{"id":"https://openalex.org/W7224993337","doi":"https://doi.org/10.1038/s41368-026-00469-w","title":"Spatial multi-omics of mouse incisor mesenchyme reveals metabolic remodeling during the MSC-to-TAC transition","display_name":"Spatial multi-omics of mouse incisor mesenchyme reveals metabolic remodeling during the MSC-to-TAC transition","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224993337","doi":"https://doi.org/10.1038/s41368-026-00469-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723473"},"language":"en","primary_location":{"id":"doi:10.1038/s41368-026-00469-w","doi":"https://doi.org/10.1038/s41368-026-00469-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41368-026-00469-w","pdf_url":"https://www.nature.com/articles/s41368-026-00469-w.pdf","source":{"id":"https://openalex.org/S44743489","display_name":"International Journal of Oral Science","issn_l":"1674-2818","issn":["1674-2818","2049-3169"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41368-026-00469-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160268098","display_name":"Yuling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuling Wang","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China","College of Life Sciences, Nankai University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]},{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160264332","display_name":"Zexi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zexi Chen","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China","Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province & Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]},{"raw_affiliation_string":"Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province & Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial, School and Hospital of Stomatology, Fujian Medical University, Fujian, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160248393","display_name":"Tingting Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tingting Chen","raw_affiliation_strings":["College of Stomatology, Qujing University of Medicine & Health Sciences, Qujing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Stomatology, Qujing University of Medicine & Health Sciences, Qujing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160247033","display_name":"Yue Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhao","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160281636","display_name":"Xiaoqian Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqian Yu","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160259923","display_name":"Qian Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Li","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160262508","display_name":"Xinshuang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinshuang Zhang","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081181286","display_name":"Zhanying Bi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhanying Bi","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China","College of Life Sciences, Nankai University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]},{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160244277","display_name":"Meng Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Ye","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160259589","display_name":"Fengzhi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengzhi Li","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150628139","display_name":"Xiangyu Zhou","orcid":"https://orcid.org/0009-0000-6161-8865","observed_orcids":["https://orcid.org/0009-0000-6161-8865"]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyu Zhou","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332603","display_name":"Zhen Li","orcid":"https://orcid.org/0000-0002-4798-4161","observed_orcids":["https://orcid.org/0000-0002-4798-4161"]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Li","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-4798-4161","affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160239354","display_name":"Li Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160279471","display_name":"Woo-pimg Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Woo-pimg Ge","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China","institution_ids":["https://openalex.org/I4210115644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147571953","display_name":"Wange Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wange Lv","raw_affiliation_strings":["College of Life Sciences, Nankai University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111236632","display_name":"Hongji Pu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hongji Pu","raw_affiliation_strings":["College of Stomatology, Qujing University of Medicine & Health Sciences, Qujing, China. hongjipu@qjmc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Stomatology, Qujing University of Medicine & Health Sciences, Qujing, China. hongjipu@qjmc.edu.cn","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042903123","display_name":"Hu Zhao","orcid":"https://orcid.org/0000-0002-2961-0086","observed_orcids":["https://orcid.org/0000-0002-2961-0086"]},"institutions":[{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hu Zhao","raw_affiliation_strings":["Chinese Institute for Brain Research (CIBR), Beijing, China. zhaohu@cibr.ac.cn"],"raw_orcid":"https://orcid.org/0000-0002-2961-0086","affiliations":[{"raw_affiliation_string":"Chinese Institute for Brain Research (CIBR), Beijing, China. zhaohu@cibr.ac.cn","institution_ids":["https://openalex.org/I4210115644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042903123","https://openalex.org/A5111236632"],"corresponding_institution_ids":["https://openalex.org/I4210115644"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74290706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.09549999982118607,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-incisor","display_name":"mouse incisor","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/transit-amplifying-cells","display_name":"transit amplifying cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/metabolic-remodeling","display_name":"metabolic remodeling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ketone-body-metabolism","display_name":"ketone body metabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nucleotide-biosynthesis","display_name":"nucleotide synthesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/acylcarnitines","display_name":"acylcarnitines","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.5529999732971191},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pseudotime-trajectory","display_name":"pseudotime trajectory","score":0.6830000281333923},{"id":"https://openalex.org/keywords/incisor-pulp","display_name":"incisor pulp","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.8235999941825867},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.49050000309944153},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48969998955726624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4666000008583069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43650001287460327},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4334000051021576},{"id":"https://openalex.org/C2778812414","wikidata":"https://www.wikidata.org/wiki/Q273543","display_name":"Incisor","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C160351604","wikidata":"https://www.wikidata.org/wiki/Q6033113","display_name":"Ingression","level":5,"score":0.31470000743865967},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.3061999976634979},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C109751979","wikidata":"https://www.wikidata.org/wiki/Q998767","display_name":"Failover","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.27160000801086426},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007180","descriptor_name":"Incisor","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007180","descriptor_name":"Incisor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41368-026-00469-w","doi":"https://doi.org/10.1038/s41368-026-00469-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41368-026-00469-w","pdf_url":"https://www.nature.com/articles/s41368-026-00469-w.pdf","source":{"id":"https://openalex.org/S44743489","display_name":"International Journal of Oral Science","issn_l":"1674-2818","issn":["1674-2818","2049-3169"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723473","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723473/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723473/pdf/41368_2026_Article_469.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oral Sci","raw_type":"Text"},{"id":"pmid:42966754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oral science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ce5825155f3448429321100f82a48335","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ce5825155f3448429321100f82a48335","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Oral Science, Vol 18, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41368-026-00469-w","doi":"https://doi.org/10.1038/s41368-026-00469-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41368-026-00469-w","pdf_url":"https://www.nature.com/articles/s41368-026-00469-w.pdf","source":{"id":"https://openalex.org/S44743489","display_name":"International Journal of Oral Science","issn_l":"1674-2818","issn":["1674-2818","2049-3169"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224993337.pdf","grobid_xml":"https://content.openalex.org/works/W7224993337.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W157502360","https://openalex.org/W1518086527","https://openalex.org/W1553978925","https://openalex.org/W1809227307","https://openalex.org/W1955394435","https://openalex.org/W1971585037","https://openalex.org/W1983711788","https://openalex.org/W1989026904","https://openalex.org/W1990171977","https://openalex.org/W1998926804","https://openalex.org/W2017711362","https://openalex.org/W2018682212","https://openalex.org/W2019737732","https://openalex.org/W2021787243","https://openalex.org/W2026205682","https://openalex.org/W2032964150","https://openalex.org/W2033807650","https://openalex.org/W2038976751","https://openalex.org/W2050400409","https://openalex.org/W2075670261","https://openalex.org/W2092769513","https://openalex.org/W2111993114","https://openalex.org/W2126527896","https://openalex.org/W2144826974","https://openalex.org/W2147822820","https://openalex.org/W2169880855","https://openalex.org/W2186508575","https://openalex.org/W2249779451","https://openalex.org/W2520894026","https://openalex.org/W2552202209","https://openalex.org/W2558158111","https://openalex.org/W2595869396","https://openalex.org/W2768341681","https://openalex.org/W2783692413","https://openalex.org/W2800440086","https://openalex.org/W2801170851","https://openalex.org/W2904209686","https://openalex.org/W2938629106","https://openalex.org/W2950512597","https://openalex.org/W2968480896","https://openalex.org/W2969784858","https://openalex.org/W2973787136","https://openalex.org/W3000775170","https://openalex.org/W3005091816","https://openalex.org/W3015450697","https://openalex.org/W3028166300","https://openalex.org/W3044541431","https://openalex.org/W3044602707","https://openalex.org/W3087790240","https://openalex.org/W3093699410","https://openalex.org/W3135612346","https://openalex.org/W3174306026","https://openalex.org/W3206687244","https://openalex.org/W4200128822","https://openalex.org/W4206796147","https://openalex.org/W4207036939","https://openalex.org/W4223592234","https://openalex.org/W4224092504","https://openalex.org/W4280598306","https://openalex.org/W4308074414","https://openalex.org/W4308159020","https://openalex.org/W4310356608","https://openalex.org/W4313454424","https://openalex.org/W4322726937","https://openalex.org/W4382051897","https://openalex.org/W4385838567","https://openalex.org/W4389685517","https://openalex.org/W4394795740","https://openalex.org/W4400448907","https://openalex.org/W4407251897","https://openalex.org/W4409485811","https://openalex.org/W4411674124","https://openalex.org/W4413698594","https://openalex.org/W4416303810","https://openalex.org/W4416758260","https://openalex.org/W7128503822"],"related_works":["https://openalex.org/W2568029254","https://openalex.org/W2068291110","https://openalex.org/W6999953859","https://openalex.org/W7035786872","https://openalex.org/W2830656115","https://openalex.org/W1973076028","https://openalex.org/W2059802876","https://openalex.org/W1987714581","https://openalex.org/W1249053493","https://openalex.org/W2406701844"],"abstract_inverted_index":{"The":[0],"continuously":[1],"growing":[2],"mouse":[3,80,224],"incisor":[4,81,225],"provides":[5,227],"a":[6,139,210],"useful":[7],"model":[8],"for":[9,92],"investigating":[10],"stem":[11,235,247],"cell":[12,26,30,236,248],"niche":[13],"organization":[14],"and":[15,28,33,44,63,100,120,125,161,169,175,199,226,240],"the":[16,38,50,75,79,86,105,114,133,145,165,179,219,223,230,244],"MSC-to-TAC":[17,76,204,220],"transition":[18,46,77,221],"because":[19],"it":[20],"contains":[21],"spatially":[22],"distinct":[23],"mesenchymal":[24],"stem/stromal":[25],"(MSC)-enriched":[27],"transit-amplifying":[29],"(TAC)-enriched":[31],"compartments":[32],"abundant":[34],"TAC":[35],"populations.":[36],"However,":[37],"metabolic":[39,71,215,231],"programs":[40,190],"associated":[41,73,95,112,217,233],"with":[42,65,74,96,113,138,218,234],"MSCs":[43],"their":[45],"to":[47,69,192],"TACs":[48],"within":[49],"native":[51,245],"tissue":[52,241],"environment":[53],"remain":[54],"poorly":[55],"understood.":[56],"Here,":[57],"we":[58],"integrated":[59],"region-resolved":[60,211],"transcriptomics,":[61],"proteomics,":[62],"metabolomics":[64],"single-cell":[66],"RNA":[67],"sequencing":[68],"characterize":[70],"remodeling":[72,216],"in":[78,132,164,178,188,222,243],"pulp.":[82,182],"We":[83],"found":[84],"that":[85],"MSC-enriched":[87,134,166],"apical":[88,135,167],"pulp":[89,108,148,168],"was":[90],"enriched":[91],"molecular":[93,110],"features":[94,232],"fatty":[97,193],"acid":[98,116,194],"\u03b2-oxidation":[99],"ketone":[101,162],"body":[102],"metabolism,":[103,198],"whereas":[104,144],"TAC-enriched":[106,146,180],"mitotic":[107,147,181],"showed":[109,149,156],"signatures":[111],"tricarboxylic":[115],"cycle,":[117],"oxidative":[118,197],"phosphorylation,":[119],"nucleotide":[121,200],"biosynthesis.":[122],"Integrated":[123],"transcriptomic":[124],"proteomic":[126],"analyses":[127],"revealed":[128],"lower":[129],"mRNA-protein":[130,151],"concordance":[131],"pulp,":[136],"consistent":[137],"contribution":[140],"of":[141,159,172,214],"post-transcriptional":[142],"regulation,":[143],"tighter":[150],"coupling.":[152],"Metabolite":[153],"profiling":[154],"further":[155],"higher":[157,170],"abundance":[158,171],"acyl-carnitines":[160],"bodies":[163],"glutamine,":[173],"aspartate,":[174],"purine":[176],"intermediates":[177],"Pseudotime":[183],"analysis":[184],"suggested":[185],"coordinated":[186],"changes":[187],"transcriptional":[189],"related":[191],"oxidation,":[195],"mitochondrial":[196],"synthesis":[201],"along":[202],"an":[203],"trajectory.":[205],"Collectively,":[206],"our":[207],"study":[208],"establishes":[209],"multi-omics":[212],"atlas":[213],"insights":[228],"into":[229],"activation,":[237],"progenitor":[238],"expansion,":[239],"homeostasis":[242],"dental":[246],"niche.":[249]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-01T00:00:00"}