association":[221,235,255],"burden":[224],"CMB":[226,261],"presence":[227,262],"hemorrhage":[230],"independent":[234],"outcome.":[238],"Fourteen":[239],"(4.1%)":[241],"developed":[242],"new":[243],"CMBs":[244],"on":[245],"MRI.":[247],"CONCLUSIONS:":[248],"between":[256],"volume":[259],"complications":[270],"cohort.":[276],"These":[277],"findings":[278],"provide":[279],"that":[282],"two":[284],"major":[289],"determinants":[290],"reversibility.":[295],"Larger":[296],"multicenter":[297],"studies":[298],"incorporating":[299],"comprehensive":[300],"disease":[302],"phenotyping":[303],"long-term":[305],"warranted.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-01T00:00:00"}