{"id":"https://openalex.org/W7225006725","doi":"https://doi.org/10.4084/mjhid.2026.086","title":"OPTIMIZATION OF THE CLINICAL JOURNEY OF UNFIT PATIENTS WITH NEWLY DIAGNOSED IDH1M ACUTE MYELOID LEUKEMIA","display_name":"OPTIMIZATION OF THE CLINICAL JOURNEY OF UNFIT PATIENTS WITH NEWLY DIAGNOSED IDH1M ACUTE MYELOID LEUKEMIA","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225006725","doi":"https://doi.org/10.4084/mjhid.2026.086"},"language":"en","primary_location":{"id":"doi:10.4084/mjhid.2026.086","doi":"https://doi.org/10.4084/mjhid.2026.086","is_oa":true,"landing_page_url":"https://doi.org/10.4084/mjhid.2026.086","pdf_url":"https://www.mjhid.org/mjhid/article/download/6534/4978","source":{"id":"https://openalex.org/S159911762","display_name":"Mediterranean Journal of Hematology and Infectious Diseases","issn_l":"2035-3006","issn":["2035-3006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mjhid.org/mjhid/article/download/6534/4978","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114377374","display_name":"Adriano Venditti","orcid":"https://orcid.org/0000-0002-0245-0553","observed_orcids":["https://orcid.org/0000-0002-0245-0553"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adriano Venditti","raw_affiliation_strings":["Universit\u00e0 Roma Torvergata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 Roma Torvergata","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104167780","display_name":"Marta Riva","orcid":"https://orcid.org/0009-0002-3837-2881","observed_orcids":["https://orcid.org/0009-0002-3837-2881"]},"institutions":[{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Riva","raw_affiliation_strings":["Department of Oncology and Hemato-Oncology, Ospedale Niguarda, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Hemato-Oncology, Ospedale Niguarda, Milano, Italy","institution_ids":["https://openalex.org/I4210094195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046025763","display_name":"Livio Pagano","orcid":"https://orcid.org/0000-0001-8287-928X","observed_orcids":["https://orcid.org/0000-0001-8287-928X"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Livio Pagano","raw_affiliation_strings":["UOC Ematologia geriatrica ed emopatie rare, Fondazione Policlinico Universitario A. Gemelli, IRCCS-Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Ematologia geriatrica ed emopatie rare, Fondazione Policlinico Universitario A. Gemelli, IRCCS-Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025719686","display_name":"Giovanni Marconi","orcid":"https://orcid.org/0000-0001-6309-0515","observed_orcids":["https://orcid.org/0000-0001-6309-0515"]},"institutions":[{"id":"https://openalex.org/I4210092828","display_name":"Ospedale \"Santa Maria delle Croci\" di Ravenna","ror":"https://ror.org/00g6kte47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210092828","https://openalex.org/I4210107542"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Marconi","raw_affiliation_strings":["UOC Ematologia, Universit\u00e0 di Bologna, Ospedale S. Maria delle Croci, Ravenna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Ematologia, Universit\u00e0 di Bologna, Ospedale S. Maria delle Croci, Ravenna, Italy","institution_ids":["https://openalex.org/I4210092828","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012932458","display_name":"Nicola Fracchiolla","orcid":"https://orcid.org/0000-0002-8982-8079","observed_orcids":["https://orcid.org/0000-0002-8982-8079"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Fracchiolla","raw_affiliation_strings":["SC Ematologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Ematologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029872615","display_name":"Romano Danesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Romano Danesi","raw_affiliation_strings":["Department of Oncology and Hemato-Oncology, University of Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Hemato-Oncology, University of Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072253025","display_name":"Antonio Curti","orcid":"https://orcid.org/0000-0002-7752-6049","observed_orcids":["https://orcid.org/0000-0002-7752-6049"]},"institutions":[{"id":"https://openalex.org/I4210117483","display_name":"Istituto di Ematologia di Bologna","ror":"https://ror.org/01mze9517","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117483"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Curti","raw_affiliation_strings":["IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \u201cSer\u00e0gnoli\u201d, Bologna, Italy","institution_ids":["https://openalex.org/I4210117483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003619706","display_name":"Anna Candoni","orcid":"https://orcid.org/0000-0003-4436-1310","observed_orcids":["https://orcid.org/0000-0003-4436-1310"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210146018","display_name":"Ca' Foncello Hospital","ror":"https://ror.org/04cb4je22","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146018"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Candoni","raw_affiliation_strings":["Department of Hematology and SCT, Ca' Foncello Hospital, Treviso, Italy. Department of Medical and Surgical Sciences University of Modena and Reggio Emilia (UNIMORE), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and SCT, Ca' Foncello Hospital, Treviso, Italy. Department of Medical and Surgical Sciences University of Modena and Reggio Emilia (UNIMORE), Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210146018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026990551","display_name":"Erika Borlenghi","orcid":"https://orcid.org/0000-0002-4666-3817","observed_orcids":["https://orcid.org/0000-0002-4666-3817"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erika Borlenghi","raw_affiliation_strings":["Dipartimento di Biomedicina e Prevenzione, Universit\u00e0 Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biomedicina e Prevenzione, Universit\u00e0 Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063825892","display_name":"Maria Teresa Voso","orcid":"https://orcid.org/0000-0002-6164-4761","observed_orcids":["https://orcid.org/0000-0002-6164-4761"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Teresa Voso","raw_affiliation_strings":["Dipartimento Oncoematologia, AOU Tor Vergata, Roma, Italy. Dipartimento di Biomedicina e Prevenzione, Universit\u00e0 Tor Vergata, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Oncoematologia, AOU Tor Vergata, Roma, Italy. Dipartimento di Biomedicina e Prevenzione, Universit\u00e0 Tor Vergata, Roma, Italy","institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4210138843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":600,"currency":"EUR","value_usd":647},"apc_paid":{"value":600,"currency":"EUR","value_usd":647},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85913754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"1","first_page":"e2026086","last_page":"e2026086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unfit-patients","display_name":"unfit patients","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ivosidenib","display_name":"ivosidenib","score":0.8410000205039978},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/differentiation-syndrome","display_name":"differentiation syndrome","score":0.8429999947547913},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.949999988079071},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.6069999933242798},{"id":"https://openalex.org/keywords/newly-diagnosed-aml","display_name":"newly diagnosed AML","score":0.5479999780654907},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9503999948501587},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7038000226020813},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5042999982833862},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5016999840736389},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.4823000133037567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46470001339912415},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46470001339912415},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.44609999656677246},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3693000078201294},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.3330000042915344},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.33250001072883606},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2985999882221222},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.2948000133037567},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C2988054608","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management strategy","level":2,"score":0.2597000002861023}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4084/mjhid.2026.086","doi":"https://doi.org/10.4084/mjhid.2026.086","is_oa":true,"landing_page_url":"https://doi.org/10.4084/mjhid.2026.086","pdf_url":"https://www.mjhid.org/mjhid/article/download/6534/4978","source":{"id":"https://openalex.org/S159911762","display_name":"Mediterranean Journal of Hematology and Infectious Diseases","issn_l":"2035-3006","issn":["2035-3006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4084/mjhid.2026.086","doi":"https://doi.org/10.4084/mjhid.2026.086","is_oa":true,"landing_page_url":"https://doi.org/10.4084/mjhid.2026.086","pdf_url":"https://www.mjhid.org/mjhid/article/download/6534/4978","source":{"id":"https://openalex.org/S159911762","display_name":"Mediterranean Journal of Hematology and Infectious Diseases","issn_l":"2035-3006","issn":["2035-3006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225006725.pdf","grobid_xml":"https://content.openalex.org/works/W7225006725.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W2009300493","https://openalex.org/W2075017638","https://openalex.org/W2121237805","https://openalex.org/W2736147055","https://openalex.org/W2769920501","https://openalex.org/W2782474271","https://openalex.org/W2806682325","https://openalex.org/W2963018209","https://openalex.org/W2995123606","https://openalex.org/W3007005703","https://openalex.org/W3008896315","https://openalex.org/W3021352118","https://openalex.org/W3030772104","https://openalex.org/W3036377779","https://openalex.org/W3088178573","https://openalex.org/W3093100939","https://openalex.org/W3130857048","https://openalex.org/W3168617320","https://openalex.org/W3172847965","https://openalex.org/W4224268151","https://openalex.org/W4283065915","https://openalex.org/W4284884567","https://openalex.org/W4286294884","https://openalex.org/W4293063769","https://openalex.org/W4362455669","https://openalex.org/W4391738483","https://openalex.org/W4392123440","https://openalex.org/W4392978085","https://openalex.org/W4394674714","https://openalex.org/W4394793419","https://openalex.org/W4394978163","https://openalex.org/W4395115688","https://openalex.org/W4400406251","https://openalex.org/W4401504326","https://openalex.org/W4402650901","https://openalex.org/W4405016154","https://openalex.org/W4405042591","https://openalex.org/W4405083111","https://openalex.org/W4407209734","https://openalex.org/W4407410660","https://openalex.org/W4409252176","https://openalex.org/W4410597204","https://openalex.org/W4410822179","https://openalex.org/W4411168907","https://openalex.org/W4411963290","https://openalex.org/W4412621220","https://openalex.org/W4412644472","https://openalex.org/W4412944153","https://openalex.org/W4413270789","https://openalex.org/W4414133635","https://openalex.org/W4415280181","https://openalex.org/W4417001560","https://openalex.org/W4417009462","https://openalex.org/W4417019989","https://openalex.org/W7108456815","https://openalex.org/W7124753025","https://openalex.org/W7139080013","https://openalex.org/W7163031042","https://openalex.org/W7165377520","https://openalex.org/W7166638529","https://openalex.org/W7204699220"],"related_works":["https://openalex.org/W7160847568","https://openalex.org/W4389247856","https://openalex.org/W4285253072","https://openalex.org/W4312209978","https://openalex.org/W3051184769","https://openalex.org/W4386019076","https://openalex.org/W7136308580","https://openalex.org/W4387110157","https://openalex.org/W2970425807","https://openalex.org/W2805036243"],"abstract_inverted_index":{"The":[0],"management":[1,53,97,125],"of":[2,20,48,75,90,98,153],"acute":[3],"myeloid":[4],"leukemia":[5],"(AML)":[6],"in":[7,126,150],"elderly":[8],"or":[9],"unfit":[10,127],"patients":[11,66,128],"has":[12,42],"undergone":[13],"a":[14,32,46,117],"paradigm":[15],"shift":[16],"with":[17,40,72,129],"the":[18,61,87,151],"integration":[19],"molecular":[21],"diagnostics":[22],"and":[23,93,119,141,147],"targeted":[24,154],"therapies.":[25,155],"Among":[26],"actionable":[27],"alterations,":[28],"IDH1":[29],"mutations":[30],"define":[31],"biologically":[33],"distinct":[34],"subgroup":[35],"for":[36,70,105,109,122],"which":[37],"ivosidenib":[38],"combined":[39],"azacitidine":[41],"recently":[43],"emerged":[44,59],"as":[45],"standard":[47],"care.":[49],"However,":[50],"initial":[51],"clinical":[52],"remains":[54],"complex.":[55],"Three":[56],"main":[57],"themes":[58],"from":[60,136],"expert":[62],"panel\u2019s":[63],"discussion:":[64],"all":[65],"should":[67],"be":[68],"tested":[69],"IDH1m,":[71],"turnaround":[73],"time":[74],"3-5":[76],"days;":[77],"adequate":[78],"patient":[79],"monitoring":[80],"during":[81],"treatment":[82],"is":[83,101],"essential":[84],"to":[85],"detect":[86],"earliest":[88],"signs":[89],"differentiation":[91],"syndrome":[92],"QTc":[94],"prolongation;":[95],"appropriate":[96],"concomitant":[99],"therapies":[100],"required,":[102],"not":[103],"only":[104],"azole":[106],"derivatives":[107],"administered":[108],"antifungal":[110,145],"prophylaxis,":[111],"where":[112],"need.":[113],"This":[114],"paper":[115],"provides":[116],"comprehensive":[118],"evidence-based":[120],"framework":[121],"optimizing":[123],"early":[124],"newly":[130],"diagnosed":[131],"IDH1-mutated":[132],"AML,":[133],"integrating":[134],"data":[135],"randomized":[137],"trials,":[138],"real-world":[139],"studies,":[140],"updated":[142],"evidence":[143],"on":[144],"prophylaxis":[146],"drug\u2013drug":[148],"interactions":[149],"era":[152]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-01T00:00:00"}
