{"id":"https://openalex.org/W7224959629","doi":"https://doi.org/10.54097/jvrbe024","title":"Advances in Fluoride Clinical Applications in Dentistry","display_name":"Advances in Fluoride Clinical Applications in Dentistry","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224959629","doi":"https://doi.org/10.54097/jvrbe024"},"language":"en","primary_location":{"id":"doi:10.54097/jvrbe024","doi":"https://doi.org/10.54097/jvrbe024","is_oa":true,"landing_page_url":"https://doi.org/10.54097/jvrbe024","pdf_url":"https://drpress.org/ojs/index.php/ijbls/article/download/36187/35338","source":{"id":"https://openalex.org/S4387286362","display_name":"International Journal of Biology and Life Sciences","issn_l":"2957-9511","issn":["2957-9511"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biology and Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://drpress.org/ojs/index.php/ijbls/article/download/36187/35338","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160198020","display_name":"Xinxin Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137506752","display_name":"North China University of Science and Technology","ror":"https://ror.org/04z4wmb81","country_code":"CN","type":"education","lineage":["https://openalex.org/I137506752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxin Xing","raw_affiliation_strings":["North China University of Science and Technology, Tangshan, Hebei, 063000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North China University of Science and Technology, Tangshan, Hebei, 063000, China","institution_ids":["https://openalex.org/I137506752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125394797","display_name":"Qing Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137506752","display_name":"North China University of Science and Technology","ror":"https://ror.org/04z4wmb81","country_code":"CN","type":"education","lineage":["https://openalex.org/I137506752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Dong","raw_affiliation_strings":["School of Stomatology, North China University of Science and Technology, Tangshan, Hebei, 063000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Stomatology, North China University of Science and Technology, Tangshan, Hebei, 063000, China","institution_ids":["https://openalex.org/I137506752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160208974","display_name":"Yong Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166292","display_name":"Baoding People's Hospital","ror":"https://ror.org/0124z6a88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Chai","raw_affiliation_strings":["The Second Hospital of Baoding, Baoding, Hebei, 071051, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Baoding, Baoding, Hebei, 071051, China","institution_ids":["https://openalex.org/I4210166292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.87830315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":"7","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoride","display_name":"fluoride","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dental-caries-prevention","display_name":"dental caries prevention","score":0.878000020980835},{"id":"https://openalex.org/keywords/remineralization","display_name":"remineralization","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dentin-desensitization","display_name":"dentin desensitization","score":0.9129999876022339},{"id":"https://openalex.org/keywords/silver-diamine-fluoride","display_name":"silver diamine fluoride","score":0.8539999723434448},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dentinal-tubule-occlusion","display_name":"dentinal tubule occlusion","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C2780828025","wikidata":"https://www.wikidata.org/wiki/Q44793182","display_name":"Fluoride","level":2,"score":0.765500009059906},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.6906999945640564},{"id":"https://openalex.org/C3025077","wikidata":"https://www.wikidata.org/wiki/Q416275","display_name":"Fluorapatite","level":3,"score":0.6729000210762024},{"id":"https://openalex.org/C2910315391","wikidata":"https://www.wikidata.org/wiki/Q5561176","display_name":"Tooth Remineralization","level":4,"score":0.6341999769210815},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.6179999709129333},{"id":"https://openalex.org/C2910267089","wikidata":"https://www.wikidata.org/wiki/Q1189904","display_name":"Dentinal Tubule","level":3,"score":0.4212999939918518},{"id":"https://openalex.org/C2776052348","wikidata":"https://www.wikidata.org/wiki/Q904488","display_name":"Demineralization","level":3,"score":0.41179999709129333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36090001463890076},{"id":"https://openalex.org/C2777084678","wikidata":"https://www.wikidata.org/wiki/Q15646788","display_name":"Chlorhexidine","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C156887251","wikidata":"https://www.wikidata.org/wiki/Q2386424","display_name":"Enamel paint","level":2,"score":0.3296000063419342},{"id":"https://openalex.org/C2780088626","wikidata":"https://www.wikidata.org/wiki/Q144083","display_name":"Tooth discoloration","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C2779234887","wikidata":"https://www.wikidata.org/wiki/Q407520","display_name":"Sodium fluoride","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2953000068664551},{"id":"https://openalex.org/C148318117","wikidata":"https://www.wikidata.org/wiki/Q7311813","display_name":"Remineralisation","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C3020334819","wikidata":"https://www.wikidata.org/wiki/Q133772","display_name":"Root caries","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2630999982357025},{"id":"https://openalex.org/C2777958113","wikidata":"https://www.wikidata.org/wiki/Q143942","display_name":"Tooth enamel","level":3,"score":0.25769999623298645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.54097/jvrbe024","doi":"https://doi.org/10.54097/jvrbe024","is_oa":true,"landing_page_url":"https://doi.org/10.54097/jvrbe024","pdf_url":"https://drpress.org/ojs/index.php/ijbls/article/download/36187/35338","source":{"id":"https://openalex.org/S4387286362","display_name":"International Journal of Biology and Life Sciences","issn_l":"2957-9511","issn":["2957-9511"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biology and Life Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.54097/jvrbe024","doi":"https://doi.org/10.54097/jvrbe024","is_oa":true,"landing_page_url":"https://doi.org/10.54097/jvrbe024","pdf_url":"https://drpress.org/ojs/index.php/ijbls/article/download/36187/35338","source":{"id":"https://openalex.org/S4387286362","display_name":"International Journal of Biology and Life Sciences","issn_l":"2957-9511","issn":["2957-9511"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biology and Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321949","display_name":"Department of Education of Hebei Province","ror":"https://ror.org/01jkyjd96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224959629.pdf","grobid_xml":"https://content.openalex.org/works/W7224959629.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1965339663","https://openalex.org/W1984098150","https://openalex.org/W2010735814","https://openalex.org/W2059473237","https://openalex.org/W2066769425","https://openalex.org/W2085620359","https://openalex.org/W2127570070","https://openalex.org/W2129792376","https://openalex.org/W2143073658","https://openalex.org/W2153413579","https://openalex.org/W2762093237","https://openalex.org/W2765108030","https://openalex.org/W2801177553","https://openalex.org/W2804366088","https://openalex.org/W2915821533","https://openalex.org/W2936685477","https://openalex.org/W2948357824","https://openalex.org/W3016463754","https://openalex.org/W3022177339","https://openalex.org/W3106640610","https://openalex.org/W3187547760","https://openalex.org/W4205699041","https://openalex.org/W4282941905","https://openalex.org/W4283745738","https://openalex.org/W4293155447","https://openalex.org/W4360604474","https://openalex.org/W4381798355","https://openalex.org/W4390059369","https://openalex.org/W4393925251","https://openalex.org/W4399786601","https://openalex.org/W4400496919","https://openalex.org/W4400804319","https://openalex.org/W4401113424","https://openalex.org/W4401244814","https://openalex.org/W4401969148","https://openalex.org/W4402014558","https://openalex.org/W4402173870","https://openalex.org/W4403928461","https://openalex.org/W4407783050","https://openalex.org/W4407864575","https://openalex.org/W4408433423","https://openalex.org/W4410221068","https://openalex.org/W4411511113","https://openalex.org/W4411551110","https://openalex.org/W4411784514","https://openalex.org/W4412794893","https://openalex.org/W4413270438","https://openalex.org/W4414397679","https://openalex.org/W7124913385","https://openalex.org/W7125183171","https://openalex.org/W7125423168","https://openalex.org/W7125645945","https://openalex.org/W7126030587"],"related_works":["https://openalex.org/W4392453156","https://openalex.org/W3168834886","https://openalex.org/W4283745738","https://openalex.org/W7167582789","https://openalex.org/W2901868656","https://openalex.org/W4415068828","https://openalex.org/W2793305975","https://openalex.org/W4417100663","https://openalex.org/W4409619388","https://openalex.org/W7203594847"],"abstract_inverted_index":{"Fluoride":[0],"plays":[1],"an":[2],"important":[3],"role":[4],"in":[5,17,43],"caries":[6,44,91],"prevention,":[7,50],"but":[8],"conventional":[9],"agents":[10],"each":[11],"has":[12],"its":[13,96],"own":[14],"drawbacks.":[15],"Advances":[16],"nanomaterials":[18],"and":[19,32,51,75,82,93,119,127,133],"related":[20],"technologies":[21],"have":[22,122],"changed":[23],"that":[24],"picture:":[25],"nanosilver":[26],"fluoride":[27,76,117],"(NSF)":[28],"keeps":[29],"the":[30,37],"antibacterial":[31,126],"remineralization":[33,81,128],"benefits\u2014and":[34],"it":[35],"avoids":[36],"staining":[38],"issue.":[39],"NSF":[40],"performs":[41],"well":[42],"management,":[45],"orthodontic":[46],"white":[47],"spot":[48],"lesion":[49],"dentin":[52],"desensitization.":[53],"It":[54],"may":[55],"therefore":[56],"serve":[57],"as":[58,108],"a":[59],"promising":[60,89],"alternative":[61],"to":[62],"silver":[63,112],"diamine":[64],"fluoride.":[65],"Fluoride-containing":[66],"bioactive":[67],"glass":[68],"(FBG)":[69],"can":[70],"slowly":[71],"release":[72],"calcium,":[73],"phosphorus,":[74],"ions.":[77],"This":[78],"supports":[79],"durable":[80],"excellent":[83],"dentinal":[84],"tubule":[85],"occlusion.":[86],"FBG":[87],"is":[88],"for":[90],"prevention":[92],"desensitization":[94],"therapy;":[95],"mechanical":[97],"properties,":[98],"however,":[99],"still":[100,141],"need":[101],"improvement.":[102],"In":[103],"addition,":[104],"novel":[105,139],"materials":[106,140],"such":[107],"copper":[109],"tetraamine":[110],"fluoride,":[111,114],"complex":[113],"nano":[115],"calcium":[116],"composites,":[118],"strontium-containing":[120],"fluorapatite":[121],"also":[123],"demonstrated":[124],"considerable":[125],"potential.":[129],"The":[130],"long-term":[131],"safety":[132],"optimal":[134],"application":[135],"protocols":[136],"of":[137],"these":[138],"warrant":[142],"further":[143],"clinical":[144],"investigation.":[145]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}