{"id":"https://openalex.org/W7225002008","doi":"https://doi.org/10.5281/zenodo.23768022","title":"Cardiovascular Events and All-Cause Mortality with SGLT2 Inhibitors versus DPP-4 Inhibitors in Patients Starting Tyrosine Kinase Inhibitors: Protocol of a Target Trial Emulation","display_name":"Cardiovascular Events and All-Cause Mortality with SGLT2 Inhibitors versus DPP-4 Inhibitors in Patients Starting Tyrosine Kinase Inhibitors: Protocol of a Target Trial Emulation","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7225002008","doi":"https://doi.org/10.5281/zenodo.23768022"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23768022","doi":"https://doi.org/10.5281/zenodo.23768022","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23768022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23768022","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160256486","display_name":"Chia-Yu Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsu, Chia-Yu","raw_affiliation_strings":["Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160271526","display_name":"Wei-Lun Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chou, Wei-Lun","raw_affiliation_strings":["Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143832767","display_name":"Jing-Huan Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Liao, Jing-Huan","raw_affiliation_strings":["Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160243948","display_name":"Wei-Cheng Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang, Wei-Cheng","raw_affiliation_strings":["Department of Ophthalmology, Universal Eye Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Universal Eye Center, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160248557","display_name":"Hsin-Yu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen, Hsin-Yu","raw_affiliation_strings":["Department of Family Medicine, Chi Mei Medical Center, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Chi Mei Medical Center, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160278353","display_name":"Hong-Jie Jhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jhou, Hong-Jie","raw_affiliation_strings":["Neurological Institute, Changhua Christian Hospital, Changhua, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Institute, Changhua Christian Hospital, Changhua, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140477101","display_name":"Cho-Hao Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lee, Cho-Hao","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","Department of Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033270000","display_name":"Po\u2010Huang Chen","orcid":"https://orcid.org/0000-0002-0280-6417","observed_orcids":["https://orcid.org/0000-0002-0280-6417"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen, Po-Huang","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","Department of Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86288631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.8859999775886536},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":1.0},{"id":"https://openalex.org/keywords/target-trial-emulation","display_name":"target trial emulation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bcr-abl-tyrosine-kinase-inhibitors","display_name":"BCR-ABL tyrosine kinase inhibitors","score":0.984000027179718},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/trinetx","display_name":"TriNetX","score":0.6470000147819519},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7526999711990356},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6579999923706055},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.48890000581741333},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46219998598098755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45350000262260437},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45249998569488525},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4496000111103058},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.44429999589920044},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4368000030517578},{"id":"https://openalex.org/C149810388","wikidata":"https://www.wikidata.org/wiki/Q5374873","display_name":"Emulation","level":2,"score":0.4189999997615814},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.4180999994277954},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4113999903202057},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.40959998965263367},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.3831999897956848},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.357699990272522},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.2980000078678131},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.2531999945640564},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25189998745918274}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5281/zenodo.23768022","doi":"https://doi.org/10.5281/zenodo.23768022","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23768022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"doi:10.5281/zenodo.23768023","doi":"https://doi.org/10.5281/zenodo.23768023","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23768023","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"doi:10.5281/zenodo.23934100","doi":"https://doi.org/10.5281/zenodo.23934100","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23934100","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23768022","doi":"https://doi.org/10.5281/zenodo.23768022","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23768022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3195289297","https://openalex.org/W3035689851","https://openalex.org/W3088446089","https://openalex.org/W3081518378","https://openalex.org/W2889203500","https://openalex.org/W3127619588","https://openalex.org/W2470197143","https://openalex.org/W7221778328","https://openalex.org/W2802245520","https://openalex.org/W2808793740"],"abstract_inverted_index":{"This":[0],"document":[1],"is":[2,49,59],"the":[3,41,55,65,74,81,85],"protocol":[4],"of":[5,12,20,30],"a":[6,13,21],"target":[7,66],"trial":[8,67],"emulation":[9],"comparing":[10],"initiation":[11,19],"sodium-glucose":[14],"cotransporter-2":[15],"inhibitor":[16,24],"(SGLT2i)":[17],"with":[18],"dipeptidyl":[22],"peptidase-4":[23],"(DPP-4i)":[25],"among":[26],"adults":[27],"starting":[28],"one":[29],"15":[31],"tyrosine":[32],"kinase":[33],"inhibitors":[34],"(VEGFR-targeting,":[35],"BCR-ABL,":[36],"or":[37],"BTK":[38],"inhibitors)":[39],"in":[40],"TriNetX":[42],"Global":[43],"Collaborative":[44],"Network.":[45],"The":[46],"primary":[47,86],"endpoint":[48,58],"major":[50],"adverse":[51],"cardiovascular":[52],"events":[53],"and":[54,68,77,88],"key":[56],"secondary":[57],"all-cause":[60],"mortality.":[61],"Table":[62,71,78],"1":[63],"specifies":[64],"its":[69],"emulation,":[70],"2":[72],"gives":[73,80],"code":[75],"definitions,":[76],"3":[79],"cohort":[82],"criteria":[83],"for":[84],"analysis":[87],"20":[89],"sensitivity":[90],"analyses.":[91]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-01T00:00:00"}