{"id":"https://openalex.org/W7224960648","doi":"https://doi.org/10.3390/ijms27219764","title":"Immune-Related Proteomic Profiling in Clear Cell Renal Cell Carcinoma: Tissue and Soluble Biofluid Biomarkers","display_name":"Immune-Related Proteomic Profiling in Clear Cell Renal Cell Carcinoma: Tissue and Soluble Biofluid Biomarkers","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224960648","doi":"https://doi.org/10.3390/ijms27219764"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27219764","doi":"https://doi.org/10.3390/ijms27219764","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219764","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27219764","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160211360","display_name":"Christina Anatoliotaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christina Anatoliotaki","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062561402","display_name":"Sevastiani Antonouli","orcid":"https://orcid.org/0000-0002-3525-2633","observed_orcids":["https://orcid.org/0000-0002-3525-2633"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sevastiani Antonouli","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052517445","display_name":"Vassilios Tzortzis","orcid":"https://orcid.org/0000-0002-9993-5943","observed_orcids":["https://orcid.org/0000-0002-9993-5943"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]},{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassilios Tzortzis","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265","https://openalex.org/I4210107217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061020970","display_name":"Panagiotis J. Vlachostergios","orcid":"https://orcid.org/0000-0002-1704-1517","observed_orcids":["https://orcid.org/0000-0002-1704-1517"]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]},{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Panagiotis J. Vlachostergios","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 45110 Ioannina, Greece","Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-1704-1517","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 45110 Ioannina, Greece","institution_ids":["https://openalex.org/I194019607","https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103083994","display_name":"Ioannis Zachos","orcid":"https://orcid.org/0000-0003-3889-9755","observed_orcids":["https://orcid.org/0000-0003-3889-9755"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]},{"id":"https://openalex.org/I4210107217","display_name":"University Hospital of Larissa","ror":"https://ror.org/01s5dt366","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210107217"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Zachos","raw_affiliation_strings":["Department of Urology, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265","https://openalex.org/I4210107217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073818624","display_name":"Eleni Thodou","orcid":"https://orcid.org/0000-0003-4988-1526","observed_orcids":["https://orcid.org/0000-0003-4988-1526"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Thodou","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076084955","display_name":"Antonis Giakountis","orcid":"https://orcid.org/0000-0001-8648-9908","observed_orcids":["https://orcid.org/0000-0001-8648-9908"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Antonis Giakountis","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":"https://orcid.org/0000-0001-8648-9908","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084671317","display_name":"\u039c\u03b1\u03c1\u03af\u03b1 \u03a3\u03b1\u03bc\u03b1\u03c1\u03ac","orcid":"https://orcid.org/0000-0003-0433-6436","observed_orcids":["https://orcid.org/0000-0003-0433-6436"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Maria Samara","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece"],"raw_orcid":"https://orcid.org/0000-0003-0433-6436","affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece","institution_ids":["https://openalex.org/I145722265"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076084955","https://openalex.org/A5084671317"],"corresponding_institution_ids":["https://openalex.org/I145722265"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87711113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"21","first_page":"9764","last_page":"9764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/immune-related-biomarkers","display_name":"immune-related biomarkers","score":0.9610000252723694},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.734000027179718},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":1.0},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8309999704360962},{"id":"https://openalex.org/keywords/immune-checkpoint-proteins","display_name":"immune checkpoint molecules","score":0.8610000014305115},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6679999828338623},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.6908000111579895},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6011999845504761},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5461000204086304},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47690001130104065},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.47620001435279846},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4584999978542328},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45570001006126404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45210000872612},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4212000072002411},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.421099990606308},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4198000133037567},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39430001378059387},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.38499999046325684},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.3538999855518341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3456000089645386},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.33309999108314514},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ijms27219764","doi":"https://doi.org/10.3390/ijms27219764","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219764","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ijms27219764","doi":"https://doi.org/10.3390/ijms27219764","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27219764","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7172388102","https://openalex.org/W7156360996","https://openalex.org/W3194915818","https://openalex.org/W4323545696","https://openalex.org/W3160296445","https://openalex.org/W3163450147","https://openalex.org/W3160579133","https://openalex.org/W6911004941","https://openalex.org/W2883869155","https://openalex.org/W7221847459"],"abstract_inverted_index":{"Clear":[0],"cell":[1,3],"renal":[2],"carcinoma":[4],"(ccRCC)":[5],"shows":[6],"complex":[7],"interactions":[8],"with":[9],"the":[10,84,98,116,142],"tumor":[11],"microenvironment,":[12],"involving":[13],"a":[14,70],"range":[15],"of":[16,87,97,123,154],"immune":[17],"checkpoint":[18],"proteins":[19],"and":[20,28,38,54,62,79,110,120,130,146,161,171],"circulating":[21,39,55,111],"biomarkers":[22,104],"that":[23,82],"may":[24],"influence":[25],"disease":[26,159],"progression":[27],"response":[29],"to":[30,75,132,141,180],"treatment.":[31],"Recent":[32],"technological":[33],"advances":[34],"have":[35],"identified":[36],"tissue-based":[37],"immune-related":[40,102],"proteomic":[41,103],"targets":[42,157],"such":[43,124],"as":[44,58,149],"programmed":[45],"death-ligand":[46],"1":[47],"(PD-L1),":[48],"cytotoxic":[49],"T-lymphocyte-associated":[50],"protein":[51],"4":[52],"(CTLA-4),":[53],"interleukin-8":[56],"(cIL-8)":[57],"potential":[59,117,131],"diagnostic,":[60,118],"prognostic":[61],"predictive":[63,121],"biomarkers.":[64,89],"Despite":[65],"significant":[66],"progress,":[67],"ccRCC":[68,182],"remains":[69],"major":[71],"clinical":[72,85],"challenge":[73],"due":[74],"its":[76],"diverse":[77],"molecular":[78],"immunological":[80],"characteristics":[81],"hinder":[83],"utility":[86],"these":[88],"The":[90],"present":[91],"review":[92],"provides":[93],"an":[94],"updated":[95],"overview":[96],"current":[99],"evidence":[100],"regarding":[101],"in":[105],"ccRCC,":[106],"including":[107],"both":[108],"tissue-derived":[109],"proteins.":[112],"Herein,":[113],"we":[114,165],"discuss":[115],"prognostic,":[119],"value":[122],"agents,":[125],"emphasizing":[126],"their":[127,147],"biological":[128],"significance":[129],"guide":[133],"personalized":[134],"immunotherapeutic":[135],"strategies.":[136],"Particular":[137],"attention":[138],"is":[139],"given":[140],"developing":[143],"liquid-biopsy-based":[144],"techniques":[145],"application":[148],"novel":[150],"minimally":[151],"invasive":[152],"methods":[153],"identifying":[155],"new":[156],"for":[158],"monitoring":[160],"treatment":[162],"evaluation.":[163],"Finally,":[164],"focus":[166],"on":[167],"emerging":[168],"therapeutic":[169],"approaches":[170],"combined":[172],"strategies,":[173],"highlighting":[174],"how":[175],"biomarker-driven":[176],"precision":[177],"oncology":[178],"continues":[179],"reshape":[181],"management.":[183]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}
