{"id":"https://openalex.org/W7225017805","doi":"https://doi.org/10.1007/s00204-026-04613-7","title":"Physiologically based pharmacokinetic modeling as a translational tool in forensic toxicology: from pig to human synthetic cannabinoid toxicokinetics using 5F-Cumyl-P7AICA and its major metabolite as a case study","display_name":"Physiologically based pharmacokinetic modeling as a translational tool in forensic toxicology: from pig to human synthetic cannabinoid toxicokinetics using 5F-Cumyl-P7AICA and its major metabolite as a case study","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225017805","doi":"https://doi.org/10.1007/s00204-026-04613-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/42965597"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-026-04613-7","doi":"https://doi.org/10.1007/s00204-026-04613-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04613-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04613-7.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04613-7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093446680","display_name":"Omar Zaher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Omar Zaher","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023520269","display_name":"Dominik Selzer","orcid":"https://orcid.org/0000-0002-4126-0816","observed_orcids":["https://orcid.org/0000-0002-4126-0816"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Selzer","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060086608","display_name":"Helena Leonie Hanae Loer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helena Loer","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160255467","display_name":"Felix Neuschwender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix Neuschwender","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114717598","display_name":"Frank Filip Steinbauer","orcid":"https://orcid.org/0009-0000-0539-3171","observed_orcids":["https://orcid.org/0009-0000-0539-3171"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Filip Steinbauer","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042636897","display_name":"Christiane Dings","orcid":"https://orcid.org/0000-0001-6550-2819","observed_orcids":["https://orcid.org/0000-0001-6550-2819"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Dings","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066134767","display_name":"Simeon R\u00fcdesheim","orcid":"https://orcid.org/0000-0002-5741-2511","observed_orcids":["https://orcid.org/0000-0002-5741-2511"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simeon R\u00fcdesheim","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany and University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany and University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210120009","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063716572","display_name":"Nicola Luigi Bragazzi","orcid":"https://orcid.org/0000-0001-8409-868X","observed_orcids":["https://orcid.org/0000-0001-8409-868X","https://orcid.org/0000-0003-3104-800X"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicola Luigi Bragazzi","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077640667","display_name":"Nadja Walle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadja Walle","raw_affiliation_strings":["Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000407982","display_name":"Adrian A. Doerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adrian A. Doerr","raw_affiliation_strings":["Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072886838","display_name":"Benjamin Peters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benjamin Peters","raw_affiliation_strings":["Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057183308","display_name":"Matthias Georg Schwab","orcid":"https://orcid.org/0000-0002-9984-075X","observed_orcids":["https://orcid.org/0000-0002-9984-075X","https://orcid.org/0000-0001-6999-1795"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Schwab","raw_affiliation_strings":["Departments of Clinical Pharmacology and of Pharmacy and Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany and University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Clinical Pharmacology and of Pharmacy and Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany and University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210120009","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023070415","display_name":"Matthias W. Laschke","orcid":"https://orcid.org/0000-0002-7847-8456","observed_orcids":["https://orcid.org/0000-0002-7847-8456"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias W. Laschke","raw_affiliation_strings":["Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Building 65/66, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Building 65/66, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109800344","display_name":"Michael D. Menger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael D. Menger","raw_affiliation_strings":["Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Building 65/66, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Building 65/66, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103693711","display_name":"Peter Harald Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter H. Schmidt","raw_affiliation_strings":["Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005967499","display_name":"Markus Robert Meyer","orcid":"https://orcid.org/0000-0003-4377-6784","observed_orcids":["https://orcid.org/0000-0003-4377-6784"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus R. Meyer","raw_affiliation_strings":["Department of Experimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), PharmaScienceHub (PSH), Saarland University, Building 48.5, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Toxicology and Pharmacology, Center for Molecular Signaling (PZMS), PharmaScienceHub (PSH), Saarland University, Building 48.5, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086293908","display_name":"Nadine Schaefer","orcid":"https://orcid.org/0000-0002-5589-9370","observed_orcids":["https://orcid.org/0000-0002-5589-9370"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine Schaefer","raw_affiliation_strings":["Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, Saarland University, Building 49.1, Homburg, 66421, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080845006","display_name":"Thorsten Lehr","orcid":"https://orcid.org/0000-0002-8372-1465","observed_orcids":["https://orcid.org/0000-0002-8372-1465"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thorsten Lehr","raw_affiliation_strings":["Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany. thorsten.lehr@uni-saarland.de"],"raw_orcid":"https://orcid.org/0000-0002-8372-1465","affiliations":[{"raw_affiliation_string":"Clinical Pharmacy, Saarland University, Campus C4 3, Saarbr\u00fccken, 66123, Germany. thorsten.lehr@uni-saarland.de","institution_ids":["https://openalex.org/I91712215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080845006"],"corresponding_institution_ids":["https://openalex.org/I91712215"],"apc_list":{"value":5690,"currency":"USD","value_usd":5690},"apc_paid":{"value":5690,"currency":"USD","value_usd":5690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83657177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-cannabinoids","display_name":"synthetic cannabinoids","score":0.925000011920929},{"id":"https://openalex.org/keywords/toxicokinetics","display_name":"toxicokinetics","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.800000011920929},{"id":"https://openalex.org/keywords/inhalation-exposure","display_name":"inhalation exposure","score":0.7310000061988831},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.7580000162124634},{"id":"https://openalex.org/keywords/allometric-scaling","display_name":"allometric scaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/forensic-toxicology","display_name":"forensic toxicology","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.781499981880188},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6352999806404114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5343000292778015},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5012000203132629},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4986000061035156},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.301800012588501},{"id":"https://openalex.org/C2777846614","wikidata":"https://www.wikidata.org/wiki/Q19904200","display_name":"Synthetic cannabinoids","level":4,"score":0.2903999984264374},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2630000114440918},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2623000144958496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26019999384880066}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00204-026-04613-7","doi":"https://doi.org/10.1007/s00204-026-04613-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04613-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04613-7.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:42965597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42965597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00204-026-04613-7","doi":"https://doi.org/10.1007/s00204-026-04613-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00204-026-04613-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00204-026-04613-7.pdf","source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1199113853","display_name":"Toxikokinetische Studien und translationale mechanistische Modellierung Neuer Psychoaktiver Substanzen unter Verwendung des Synthetischen Cannabinoids Cumyl5FP7AICA","funder_award_id":"508380150","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320869","display_name":"Robert Bosch Stiftung","ror":"https://ror.org/012kqkf58"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323322","display_name":"Universit\u00e4t des Saarlandes","ror":"https://ror.org/01jdpyv68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225017805.pdf","grobid_xml":"https://content.openalex.org/works/W7225017805.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1570348606","https://openalex.org/W1608678137","https://openalex.org/W1965987183","https://openalex.org/W2018943943","https://openalex.org/W2027143209","https://openalex.org/W2042099048","https://openalex.org/W2044110948","https://openalex.org/W2045690571","https://openalex.org/W2048397943","https://openalex.org/W2079192244","https://openalex.org/W2080843536","https://openalex.org/W2099474947","https://openalex.org/W2109128239","https://openalex.org/W2120416054","https://openalex.org/W2121820971","https://openalex.org/W2123063654","https://openalex.org/W2132006762","https://openalex.org/W2134794720","https://openalex.org/W2167227549","https://openalex.org/W2168207691","https://openalex.org/W2172669946","https://openalex.org/W2328165165","https://openalex.org/W2345293717","https://openalex.org/W2522795135","https://openalex.org/W2528031783","https://openalex.org/W2751534537","https://openalex.org/W2754984263","https://openalex.org/W2773219177","https://openalex.org/W2786070257","https://openalex.org/W2895782801","https://openalex.org/W2901071477","https://openalex.org/W2907814269","https://openalex.org/W2917618396","https://openalex.org/W2954696203","https://openalex.org/W3012453544","https://openalex.org/W3026957833","https://openalex.org/W3028648868","https://openalex.org/W3043029046","https://openalex.org/W3094477507","https://openalex.org/W3112564761","https://openalex.org/W3132385004","https://openalex.org/W3158683963","https://openalex.org/W3197950436","https://openalex.org/W4309700917","https://openalex.org/W4318472695","https://openalex.org/W4376642952","https://openalex.org/W4387638695","https://openalex.org/W4399282081","https://openalex.org/W4403289565","https://openalex.org/W4404511389","https://openalex.org/W4404995521","https://openalex.org/W4406042703"],"related_works":["https://openalex.org/W4404598944","https://openalex.org/W2345293717","https://openalex.org/W2883149569","https://openalex.org/W4404995521","https://openalex.org/W2921115934","https://openalex.org/W4291290990","https://openalex.org/W3014240615","https://openalex.org/W2012109295","https://openalex.org/W4307092588","https://openalex.org/W3083227386"],"abstract_inverted_index":{"Synthetic":[0],"cannabinoids":[1],"are":[2,28],"increasingly":[3],"associated":[4],"with":[5,141],"severe":[6],"adverse":[7],"events":[8],"and":[9,30,54,63,71,88,100,108,131,138,159,164,169,199,209,232,240,245],"fatalities.":[10],"The":[11,110,149,184],"SC":[12],"5F-Cumyl-P7AICA":[13],"(5FC)":[14],"is":[15],"particularly":[16],"concerning":[17],"due":[18],"to":[19,66,114,125,193],"its":[20,55],"high":[21],"potency.":[22],"Human":[23],"studies":[24],"of":[25,36,144,177],"such":[26],"compounds":[27],"ethically":[29],"practically":[31],"constrained,":[32],"highlighting":[33],"the":[34,75,227],"value":[35],"physiologically":[37],"based":[38],"pharmacokinetic/toxicokinetic":[39],"(PBTK)":[40],"modeling":[41],"as":[42,121,123],"a":[43,49,91,145],"translational":[44],"tool.":[45],"Here,":[46],"we":[47],"developed":[48],"PBTK":[50,93,186,228],"model":[51,94,111,151,187,229],"for":[52,68,106,161,166,180,222],"5FC":[53,84,190,231],"primary":[56],"metabolite":[57],"N-pentanoic":[58],"acid":[59],"(NPA)":[60],"in":[61,79,119,132,216,235],"pigs":[62,80,120],"translated":[64,124],"it":[65],"humans":[67,126,217],"predicting":[69],"systemic":[70,244],"tissue-specific":[72],"exposure.":[73],"Using":[74],"published":[76],"toxicokinetic":[77],"data":[78],"receiving":[81],"200":[82],"\u00b5g/kg":[83],"via":[85],"intravenous":[86],"(IV)":[87],"inhalation":[89,200,212],"routes,":[90],"parent-metabolite":[92],"was":[95,112,205],"built.":[96],"Serum,":[97],"whole":[98],"blood,":[99],"fat":[101],"tissue":[102,117,238,246],"concentrations":[103,118,239],"were":[104],"used":[105,113],"calibration":[107],"evaluation.":[109],"predict":[115],"various":[116],"well":[122],"using":[127],"species-specific":[128],"physiological":[129],"parameters":[130],"vitro-measured":[133],"human":[134,185,243],"plasma":[135],"protein":[136],"binding":[137],"subsequently":[139],"compared":[140,192],"allometric":[142,194],"scaling":[143,195],"population":[146],"TK":[147,182],"model.":[148],"pig":[150],"accurately":[152],"predicted":[153,188],"mean":[154],"concentration-time":[155],"profiles":[156],"(MRD:":[157],"1.49":[158],"2.19":[160],"5FC,":[162],"1.51":[163],"1.62":[165],"NPA,":[167],"IV":[168,198,208],"inhalation,":[170],"respectively).":[171],"Individual":[172],"predictions":[173],"fell":[174],"within":[175],"two-fold":[176],"observed":[178],"values":[179],"all":[181],"parameters.":[183],"lower":[189],"exposure":[191,204,247],"after":[196,207,211],"both":[197,223],"dosing,":[201],"while":[202],"NPA":[203,233],"comparable":[206],"higher":[210],"dosing.":[213],"Tissue-level":[214],"simulations":[215],"showed":[218],"organ-specific":[219],"distribution":[220],"patterns":[221],"compounds.":[224],"In":[225],"conclusion,":[226],"described":[230],"disposition":[234],"pigs,":[236],"including":[237],"generated":[241],"exploratory":[242],"predictions.":[248]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-01T00:00:00"}
