{"id":"https://openalex.org/W7225005412","doi":"https://doi.org/10.1021/acs.orglett.6c03982","title":"Iron-Catalyzed Intramolecular C(sp3)\u2013H Amination toward C2-Spiroindolines","display_name":"Iron-Catalyzed Intramolecular C(sp3)\u2013H Amination toward C2-Spiroindolines","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225005412","doi":"https://doi.org/10.1021/acs.orglett.6c03982"},"language":"en","primary_location":{"id":"doi:10.1021/acs.orglett.6c03982","doi":"https://doi.org/10.1021/acs.orglett.6c03982","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.6c03982","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160267870","display_name":"Yunhai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunhai Wang","raw_affiliation_strings":["Soochow University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University , , ,","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100542448","display_name":"Yang Xing","orcid":"https://orcid.org/0000-0001-7323-4201","observed_orcids":["https://orcid.org/0000-0001-7323-4201"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xing","raw_affiliation_strings":["Soochow University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University , , ,","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040237244","display_name":"Xinxin Tang","orcid":"https://orcid.org/0000-0002-4013-851X","observed_orcids":["https://orcid.org/0000-0002-4013-851X"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinxin Tang","raw_affiliation_strings":["Soochow University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-4013-851X","affiliations":[{"raw_affiliation_string":"Soochow University , , ,","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040237244"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7260748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12251","display_name":"Synthesis and Catalytic Reactions","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12251","display_name":"Synthesis and Catalytic Reactions","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.21619999408721924,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-catalysis","display_name":"iron catalysis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/aryl-azides","display_name":"aryl azides","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tetrazoles","display_name":"tetrazoles","score":0.996999979019165},{"id":"https://openalex.org/keywords/site-selective-synthesis","display_name":"site-selective synthesis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/gram-scale-synthesis","display_name":"gram-scale synthesis","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.963699996471405},{"id":"https://openalex.org/C198503264","wikidata":"https://www.wikidata.org/wiki/Q471635","display_name":"Amination","level":3,"score":0.9114999771118164},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.8801000118255615},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6018000245094299},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.5648999810218811},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.39739999175071716},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.37049999833106995},{"id":"https://openalex.org/C2779938440","wikidata":"https://www.wikidata.org/wiki/Q549876","display_name":"Reductive amination","level":3,"score":0.36890000104904175},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C172456720","wikidata":"https://www.wikidata.org/wiki/Q2945392","display_name":"Intramolecular reaction","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C2989255885","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Molecular conformation","level":3,"score":0.3052000105381012},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.2831999957561493},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C129694887","wikidata":"https://www.wikidata.org/wiki/Q47455153","display_name":"Stereoisomerism","level":3,"score":0.27730000019073486}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.orglett.6c03982","doi":"https://doi.org/10.1021/acs.orglett.6c03982","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.6c03982","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324720","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1992259722","https://openalex.org/W1995456578","https://openalex.org/W2002988876","https://openalex.org/W2004632308","https://openalex.org/W2008962748","https://openalex.org/W2039397684","https://openalex.org/W2044071145","https://openalex.org/W2080183992","https://openalex.org/W2081300517","https://openalex.org/W2094844841","https://openalex.org/W2112099544","https://openalex.org/W2112497272","https://openalex.org/W2125368188","https://openalex.org/W2154210943","https://openalex.org/W2313737475","https://openalex.org/W2322518934","https://openalex.org/W2326727947","https://openalex.org/W2569012662","https://openalex.org/W2601407920","https://openalex.org/W2742049577","https://openalex.org/W2756183863","https://openalex.org/W2797193450","https://openalex.org/W2809945845","https://openalex.org/W2884979092","https://openalex.org/W2888296822","https://openalex.org/W2894152400","https://openalex.org/W2910002595","https://openalex.org/W2913540697","https://openalex.org/W2951435261","https://openalex.org/W2951616963","https://openalex.org/W2978631752","https://openalex.org/W3017132829","https://openalex.org/W3033619969","https://openalex.org/W3045287930","https://openalex.org/W3081530808","https://openalex.org/W3083370475","https://openalex.org/W3084578731","https://openalex.org/W3095509408","https://openalex.org/W3126036341","https://openalex.org/W3140299548","https://openalex.org/W3163381942","https://openalex.org/W4205574020","https://openalex.org/W4297820399","https://openalex.org/W4304975313","https://openalex.org/W4310141939","https://openalex.org/W4318542897","https://openalex.org/W4382653330","https://openalex.org/W4382936944","https://openalex.org/W4387518093","https://openalex.org/W4389780815","https://openalex.org/W4390581772","https://openalex.org/W4392761980","https://openalex.org/W4396661018","https://openalex.org/W4399556143","https://openalex.org/W4404299392","https://openalex.org/W4409662818","https://openalex.org/W4413138624","https://openalex.org/W7122908259"],"related_works":["https://openalex.org/W2950602515","https://openalex.org/W2033511623","https://openalex.org/W4415917974","https://openalex.org/W2739819163","https://openalex.org/W4376471379","https://openalex.org/W3201950930","https://openalex.org/W4283271571","https://openalex.org/W4408082403","https://openalex.org/W4416322140","https://openalex.org/W3202227386"],"abstract_inverted_index":{"Abstract":[0],"C2-Spiroindolines":[1],"are":[2],"valuable":[3],"three-dimensional":[4],"scaffolds,":[5],"yet":[6],"direct":[7],"synthetic":[8,58],"methods":[9],"remain":[10],"limited.":[11],"Here,":[12],"we":[13],"report":[14],"an":[15],"iron-catalyzed":[16],"intramolecular":[17],"C(sp3)\u2013H":[18],"amination":[19],"of":[20,30],"readily":[21],"accessible":[22],"aryl":[23],"azides":[24],"and":[25,32,41,44,54],"tetrazoles,":[26],"enabling":[27],"site-selective":[28],"construction":[29],"C2-spiroindolines":[31],"their":[33],"aza":[34],"bioisosteres.":[35],"The":[36],"reaction":[37],"accommodates":[38],"diverse":[39],"carbocyclic":[40],"heterocyclic":[42],"motifs":[43],"affords":[45],"products":[46],"in":[47,67],"up":[48],"to":[49],"89%":[50],"yield.":[51],"Gram-scale":[52],"synthesis":[53],"downstream":[55],"derivatizations":[56],"demonstrate":[57],"utility,":[59],"providing":[60],"spirocyclic":[61],"building":[62],"blocks":[63],"with":[64],"potential":[65],"applications":[66],"medicinal":[68],"chemistry.":[69]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-11-01T00:00:00"}