{"id":"https://openalex.org/W7225004455","doi":"https://doi.org/10.64898/2026.10.26.757846","title":"A human induced pluripotent stem cell-based high-throughput screening platform for teratogenicity hazard identification","display_name":"A human induced pluripotent stem cell-based high-throughput screening platform for teratogenicity hazard identification","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7225004455","doi":"https://doi.org/10.64898/2026.10.26.757846"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.26.757846","doi":"https://doi.org/10.64898/2026.10.26.757846","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.26.757846","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.26.757846.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.26.757846.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029407244","display_name":"Henrik Renner","orcid":"https://orcid.org/0000-0002-9621-4569","observed_orcids":["https://orcid.org/0000-0002-9621-4569"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henrik Renner","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9621-4569","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160257361","display_name":"Kinga Maria Wrona","orcid":"https://orcid.org/0000-0002-5123-2990","observed_orcids":["https://orcid.org/0000-0002-5123-2990"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kinga Maria Wrona","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5123-2990","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067270697","display_name":"Christopher Bruhn","orcid":"https://orcid.org/0000-0001-6656-996X","observed_orcids":["https://orcid.org/0000-0001-6656-996X"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher Bruhn","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6656-996X","affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046203546","display_name":"Alice Drobny","orcid":"https://orcid.org/0000-0001-7957-4565","observed_orcids":["https://orcid.org/0000-0001-7957-4565"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alice Schneider","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7957-4565","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160252695","display_name":"Rachel McCannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rachel McCannon","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148606873","display_name":"Fabrizia Zoppetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabrizia Zoppetti","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051828960","display_name":"Meik Henningsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Meik Henningsen","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147736469","display_name":"Kornelia Kuc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kornelia Kuc","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086080368","display_name":"Carsten J\u00f6rn Beese","orcid":"https://orcid.org/0000-0002-0437-6764","observed_orcids":["https://orcid.org/0000-0002-0437-6764"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten J\u00f6rn Beese","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0437-6764","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059962179","display_name":"Carina Wollnik","orcid":"https://orcid.org/0009-0000-0964-3051","observed_orcids":["https://orcid.org/0009-0000-0964-3051"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carina Wollnik","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0000-0964-3051","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029400117","display_name":"Vladimir Galatenko","orcid":"https://orcid.org/0000-0003-3029-3628","observed_orcids":["https://orcid.org/0000-0003-3029-3628"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vladimir Galatenko","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3029-3628","affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012482863","display_name":"Alexandra Hackmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Hackmann","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020906604","display_name":"Sandra Lubitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra Lubitz","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072773886","display_name":"Bastian Zimmer","orcid":"https://orcid.org/0000-0003-0004-4890","observed_orcids":["https://orcid.org/0000-0003-0004-4890"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bastian Zimmer","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0004-4890","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072773886"],"corresponding_institution_ids":["https://openalex.org/I4210130816"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.2029999941587448,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/human-induced-pluripotent-stem-cells","display_name":"human induced pluripotent stem cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hazard-identification","display_name":"hazard identification","score":0.7289999723434448},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5569999814033508},{"id":"https://openalex.org/keywords/women-of-reproductive-age","display_name":"women of reproductive age","score":0.9359999895095825},{"id":"https://openalex.org/keywords/teratogens","display_name":"teratogens","score":0.628000020980835},{"id":"https://openalex.org/keywords/three-germ-layers","display_name":"three germ layers","score":0.7210000157356262},{"id":"https://openalex.org/keywords/chemically-defined-media","display_name":"chemically defined medium","score":0.8339999914169312},{"id":"https://openalex.org/keywords/high-content-imaging","display_name":"high-content imaging","score":0.8980000019073486},{"id":"https://openalex.org/keywords/automated-screening","display_name":"automated screening","score":0.4690000116825104},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5856999754905701},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5241000056266785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5153999924659729},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.49869999289512634},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4595000147819519},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.4251999855041504},{"id":"https://openalex.org/C2776654903","wikidata":"https://www.wikidata.org/wiki/Q2601463","display_name":"SAFER","level":2,"score":0.4074000120162964},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3939000070095062},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.38940000534057617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3799999952316284},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36820000410079956},{"id":"https://openalex.org/C206355099","wikidata":"https://www.wikidata.org/wiki/Q3614972","display_name":"Hazard analysis","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C49261128","wikidata":"https://www.wikidata.org/wiki/Q1132455","display_name":"Hazard","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33489999175071716},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3325999975204468},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.305400013923645},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.2709999978542328},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2639000117778778}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.26.757846","doi":"https://doi.org/10.64898/2026.10.26.757846","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.26.757846","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.26.757846.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.26.757846","doi":"https://doi.org/10.64898/2026.10.26.757846","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.26.757846","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.26.757846.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225004455.pdf","grobid_xml":"https://content.openalex.org/works/W7225004455.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W194388979","https://openalex.org/W1935109912","https://openalex.org/W1964139194","https://openalex.org/W1973690819","https://openalex.org/W1981457253","https://openalex.org/W1998721413","https://openalex.org/W2029955364","https://openalex.org/W2041695580","https://openalex.org/W2047746096","https://openalex.org/W2049411261","https://openalex.org/W2076588922","https://openalex.org/W2099692128","https://openalex.org/W2123308898","https://openalex.org/W2134430464","https://openalex.org/W2138977668","https://openalex.org/W2164812139","https://openalex.org/W2166256370","https://openalex.org/W2169456326","https://openalex.org/W2232521592","https://openalex.org/W2254528831","https://openalex.org/W2254866812","https://openalex.org/W2316940481","https://openalex.org/W2611645197","https://openalex.org/W2622900957","https://openalex.org/W2811329289","https://openalex.org/W2884759401","https://openalex.org/W2886400004","https://openalex.org/W2970417926","https://openalex.org/W3007932435","https://openalex.org/W3033773215","https://openalex.org/W3036555894","https://openalex.org/W3194587416","https://openalex.org/W4226105062","https://openalex.org/W4295905061","https://openalex.org/W4309560738","https://openalex.org/W4388894525","https://openalex.org/W4388939343","https://openalex.org/W4402823061","https://openalex.org/W4410431675","https://openalex.org/W4414005501","https://openalex.org/W4415147476"],"related_works":["https://openalex.org/W3094772932","https://openalex.org/W2134430464","https://openalex.org/W2744006509","https://openalex.org/W1597670034","https://openalex.org/W6906515559","https://openalex.org/W2886400004","https://openalex.org/W4221085776","https://openalex.org/W6981054666","https://openalex.org/W2551177095","https://openalex.org/W2990672986"],"abstract_inverted_index":{"Abstract":[0],"Teratogenic":[1],"liability":[2,18],"is":[3,22,188],"a":[4,42,70,121],"major":[5],"concern":[6],"around":[7],"any":[8],"drug":[9,20,29,83,193,211],"taken":[10],"by":[11],"women":[12,61],"of":[13,19,52,62,91,124,140,145,171,173],"childbearing":[14,63],"potential.":[15],"However,":[16],"teratogenic":[17,43],"candidates":[21],"usually":[23],"assessed":[24],"very":[25],"late":[26],"in":[27,50,72,81,100,161,175,180],"the":[28,40,53,67,82,116,134,186,208],"discovery":[30,84,194],"process":[31,85],"using":[32,158],"time-":[33],"and":[34,130,156,203],"cost-intensive":[35],"animal":[36],"models.":[37],"Depending":[38],"on":[39,105,152],"indication,":[41],"outcome":[44],"at":[45],"this":[46,95],"stage":[47],"can":[48],"result":[49],"termination":[51],"entire":[54],"program":[55],"or":[56],"create":[57],"significant":[58],"barriers":[59],"for":[60,78],"potential":[64],"to":[65,178,191,206],"use":[66],"drug.":[68],"Therefore,":[69],"human":[71,108],"vitro":[73,101],"assay":[74],"allowing":[75],"high-throughput":[76],"screening":[77],"teratogenicity":[79,102],"early":[80,198],"would":[86],"enable":[87],"more":[88],"efficient":[89],"development":[90],"safer":[92],"drugs.":[93],"To":[94],"end,":[96],"we":[97],"developed":[98],"an":[99,137],"platform":[103,135,187],"based":[104,151],"four":[106],"different":[107],"induced":[109],"pluripotent":[110],"stem":[111],"cell":[112],"(hiPSC)":[113],"models":[114],"covering":[115],"three":[117],"germ":[118],"layers.":[119],"Screening":[120],"reference":[122],"set":[123],"146":[125],"compounds":[126,174],"(90":[127],"known":[128,132,146],"teratogens":[129],"56":[131],"non-teratogens),":[133],"delivered":[136],"overall":[138],"accuracy":[139],"83%,":[141],"correctly":[142],"identifying":[143],"88%":[144],"teratogens.":[147],"All":[148],"workflows":[149],"are":[150],"chemically":[153],"defined":[154],"media":[155],"performed":[157],"automated":[159],"systems":[160],"384-well":[162],"plates":[163],"analyzed":[164],"via":[165],"high-content":[166],"imaging.":[167],"This":[168],"enables":[169],"testing":[170],"hundreds":[172],"dose":[176,182],"response":[177],"thousands":[179],"single":[181],"per":[183],"month.":[184],"Thus,":[185],"ideally":[189],"suited":[190],"support":[192],"programs":[195],"starting":[196],"from":[197],"stages":[199],"enabling":[200],"hazard":[201],"assessment":[202],"risk":[204],"mitigation":[205],"develop":[207],"safest":[209],"possible":[210],"candidates.":[212]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-01T00:00:00"}