{"id":"https://openalex.org/W7224989508","doi":"https://doi.org/10.1016/j.bbrep.2026.102851","title":"Optimization of ultrasound-assisted extraction of polyphenols from Mansoa alliacea flowers and evaluation of their antioxidant, anti-inflammatory-related, and digestive enzyme inhibitory activities","display_name":"Optimization of ultrasound-assisted extraction of polyphenols from Mansoa alliacea flowers and evaluation of their antioxidant, anti-inflammatory-related, and digestive enzyme inhibitory activities","publication_year":2026,"publication_date":"2026-10-31","ids":{"openalex":"https://openalex.org/W7224989508","doi":"https://doi.org/10.1016/j.bbrep.2026.102851"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrep.2026.102851","doi":"https://doi.org/10.1016/j.bbrep.2026.102851","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102851","pdf_url":null,"source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.bbrep.2026.102851","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001657945","display_name":"Nguy\u1ec5n Qu\u1ed1c Trung","orcid":"https://orcid.org/0000-0002-8788-822X","observed_orcids":["https://orcid.org/0000-0002-8788-822X"]},"institutions":[{"id":"https://openalex.org/I123565023","display_name":"Vietnam National University Ho Chi Minh City","ror":"https://ror.org/00waaqh38","country_code":"VN","type":"education","lineage":["https://openalex.org/I123565023"]},{"id":"https://openalex.org/I23582244","display_name":"Ho Chi Minh City University of Science","ror":"https://ror.org/05jfbgm49","country_code":"VN","type":"education","lineage":["https://openalex.org/I123565023","https://openalex.org/I23582244"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Quoc Trung Nguyen","raw_affiliation_strings":["Faculty of Chemistry, University of Science, Ho Chi Minh City, 700000, Viet Nam","Vietnam National University, Ho Chi Minh City, 700000, Viet Nam"],"raw_orcid":"https://orcid.org/0000-0002-8788-822X","affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Science, Ho Chi Minh City, 700000, Viet Nam","institution_ids":["https://openalex.org/I23582244"]},{"raw_affiliation_string":"Vietnam National University, Ho Chi Minh City, 700000, Viet Nam","institution_ids":["https://openalex.org/I123565023"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004029349","display_name":"Tr\u1ea7n Ch\u00ed Linh","orcid":"https://orcid.org/0000-0002-9068-8798","observed_orcids":["https://orcid.org/0000-0002-9068-8798"]},"institutions":[{"id":"https://openalex.org/I4405259862","display_name":"Nam Can Tho University","ror":"https://ror.org/02vwfma54","country_code":"VN","type":"education","lineage":["https://openalex.org/I4405259862"]}],"countries":["VN"],"is_corresponding":true,"raw_author_name":"Tran Chi Linh","raw_affiliation_strings":["Faculty of Medicine, College of Health Sciences, Nam Can Tho University, 168 Nguyen Van Cu Extension Street, An Binh Ward, Can Tho, 94000, Viet Nam"],"raw_orcid":"https://orcid.org/0000-0002-9068-8798","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, College of Health Sciences, Nam Can Tho University, 168 Nguyen Van Cu Extension Street, An Binh Ward, Can Tho, 94000, Viet Nam","institution_ids":["https://openalex.org/I4405259862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004029349"],"corresponding_institution_ids":["https://openalex.org/I4405259862"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78894793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"102851","last_page":"102851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mansoa-alliacea","display_name":"Mansoa alliacea","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ultrasound-assisted-extraction","display_name":"ultrasound-assisted extraction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extraction-optimization","display_name":"extraction optimization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/luteolin-7-o-glucoside","display_name":"luteolin-7-O-glucoside","score":0.9580000042915344},{"id":"https://openalex.org/keywords/luteolin-7-o-glucuronide","display_name":"luteolin-7-O-glucuronide","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.984000027179718},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":1.0},{"id":"https://openalex.org/keywords/digestive-enzyme-inhibition","display_name":"digestive enzyme inhibition","score":0.746999979019165},{"id":"https://openalex.org/keywords/protein-denaturation","display_name":"protein denaturation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/erythrocyte-membrane-stabilization","display_name":"erythrocyte membrane stabilization","score":0.8429999947547913},{"id":"https://openalex.org/keywords/phytochemical-profiling","display_name":"phytochemical profiling","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.9017999768257141},{"id":"https://openalex.org/C2781031786","wikidata":"https://www.wikidata.org/wiki/Q287582","display_name":"ABTS","level":4,"score":0.7954000234603882},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7258999943733215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6003999710083008},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5882999897003174},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.5291000008583069},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.49380001425743103},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4814999997615814},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43810001015663147},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.43689998984336853},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.34209999442100525},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32820001244544983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28780001401901245},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.25360000133514404}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrep.2026.102851","doi":"https://doi.org/10.1016/j.bbrep.2026.102851","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102851","pdf_url":null,"source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:14913749076e4b2085462122f80fe285","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/14913749076e4b2085462122f80fe285","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry and Biophysics Reports, Vol 48, Iss , Pp 102851- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrep.2026.102851","doi":"https://doi.org/10.1016/j.bbrep.2026.102851","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2026.102851","pdf_url":null,"source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1557900516","https://openalex.org/W1982653023","https://openalex.org/W1998501014","https://openalex.org/W2015544289","https://openalex.org/W2048367496","https://openalex.org/W2084977717","https://openalex.org/W2123549693","https://openalex.org/W2464356132","https://openalex.org/W2555727071","https://openalex.org/W2561774922","https://openalex.org/W2742953301","https://openalex.org/W2789673374","https://openalex.org/W2810941960","https://openalex.org/W2845362540","https://openalex.org/W2901627809","https://openalex.org/W2902118901","https://openalex.org/W2907438831","https://openalex.org/W2973191177","https://openalex.org/W2997184920","https://openalex.org/W3012222092","https://openalex.org/W3082096268","https://openalex.org/W3092950334","https://openalex.org/W3120331759","https://openalex.org/W3129087978","https://openalex.org/W3141235947","https://openalex.org/W4213365861","https://openalex.org/W4220942692","https://openalex.org/W4224062070","https://openalex.org/W4283395414","https://openalex.org/W4284977032","https://openalex.org/W4286517143","https://openalex.org/W4287009973","https://openalex.org/W4307547655","https://openalex.org/W4321768034","https://openalex.org/W4362670009","https://openalex.org/W4378087302","https://openalex.org/W4378882668","https://openalex.org/W4396840019","https://openalex.org/W4400350409","https://openalex.org/W4410742593"],"related_works":["https://openalex.org/W4410742593","https://openalex.org/W7139989537","https://openalex.org/W4391023478","https://openalex.org/W2054047546","https://openalex.org/W3169419016","https://openalex.org/W4416449856","https://openalex.org/W4229050442","https://openalex.org/W4206477036","https://openalex.org/W7112937294","https://openalex.org/W4406638431"],"abstract_inverted_index":{"Background":[0],"Mansoa":[1],"alliacea":[2,36,282,297],"is":[3],"traditionally":[4],"used":[5],"to":[6,94],"treat":[7],"inflammation,":[8],"infections,":[9],"and":[10,16,38,45,64,82,87,132,136,145,182,207,214,235,239,246,260,272,275,298],"metabolic":[11],"disorders.":[12],"However,":[13],"the":[14,40,51,104,186,189,258,262,292],"phytochemical":[15,113],"biological":[17,197],"potential":[18],"of":[19,32,50,142,203,224,280,295],"its":[20,301],"flowers":[21,37],"remains":[22],"poorly":[23],"characterized.":[24],"Purpose":[25],"This":[26],"study":[27],"optimized":[28,52,89,116,190],"ultrasound-assisted":[29],"extraction":[30,56,60,62,150],"(UAE)":[31],"polyphenols":[33],"from":[34],"M.":[35,281,296],"evaluated":[39,119],"in":[41,121,195,212,257,263],"vitro":[42,122,196,264],"antioxidant,":[43],"anti-inflammatory-related,":[44],"digestive":[46,137],"enzyme":[47,138,277],"inhibitory":[48,139,278],"activities":[49,140,279],"extract.":[53,166,284],"Methods":[54],"Four":[55],"parameters":[57],"(ethanol":[58],"concentration,":[59],"temperature,":[61],"time,":[63,81],"solid-to-solvent":[65],"ratio)":[66],"were":[67,85,177],"initially":[68],"screened":[69],"by":[70],"single-factor":[71],"experiments.":[72],"Based":[73],"on":[74],"these":[75],"results,":[76],"three":[77],"key":[78],"factors":[79],"(temperature,":[80],"ethanol":[83],"concentration)":[84],"selected":[86],"further":[88,311],"using":[90,103],"a":[91,307,314],"Box\u2013Behnken":[92],"design":[93],"maximize":[95],"polyphenol":[96,99,255],"yield.":[97],"Total":[98],"content":[100],"was":[101,109,118],"quantified":[102],"Folin\u2013Ciocalteu":[105],"method.":[106],"UHPLC\u2013MS":[107,167],"profiling":[108],"conducted":[110],"for":[111,120,222,231,244,291,310],"tentative":[112],"characterization.":[114],"The":[115],"extract":[117,191,259,303],"antioxidant":[123,265],"activity":[124,129],"(DPPH,":[125],"ABTS":[126,215],"assays),":[127],"anti-inflammatory":[128],"(protein":[130],"denaturation":[131,271],"RBC":[133,232,273],"membrane":[134,233],"stabilization),":[135],"(inhibition":[141],"\u03b1":[143,146],"-amylase":[144],"-glucosidase).":[147],"Results":[148],"Optimal":[149],"conditions":[151],"(60%":[152],"ethanol,":[153],"79":[154],"\u00b0C,":[155],"15":[156],"min,":[157],"1:10":[158],"w/v)":[159],"yielded":[160],"275.37":[161],"\u00b1":[162,205,209,219,228,237,241],"1.55":[163],"mg":[164],"GAE/g":[165],"analysis":[168],"revealed":[169],"nine":[170],"major":[171],"peaks,":[172],"among":[173],"which":[174],"two":[175],"compounds":[176],"provisionally":[178],"assigned":[179],"as":[180,306,313],"luteolin-7-O-glucoside":[181],"luteolin-7-O-glucuronide.":[183],"Compared":[184],"with":[185,199],"unoptimized":[187],"extract,":[188],"exhibited":[192],"markedly":[193],"stronger":[194],"activities,":[198],"IC":[200],"50":[201],"values":[202],"11.88":[204],"0.28":[206],"15.58":[208],"0.33":[210],"\u03bcg/mL":[211,221,230,243],"DPPH":[213],"assays,":[216],"respectively;":[217],"38.77":[218],"0.93":[220],"inhibition":[223],"protein":[225,270],"denaturation;":[226],"30.74":[227],"0.18":[229],"stabilization;":[234],"30.94":[236],"0.54":[238],"13.32":[240],"0.19":[242],"\u03b1-amylase":[245],"\u03b1-glucosidase":[247],"inhibition,":[248],"respectively.":[249],"Conclusion":[250],"Optimized":[251],"UAE":[252],"significantly":[253],"enhanced":[254],"enrichment":[256],"improved":[261],"capacity,":[266],"protective":[267],"effects":[268],"against":[269],"hemolysis,":[274],"carbohydrate-hydrolyzing":[276],"flower":[283],"These":[285],"findings":[286],"provide":[287],"preliminary":[288],"scientific":[289],"support":[290],"traditional":[293],"use":[294],"suggest":[299],"that":[300],"polyphenol-rich":[302],"may":[304],"serve":[305],"promising":[308],"candidate":[309],"investigation":[312],"functional":[315],"or":[316],"phytopharmaceutical":[317],"ingredient.":[318]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-11-01T00:00:00"}