{"id":"https://openalex.org/W7224992176","doi":"https://doi.org/10.1093/jacamr/dlag226","title":"Responsible use of new antibiotics for critically ill patients suffering from infections due to carbapenem-resistant organisms\u2014a narrative review for an enablement strategy","display_name":"Responsible use of new antibiotics for critically ill patients suffering from infections due to carbapenem-resistant organisms\u2014a narrative review for an enablement strategy","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224992176","doi":"https://doi.org/10.1093/jacamr/dlag226","pmid":"https://pubmed.ncbi.nlm.nih.gov/42967154","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13723160"},"language":"en","primary_location":{"id":"doi:10.1093/jacamr/dlag226","doi":"https://doi.org/10.1093/jacamr/dlag226","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jacamr/dlag226","pdf_url":"https://academic.oup.com/jacamr/article-pdf/8/6/dlag226/72652622/dlag226.pdf","source":{"id":"https://openalex.org/S4210190703","display_name":"JAC-Antimicrobial Resistance","issn_l":"2632-1823","issn":["2632-1823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-Antimicrobial Resistance","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jacamr/article-pdf/8/6/dlag226/72652622/dlag226.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015882261","display_name":"Christian Eckmann","orcid":"https://orcid.org/0000-0002-4516-0441","observed_orcids":["https://orcid.org/0000-0002-4516-0441"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christian Eckmann","raw_affiliation_strings":["AMS Team and Department of General, Visceral and Thoracic Surgery, Klinikum Hannoversch-Muenden, Goettingen University , Hannoversch-Muenden D-34346 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AMS Team and Department of General, Visceral and Thoracic Surgery, Klinikum Hannoversch-Muenden, Goettingen University , Hannoversch-Muenden D-34346 ,","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054863331","display_name":"Murat Akova","orcid":"https://orcid.org/0000-0002-6904-9473","observed_orcids":["https://orcid.org/0000-0002-6904-9473"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Akova","raw_affiliation_strings":["Department of Infectious Diseases, Hacettepe University School of Medicine , Ankara ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Hacettepe University School of Medicine , Ankara ,","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030961669","display_name":"Massimo M. Antonelli","orcid":"https://orcid.org/0000-0003-3007-1670","observed_orcids":["https://orcid.org/0000-0003-3007-1670"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Antonelli","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart , Rome ,","Department of Emergency, Intensive Care Medicine and Anesthesia, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart , Rome ,","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Emergency, Intensive Care Medicine and Anesthesia, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome ,","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039694085","display_name":"Matteo Bassetti","orcid":"https://orcid.org/0000-0002-0145-9740","observed_orcids":["https://orcid.org/0000-0002-0145-9740"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Bassetti","raw_affiliation_strings":["Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","UO Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"UO Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino , Genoa ,","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036220332","display_name":"Rafael Cant\u00f3n","orcid":"https://orcid.org/0000-0003-1675-3173","observed_orcids":["https://orcid.org/0000-0003-1675-3173"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]},{"id":"https://openalex.org/I4405268343","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Infecciosas","ror":"https://ror.org/00nd8zg79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268343"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Cant\u00f3n","raw_affiliation_strings":["CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","Servicio de Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid ,"],"raw_orcid":"https://orcid.org/0000-0003-1675-3173","affiliations":[{"raw_affiliation_string":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid ,","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4405268343"]},{"raw_affiliation_string":"Servicio de Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid ,","institution_ids":["https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010679786","display_name":"Matthew Dryden","orcid":"https://orcid.org/0000-0002-8967-169X","observed_orcids":["https://orcid.org/0000-0002-8967-169X"]},"institutions":[{"id":"https://openalex.org/I4387153084","display_name":"UK Health Security Agency","ror":"https://ror.org/018h10037","country_code":"GB","type":"government","lineage":["https://openalex.org/I1311074006","https://openalex.org/I4387153084"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew Dryden","raw_affiliation_strings":["Global Operations, UK Health Security Agency , Porton Down ,"],"raw_orcid":"https://orcid.org/0000-0002-8967-169X","affiliations":[{"raw_affiliation_string":"Global Operations, UK Health Security Agency , Porton Down ,","institution_ids":["https://openalex.org/I4387153084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048088023","display_name":"Marco Falcone","orcid":"https://orcid.org/0000-0003-3813-8796","observed_orcids":["https://orcid.org/0000-0003-3813-8796"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Falcone","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa , Pisa ,"],"raw_orcid":"https://orcid.org/0000-0003-3813-8796","affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa , Pisa ,","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023218990","display_name":"Souha Sami Kanj","orcid":"https://orcid.org/0000-0001-6413-3396","observed_orcids":["https://orcid.org/0000-0001-6413-3396"]},"institutions":[{"id":"https://openalex.org/I98635879","display_name":"American University of Beirut","ror":"https://ror.org/04pznsd21","country_code":"LB","type":"education","lineage":["https://openalex.org/I98635879"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Souha S Kanj","raw_affiliation_strings":["Division of Infectious Diseases, Infection Control and Prevention Program, Center for Infectious Diseases Research (CIDR), American University of Beirut , Beirut ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Infection Control and Prevention Program, Center for Infectious Diseases Research (CIDR), American University of Beirut , Beirut ,","institution_ids":["https://openalex.org/I98635879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086641466","display_name":"Sasisopin Kiertiburanakul","orcid":"https://orcid.org/0000-0003-4379-4704","observed_orcids":["https://orcid.org/0000-0003-4379-4704"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sasisopin Kiertiburanakul","raw_affiliation_strings":["Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok ,","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102908968","display_name":"Mark J. Gilchrist","orcid":"https://orcid.org/0009-0003-0625-3535","observed_orcids":["https://orcid.org/0009-0003-0625-3535","https://orcid.org/0000-0003-4529-0243"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Gilchrist","raw_affiliation_strings":["Department of Infection/Pharmacy, Imperial Healthcare NHS Trust , London ,","Department of Infectious Disease, Faculty of Medicine, Imperial College London , London ,"],"raw_orcid":"https://orcid.org/0009-0003-0625-3535","affiliations":[{"raw_affiliation_string":"Department of Infection/Pharmacy, Imperial Healthcare NHS Trust , London ,","institution_ids":["https://openalex.org/I153355300"]},{"raw_affiliation_string":"Department of Infectious Disease, Faculty of Medicine, Imperial College London , London ,","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065319132","display_name":"Philippe Montravers","orcid":"https://orcid.org/0000-0002-3422-5705","observed_orcids":["https://orcid.org/0000-0002-3422-5705","https://orcid.org/0000-0002-4010-0052"]},"institutions":[{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Montravers","raw_affiliation_strings":["Department of Anaesthesiology and Surgical Intensive Care, Bichat-Claude Bernard , Paris ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology and Surgical Intensive Care, Bichat-Claude Bernard , Paris ,","institution_ids":["https://openalex.org/I4210145170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015076483","display_name":"David L. Paterson","orcid":"https://orcid.org/0000-0003-2079-4437","observed_orcids":["https://orcid.org/0000-0003-2079-4437","https://orcid.org/0000-0002-0826-0654","https://orcid.org/0000-0003-0409-9012"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"David L Paterson","raw_affiliation_strings":["Saw Swee Hock School of Public Health, National University of Singapore and National University Health System , Singapore ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saw Swee Hock School of Public Health, National University of Singapore and National University Health System , Singapore ,","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021724884","display_name":"\u00c9ric Senneville","orcid":"https://orcid.org/0000-0002-5720-8908","observed_orcids":["https://orcid.org/0000-0002-5720-8908"]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Senneville","raw_affiliation_strings":["Discipline of Infectious Diseases, The University of Lille, Gustave Dron Hospital , Tourcoing ,"],"raw_orcid":"https://orcid.org/0000-0002-5720-8908","affiliations":[{"raw_affiliation_string":"Discipline of Infectious Diseases, The University of Lille, Gustave Dron Hospital , Tourcoing ,","institution_ids":["https://openalex.org/I2279609970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026597427","display_name":"\u00c0lex Soriano","orcid":"https://orcid.org/0000-0002-9374-0811","observed_orcids":["https://orcid.org/0000-0002-9374-0811"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I4405268343","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Infecciosas","ror":"https://ror.org/00nd8zg79","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4405268343"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alex Soriano","raw_affiliation_strings":["CIBERINFEC, Ciber in Infectious Diseases, ISCIII , Madrid ,","IDIBAPS , Barcelona ,","Infectious Disease Department, Hospital Cl\u00ednic de Barcelona, University of Barcelona , Barcelona ,"],"raw_orcid":"https://orcid.org/0000-0002-9374-0811","affiliations":[{"raw_affiliation_string":"CIBERINFEC, Ciber in Infectious Diseases, ISCIII , Madrid ,","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4405268343"]},{"raw_affiliation_string":"IDIBAPS , Barcelona ,","institution_ids":["https://openalex.org/I4210160192"]},{"raw_affiliation_string":"Infectious Disease Department, Hospital Cl\u00ednic de Barcelona, University of Barcelona , Barcelona ,","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057058749","display_name":"Jean\u2010Fran\u00e7ois Timsit","orcid":"https://orcid.org/0000-0002-6063-7383","observed_orcids":["https://orcid.org/0000-0002-6063-7383","https://orcid.org/0000-0003-3400-6200"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"id":"https://openalex.org/I4387156044","display_name":"Infection, Anti-microbiens, Mod\u00e9lisation, Evolution","ror":"https://ror.org/05hqep952","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Timsit","raw_affiliation_strings":["Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat-Claude Bernard University Hospital , Paris ,","UMR 1137, Universit\u00e9 Paris-Cit\u00e9, INSERM, IAME , Paris 75018 ,"],"raw_orcid":"https://orcid.org/0000-0002-6063-7383","affiliations":[{"raw_affiliation_string":"Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat-Claude Bernard University Hospital , Paris ,","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]},{"raw_affiliation_string":"UMR 1137, Universit\u00e9 Paris-Cit\u00e9, INSERM, IAME , Paris 75018 ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4387156044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075014516","display_name":"Mar\u00eda Virginia Villegas","orcid":"https://orcid.org/0000-0003-1898-9067","observed_orcids":["https://orcid.org/0000-0003-1898-9067"]},"institutions":[{"id":"https://openalex.org/I189460059","display_name":"Universidad El Bosque","ror":"https://ror.org/04m9gzq43","country_code":"CO","type":"education","lineage":["https://openalex.org/I189460059"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Maria Virginia Villegas","raw_affiliation_strings":["Grupo de Investigaci\u00f3n en Resistencia Antimicrobiana y Epidemiolog\u00eda Hospitalaria (RAEH), Universidad El Bosque , Bogot\u00e1 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n en Resistencia Antimicrobiana y Epidemiolog\u00eda Hospitalaria (RAEH), Universidad El Bosque , Bogot\u00e1 ,","institution_ids":["https://openalex.org/I189460059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045135007","display_name":"Pierluigi Viale","orcid":"https://orcid.org/0000-0003-1264-0008","observed_orcids":["https://orcid.org/0000-0003-1264-0008"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierluigi Viale","raw_affiliation_strings":["Infectious Diseases Unit, Scientific Institute for Research, Hospitalization and Healthcare, Azienda Ospedaliero-Universitaria di Bologna , Bologna ,"],"raw_orcid":"https://orcid.org/0000-0003-1264-0008","affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, Scientific Institute for Research, Hospitalization and Healthcare, Azienda Ospedaliero-Universitaria di Bologna , Bologna ,","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":10,"institutions_distinct_count":34,"corresponding_author_ids":["https://openalex.org/A5015882261"],"corresponding_institution_ids":["https://openalex.org/I74656192"],"apc_list":{"value":1978,"currency":"GBP","value_usd":2609},"apc_paid":{"value":1978,"currency":"GBP","value_usd":2609},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62804548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"6","first_page":"dlag226","last_page":"dlag226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbapenem-resistant-organisms","display_name":"carbapenem-resistant bacteria","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multidrug-resistant-gram-negative-bacteria","display_name":"multidrug-resistant Gram-negative bacteria","score":0.9390000104904175},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antimicrobial-stewardship","display_name":"antimicrobial stewardship","score":0.9430000185966492},{"id":"https://openalex.org/keywords/new-antibiotics","display_name":"novel antibiotics","score":0.7089999914169312},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7770000100135803},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.46000000834465027},{"id":"https://openalex.org/keywords/treatment-algorithm","display_name":"treatment algorithm","score":0.546999990940094},{"id":"https://openalex.org/keywords/multidisciplinary-collaboration","display_name":"multidisciplinary collaboration","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.7736999988555908},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7497000098228455},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6931999921798706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6535000205039978},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.6315000057220459},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.5669999718666077},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5529999732971191},{"id":"https://openalex.org/C2776040555","wikidata":"https://www.wikidata.org/wiki/Q19903321","display_name":"Antimicrobial stewardship","level":4,"score":0.5400999784469604},{"id":"https://openalex.org/C2911146124","wikidata":"https://www.wikidata.org/wiki/Q19903321","display_name":"Antibiotic Stewardship","level":4,"score":0.5325999855995178},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4277999997138977},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.41990000009536743},{"id":"https://openalex.org/C2778139618","wikidata":"https://www.wikidata.org/wiki/Q13440398","display_name":"Workforce","level":2,"score":0.41659998893737793},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.38089999556541443},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.3741999864578247},{"id":"https://openalex.org/C2777950569","wikidata":"https://www.wikidata.org/wiki/Q17021836","display_name":"Stewardship (theology)","level":3,"score":0.3741999864578247},{"id":"https://openalex.org/C184356942","wikidata":"https://www.wikidata.org/wiki/Q830382","display_name":"Best practice","level":2,"score":0.3366999924182892},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C199033989","wikidata":"https://www.wikidata.org/wiki/Q1318295","display_name":"Narrative","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/jacamr/dlag226","doi":"https://doi.org/10.1093/jacamr/dlag226","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jacamr/dlag226","pdf_url":"https://academic.oup.com/jacamr/article-pdf/8/6/dlag226/72652622/dlag226.pdf","source":{"id":"https://openalex.org/S4210190703","display_name":"JAC-Antimicrobial Resistance","issn_l":"2632-1823","issn":["2632-1823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-Antimicrobial Resistance","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13723160","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723160/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13723160/pdf/dlag226.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC Antimicrob Resist","raw_type":"Text"},{"id":"pmid:42967154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42967154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-antimicrobial resistance","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jacamr/dlag226","doi":"https://doi.org/10.1093/jacamr/dlag226","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jacamr/dlag226","pdf_url":"https://academic.oup.com/jacamr/article-pdf/8/6/dlag226/72652622/dlag226.pdf","source":{"id":"https://openalex.org/S4210190703","display_name":"JAC-Antimicrobial Resistance","issn_l":"2632-1823","issn":["2632-1823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-Antimicrobial Resistance","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F3070105980","display_name":"Centro de Investigaci\u00f3n Biotecnol\u00f3gica en Red de Enfermedades Infecciosas","ror":"https://ror.org/00nd8zg79"},{"id":"https://openalex.org/F4320328419","display_name":"Menarini Group","ror":"https://ror.org/02h1wg091"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224992176.pdf","grobid_xml":"https://content.openalex.org/works/W7224992176.grobid-xml"},"referenced_works_count":193,"referenced_works":["https://openalex.org/W851687779","https://openalex.org/W1574630028","https://openalex.org/W1612376079","https://openalex.org/W1967898453","https://openalex.org/W1969500929","https://openalex.org/W1970599332","https://openalex.org/W1992455801","https://openalex.org/W2017626731","https://openalex.org/W2046851147","https://openalex.org/W2073316020","https://openalex.org/W2100931621","https://openalex.org/W2104747240","https://openalex.org/W2110880963","https://openalex.org/W2116044020","https://openalex.org/W2116140206","https://openalex.org/W2121609323","https://openalex.org/W2134340025","https://openalex.org/W2140007752","https://openalex.org/W2142188564","https://openalex.org/W2142212618","https://openalex.org/W2147387492","https://openalex.org/W2156918227","https://openalex.org/W2162268639","https://openalex.org/W2321501255","https://openalex.org/W2328992505","https://openalex.org/W2331405334","https://openalex.org/W2334714747","https://openalex.org/W2337544276","https://openalex.org/W2407151623","https://openalex.org/W2416627116","https://openalex.org/W2472793917","https://openalex.org/W2486226358","https://openalex.org/W2536721813","https://openalex.org/W2550643720","https://openalex.org/W2560311764","https://openalex.org/W2568058100","https://openalex.org/W2586169463","https://openalex.org/W2592969231","https://openalex.org/W2599245417","https://openalex.org/W2614741637","https://openalex.org/W2620266053","https://openalex.org/W2747074371","https://openalex.org/W2756266760","https://openalex.org/W2766370714","https://openalex.org/W2769899821","https://openalex.org/W2788197198","https://openalex.org/W2788258230","https://openalex.org/W2792003130","https://openalex.org/W2793280651","https://openalex.org/W2794276483","https://openalex.org/W2801851274","https://openalex.org/W2885405322","https://openalex.org/W2885943529","https://openalex.org/W2888104887","https://openalex.org/W2889484854","https://openalex.org/W2889629084","https://openalex.org/W2889630471","https://openalex.org/W2892013439","https://openalex.org/W2893278377","https://openalex.org/W2894551919","https://openalex.org/W2895593384","https://openalex.org/W2896418674","https://openalex.org/W2898144230","https://openalex.org/W2899247965","https://openalex.org/W2899536177","https://openalex.org/W2899841051","https://openalex.org/W2902532896","https://openalex.org/W2904230285","https://openalex.org/W2905148412","https://openalex.org/W2911566892","https://openalex.org/W2912293410","https://openalex.org/W2912691820","https://openalex.org/W2912904466","https://openalex.org/W2915523134","https://openalex.org/W2942184614","https://openalex.org/W2944770038","https://openalex.org/W2950651849","https://openalex.org/W2962248781","https://openalex.org/W2967455168","https://openalex.org/W2968244461","https://openalex.org/W2970287551","https://openalex.org/W2971663956","https://openalex.org/W2972119750","https://openalex.org/W2975920332","https://openalex.org/W2982640231","https://openalex.org/W2990292797","https://openalex.org/W2995636661","https://openalex.org/W3003721827","https://openalex.org/W3005792480","https://openalex.org/W3007464332","https://openalex.org/W3010841485","https://openalex.org/W3011694624","https://openalex.org/W3026777707","https://openalex.org/W3036978962","https://openalex.org/W3038719387","https://openalex.org/W3042258129","https://openalex.org/W3049761879","https://openalex.org/W3086299083","https://openalex.org/W3092173712","https://openalex.org/W3092383626","https://openalex.org/W3093103037","https://openalex.org/W3097796063","https://openalex.org/W3113030996","https://openalex.org/W3120857221","https://openalex.org/W3129622642","https://openalex.org/W3129965648","https://openalex.org/W3130451024","https://openalex.org/W3131457386","https://openalex.org/W3162225948","https://openalex.org/W3163870295","https://openalex.org/W3175135562","https://openalex.org/W3175792336","https://openalex.org/W3178857106","https://openalex.org/W3188089457","https://openalex.org/W3193930247","https://openalex.org/W3202964273","https://openalex.org/W3213646299","https://openalex.org/W3215867221","https://openalex.org/W3217749790","https://openalex.org/W4200250437","https://openalex.org/W4200357335","https://openalex.org/W4200364409","https://openalex.org/W4206677002","https://openalex.org/W4210528437","https://openalex.org/W4210612285","https://openalex.org/W4211020493","https://openalex.org/W4213150995","https://openalex.org/W4213273141","https://openalex.org/W4214646227","https://openalex.org/W4220764592","https://openalex.org/W4221096196","https://openalex.org/W4224088724","https://openalex.org/W4225083527","https://openalex.org/W4225565706","https://openalex.org/W4225984134","https://openalex.org/W4280509279","https://openalex.org/W4281923974","https://openalex.org/W4290975359","https://openalex.org/W4294236078","https://openalex.org/W4295279594","https://openalex.org/W4300690666","https://openalex.org/W4300981157","https://openalex.org/W4303453964","https://openalex.org/W4309335996","https://openalex.org/W4309788951","https://openalex.org/W4310508478","https://openalex.org/W4312064895","https://openalex.org/W4313277149","https://openalex.org/W4313857631","https://openalex.org/W4315619411","https://openalex.org/W4318334726","https://openalex.org/W4321478399","https://openalex.org/W4322498135","https://openalex.org/W4323066384","https://openalex.org/W4365444049","https://openalex.org/W4372354528","https://openalex.org/W4376126609","https://openalex.org/W4380323581","https://openalex.org/W4382597977","https://openalex.org/W4383710266","https://openalex.org/W4384665204","https://openalex.org/W4385357997","https://openalex.org/W4385406392","https://openalex.org/W4385479531","https://openalex.org/W4386224701","https://openalex.org/W4386257904","https://openalex.org/W4386946797","https://openalex.org/W4387451099","https://openalex.org/W4387843747","https://openalex.org/W4388446470","https://openalex.org/W4389136711","https://openalex.org/W4391824460","https://openalex.org/W4393898796","https://openalex.org/W4396646140","https://openalex.org/W4396793156","https://openalex.org/W4396813863","https://openalex.org/W4397041605","https://openalex.org/W4398142323","https://openalex.org/W4399364110","https://openalex.org/W4402036755","https://openalex.org/W4402234327","https://openalex.org/W4402286724","https://openalex.org/W4402422596","https://openalex.org/W4402576008","https://openalex.org/W4403176298","https://openalex.org/W4403293512","https://openalex.org/W4404138904","https://openalex.org/W4404843749","https://openalex.org/W4413893594","https://openalex.org/W4415595307","https://openalex.org/W4417085609","https://openalex.org/W7128381714","https://openalex.org/W7140100880"],"related_works":["https://openalex.org/W4364856267","https://openalex.org/W4414618968","https://openalex.org/W2089469788","https://openalex.org/W4307904635","https://openalex.org/W4296312275","https://openalex.org/W3215068065","https://openalex.org/W4415586945","https://openalex.org/W7146937374","https://openalex.org/W2790823202","https://openalex.org/W2153415778"],"abstract_inverted_index":{"Infections":[0],"caused":[1],"by":[2],"multidrug-resistant":[3],"Gram-negative":[4],"(MDR-GN)":[5],"bacteria,":[6],"particularly":[7],"carbapenem-resistant":[8],"organisms":[9],"(CROs),":[10],"constitute":[11],"a":[12,163],"significant":[13],"burden":[14],"in":[15,30,110,167,187],"critically":[16],"ill":[17],"patients":[18],"(CIPs).":[19],"A":[20],"multidisciplinary,":[21],"collaborative":[22],"approach":[23,166],"is":[24,52,98],"essential":[25],"for":[26,35,107,180,184],"responsible":[27],"antibiotic":[28,94,121],"use":[29,122],"CIPs,":[31,168],"balancing":[32],"the":[33,45,66,83,170,212],"necessity":[34],"effective":[36],"treatment":[37,130],"with":[38,112,189,199],"mitigation":[39],"of":[40,47,69,85,172,214],"antimicrobial":[41],"resistance":[42,57],"(AMR).":[43],"While":[44,115],"efficacy":[46],"existing":[48],"antibiotics":[49,109,186],"against":[50],"CROs":[51],"increasingly":[53],"limited":[54,76],"due":[55],"to":[56,92,123,193],"development":[58],"and":[59,80,104,131,141,149,155,175,196],"suboptimal":[60],"pharmacokinetic/pharmacodynamic":[61],"properties,":[62],"several":[63],"barriers":[64],"impede":[65],"widespread":[67],"adoption":[68],"new":[70,108,185],"agents,":[71],"including":[72],"selective":[73],"susceptibility":[74],"testing,":[75],"availability,":[77],"high":[78],"costs,":[79],"concerns":[81],"regarding":[82],"fostering":[84],"resistance.":[86],"Antimicrobial":[87],"stewardship":[88],"(AMS)":[89],"strategies":[90,117,137],"aim":[91],"optimize":[93],"use;":[95],"however,":[96],"there":[97],"an":[99,160,181],"ongoing":[100],"debate":[101],"between":[102],"restrictive":[103,116],"enabling":[105],"approaches":[106],"CIPs":[111,188],"CRO":[113],"infections.":[114],"focus":[118],"on":[119],"limiting":[120],"mitigate":[124],"resistance,":[125],"they":[126],"may":[127],"delay":[128],"necessary":[129],"negatively":[132],"impact":[133],"professional":[134],"culture.":[135],"Enablement":[136],"promote":[138],"informed":[139],"decision-making":[140],"accessibility":[142],"when":[143],"needed":[144],"but":[145],"require":[146],"substantial":[147],"workforce":[148],"expertise.":[150],"In":[151],"this":[152],"narrative":[153],"review":[154],"expert":[156],"opinion,":[157],"we":[158],"propose":[159],"algorithm":[161],"supporting":[162],"coordinated":[164],"AMS":[165,209],"emphasizing":[169],"importance":[171],"early":[173],"diagnosis":[174],"appropriate":[176],"therapy.":[177],"We":[178],"advocate":[179],"enablement":[182],"strategy":[183,203],"MDR-GN":[190],"infections,":[191],"aiming":[192],"reduce":[194],"mortality":[195],"toxicity":[197],"associated":[198],"older":[200],"agents.":[201],"This":[202],"should":[204],"be":[205],"integrated":[206],"into":[207],"local":[208],"programmes":[210],"under":[211],"guidance":[213],"experienced":[215],"clinicians.":[216]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-01T00:00:00"}
