{"id":"https://openalex.org/W7225018345","doi":"https://doi.org/10.2147/ijn.s641926","title":"\u03b1-Mangostin-Loaded Gold Nanorod-Integrated MOF Nanoplatform for Photoacoustic Imaging-Guided Photothermal Therapy of Melanoma Involving Pyroptosis-Related Signaling","display_name":"\u03b1-Mangostin-Loaded Gold Nanorod-Integrated MOF Nanoplatform for Photoacoustic Imaging-Guided Photothermal Therapy of Melanoma Involving Pyroptosis-Related Signaling","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225018345","doi":"https://doi.org/10.2147/ijn.s641926","pmid":"https://pubmed.ncbi.nlm.nih.gov/42992166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13738227"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s641926","doi":"https://doi.org/10.2147/ijn.s641926","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s641926","pdf_url":"https://www.dovepress.com/article/download/121711","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002788456","display_name":"Huiping Fan","orcid":"https://orcid.org/0000-0001-8424-2792","observed_orcids":["https://orcid.org/0000-0001-8424-2792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiping Fan","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073410008","display_name":"Mogen Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mogen Zhang","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160279418","display_name":"Rui Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Sun","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321311","display_name":"Hua Liu","orcid":"https://orcid.org/0000-0002-1469-8417","observed_orcids":["https://orcid.org/0000-0002-1469-8417","https://orcid.org/0009-0007-8715-2988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Liu","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0007-8715-2988","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160265645","display_name":"Chengqi Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chengqi Liu","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366090","display_name":"Dong Zhang","orcid":"https://orcid.org/0000-0002-0621-0645","observed_orcids":["https://orcid.org/0000-0002-0621-0645"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dong Zhang","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-0621-0645","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108211404","display_name":"W Ma","orcid":"https://orcid.org/0009-0001-0593-1299","observed_orcids":["https://orcid.org/0009-0001-0593-1299"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiyuan Ma","raw_affiliation_strings":["Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0001-0593-1299","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People's Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100366090"],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71697911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 21","issue":null,"first_page":"1","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.828000009059906},{"id":"https://openalex.org/keywords/alpha-mangostin","display_name":"\u03b1-mangostin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gold-nanorods","display_name":"gold nanorods","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metal-organic-frameworks","display_name":"metal-organic frameworks","score":0.8650000095367432},{"id":"https://openalex.org/keywords/zif-8","display_name":"ZIF-8","score":0.996999979019165},{"id":"https://openalex.org/keywords/photoacoustic-imaging","display_name":"photoacoustic imaging","score":0.8420000076293945},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9570000171661377},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.9869999885559082},{"id":"https://openalex.org/keywords/theranostic-nanoplatform","display_name":"theranostic nanoplatform","score":0.9639999866485596},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.8130000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.8427000045776367},{"id":"https://openalex.org/C54932901","wikidata":"https://www.wikidata.org/wiki/Q7187705","display_name":"Photoacoustic imaging in biomedicine","level":2,"score":0.7156000137329102},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6322000026702881},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5059999823570251},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4625999927520752},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3959999978542328},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.38960000872612},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3402999937534332},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.335099995136261},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2777742735","wikidata":"https://www.wikidata.org/wiki/Q7187921","display_name":"Photothermal effect","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.2524000108242035}],"mesh":[{"descriptor_ui":"D000068936","descriptor_name":"Theranostic Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000082703","descriptor_name":"Photothermal Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043942","descriptor_name":"Nanotubes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061088","descriptor_name":"Photoacoustic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s641926","doi":"https://doi.org/10.2147/ijn.s641926","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s641926","pdf_url":"https://www.dovepress.com/article/download/121711","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:42992166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42992166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13738227","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738227/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c6da6c3dabc8415c81f41a3fea3462f7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c6da6c3dabc8415c81f41a3fea3462f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 21, Iss Issue 1, Pp 1-19 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121711","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/-mangostin-loaded-gold-nanorod-integrated-mof-nanoplatform-for-photoac-peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s641926","doi":"https://doi.org/10.2147/ijn.s641926","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s641926","pdf_url":"https://www.dovepress.com/article/download/121711","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225018345.pdf","grobid_xml":"https://content.openalex.org/works/W7225018345.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1770161268","https://openalex.org/W1971646119","https://openalex.org/W2018563185","https://openalex.org/W2018607502","https://openalex.org/W2071808943","https://openalex.org/W2098535015","https://openalex.org/W2101302460","https://openalex.org/W2123676882","https://openalex.org/W2776231048","https://openalex.org/W2806019359","https://openalex.org/W2912456393","https://openalex.org/W3014124196","https://openalex.org/W3033485776","https://openalex.org/W3045872953","https://openalex.org/W3089982665","https://openalex.org/W3119217097","https://openalex.org/W3127243453","https://openalex.org/W3128646645","https://openalex.org/W3212082167","https://openalex.org/W4200615556","https://openalex.org/W4206031044","https://openalex.org/W4220856798","https://openalex.org/W4296713818","https://openalex.org/W4310225317","https://openalex.org/W4319318536","https://openalex.org/W4362523622","https://openalex.org/W4385711585","https://openalex.org/W4392380079","https://openalex.org/W4392689042","https://openalex.org/W4400212111","https://openalex.org/W4400800708","https://openalex.org/W4403946911","https://openalex.org/W4408692637","https://openalex.org/W4409152771","https://openalex.org/W4409591625","https://openalex.org/W4409961799","https://openalex.org/W4410774204","https://openalex.org/W4411640478","https://openalex.org/W4411930281","https://openalex.org/W4412588646","https://openalex.org/W4413826627","https://openalex.org/W4416380892","https://openalex.org/W4416403200","https://openalex.org/W7117373453","https://openalex.org/W7124849226","https://openalex.org/W7128372808","https://openalex.org/W7128601504","https://openalex.org/W7129059474","https://openalex.org/W7154181188","https://openalex.org/W7155216313","https://openalex.org/W7164035766","https://openalex.org/W7165812321"],"related_works":["https://openalex.org/W2794135941","https://openalex.org/W2883871543","https://openalex.org/W2559272854","https://openalex.org/W2477710195","https://openalex.org/W2778314306","https://openalex.org/W6980290759","https://openalex.org/W2541645908","https://openalex.org/W2603701114","https://openalex.org/W3016050093","https://openalex.org/W2594663084"],"abstract_inverted_index":{"Purpose:":[0],"Melanoma":[1],"remains":[2],"a":[3,31,69,152,159,176],"highly":[4],"aggressive":[5],"malignancy":[6],"with":[7,52,73,151,196,223,235,299],"limited":[8],"therapeutic":[9],"options,":[10],"largely":[11],"due":[12],"to":[13,20,29,48,62,77],"poor":[14],"tumor":[15,202,227],"selectivity":[16],"and":[17,47,66,88,97,108,117,147,175,246,274,289,293],"acquired":[18],"resistance":[19],"conventional":[21],"treatments":[22],"in":[23,99,113,118,124,209],"advanced":[24],"disease.":[25],"This":[26,280],"study":[27],"aimed":[28],"develop":[30],"gold":[32,320],"nanorod":[33],"(AuNR)-integrated":[34],"metal-organic":[35,318],"framework":[36],"(MOF)":[37],"theranostic":[38],"nanoplatform":[39,58,138,206,282],"for":[40,312],"photoacoustic":[41,287],"imaging-guided":[42],"photothermal":[43,93,149,251,272,291,323],"therapy":[44],"of":[45,155,162,171,179,204,240,268,276,301,309],"melanoma":[46,115,314],"investigate":[49],"its":[50,294],"association":[51],"pyroptosis-related":[53,128,244,277,302],"signaling.":[54,278,303],"Methods:":[55],"The":[56,127,137,211],"\u03b1-MG/AuNR@ZIF-8/FA-PEG":[57],"was":[59,122,131,194,207,233],"rationally":[60],"engineered":[61],"co-deliver":[63],"\u03b1-mangostin":[64],"(\u03b1-MG)":[65],"AuNRs":[67],"within":[68],"pH-responsive":[70,143],"ZIF-8":[71],"matrix,":[72],"folate-PEG":[74],"surface":[75],"modification":[76,193],"enhance":[78],"cellular":[79,109,198],"uptake.":[80],"Physicochemical":[81],"properties":[82],"were":[83,102,111,297],"characterized":[84],"by":[85,133],"TEM,":[86],"DLS,":[87],"FTIR.":[89],"Drug":[90],"release":[91],"profiles,":[92],"conversion":[94],"efficiency,":[95],"hemocompatibility,":[96],"short-term":[98],"vivo":[100,119],"tolerability":[101],"systematically":[103],"evaluated.":[104],"In":[105],"vitro":[106],"cytotoxicity":[107],"uptake":[110],"assessed":[112],"A375":[114],"cells,":[116],"antitumor":[120,216,261,295],"efficacy":[121,262],"validated":[123],"tumor-bearing":[125],"mice.":[126],"signaling":[129],"pathway":[130],"investigated":[132],"Western":[134],"blotting.":[135],"Results:":[136],"exhibited":[139],"favorable":[140],"colloidal":[141],"stability,":[142],"controlled":[144,290],"drug":[145],"release,":[146],"excellent":[148],"performance,":[150],"hydrodynamic":[153],"diameter":[154],"approximately":[156,163,180,225],"212.1":[157],"nm,":[158],"zeta":[160],"potential":[161],"\u2212":[164],"22":[165],"mV,":[166],"an":[167,224],"\u03b1-MG":[168,284],"loading":[169],"capacity":[170],"21.89":[172],"\u00b1":[173],"0.02%,":[174],"peak":[177],"temperature":[178],"56.5":[181],"\u00b0C":[182],"under":[183],"808":[184],"nm":[185],"laser":[186],"irradiation":[187],"(1.0":[188],"W/cm":[189],"2":[190],").":[191],"FA-PEG":[192],"associated":[195,234,298],"enhanced":[197,247],"uptake,":[199],"while":[200],"time-dependent":[201],"accumulation":[203],"the":[205,219,241,259,265],"observed":[208],"vivo.":[210],"combined":[212,266],"treatment":[213,232],"produced":[214],"greater":[215],"effects":[217,267,296],"than":[218],"tested":[220],"comparator":[221],"groups,":[222],"70%":[226],"growth":[228],"inhibition":[229],"rate.":[230],"Mechanistically,":[231],"increased":[236],"oxidative":[237,270],"stress,":[238,271],"activation":[239,275,300],"canonical":[242],"NLRP3/caspase-1/GSDMD":[243],"pathway,":[245],"cell":[248],"death.":[249],"AuNR-mediated":[250],"heating":[252],"further":[253,307],"strengthened":[254],"these":[255],"responses,":[256],"suggesting":[257],"that":[258],"improved":[260],"may":[263],"involve":[264],"\u03b1-MG-induced":[269],"injury,":[273],"Conclusion:":[279],"multifunctional":[281],"integrates":[283],"delivery,":[285],"real-time":[286],"imaging,":[288],"activation,":[292],"These":[304],"findings":[305],"support":[306],"investigation":[308],"this":[310],"platform":[311],"image-guided":[313],"therapy.":[315],"Keywords:":[316],"\u03b1-mangostin,":[317],"frameworks,":[319],"nanorods,":[321],"melanoma,":[322],"therapy,":[324],"pyroptosis":[325]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-01T00:00:00"}