{"id":"https://openalex.org/W7225002438","doi":"https://doi.org/10.1038/s41419-026-09374-w","title":"SOX4 drives ferroptosis resistance of non-small cell lung cancer by regulating PI3K/AKT/SREBP1/SCD1 signaling axis","display_name":"SOX4 drives ferroptosis resistance of non-small cell lung cancer by regulating PI3K/AKT/SREBP1/SCD1 signaling axis","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225002438","doi":"https://doi.org/10.1038/s41419-026-09374-w"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-026-09374-w","doi":"https://doi.org/10.1038/s41419-026-09374-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09374-w","pdf_url":"https://www.nature.com/articles/s41419-026-09374-w_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-026-09374-w_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031576616","display_name":"Xueping Lei","orcid":"https://orcid.org/0000-0002-2075-0461","observed_orcids":["https://orcid.org/0000-0002-2075-0461"]},"institutions":[{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueping Lei","raw_affiliation_strings":["The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-2075-0461","affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046667658","display_name":"Jieyao Liu","orcid":"https://orcid.org/0009-0000-4873-7907","observed_orcids":["https://orcid.org/0009-0000-4873-7907"]},"institutions":[{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieyao Liu","raw_affiliation_strings":["GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China","The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I2802148028","https://openalex.org/I92039509"]},{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002004952","display_name":"\u53e4\u7ee7\u7ea2","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihong Gu","raw_affiliation_strings":["Chinese Medicine Guangdong Laboratory, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Guangdong Laboratory, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160279549","display_name":"Lijuan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Huang","raw_affiliation_strings":["The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107949111","display_name":"Weisong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weisong Zhang","raw_affiliation_strings":["The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151334895","display_name":"Zhiling Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiling Liu","raw_affiliation_strings":["The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061393432","display_name":"Boyin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boyin Li","raw_affiliation_strings":["The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160264210","display_name":"Kunpei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunpei Wu","raw_affiliation_strings":["The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210154954","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160274847","display_name":"Ming Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Liu","raw_affiliation_strings":["GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I2802148028","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101625382","display_name":"Haiyan Sun","orcid":"https://orcid.org/0009-0009-6317-276X","observed_orcids":["https://orcid.org/0009-0009-6317-276X"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyan Sun","raw_affiliation_strings":["Department of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0009-6317-276X","affiliations":[{"raw_affiliation_string":"Department of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157978712","display_name":"Jianglin Wang","orcid":"https://orcid.org/0009-0002-0838-8575","observed_orcids":["https://orcid.org/0009-0002-0838-8575"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianglin Wang","raw_affiliation_strings":["Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0009-0002-0838-8575","affiliations":[{"raw_affiliation_string":"Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005285929","display_name":"Qiudi Deng","orcid":"https://orcid.org/0000-0001-6378-0209","observed_orcids":["https://orcid.org/0000-0001-6378-0209"]},"institutions":[{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiudi Deng","raw_affiliation_strings":["GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-6378-0209","affiliations":[{"raw_affiliation_string":"GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I2802148028","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005285929","https://openalex.org/A5101625382","https://openalex.org/A5157978712"],"corresponding_institution_ids":["https://openalex.org/I180726961","https://openalex.org/I2802148028","https://openalex.org/I92039509"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86344127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox4","display_name":"SOX4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ferroptosis-resistance","display_name":"ferroptosis resistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/rsl3","display_name":"RSL3","score":0.8479999899864197},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7509999871253967},{"id":"https://openalex.org/keywords/regulated-cell-death","display_name":"regulated cell death","score":0.6959999799728394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.875}],"concepts":[{"id":"https://openalex.org/C139259183","wikidata":"https://www.wikidata.org/wiki/Q18031651","display_name":"SOX4","level":5,"score":0.8745999932289124},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7602999806404114},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6963000297546387},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6669999957084656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6126000285148621},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5651999711990356},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.510200023651123},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49410000443458557},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42879998683929443},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37459999322891235},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.36899998784065247},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3578999936580658},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35600000619888306},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.34709998965263367},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.3330000042915344},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33219999074935913},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3077000081539154},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29440000653266907},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41419-026-09374-w","doi":"https://doi.org/10.1038/s41419-026-09374-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09374-w","pdf_url":"https://www.nature.com/articles/s41419-026-09374-w_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41419-026-09374-w","doi":"https://doi.org/10.1038/s41419-026-09374-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-026-09374-w","pdf_url":"https://www.nature.com/articles/s41419-026-09374-w_reference.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225002438.pdf","grobid_xml":"https://content.openalex.org/works/W7225002438.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388651826","https://openalex.org/W4378902937","https://openalex.org/W4200370007","https://openalex.org/W4416455346","https://openalex.org/W3135918052","https://openalex.org/W7161188022","https://openalex.org/W3189264692","https://openalex.org/W7143375910","https://openalex.org/W7171409963","https://openalex.org/W4415726122"],"abstract_inverted_index":{"Abstract":[0],"Non-small":[1],"cell":[2,29],"lung":[3],"cancer":[4,204],"(NSCLC)":[5],"remains":[6],"a":[7,23,41,128,169,180],"challenging":[8],"disease":[9],"due":[10],"to":[11,67,108,118],"its":[12,57,93],"high":[13],"heterogeneity":[14],"and":[15,72,92,174,201],"the":[16,33,52,137,147,176,196],"lack":[17],"of":[18,27,35,54,132,140,172],"effective":[19],"treatment":[20],"strategies.":[21],"Ferroptosis,":[22],"recently":[24],"identified":[25,126],"form":[26],"regulated":[28],"death":[30],"driven":[31],"by":[32,157],"accumulation":[34],"lipid":[36],"hydroperoxides,":[37],"has":[38],"emerged":[39],"as":[40,127,168,179],"promising":[42],"therapeutic":[43,182],"strategy":[44],"in":[45,90,187,203],"NSCLC.":[46,188],"Whereas":[47],"ferroptosis-based":[48],"therapy":[49],"also":[50,191],"faces":[51],"challenge":[53],"resistance,":[55],"hindering":[56],"further":[58],"clinical":[59],"translation.":[60],"Thus,":[61],"there":[62],"is":[63,87],"an":[64],"urgent":[65],"need":[66],"identify":[68],"novel":[69],"ferroptosis":[70,109,173,186],"regulators":[71],"elucidate":[73],"their":[74],"mechanisms.":[75],"In":[76,162],"this":[77],"study,":[78],"we":[79],"found":[80],"that":[81],"SRY-box":[82],"transcription":[83],"factor":[84],"4":[85],"(SOX4)":[86],"frequently":[88],"overexpressed":[89],"NSCLC,":[91],"elevated":[94],"expression":[95,156],"correlates":[96],"with":[97],"poor":[98],"patient":[99],"survival.":[100],"Importantly,":[101],"SOX4":[102,113,141,148,153,167,200],"overexpression":[103,135],"conferred":[104],"NSCLC":[105],"cells":[106],"resistance":[107],"inducer":[110],"RSL3,":[111],"whereas":[112,143],"knockdown":[114],"enhanced":[115],"cellular":[116],"sensitivity":[117],"RSL3.":[119],"Mechanistically,":[120],"stearoyl-CoA":[121],"desaturase":[122],"1":[123],"(SCD1)":[124],"was":[125],"key":[129],"downstream":[130],"effector":[131],"SOX4.":[133],"SCD1":[134,144,155,202],"counteracted":[136],"pro-ferroptotic":[138],"effects":[139],"knockdown,":[142],"silencing":[145],"reversed":[146],"overexpression-induced":[149],"anti-ferroptotic":[150],"phenotype.":[151],"Furthermore,":[152],"promoted":[154],"activating":[158],"PI3K/AKT/SREBP1":[159],"signaling":[160],"pathway.":[161],"summary,":[163],"our":[164],"results":[165],"establish":[166],"critical":[170],"regulator":[171],"propose":[175],"SOX4\u2013SCD1":[177],"axis":[178],"candidate":[181],"target":[183],"for":[184],"inducing":[185],"These":[189],"findings":[190],"provide":[192],"new":[193],"insights":[194],"into":[195],"mechanistic":[197],"link":[198],"between":[199],"biology.":[205]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-11-01T00:00:00"}