{"id":"https://openalex.org/W7224959836","doi":"https://doi.org/10.1002/jts.70131","title":"Examining the multivariate genetic architectures of posttraumatic stress disorder and cardiovascular disease phenotypes","display_name":"Examining the multivariate genetic architectures of posttraumatic stress disorder and cardiovascular disease phenotypes","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224959836","doi":"https://doi.org/10.1002/jts.70131","pmid":"https://pubmed.ncbi.nlm.nih.gov/42960550"},"language":"en","primary_location":{"id":"doi:10.1002/jts.70131","doi":"https://doi.org/10.1002/jts.70131","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jts.70131","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jts.70131","source":{"id":"https://openalex.org/S176794141","display_name":"Journal of Traumatic Stress","issn_l":"0894-9867","issn":["0894-9867","1573-6598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Traumatic Stress","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jts.70131","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001012034","display_name":"Shannon E. Cusack","orcid":"https://orcid.org/0000-0001-8103-0575","observed_orcids":["https://orcid.org/0000-0001-8103-0575"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon E. Cusack","raw_affiliation_strings":["Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"],"raw_orcid":"https://orcid.org/0000-0001-8103-0575","affiliations":[{"raw_affiliation_string":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050029604","display_name":"Nina Adler","orcid":"https://orcid.org/0000-0002-0297-2706","observed_orcids":["https://orcid.org/0000-0002-0297-2706"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I4210130843","display_name":"Sinai Health System","ror":"https://ror.org/044790d95","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nina Adler","raw_affiliation_strings":["Department of Anthropology University of Toronto  Toronto Ontario Canada","Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health  Toronto Ontario Canada"],"raw_orcid":"https://orcid.org/0000-0002-0297-2706","affiliations":[{"raw_affiliation_string":"Department of Anthropology University of Toronto  Toronto Ontario Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Prosserman Centre for Population Health Research Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health  Toronto Ontario Canada","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I4210130843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007591579","display_name":"Peter B. Barr","orcid":"https://orcid.org/0000-0001-9321-657X","observed_orcids":["https://orcid.org/0000-0001-9321-657X"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]},{"id":"https://openalex.org/I2800015068","display_name":"VA NY Harbor Healthcare System","ror":"https://ror.org/03s5r4e84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800015068","https://openalex.org/I4210094901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter B. Barr","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences State University of New York Downstate Health Sciences University  Brooklyn New York USA","Institute for Genomics in Health State University of New York Downstate Health Sciences University  Brooklyn New York USA","VA New York Harbor Healthcare System  Brooklyn New York USA"],"raw_orcid":"https://orcid.org/0000-0001-9321-657X","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences State University of New York Downstate Health Sciences University  Brooklyn New York USA","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Institute for Genomics in Health State University of New York Downstate Health Sciences University  Brooklyn New York USA","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"VA New York Harbor Healthcare System  Brooklyn New York USA","institution_ids":["https://openalex.org/I2800015068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619171","display_name":"Xiang Zhao","orcid":"https://orcid.org/0000-0003-1720-5996","observed_orcids":["https://orcid.org/0000-0003-1720-5996"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Zhao","raw_affiliation_strings":["Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"],"raw_orcid":"https://orcid.org/0000-0003-1720-5996","affiliations":[{"raw_affiliation_string":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019071414","display_name":"Antonia V. Seligowski","orcid":"https://orcid.org/0000-0001-6946-6376","observed_orcids":["https://orcid.org/0000-0001-6946-6376"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonia V. Seligowski","raw_affiliation_strings":["Department of Psychiatry Harvard Medical School  Boston Massachusetts USA","Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Harvard Medical School  Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056448263","display_name":"Sage E. Hawn","orcid":"https://orcid.org/0000-0001-8501-4169","observed_orcids":["https://orcid.org/0000-0001-8501-4169"]},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sage E. Hawn","raw_affiliation_strings":["Department of Psychology Old Dominion University  Norfolk Virginia USA","Virginia Consortium Program in Clinical Psychology  Norfolk Virginia USA"],"raw_orcid":"https://orcid.org/0000-0001-8501-4169","affiliations":[{"raw_affiliation_string":"Department of Psychology Old Dominion University  Norfolk Virginia USA","institution_ids":["https://openalex.org/I81365321"]},{"raw_affiliation_string":"Virginia Consortium Program in Clinical Psychology  Norfolk Virginia USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066579892","display_name":"Erika J. Wolf","orcid":"https://orcid.org/0000-0003-2666-2435","observed_orcids":["https://orcid.org/0000-0003-2666-2435"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika J. Wolf","raw_affiliation_strings":["Department of Psychiatry Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA","National Center for PTSD at VA Boston Healthcare System  Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"National Center for PTSD at VA Boston Healthcare System  Boston Massachusetts USA","institution_ids":["https://openalex.org/I2801671727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160216539","display_name":"PGC\u2010PTSD Physical Health Workgroup","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PGC\u2010PTSD Physical Health Workgroup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070636268","display_name":"Jennifer A. Sumner","orcid":"https://orcid.org/0000-0002-0217-7171","observed_orcids":["https://orcid.org/0000-0002-0217-7171"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Sumner","raw_affiliation_strings":["Department of Psychology University of California Los Angeles  Los Angeles California USA"],"raw_orcid":"https://orcid.org/0000-0002-0217-7171","affiliations":[{"raw_affiliation_string":"Department of Psychology University of California Los Angeles  Los Angeles California USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073155296","display_name":"Ananda B. Amstadter","orcid":"https://orcid.org/0000-0001-6285-9943","observed_orcids":["https://orcid.org/0000-0001-6285-9943"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananda B. Amstadter","raw_affiliation_strings":["Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA"],"raw_orcid":"https://orcid.org/0000-0001-6285-9943","affiliations":[{"raw_affiliation_string":"Department of Psychiatry Virginia Commonwealth University  Richmond Virginia USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5001012034"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":3120,"currency":"USD","value_usd":3120},"apc_paid":{"value":3120,"currency":"USD","value_usd":3120},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82502425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9700000286102295},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/polygenic-overlap","display_name":"polygenic overlap","score":0.8019999861717224},{"id":"https://openalex.org/keywords/shared-genetic-risk","display_name":"shared genetic risk","score":0.7099999785423279},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8109999895095825},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.8050000071525574},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8560000061988831},{"id":"https://openalex.org/keywords/rna-metabolism","display_name":"RNA metabolism","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6620000004768372},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5540000200271606},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5360000133514404},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.49900001287460327},{"id":"https://openalex.org/C70616004","wikidata":"https://www.wikidata.org/wiki/Q5532885","display_name":"Genetic correlation","level":4,"score":0.49880000948905945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4242999851703644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41339999437332153},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.40610000491142273},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.36899998784065247},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3538999855518341},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3375000059604645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32910001277923584},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.32440000772476196},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.32260000705718994},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.32010000944137573},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C169594400","wikidata":"https://www.wikidata.org/wiki/Q244775","display_name":"Twin study","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.30649998784065247},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.2987000048160553},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jts.70131","doi":"https://doi.org/10.1002/jts.70131","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jts.70131","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jts.70131","source":{"id":"https://openalex.org/S176794141","display_name":"Journal of Traumatic Stress","issn_l":"0894-9867","issn":["0894-9867","1573-6598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Traumatic Stress","raw_type":"journal-article"},{"id":"pmid:42960550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42960550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of traumatic stress","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jts.70131","doi":"https://doi.org/10.1002/jts.70131","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jts.70131","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jts.70131","source":{"id":"https://openalex.org/S176794141","display_name":"Journal of Traumatic Stress","issn_l":"0894-9867","issn":["0894-9867","1573-6598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Traumatic Stress","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000879214","display_name":"ResearchTraining: Psychiatric and Statistical Genetics","funder_award_id":"T32MH020030","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224959836.pdf","grobid_xml":"https://content.openalex.org/works/W7224959836.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1976213519","https://openalex.org/W2047783882","https://openalex.org/W2075797384","https://openalex.org/W2082704080","https://openalex.org/W2091092822","https://openalex.org/W2097383944","https://openalex.org/W2097572487","https://openalex.org/W2112848098","https://openalex.org/W2163146990","https://openalex.org/W2238851414","https://openalex.org/W2610359325","https://openalex.org/W2734654187","https://openalex.org/W2751803762","https://openalex.org/W2791863121","https://openalex.org/W2792709813","https://openalex.org/W2807295499","https://openalex.org/W2889800760","https://openalex.org/W2903416893","https://openalex.org/W2937611850","https://openalex.org/W2938527140","https://openalex.org/W2964961432","https://openalex.org/W2972730029","https://openalex.org/W3003748381","https://openalex.org/W3012049218","https://openalex.org/W3047590654","https://openalex.org/W3082061616","https://openalex.org/W3174127247","https://openalex.org/W3179479229","https://openalex.org/W3181537867","https://openalex.org/W3202209876","https://openalex.org/W3202848931","https://openalex.org/W4220764353","https://openalex.org/W4247665917","https://openalex.org/W4282549953","https://openalex.org/W4289261048","https://openalex.org/W4291019306","https://openalex.org/W4294919357","https://openalex.org/W4297933373","https://openalex.org/W4384925653","https://openalex.org/W4394924136","https://openalex.org/W4396977241","https://openalex.org/W4398775493","https://openalex.org/W4401689666","https://openalex.org/W4405025295","https://openalex.org/W4406060500"],"related_works":["https://openalex.org/W4294919357","https://openalex.org/W4401689666","https://openalex.org/W4406060500","https://openalex.org/W4401891549","https://openalex.org/W4411887113","https://openalex.org/W4297933373","https://openalex.org/W2075877982","https://openalex.org/W4290729419","https://openalex.org/W2522492694","https://openalex.org/W4388141055"],"abstract_inverted_index":{"Abstract":[0],"Posttraumatic":[1],"stress":[2],"disorder":[3],"(PTSD)":[4],"is":[5,20],"associated":[6],"with":[7,102,138,155,201,247],"elevated":[8],"cardiovascular":[9],"disease":[10],"(CVD)":[11],"risk,":[12],"but":[13,151,253],"the":[14,120,171,231],"extent":[15],"of":[16,31,99],"shared":[17,167],"inherited":[18],"liability":[19,169],"unclear.":[21],"Large":[22],"genome\u2010wide":[23],"association":[24],"studies":[25],"(GWAS)":[26],"allow":[27],"for":[28,41,179,182,188,214,219,239],"multivariate":[29,97],"evaluation":[30],"common":[32],"genetic":[33,88,136,153,168],"architecture.":[34],"We":[35],"analyzed":[36],"European\u2010ancestry":[37],"GWAS":[38,98,175],"summary":[39],"statistics":[40],"PTSD":[42,91,132,205,215,242],"(":[43],"N":[44,59,77],"_eff":[45,60],"\u2248":[46],"1.22":[47],"million),":[48],"CVD":[49,64,93,112,116,139,156,183,189,207,220,250],"outcomes":[50,52,117,157,190],"(CVD":[51,67],";":[53,69],"coronary":[54],"artery":[55],"disease,":[56],"stroke,":[57],"hypertension;":[58],"=":[61,78,124,127,130,143,160],"126,000\u2013574,000),":[62],"and":[63,92,95,104,115,148,186,197,206,216,265],"risk":[65,68,113,140,184,208,251],"factors":[66,101],"high\u2010density":[70],"lipoprotein,":[71],"triglycerides,":[72],"fasting":[73],"glucose,":[74],"waist":[75],"circumference;":[76],"211,000\u2013526,000).":[79],"Using":[80],"genomic":[81,228],"structural":[82],"equation":[83],"modeling,":[84],"we":[85],"modeled":[86],"latent":[87,100],"structure":[89],"across":[90],"phenotypes":[94],"conducted":[96],"gene":[103],"gene\u2010set":[105],"annotation.":[106],"A":[107],"three\u2010factor":[108],"model":[109],"distinguishing":[110],"PTSD,":[111,180],",":[114,141,158,185,252],"best":[118],"fit":[119],"data,":[121],"\u03c7":[122],"2":[123],"256.9,":[125],"CFI":[126],".990,":[128],"SRMR":[129],".040.":[131],"showed":[133],"a":[134,149,227],"moderate":[135,244],"correlation":[137,154],"rg":[142,159],".340,":[144],"p":[145,162],"<":[146,163],".001,":[147,164],"significant":[150],"negligible":[152],"0.030,":[161],"suggesting":[165],"minimal":[166],"at":[170],"latent\u2010factor":[172],"level.":[173],"Multivariate":[174],"identified":[176],"seven":[177],"loci":[178,255],"96":[181],"51":[187],".":[191,209],"Gene\u2010based":[192],"tests":[193],"implicated":[194],"85,":[195],"910,":[196],"390":[198],"genes,":[199],"respectively,":[200],"18":[202],"overlapping":[203],"between":[204],"Enrichment":[210],"highlighted":[211],"RNA":[212,266],"metabolism":[213],"lipid/vascular":[217],"pathways":[218],"traits.":[221],"Additional":[222],"locus\u2010level":[223],"overlaps":[224],"emerged,":[225],"including":[226],"hub":[229],"in":[230],"major":[232],"histocompatibility":[233],"complex":[234],"region":[235],"on":[236],"Chromosome":[237],"6":[238],"both":[240],"phenotypes.":[241],"shares":[243],"polygenic":[245],"overlap":[246],"CVD,":[248],"particularly":[249],"many":[254],"are":[256],"trait\u2010specific,":[257],"implicating":[258],"lipid":[259],"metabolism,":[260],"vascular":[261],"tone,":[262],"immune/inflammatory":[263],"pathways,":[264],"regulation":[267],"as":[268],"potential":[269],"links.":[270]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}
