{"id":"https://openalex.org/W7224992195","doi":"https://doi.org/10.5281/zenodo.23838666","title":"Chasing Puddles: Why Medical Compartmentalization Misses Common Systemic Etiologies","display_name":"Chasing Puddles: Why Medical Compartmentalization Misses Common Systemic Etiologies","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224992195","doi":"https://doi.org/10.5281/zenodo.23838666"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23838666","doi":"https://doi.org/10.5281/zenodo.23838666","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23838666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23838666","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038574926","display_name":"Filip Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Roth, Filip","raw_affiliation_strings":["Independent Researcher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent Researcher","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038574926"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12766","display_name":"Interdisciplinary Research and Collaboration","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gliadin-peptides","display_name":"gliadin peptides","score":0.7979999780654907},{"id":"https://openalex.org/keywords/gut-mucosal-barrier","display_name":"gut mucosal barrier","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6610000133514404},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.5049999952316284},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fibromyalgia","display_name":"fibromyalgia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.921999990940094},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/non-celiac-gluten-sensitivity","display_name":"non-celiac gluten sensitivity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/non-monotonic-dose-response","display_name":"non-monotonic dose-response","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dietary-toxicity","display_name":"dietary toxicity","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6880000233650208},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.6158000230789185},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5954999923706055},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.5612000226974487},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4018999934196472},{"id":"https://openalex.org/C199521495","wikidata":"https://www.wikidata.org/wiki/Q181487","display_name":"Audit","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.33399999141693115},{"id":"https://openalex.org/C2781256819","wikidata":"https://www.wikidata.org/wiki/Q16828835","display_name":"Antecedent (behavioral psychology)","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30309998989105225},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C166151441","wikidata":"https://www.wikidata.org/wiki/Q4923601","display_name":"Causation","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27250000834465027},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C185874996","wikidata":"https://www.wikidata.org/wiki/Q269699","display_name":"Interdependence","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.265500009059906},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C50335755","wikidata":"https://www.wikidata.org/wiki/Q483247","display_name":"Phenomenon","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C2776916960","wikidata":"https://www.wikidata.org/wiki/Q637156","display_name":"Warrant","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.2556999921798706},{"id":"https://openalex.org/C187029079","wikidata":"https://www.wikidata.org/wiki/Q958679","display_name":"Cognitive reframing","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23838666","doi":"https://doi.org/10.5281/zenodo.23838666","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23838666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23838667","doi":"https://doi.org/10.5281/zenodo.23838667","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23838667","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23838666","doi":"https://doi.org/10.5281/zenodo.23838666","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23838666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7140986184","https://openalex.org/W7117900029","https://openalex.org/W7024059636","https://openalex.org/W7161677459","https://openalex.org/W70641292","https://openalex.org/W2781114166","https://openalex.org/W2166496055","https://openalex.org/W2013873810","https://openalex.org/W7214187422","https://openalex.org/W2410221005"],"abstract_inverted_index":{"Modern":[0],"allopathic":[1],"medicine":[2],"has":[3],"achieved":[4],"unprecedented":[5],"micro-specialization,":[6],"yet":[7],"chronic":[8],"inflammatory,":[9],"autoimmune,":[10],"psychiatric,":[11],"and":[12,60,72,110,122,190,207],"cardiovascular":[13],"disorders":[14],"continue":[15],"to":[16,89,141,167,197,224],"rise":[17],"globally.":[18],"In":[19],"this":[20],"theoretical":[21],"paper,":[22],"we":[23,102,172,213],"examine":[24],"a":[25,36,43,97,136],"fundamental":[26],"structural":[27],"flaw":[28],"in":[29,99,228],"modern":[30,229],"diagnostic":[31],"paradigms:":[32],"clinical":[33],"compartmentalization":[34],"as":[35,48,126,161,185],"localized":[37,113],"manifestation":[38],"of":[39,84,156,178],"compartmentalized":[40],"science.":[41],"When":[42],"single":[44],"underlying":[45],"systemic":[46,64,226],"trigger\u2014such":[47],"gut":[49],"mucosal":[50],"barrier":[51],"breakdown":[52],"induced":[53],"by":[54],"non-celiac":[55],"wheat":[56],"amylase-trypsin":[57],"inhibitors":[58],"(ATIs)":[59],"gliadin":[61],"peptides\u2014activates":[62],"generalized":[63],"inflammatory":[65],"cascades,":[66],"individual":[67],"specialist":[68],"disciplines":[69],"observe,":[70],"name,":[71],"treat":[73,112],"isolated":[74],"organ":[75],"manifestations":[76],"within":[77],"their":[78],"own":[79],"silos.":[80],"Using":[81],"the":[82,100,154,175,186],"metaphor":[83],"six":[85,91],"specialized":[86],"contractors":[87],"attempting":[88],"repair":[90],"separate":[92],"damaged":[93],"rooms":[94],"while":[95],"ignoring":[96],"hole":[98],"roof,":[101],"show":[103],"how":[104,131],"gastroenterology,":[105],"dermatology,":[106],"rheumatology,":[107],"neurology,":[108],"periodontology,":[109],"cardiology":[111],"downstream":[114],"symptoms":[115],"(IBS,":[116],"acne":[117],"vulgaris,":[118],"fibromyalgia,":[119],"ataxia,":[120],"periodontitis,":[121],"atherosclerotic":[123],"plaque":[124],"instability)":[125],"independent":[127],"pathologies.":[128],"We":[129],"demonstrate":[130],"epidemiological":[132],"studies":[133,183],"suffer":[134],"from":[135],"skewed":[137],"baseline":[138],"phenomenon":[139],"analogous":[140],"historical":[142],"lead":[143],"exposure,":[144],"perfluorinated":[145],"alkyl":[146],"substances":[147],"(PFAS),":[148],"or":[149],"universal":[150],"tobacco":[151],"use,":[152],"where":[153],"absence":[155],"unexposed":[157],"control":[158],"groups":[159],"(such":[160,184],"non-cereal":[162],"indigenous":[163],"populations)":[164],"blinds":[165],"researchers":[166],"population-wide":[168],"dietary":[169,192],"toxicity.":[170],"Furthermore,":[171],"explicitly":[173],"audit":[174],"methodological":[176],"errors":[177],"widely":[179],"cited":[180],"prospective":[181],"cohort":[182],"26-year":[187],"BMJ":[188],"analysis)":[189],"short-term":[191],"intervention":[193],"trials":[194],"that":[195],"fail":[196],"account":[198],"for":[199,219],"non-monotonic":[200],"threshold":[201],"kinetics,":[202],"tissue-specific":[203],"cell":[204],"turnover":[205],"dynamics,":[206],"multi-year":[208],"immune":[209],"clearance":[210],"horizons.":[211],"Finally,":[212],"articulate":[214],"an":[215],"epistemic":[216],"framework":[217],"advocating":[218],"cross-disciplinary":[220],"systems":[221],"engineering":[222],"approaches":[223],"resolve":[225],"etiologies":[227],"medicine.":[230]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-11-01T00:00:00"}
