{"id":"https://openalex.org/W7224993718","doi":"https://doi.org/10.5281/zenodo.23844918","title":"Adaptive Risk Models for Early Cancer Detection: Why Diagnostics Should Keep Learning","display_name":"Adaptive Risk Models for Early Cancer Detection: Why Diagnostics Should Keep Learning","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224993718","doi":"https://doi.org/10.5281/zenodo.23844918"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23844918","doi":"https://doi.org/10.5281/zenodo.23844918","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23844918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23844918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087769710","display_name":"Sean McCafferty","orcid":"https://orcid.org/0000-0002-4624-5615","observed_orcids":["https://orcid.org/0000-0002-4624-5615"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sean, McCafferty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4624-5615","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087769710"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.25850000977516174,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.25850000977516174,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.2069000005722046,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.13210000097751617,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.9909999966621399},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.722000002861023},{"id":"https://openalex.org/keywords/model-recalibration","display_name":"model recalibration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/model-drift-monitoring","display_name":"model drift monitoring","score":0.7179999947547913},{"id":"https://openalex.org/keywords/model-versioning","display_name":"model versioning","score":0.796999990940094},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.6579999923706055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6090999841690063},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.47920000553131104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4542999863624573},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3878999948501587},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.335099995136261},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3325999975204468},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2766999900341034},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.2696000039577484},{"id":"https://openalex.org/C107464732","wikidata":"https://www.wikidata.org/wiki/Q235781","display_name":"Adaptive control","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23844918","doi":"https://doi.org/10.5281/zenodo.23844918","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23844918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23844919","doi":"https://doi.org/10.5281/zenodo.23844919","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23844919","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23844918","doi":"https://doi.org/10.5281/zenodo.23844918","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23844918","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6922607584","https://openalex.org/W7119519439","https://openalex.org/W3036143914","https://openalex.org/W7096000416","https://openalex.org/W4405151513","https://openalex.org/W3120293480","https://openalex.org/W7169550225","https://openalex.org/W2396216122","https://openalex.org/W3153744031","https://openalex.org/W2023049925"],"abstract_inverted_index":{"Most":[0],"blood-based":[1],"cancer":[2],"detection":[3],"tests":[4],"are":[5],"locked":[6],"at":[7],"launch,":[8],"even":[9],"though":[10],"the":[11,57],"populations,":[12],"assays":[13],"and":[14,35,43,60],"clinical":[15],"practices":[16],"around":[17],"them":[18],"keep":[19],"changing.":[20],"We":[21],"argue":[22],"that":[23],"multi-analyte":[24],"early-detection":[25],"models":[26],"should":[27],"be":[28],"adaptive:":[29],"recalibrated":[30],"as":[31,50],"outcome-linked":[32],"results":[33],"accumulate,":[34],"governed":[36],"by":[37],"versioning,":[38],"human-gated":[39],"updates,":[40],"drift":[41],"monitoring":[42],"documented":[44],"re-validation.":[45],"Using":[46],"pancreatic":[47],"ductal":[48],"adenocarcinoma":[49],"a":[51],"case":[52],"study,":[53],"we":[54],"describe":[55],"how":[56],"CLIA":[58],"framework":[59],"FDA":[61],"Predetermined":[62],"Change":[63],"Control":[64],"Plans":[65],"can":[66],"support":[67],"safe,":[68],"continuous":[69],"improvement.":[70]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-01T00:00:00"}
