{"id":"https://openalex.org/W7224993379","doi":"https://doi.org/10.1136/egastro-2026-100708","title":"Targeting the IL-23 pathway in inflammatory bowel disease: from cytokine inhibition to oral IL-23 receptor blockade","display_name":"Targeting the IL-23 pathway in inflammatory bowel disease: from cytokine inhibition to oral IL-23 receptor blockade","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224993379","doi":"https://doi.org/10.1136/egastro-2026-100708","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968944","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723900"},"language":"en","primary_location":{"id":"doi:10.1136/egastro-2026-100708","doi":"https://doi.org/10.1136/egastro-2026-100708","is_oa":true,"landing_page_url":"https://doi.org/10.1136/egastro-2026-100708","pdf_url":null,"source":{"id":"https://openalex.org/S4387291355","display_name":"eGastroenterology","issn_l":"2766-0125","issn":["2766-0125","2976-7296"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","oarl"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eGastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1136/egastro-2026-100708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020137601","display_name":"Sailish Honap","orcid":"https://orcid.org/0000-0001-6657-2763","observed_orcids":["https://orcid.org/0000-0001-6657-2763"]},"institutions":[{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]},{"id":"https://openalex.org/I4401726869","display_name":"City St George's, University of London","ror":"https://ror.org/047ybhc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sailish Honap","raw_affiliation_strings":["Department of Gastroenterology, St George\u2019s University Hospitals NHS Foundation Trust, London, UK","Infection and Immunity Research Institute, City St George\u2019s, University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-6657-2763","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, St George\u2019s University Hospitals NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I2801196673"]},{"raw_affiliation_string":"Infection and Immunity Research Institute, City St George\u2019s, University of London, London, UK","institution_ids":["https://openalex.org/I4401726869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015303619","display_name":"Michael Colwill","orcid":"https://orcid.org/0000-0001-6925-8358","observed_orcids":["https://orcid.org/0000-0001-6925-8358"]},"institutions":[{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]},{"id":"https://openalex.org/I4401726869","display_name":"City St George's, University of London","ror":"https://ror.org/047ybhc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Colwill","raw_affiliation_strings":["Department of Gastroenterology, St George\u2019s University Hospitals NHS Foundation Trust, London, UK","Infection and Immunity Research Institute, City St George\u2019s, University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, St George\u2019s University Hospitals NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I2801196673"]},{"raw_affiliation_string":"Infection and Immunity Research Institute, City St George\u2019s, University of London, London, UK","institution_ids":["https://openalex.org/I4401726869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041223408","display_name":"Axel U Dignass","orcid":"https://orcid.org/0000-0002-9724-054X","observed_orcids":["https://orcid.org/0000-0002-9724-054X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210148372","display_name":"Agaplesion Markus Hospital","ror":"https://ror.org/04hd04g86","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210117177","https://openalex.org/I4210148372"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Dignass","raw_affiliation_strings":["Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210148372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101456326","display_name":"Vipul Jairath","orcid":"https://orcid.org/0000-0003-1590-0338","observed_orcids":["https://orcid.org/0000-0003-1590-0338"]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vipul Jairath","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada","Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123453099","display_name":"Fernando Magro","orcid":"https://orcid.org/0000-0003-2634-9668","observed_orcids":["https://orcid.org/0000-0003-2634-9668"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210137384","display_name":"Centre for Health Technology and Services Research","ror":"https://ror.org/0434vme59","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210137384"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernando Magro","raw_affiliation_strings":["CINTESIS@RISE Department, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINTESIS@RISE Department, Faculdade de Medicina da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210137384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047563454","display_name":"Silvio Danese","orcid":"https://orcid.org/0000-0001-7341-1351","observed_orcids":["https://orcid.org/0000-0001-7341-1351"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvio Danese","raw_affiliation_strings":["Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele, Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042884495","display_name":"Laurent Peyrin\u2010Biroulet","orcid":"https://orcid.org/0000-0003-2536-6618","observed_orcids":["https://orcid.org/0000-0003-2536-6618"]},"institutions":[{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurent Peyrin-Biroulet","raw_affiliation_strings":["Northwestern Medicine, Digestive Health Institute, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Medicine, Digestive Health Institute, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I4210147348"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5020137601"],"corresponding_institution_ids":["https://openalex.org/I2801196673","https://openalex.org/I4401726869"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63545296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"4","first_page":"e100708","last_page":"e100708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrocyclic-peptides","display_name":"macrocyclic peptides","score":0.8169999718666077},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/endoscopic-outcomes","display_name":"endoscopic outcomes","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6676999926567078},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6134999990463257},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6061999797821045},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4562999904155731},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4447999894618988},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44209998846054077},{"id":"https://openalex.org/C2775855021","wikidata":"https://www.wikidata.org/wiki/Q968436","display_name":"Cytokine receptor","level":3,"score":0.3946000039577484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38089999556541443},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34860000014305115},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2896000146865845},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.2840000092983246},{"id":"https://openalex.org/C154390347","wikidata":"https://www.wikidata.org/wiki/Q14914522","display_name":"Janus kinase 1","level":4,"score":0.27950000762939453},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1136/egastro-2026-100708","doi":"https://doi.org/10.1136/egastro-2026-100708","is_oa":true,"landing_page_url":"https://doi.org/10.1136/egastro-2026-100708","pdf_url":null,"source":{"id":"https://openalex.org/S4387291355","display_name":"eGastroenterology","issn_l":"2766-0125","issn":["2766-0125","2976-7296"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","oarl"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eGastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723900","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723900/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723900/pdf/egastro-4-4.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eGastroenterology","raw_type":"Text"},{"id":"pmid:42968944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eGastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:82cf95c5c7194395987261ee3b2e6ad2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/82cf95c5c7194395987261ee3b2e6ad2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eGastroenterology, Vol 4, Iss 4 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/egastro-2026-100708","doi":"https://doi.org/10.1136/egastro-2026-100708","is_oa":true,"landing_page_url":"https://doi.org/10.1136/egastro-2026-100708","pdf_url":null,"source":{"id":"https://openalex.org/S4387291355","display_name":"eGastroenterology","issn_l":"2766-0125","issn":["2766-0125","2976-7296"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","oarl"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eGastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224993379.pdf","grobid_xml":"https://content.openalex.org/works/W7224993379.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1480238487","https://openalex.org/W1526112396","https://openalex.org/W1671478536","https://openalex.org/W1968289697","https://openalex.org/W1981714996","https://openalex.org/W2018957399","https://openalex.org/W2080702126","https://openalex.org/W2087905758","https://openalex.org/W2093949724","https://openalex.org/W2150005144","https://openalex.org/W2172589221","https://openalex.org/W2594502287","https://openalex.org/W2780850472","https://openalex.org/W2789757575","https://openalex.org/W2806044202","https://openalex.org/W2828329901","https://openalex.org/W2884774799","https://openalex.org/W2903981788","https://openalex.org/W2995755986","https://openalex.org/W3025104776","https://openalex.org/W3045091446","https://openalex.org/W3133025128","https://openalex.org/W3133712367","https://openalex.org/W3173649223","https://openalex.org/W3175200872","https://openalex.org/W4214924886","https://openalex.org/W4281627373","https://openalex.org/W4281924689","https://openalex.org/W4318762665","https://openalex.org/W4382363169","https://openalex.org/W4385728359","https://openalex.org/W4385969114","https://openalex.org/W4387637074","https://openalex.org/W4391162963","https://openalex.org/W4391618252","https://openalex.org/W4392364674","https://openalex.org/W4394817614","https://openalex.org/W4400115210","https://openalex.org/W4400723326","https://openalex.org/W4400883057","https://openalex.org/W4401113330","https://openalex.org/W4404368241","https://openalex.org/W4404581096","https://openalex.org/W4405467033","https://openalex.org/W4406542819","https://openalex.org/W4406705791","https://openalex.org/W4407007323","https://openalex.org/W4408205609","https://openalex.org/W4408379574","https://openalex.org/W4408567665","https://openalex.org/W4408719903","https://openalex.org/W4409868371","https://openalex.org/W4412157288","https://openalex.org/W4412555545","https://openalex.org/W4413637476","https://openalex.org/W4414335360","https://openalex.org/W4415992105","https://openalex.org/W4417021544","https://openalex.org/W4417197554","https://openalex.org/W4417539245","https://openalex.org/W7118754517","https://openalex.org/W7123756058","https://openalex.org/W7125132947","https://openalex.org/W7125212646","https://openalex.org/W7130384642","https://openalex.org/W7133503675","https://openalex.org/W7133607418","https://openalex.org/W7134918887","https://openalex.org/W7152046869","https://openalex.org/W7160106612","https://openalex.org/W7160157501","https://openalex.org/W7160171968","https://openalex.org/W7160301954","https://openalex.org/W7163811009","https://openalex.org/W7165383029","https://openalex.org/W7165394877","https://openalex.org/W7221790083"],"related_works":["https://openalex.org/W3158585071","https://openalex.org/W2889622642","https://openalex.org/W7214149195","https://openalex.org/W2586882962","https://openalex.org/W2533384923","https://openalex.org/W4400115210","https://openalex.org/W4308073683","https://openalex.org/W4408073657","https://openalex.org/W2580354001","https://openalex.org/W4408725046"],"abstract_inverted_index":{"Interleukin":[0],"(IL)-23":[1],"inhibition":[2,52,77],"is":[3,82],"now":[4],"an":[5,48,90],"established":[6,102],"therapeutic":[7],"strategy":[8],"in":[9,23,33,78,99,121,125,141],"inflammatory":[10,56,183],"bowel":[11],"disease":[12,26],"(IBD),":[13],"supported":[14],"by":[15,131],"the":[16,43,54,62,67,71,85,103,110],"efficacy":[17,104,120,157],"of":[18,42,53,88,105,119,134,181],"selective":[19,75,178],"IL-23p19":[20,76,164],"monoclonal":[21,165],"antibodies":[22],"both":[24],"Crohn's":[25],"(CD)":[27],"and":[28,70,127,143,155,158],"ulcerative":[29],"colitis":[30],"(UC).":[31],"Advances":[32],"peptide":[34,93],"engineering":[35],"have":[36,101,186],"also":[37],"enabled":[38],"direct":[39],"oral":[40,91,106,148,179],"targeting":[41,66,180],"IL-23":[44],"receptor":[45],"(IL-23R),":[46],"introducing":[47],"alternative":[49],"approach":[50,170],"to":[51,84],"same":[55],"pathway.":[57],"This":[58],"narrative":[59],"review":[60],"examines":[61],"biological":[63,189],"rationale":[64],"for":[65],"IL-23-IL-23R":[68],"axis":[69],"clinical":[72,86,117,126,154],"evidence":[73,118,133],"establishing":[74],"IBD.":[79],"Particular":[80],"attention":[81],"given":[83],"development":[87],"icotrokinra,":[89],"macrocyclic":[92],"IL-23R":[94,107,149],"antagonist.":[95],"Phase":[96],"3":[97,139],"studies":[98],"psoriasis":[100],"antagonism,":[108],"while":[109],"phase":[111,138],"2b":[112],"ANTHEM-UC":[113],"study":[114],"has":[115],"provided":[116],"IBD,":[122],"with":[123],"improvements":[124],"endoscopic":[128,156],"outcomes":[129],"accompanied":[130],"translational":[132],"pathway":[135],"suppression.":[136],"Ongoing":[137],"programmes":[140],"UC":[142],"CD":[144],"will":[145],"determine":[146],"whether":[147],"antagonism":[150],"can":[151],"achieve":[152],"durable":[153],"establish":[159],"its":[160],"place":[161],"alongside":[162],"existing":[163],"antibodies.":[166],"If":[167],"successful,":[168],"this":[169],"could":[171],"represent":[172],"a":[173],"broader":[174],"shift":[175],"towards":[176],"highly":[177],"extracellular":[182],"pathways":[184],"that":[185],"traditionally":[187],"required":[188],"therapy.":[190]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-01T00:00:00"}
