{"id":"https://openalex.org/W7224979786","doi":null,"title":"Establecimiento de un m\u00e9todo de cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n para la cuantificaci\u00f3n de prote\u00edna no enlazada en el conjugado de la vacuna SOBERANA\u00ae02","display_name":"Establecimiento de un m\u00e9todo de cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n para la cuantificaci\u00f3n de prote\u00edna no enlazada en el conjugado de la vacuna SOBERANA\u00ae02","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7224979786"},"language":"es","primary_location":{"id":"pmh:oai:vaccimonitor.finlay.edu.cu:article/9311","doi":null,"is_oa":true,"landing_page_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/view/9311","pdf_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/download/9311/671/","source":{"id":"https://openalex.org/S2736920902","display_name":"Vaccimonitor/VacciMonitor","issn_l":"1025-028X","issn":["1025-028X","1025-0298"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310314860","host_organization_name":"Finlay Ediciones","host_organization_lineage":["https://openalex.org/P4310314860"],"host_organization_lineage_names":["Finlay Ediciones"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1025-0298","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/download/9311/671/","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160153411","display_name":"Aida Yaima Merch\u00e1n-Milia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merch\u00e1n-Milia, Aida Yaima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160164444","display_name":"Yalaydis Plutin-Oca\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Plutin-Oca\u00f1a, Yalaydis","raw_affiliation_strings":["Bioqu\u00edmica , MSc. , Especialista de Alta Tecnolog\u00eda en Control de la Calidad . Instituto Finlay de Vacunas. La Habana , Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioqu\u00edmica , MSc. , Especialista de Alta Tecnolog\u00eda en Control de la Calidad . Instituto Finlay de Vacunas. La Habana , Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042321224","display_name":"Mario Landys Chovel Cuervo","orcid":"https://orcid.org/0000-0002-6991-7007","observed_orcids":["https://orcid.org/0000-0002-6991-7007"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Chovel-Cuervo, Mario Landys","raw_affiliation_strings":["Instituto Finlay de Vacunas , La Habana , Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay de Vacunas , La Habana , Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160152209","display_name":"Ileana Delgado-Arrieta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Delgado-Arrieta, Ileana","raw_affiliation_strings":["Instituto Finlay de Vacunas , La Habana , Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay de Vacunas , La Habana , Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160153243","display_name":"Lucy Herrera-Guada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Herrera-Guada, Lucy","raw_affiliation_strings":["Instituto Finlay de Vacunas , La Habana , Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay de Vacunas , La Habana , Cuba","institution_ids":["https://openalex.org/I4210100398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033282725","display_name":"Darielys Santana-Mederos","orcid":"https://orcid.org/0000-0001-5333-554X","observed_orcids":["https://orcid.org/0000-0001-5333-554X"]},"institutions":[{"id":"https://openalex.org/I4210100398","display_name":"Finlay Institute","ror":"https://ror.org/00kq7a553","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210100398"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Santana-Mederos, Darielys","raw_affiliation_strings":["Instituto Finlay de Vacunas , La Habana , Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Finlay de Vacunas , La Habana , Cuba","institution_ids":["https://openalex.org/I4210100398"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.8220000267028809},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.6499999761581421},{"id":"https://openalex.org/keywords/spike-receptor-binding-domain","display_name":"spike protein receptor-binding domain","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tetanus-toxoid","display_name":"tetanus toxoid","score":0.7789999842643738},{"id":"https://openalex.org/keywords/aluminum-hydroxide-adjuvant","display_name":"aluminum hydroxide adjuvant","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hplc-method-validation","display_name":"HPLC method validation","score":0.828000009059906},{"id":"https://openalex.org/keywords/size-exclusion-chromatography","display_name":"size exclusion chromatography","score":0.9229999780654907},{"id":"https://openalex.org/keywords/vaccine-quality-control","display_name":"vaccine quality control","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.6593000292778015},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5612999796867371},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5024999976158142},{"id":"https://openalex.org/C122342681","wikidata":"https://www.wikidata.org/wiki/Q330828","display_name":"Skewness","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.44040000438690186},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.43619999289512634},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.42809998989105225},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.3853999972343445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37700000405311584},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.37040001153945923},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.35370001196861267},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3379000127315521},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.2827000021934509}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:vaccimonitor.finlay.edu.cu:article/9311","doi":null,"is_oa":true,"landing_page_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/view/9311","pdf_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/download/9311/671/","source":{"id":"https://openalex.org/S2736920902","display_name":"Vaccimonitor/VacciMonitor","issn_l":"1025-028X","issn":["1025-028X","1025-0298"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310314860","host_organization_name":"Finlay Ediciones","host_organization_lineage":["https://openalex.org/P4310314860"],"host_organization_lineage_names":["Finlay Ediciones"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1025-0298","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:vaccimonitor.finlay.edu.cu:article/9311","doi":null,"is_oa":true,"landing_page_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/view/9311","pdf_url":"https://vaccimonitor.finlay.edu.cu/index.php/vaccimonitor/article/download/9311/671/","source":{"id":"https://openalex.org/S2736920902","display_name":"Vaccimonitor/VacciMonitor","issn_l":"1025-028X","issn":["1025-028X","1025-0298"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310314860","host_organization_name":"Finlay Ediciones","host_organization_lineage":["https://openalex.org/P4310314860"],"host_organization_lineage_names":["Finlay Ediciones"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1025-0298","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224979786.pdf","grobid_xml":"https://content.openalex.org/works/W7224979786.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2773527998","https://openalex.org/W3159772492"],"related_works":["https://openalex.org/W3172934103","https://openalex.org/W3048776962","https://openalex.org/W4412491095","https://openalex.org/W7215167183","https://openalex.org/W2377463140","https://openalex.org/W1990048399","https://openalex.org/W7005511156","https://openalex.org/W2409097623","https://openalex.org/W2898434193","https://openalex.org/W2104700955"],"abstract_inverted_index":{"SOBERANA\u00ae02":[0],"is":[1,42],"a":[2,6,43,99,103,108,113,121,125,220],"vaccine":[3,60,278],"based":[4],"on":[5,98],"protein":[7,27,38],"subunit":[8],"platform,":[9],"produced":[10],"by":[11,95,204],"chemically":[12],"conjugating":[13],"the":[14,19,36,40,48,51,56,59,75,129,167,177,185,200,205,238,244,255,258,265,272,275],"recombinant":[15],"receptor-binding":[16],"domain":[17],"of":[18,50,58,64,82,89,143,147,151,159,174,199,222,224,235,246,257,267,274],"severe":[20],"acute":[21],"respiratory":[22],"syndrome":[23],"coronavirus":[24],"2":[25,226],"spike":[26],"to":[28,68,102],"tetanus":[29],"toxoid":[30],"absorbed":[31],"in":[32,39,157,176,277],"aluminum":[33],"hydroxide.":[34],"Quantifying":[35],"unbound":[37,76,268],"conjugate":[41,90,276],"critical":[44],"attribute":[45],"for":[46,73,153,188,237,264],"evaluating":[47,154],"effectiveness":[49],"conjugation":[52],"process":[53],"and":[54,93,107,128,137,145,166,179,193,211,214,243,260],"ensuring":[55,271],"quality":[57,273],"product.":[61],"The":[62,149,172,197,232,251],"objective":[63],"this":[65],"work":[66],"was":[67,163,170,202,228,240,248],"validate":[69],"an":[70,79],"HPLC":[71],"method":[72,201,239,259],"quantifying":[74],"protein,":[77],"establishing":[78],"acceptance":[80],"limit":[81,142,146,234,245],"less":[83],"than":[84],"20":[85],"%.":[86],"Three":[87],"batches":[88],"were":[91,118,132,183],"used":[92],"evaluated":[94],"size-exclusion":[96],"chromatography":[97],"system":[100,134,155],"coupled":[101],"diode":[104],"array":[105],"detector":[106],"Superdex":[109],"75":[110],"column":[111],"with":[112],"10/300":[114],"increment":[115],"(Cytiva).":[116],"Concentrations":[117],"determined":[119],"from":[120],"calibration":[122],"curve":[123],"using":[124],"reference":[126],"material,":[127],"following":[130],"parameters":[131],"evaluated:":[133],"suitability":[135,156],"(linearity":[136],"range),":[138],"precision,":[139],"accuracy,":[140],"specificity,":[141],"quantification,":[144],"detection.":[148],"coefficient":[150,221],"variation":[152,175,223],"terms":[158],"retention":[160],"time":[161],"precision":[162,181],"0.011":[164],"%,":[165],"skewness":[168],"factor":[169],"1.18.":[171],"coefficients":[173],"intra-":[178],"inter-assay":[180],"tests":[182],"within":[184],"established":[186],"ranges":[187],"each":[189],"(\u2264":[190],"1":[191],"%":[192,210,227],"\u2264":[194],"5":[195],"%).":[196],"accuracy":[198],"demonstrated":[203],"recovery":[206],"percentages":[207],"obtained":[208,229,253],"(90":[209],"110":[212],"%),":[213],"at":[215],"all":[216],"concentration":[217],"levels":[218],"studied,":[219],"<":[225],"between":[230],"recoveries.":[231],"calculated":[233],"quantification":[236,266],"0.0129":[241],"\u00b5g/mL,":[242],"detection":[247],"0.0043":[249],"\u00b5g/mL.":[250],"results":[252],"confirm":[254],"robustness":[256],"support":[261],"its":[262],"use":[263],"proteins,":[269],"thus":[270],"samples.":[279]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-31T00:00:00"}
