{"id":"https://openalex.org/W7224959118","doi":"https://doi.org/10.2147/pgpm.s602618","title":"Recent Trends in Drug Development and Clinical Trials for Hyperuricemia: A Pharmaprojects-Based Landscape Analysis","display_name":"Recent Trends in Drug Development and Clinical Trials for Hyperuricemia: A Pharmaprojects-Based Landscape Analysis","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7224959118","doi":"https://doi.org/10.2147/pgpm.s602618","pmid":"https://pubmed.ncbi.nlm.nih.gov/42979231","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13730066"},"language":"en","primary_location":{"id":"doi:10.2147/pgpm.s602618","doi":"https://doi.org/10.2147/pgpm.s602618","is_oa":true,"landing_page_url":"https://doi.org/10.2147/pgpm.s602618","pdf_url":"https://www.dovepress.com/article/download/121617","source":{"id":"https://openalex.org/S2764709116","display_name":"Pharmacogenomics and Personalized Medicine","issn_l":"1178-7066","issn":["1178-7066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160153717","display_name":"Hu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu Zhang","raw_affiliation_strings":["Guang'anmen Hospital Heilongjiang China Academy of Chinese Medical Sciences, Harbin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang'anmen Hospital Heilongjiang China Academy of Chinese Medical Sciences, Harbin, People's Republic of China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160166086","display_name":"Senyue Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senyue Zhang","raw_affiliation_strings":["Jiamusi Hospital of Traditional Chinese Medicine, Jiamusi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiamusi Hospital of Traditional Chinese Medicine, Jiamusi, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027923142","display_name":"Tong Fu","orcid":"https://orcid.org/0000-0002-0596-6408","observed_orcids":["https://orcid.org/0000-0002-0596-6408"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Fu","raw_affiliation_strings":["Department of Psychology, Brandeis University, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Brandeis University, Waltham, MA, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160206421","display_name":"Mingzhu Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingzhu Zhang","raw_affiliation_strings":["Department of Rheumatology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160195110","display_name":"Cunyue Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cunyue Yu","raw_affiliation_strings":["Department of Geriatrics, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160204396","display_name":"Jianing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianing Li","raw_affiliation_strings":["China Academy of Chinese Medical Sciences, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Academy of Chinese Medical Sciences, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I4210141683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114734468","display_name":"Ying Tong","orcid":"https://orcid.org/0009-0000-6333-8402","observed_orcids":["https://orcid.org/0009-0000-6333-8402","https://orcid.org/0009-0006-9998-9550"]},"institutions":[{"id":"https://openalex.org/I4210102855","display_name":"First Affiliated Hospital of Heilongjiang University of Chinese Medicine","ror":"https://ror.org/01c0exk17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102855"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Tong","raw_affiliation_strings":["Department of Oncology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, People's Republic of China","institution_ids":["https://openalex.org/I4210102855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5114734468","https://openalex.org/A5160204396"],"corresponding_institution_ids":["https://openalex.org/I4210102855","https://openalex.org/I4210141683"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84364705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":1.0},{"id":"https://openalex.org/keywords/drug-pipeline","display_name":"drug development pipeline","score":0.9240000247955322},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6809999942779541},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.8500000238418579},{"id":"https://openalex.org/keywords/urat1","display_name":"URAT1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/slc22a12","display_name":"SLC22A12","score":0.9980000257492065},{"id":"https://openalex.org/keywords/xanthine-oxidase-inhibitors","display_name":"xanthine oxidase inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5370000004768372},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.75},{"id":"https://openalex.org/keywords/therapeutic-mechanisms","display_name":"therapeutic mechanisms","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8871999979019165},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.7578999996185303},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7419999837875366},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.5684999823570251},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.49050000309944153},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.42480000853538513},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.398499995470047},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.36649999022483826},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.258899986743927}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/pgpm.s602618","doi":"https://doi.org/10.2147/pgpm.s602618","is_oa":true,"landing_page_url":"https://doi.org/10.2147/pgpm.s602618","pdf_url":"https://www.dovepress.com/article/download/121617","source":{"id":"https://openalex.org/S2764709116","display_name":"Pharmacogenomics and Personalized Medicine","issn_l":"1178-7066","issn":["1178-7066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and Personalized Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13730066","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730066/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13730066/pdf/PGPM-19-602618.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmgenomics Pers Med","raw_type":"Text"},{"id":"pmid:42979231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42979231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and personalized medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d831a4dfc94b4aefab5788d1ce5e5efe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d831a4dfc94b4aefab5788d1ce5e5efe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacogenomics and Personalized Medicine, Vol Volume 19, Iss Issue 1, Pp 1-9 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121617","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/recent-trends-in-drug-development-and-clinical-trials-for-hyperuricemi-peer-reviewed-fulltext-article-PGPM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/pgpm.s602618","doi":"https://doi.org/10.2147/pgpm.s602618","is_oa":true,"landing_page_url":"https://doi.org/10.2147/pgpm.s602618","pdf_url":"https://www.dovepress.com/article/download/121617","source":{"id":"https://openalex.org/S2764709116","display_name":"Pharmacogenomics and Personalized Medicine","issn_l":"1178-7066","issn":["1178-7066"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics and Personalized Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224959118.pdf","grobid_xml":"https://content.openalex.org/works/W7224959118.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1988152889","https://openalex.org/W2023684970","https://openalex.org/W2775349389","https://openalex.org/W3041521407","https://openalex.org/W3162771804","https://openalex.org/W4225433535","https://openalex.org/W4286447666","https://openalex.org/W4292476182","https://openalex.org/W4385999933","https://openalex.org/W4400439918","https://openalex.org/W4401977857","https://openalex.org/W4404876391","https://openalex.org/W4405731204","https://openalex.org/W4408002100","https://openalex.org/W4408070893","https://openalex.org/W4408522573","https://openalex.org/W4409048666","https://openalex.org/W4409534268","https://openalex.org/W4409799321","https://openalex.org/W4412548079","https://openalex.org/W4412587241"],"related_works":["https://openalex.org/W2801547292","https://openalex.org/W2050548281","https://openalex.org/W1514375759","https://openalex.org/W3202677601","https://openalex.org/W4417483576","https://openalex.org/W2004430474","https://openalex.org/W2369458111","https://openalex.org/W2805641932","https://openalex.org/W7203452370","https://openalex.org/W4405994721"],"abstract_inverted_index":{"Background:":[0],"Hyperuricemia":[1],"is":[2,6,23,214],"increasingly":[3,216],"prevalent":[4],"and":[5,11,14,28,49,80,85,104,127,145,151,180,192,209,221,230],"closely":[7],"associated":[8],"with":[9,131],"gout":[10],"several":[12],"cardiometabolic":[13],"renal":[15],"disorders.":[16],"Although":[17],"pharmacological":[18,78],"development":[19,34,48,81,161,164,201],"in":[20,46,125,218],"this":[21],"field":[22],"expanding,":[24],"the":[25,32,61,152,159,183,238],"overall":[26],"structure":[27],"recent":[29,44],"evolution":[30],"of":[31,100,113,241],"global":[33,200],"pipeline":[35,121,202],"remain":[36],"incompletely":[37],"characterized.":[38],"This":[39],"study":[40],"aimed":[41],"to":[42,67,75,158,236],"characterize":[43],"trends":[45],"drug":[47],"clinical":[50,129,211,226,239],"research":[51],"for":[52,135,139,143,148,203],"hyperuricemia.":[53],"Methods:":[54],"Hyperuricemia-related":[55],"drug-development":[56,116],"records":[57,90,117],"were":[58,72,91,107,118,178,195],"retrieved":[59],"from":[60,64],"Pharmaprojects":[62],"database":[63,65],"inception":[66],"July":[68],"31,":[69],"2025.":[70],"Records":[71],"screened":[73],"according":[74],"disease":[76],"classification,":[77],"relevance,":[79],"status.":[82],"After":[83],"screening":[84],"data":[86],"verification,":[87],"69":[88,114],"eligible":[89,115],"included.":[92,119],"Development":[93],"stage,":[94],"geographical":[95],"distribution,":[96],"therapeutic":[97,219,243],"class,":[98],"mechanism":[99],"action,":[101],"molecular":[102,187,222],"target,":[103],"commencement":[105],"date":[106],"analyzed":[108],"descriptively.":[109],"Results:":[110],"A":[111],"total":[112],"The":[120,163,199],"was":[122,166,182],"predominantly":[123],"concentrated":[124],"preclinical":[126,132,208],"early":[128,210],"development,":[130],"programs":[133],"accounting":[134],"31.88%,":[136],"Phase":[137,141,146],"I":[138],"20.29%,":[140],"II":[142],"18.84%,":[144],"III":[147],"17.39%.":[149],"China":[150],"United":[153],"States":[154],"represented":[155,186],"important":[156],"contributors":[157],"identified":[160],"activities.":[162],"portfolio":[165],"dominated":[167],"by":[168],"gout-related":[169],"therapies":[170],"but":[171,213],"showed":[172],"increasing":[173],"mechanistic":[174],"diversity.":[175],"URAT1-related":[176],"approaches":[177],"prominent,":[179],"SLC22A12":[181],"most":[184],"frequently":[185],"target.":[188],"Xanthine":[189],"oxidase-,":[190],"uricase-,":[191],"inflammation-related":[193],"mechanisms":[194,220],"also":[196],"represented.":[197],"Conclusion:":[198],"hyperuricemia":[204],"remains":[205],"weighted":[206],"toward":[207],"stages":[212],"becoming":[215],"diverse":[217],"targets.":[223],"Further":[224],"late-stage":[225],"evaluation,":[227],"multicenter":[228],"studies,":[229],"long-term":[231],"safety":[232],"assessment":[233],"are":[234],"required":[235],"establish":[237],"value":[240],"emerging":[242],"strategies.":[244]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-31T00:00:00"}
