{"id":"https://openalex.org/W7224996850","doi":"https://doi.org/10.1016/j.biopha.2026.120009","title":"FTO mediated glycolytic metabolism for papillary renal cell carcinoma immune evasion","display_name":"FTO mediated glycolytic metabolism for papillary renal cell carcinoma immune evasion","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224996850","doi":"https://doi.org/10.1016/j.biopha.2026.120009","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966346"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2026.120009","doi":"https://doi.org/10.1016/j.biopha.2026.120009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.120009","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2026.120009","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021160928","display_name":"Catarina Guimar\u00e3es\u2010Teixeira","orcid":"https://orcid.org/0000-0003-2212-3872","observed_orcids":["https://orcid.org/0000-0003-2212-3872"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Guimar\u00e3es-Teixeira","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; PhD Programme in Pathology & Molecular Genetics, ICBAS-School of Medicine & Biomedical Sciences-University of Porto, Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-2212-3872","affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; PhD Programme in Pathology & Molecular Genetics, ICBAS-School of Medicine & Biomedical Sciences-University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164","https://openalex.org/I4405263123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101509721","display_name":"Sandra P. Nunes","orcid":"https://orcid.org/0000-0003-4466-037X","observed_orcids":["https://orcid.org/0000-0003-4466-037X"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4210165411","display_name":"Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas","ror":"https://ror.org/05xx77y52","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165411"]}],"countries":["ES","PT"],"is_corresponding":false,"raw_author_name":"Sandra P. Nunes","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Molecular Oncology Unit, Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT), Madrid, Spain; Biomedical Research Institute I+12, University Hospital \"12 de Octubre\", Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Molecular Oncology Unit, Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnol\u00f3gicas (CIEMAT), Madrid, Spain; Biomedical Research Institute I+12, University Hospital \"12 de Octubre\", Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210111164","https://openalex.org/I4210165411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056183214","display_name":"Alberto Bueno-Costa","orcid":"https://orcid.org/0000-0001-8700-2540","observed_orcids":["https://orcid.org/0000-0001-8700-2540"]},"institutions":[{"id":"https://openalex.org/I4210089592","display_name":"Josep Carreras Leukaemia Research Institute","ror":"https://ror.org/00btzwk36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089592","https://openalex.org/I4210144824","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Bueno-Costa","raw_affiliation_strings":["Cancer Epigenetics Group, Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8700-2540","affiliations":[{"raw_affiliation_string":"Cancer Epigenetics Group, Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210089592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032744768","display_name":"Laura Martinez\u2010Verbo","orcid":"https://orcid.org/0000-0003-0817-3056","observed_orcids":["https://orcid.org/0000-0003-0817-3056"]},"institutions":[{"id":"https://openalex.org/I4210089592","display_name":"Josep Carreras Leukaemia Research Institute","ror":"https://ror.org/00btzwk36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089592","https://openalex.org/I4210144824","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Martinez-Verbo","raw_affiliation_strings":["Cancer Epigenetics Group, Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epigenetics Group, Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210089592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051999472","display_name":"Iola F. Duarte","orcid":"https://orcid.org/0000-0003-4289-9256","observed_orcids":["https://orcid.org/0000-0003-4289-9256"]},"institutions":[{"id":"https://openalex.org/I4391767730","display_name":"LAQV Requimte","ror":"https://ror.org/047td8p12","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210138594","https://openalex.org/I4391767730","https://openalex.org/I60858718","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I60858718","display_name":"University of Aveiro","ror":"https://ror.org/00nt41z93","country_code":"PT","type":"education","lineage":["https://openalex.org/I60858718"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Iola F. Duarte","raw_affiliation_strings":["Department of Chemistry, CICECO - Aveiro Institute of Materials and LAQV-REQUIMTE, University of Aveiro, Aveiro, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-4289-9256","affiliations":[{"raw_affiliation_string":"Department of Chemistry, CICECO - Aveiro Institute of Materials and LAQV-REQUIMTE, University of Aveiro, Aveiro, Portugal","institution_ids":["https://openalex.org/I4391767730","https://openalex.org/I60858718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116179903","display_name":"\u00cdris R. Carri\u00e7o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"\u00cdris R. Carri\u00e7o","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; PhD Programme in Pathology & Molecular Genetics, ICBAS-School of Medicine & Biomedical Sciences-University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; PhD Programme in Pathology & Molecular Genetics, ICBAS-School of Medicine & Biomedical Sciences-University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164","https://openalex.org/I4405263123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068249683","display_name":"Daniela Barros\u2010Silva","orcid":"https://orcid.org/0000-0001-6746-6807","observed_orcids":["https://orcid.org/0000-0001-6746-6807"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Daniela Barros-Silva","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087200653","display_name":"Jo\u00e3o Lobo","orcid":"https://orcid.org/0000-0001-6829-1391","observed_orcids":["https://orcid.org/0000-0001-6829-1391"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405260822","display_name":"RISE - Health Research Network","ror":"https://ror.org/04asa4p95","country_code":"PT","type":"other","lineage":["https://openalex.org/I4405260822"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Lobo","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6829-1391","affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164","https://openalex.org/I4405260822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057879270","display_name":"Rui Henrique","orcid":"https://orcid.org/0000-0003-3171-4666","observed_orcids":["https://orcid.org/0000-0003-3171-4666"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405260822","display_name":"RISE - Health Research Network","ror":"https://ror.org/04asa4p95","country_code":"PT","type":"other","lineage":["https://openalex.org/I4405260822"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Henrique","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-3171-4666","affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal; Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164","https://openalex.org/I4405260822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010137759","display_name":"Manel Esteller","orcid":"https://orcid.org/0000-0003-4490-6093","observed_orcids":["https://orcid.org/0000-0003-4490-6093"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I4210089592","display_name":"Josep Carreras Leukaemia Research Institute","ror":"https://ror.org/00btzwk36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089592","https://openalex.org/I4210144824","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manel Esteller","raw_affiliation_strings":["Cancer Epigenetics Group, Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigaci\u00f3n Biomedica en Red Cancer (CIBERONC), Madrid, Spain; Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Catalonia, Spain; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Epigenetics Group, Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigaci\u00f3n Biomedica en Red Cancer (CIBERONC), Madrid, Spain; Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Catalonia, Spain; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I11932220","https://openalex.org/I4210089592","https://openalex.org/I4210115082","https://openalex.org/I4210158561","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047929505","display_name":"Vera Miranda\u2010Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-4231-5532","observed_orcids":["https://orcid.org/0000-0002-4231-5532"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Vera Miranda-Gon\u00e7alves","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042199157","display_name":"C\u00e1rmen Jer\u00f3nimo","orcid":"https://orcid.org/0000-0003-4186-5345","observed_orcids":["https://orcid.org/0000-0003-4186-5345"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Carmen Jer\u00f3nimo","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal. Electronic address: carmenjeronimo@ipoporto.min-saude.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, IPO Porto Research Center, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal; RISE Associate Laboratory (Health Research Network), Portugal; Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal; Department of Pathology and Molecular Immunology, ICBAS-School of Medicine & Biomedical Sciences, University of Porto, Porto, Portugal. Electronic address: carmenjeronimo@ipoporto.min-saude.pt","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5042199157"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7218386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"204","issue":null,"first_page":"120009","last_page":"120009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.9409999847412109},{"id":"https://openalex.org/keywords/n6-methyladenosine-demethylation","display_name":"N6-methyladenosine demethylation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/papillary-renal-cell-carcinoma","display_name":"papillary renal cell carcinoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glycolytic-reprogramming","display_name":"glycolytic reprogramming","score":0.7799999713897705},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.8880000114440918},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cd8-t-cell-activation","display_name":"CD8+ T cell activation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5879999995231628},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6633999943733215},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6377000212669373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5590000152587891},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5415999889373779},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5087000131607056},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.474700003862381},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.4503999948501587},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.39419999718666077},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.38850000500679016},{"id":"https://openalex.org/C88099638","wikidata":"https://www.wikidata.org/wiki/Q412856","display_name":"Pyruvate dehydrogenase complex","level":3,"score":0.3846000134944916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3804999887943268},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.3752000033855438},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.3720000088214874},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.36649999022483826},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3458000123500824},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33880001306533813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32820001244544983},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3034999966621399},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C2776531350","wikidata":"https://www.wikidata.org/wiki/Q16877679","display_name":"Papillary renal cell carcinomas","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.2531000077724457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2026.120009","doi":"https://doi.org/10.1016/j.biopha.2026.120009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.120009","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:42966346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2026.120009","doi":"https://doi.org/10.1016/j.biopha.2026.120009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.120009","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W900373682","https://openalex.org/W1964611724","https://openalex.org/W1964736484","https://openalex.org/W1971587845","https://openalex.org/W1976884735","https://openalex.org/W2009705209","https://openalex.org/W2021793290","https://openalex.org/W2060878129","https://openalex.org/W2071930821","https://openalex.org/W2117692326","https://openalex.org/W2140741923","https://openalex.org/W2161899881","https://openalex.org/W2321711202","https://openalex.org/W2519020116","https://openalex.org/W2548475758","https://openalex.org/W2565408756","https://openalex.org/W2607129810","https://openalex.org/W2607136415","https://openalex.org/W2625416742","https://openalex.org/W2756153909","https://openalex.org/W2795319633","https://openalex.org/W2795915709","https://openalex.org/W2910697460","https://openalex.org/W2915777758","https://openalex.org/W2922101574","https://openalex.org/W2969705945","https://openalex.org/W2992958546","https://openalex.org/W3007237592","https://openalex.org/W3010177010","https://openalex.org/W3014891010","https://openalex.org/W3019428224","https://openalex.org/W3068085031","https://openalex.org/W3082743306","https://openalex.org/W3087313556","https://openalex.org/W3127280906","https://openalex.org/W3158263555","https://openalex.org/W3158589775","https://openalex.org/W3184013170","https://openalex.org/W3185779453","https://openalex.org/W3194895845","https://openalex.org/W3195051150","https://openalex.org/W3197263514","https://openalex.org/W3203659437","https://openalex.org/W3207384678","https://openalex.org/W4210744364","https://openalex.org/W4210813406","https://openalex.org/W4213066403","https://openalex.org/W4220686844","https://openalex.org/W4220974672","https://openalex.org/W4281915549","https://openalex.org/W4282932154","https://openalex.org/W4285171522","https://openalex.org/W4285489723","https://openalex.org/W4294740346","https://openalex.org/W4306912917","https://openalex.org/W4307447022","https://openalex.org/W4307503888","https://openalex.org/W4310718209","https://openalex.org/W4313638908","https://openalex.org/W4318985524","https://openalex.org/W4385837379","https://openalex.org/W4387966469","https://openalex.org/W4389817728","https://openalex.org/W4390012521","https://openalex.org/W4393390765","https://openalex.org/W4396729188","https://openalex.org/W4398196692","https://openalex.org/W4402878934"],"related_works":["https://openalex.org/W3158589775","https://openalex.org/W2910561108","https://openalex.org/W6920903235","https://openalex.org/W4415810295","https://openalex.org/W4408110536","https://openalex.org/W4210813406","https://openalex.org/W4290888540","https://openalex.org/W4415380121","https://openalex.org/W4391229108","https://openalex.org/W4411401782"],"abstract_inverted_index":{"N6-methyladenosine":[0],"(m6A)":[1],"methylation":[2,14],"is":[3,45],"the":[4,13,18,25,60,66],"predominant":[5],"internal":[6],"modification":[7],"in":[8,36,70,76,81,114,126,133],"eukaryotic":[9],"mRNA,":[10],"characterized":[11,46],"by":[12,47,90,104],"of":[15,68],"adenosine":[16],"at":[17],"nitrogen-6":[19],"position.":[20],"A":[21,85],"key":[22],"m6A":[23],"demethylase,":[24],"Fat":[26],"Mass":[27],"and":[28,51,73,94,130],"Obesity-associated":[29],"protein":[30],"(FTO)":[31],"play":[32],"a":[33,52,82,121,139],"significant":[34],"role":[35,67,123],"metabolism.":[37],"Renal":[38],"cell":[39,110],"carcinoma":[40],"(RCC),":[41],"particularly":[42],"papillary":[43],"RCC,":[44],"increased":[48,115],"glucose":[49],"uptake":[50],"shift":[53],"towards":[54],"anaerobic":[55],"glycolysis,":[56],"commonly":[57],"known":[58],"as":[59,138],"\u201cWarburg":[61],"effect\u201d.":[62],"This":[63],"study":[64],"investigates":[65],"FTO":[69,78,101,125],"glycolytic":[71],"reprogramming":[72],"immune":[74,131],"evasion":[75],"RCC.":[77],"disruption":[79],"resulted":[80],"Lactate":[83],"Dehydrogenase":[84],"(LDHA)":[86],"expression":[87],"downregulation,":[88],"followed":[89],"lactate":[91],"production":[92],"reduction":[93],"CD8":[95,107],"+":[96,108],"T":[97,109],"cells":[98],"activation.":[99],"Furthermore,":[100],"pharmacological":[102],"inhibition":[103],"DAC51":[105],"promoted":[106],"activation,":[111],"also":[112],"resulting":[113],"apoptotic":[116],"activity.":[117],"These":[118],"findings":[119],"reveal":[120],"novel":[122],"for":[124,142],"regulating":[127],"tumor":[128],"metabolism":[129],"escape":[132],"pRCC,":[134],"highlighting":[135],"its":[136],"potential":[137],"therapeutic":[140],"target":[141],"cancer":[143],"immunotherapy.":[144]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-11-01T00:00:00"}
