{"id":"https://openalex.org/W7225018048","doi":"https://doi.org/10.1007/s13205-026-05121-2","title":"Rational design of L-Pantolactone dehydrogenase to enhance the activity of whole-cell biocatalyst","display_name":"Rational design of L-Pantolactone dehydrogenase to enhance the activity of whole-cell biocatalyst","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225018048","doi":"https://doi.org/10.1007/s13205-026-05121-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723627"},"language":"en","primary_location":{"id":"doi:10.1007/s13205-026-05121-2","doi":"https://doi.org/10.1007/s13205-026-05121-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13205-026-05121-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210190239","display_name":"3 Biotech","issn_l":"2190-572X","issn":["2190-572X","2190-5738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723627/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160257662","display_name":"Shichang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shichang Liu","raw_affiliation_strings":["College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China","institution_ids":["https://openalex.org/I34155123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042653588","display_name":"Chen Shen","orcid":"https://orcid.org/0000-0001-7212-4588","observed_orcids":["https://orcid.org/0000-0001-7212-4588"]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Shen","raw_affiliation_strings":["College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China","institution_ids":["https://openalex.org/I34155123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160266180","display_name":"Xinya Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinya Chen","raw_affiliation_strings":["College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China","institution_ids":["https://openalex.org/I34155123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104144083","display_name":"Guimiao Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guimiao Tian","raw_affiliation_strings":["College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China","institution_ids":["https://openalex.org/I34155123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103085231","display_name":"Xiaolian Li","orcid":"https://orcid.org/0000-0002-9342-0367","observed_orcids":["https://orcid.org/0000-0002-9342-0367"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolian Li","raw_affiliation_strings":["State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160249809","display_name":"Ziqiang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210133325","display_name":"Institute of Process Engineering","ror":"https://ror.org/03j4x9j18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziqiang Wang","raw_affiliation_strings":["State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210133325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5143451728","display_name":"Peng Wang","orcid":"https://orcid.org/0009-0003-9209-076X","observed_orcids":["https://orcid.org/0009-0003-9209-076X"]},"institutions":[{"id":"https://openalex.org/I34155123","display_name":"Hebei University of Science and Technology","ror":"https://ror.org/05h3pkk68","country_code":"CN","type":"education","lineage":["https://openalex.org/I34155123"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Wang","raw_affiliation_strings":["College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China"],"raw_orcid":"https://orcid.org/0009-0003-9209-076X","affiliations":[{"raw_affiliation_string":"College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018 China","institution_ids":["https://openalex.org/I34155123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042653588","https://openalex.org/A5143451728","https://openalex.org/A5160249809"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I34155123","https://openalex.org/I4210133325"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72315038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"485","last_page":"485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/whole-cell-biocatalyst","display_name":"whole-cell biocatalyst","score":0.8199999928474426},{"id":"https://openalex.org/keywords/rational-protein-design","display_name":"rational protein design","score":0.6269999742507935},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.8949999809265137},{"id":"https://openalex.org/keywords/amycolatopsis-methanolica","display_name":"Amycolatopsis methanolica","score":0.8679999709129333},{"id":"https://openalex.org/keywords/chiral-pharmaceutical-intermediates","display_name":"chiral pharmaceutical intermediates","score":0.8600000143051147},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/surface-loops","display_name":"surface loops","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.8820000290870667},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.8248999714851379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6729000210762024},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5662999749183655},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.44369998574256897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44110000133514404},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.43650001287460327},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.4287000000476837},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.4262999892234802},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4203000068664551},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.35569998621940613},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3422999978065491},{"id":"https://openalex.org/C28173026","wikidata":"https://www.wikidata.org/wiki/Q337361","display_name":"Kinetic resolution","level":4,"score":0.33889999985694885},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C2993359049","wikidata":"https://www.wikidata.org/wiki/Q7575016","display_name":"Catalytic efficiency","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26989999413490295},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.25369998812675476}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13205-026-05121-2","doi":"https://doi.org/10.1007/s13205-026-05121-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13205-026-05121-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210190239","display_name":"3 Biotech","issn_l":"2190-572X","issn":["2190-572X","2190-5738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"journal-article"},{"id":"pmid:42968757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723627","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723627/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13723627","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723627/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1579721619","https://openalex.org/W1593953517","https://openalex.org/W1978096041","https://openalex.org/W1991844472","https://openalex.org/W2023490488","https://openalex.org/W2055043387","https://openalex.org/W2060079863","https://openalex.org/W2106882534","https://openalex.org/W2123906667","https://openalex.org/W2132262459","https://openalex.org/W2147993766","https://openalex.org/W2376573086","https://openalex.org/W2404280981","https://openalex.org/W2473135273","https://openalex.org/W2944930475","https://openalex.org/W2976650570","https://openalex.org/W3168436232","https://openalex.org/W3177828909","https://openalex.org/W4328136056","https://openalex.org/W4383954703"],"related_works":["https://openalex.org/W4328136056","https://openalex.org/W4390838268","https://openalex.org/W2107803024","https://openalex.org/W4390629520","https://openalex.org/W3129520255","https://openalex.org/W2804103075","https://openalex.org/W4310331341","https://openalex.org/W4393211042","https://openalex.org/W4383954703","https://openalex.org/W2161780515"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-01T00:00:00"}
