{"id":"https://openalex.org/W7224955571","doi":"https://doi.org/10.1093/jxb/erag556","title":"Mechanistic Insights into PTM-Mediated Architectural Rewiring of the Leaf Senescence Program","display_name":"Mechanistic Insights into PTM-Mediated Architectural Rewiring of the Leaf Senescence Program","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W7224955571","doi":"https://doi.org/10.1093/jxb/erag556","pmid":"https://pubmed.ncbi.nlm.nih.gov/42960543"},"language":"en","primary_location":{"id":"doi:10.1093/jxb/erag556","doi":"https://doi.org/10.1093/jxb/erag556","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jxb/erag556","pdf_url":null,"source":{"id":"https://openalex.org/S32610980","display_name":"Journal of Experimental Botany","issn_l":"0022-0957","issn":["0022-0957","1460-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Botany","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143708186","display_name":"Xin Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4392021092","display_name":"State Key Laboratory of Tree Genetics and Breeding","ror":"https://ror.org/03a1zvg88","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210128615","https://openalex.org/I4210134523","https://openalex.org/I4392021092","https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Pang","raw_affiliation_strings":["State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing, 100083 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing, 100083 ,","institution_ids":["https://openalex.org/I31683504","https://openalex.org/I4392021092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388769","display_name":"Jiawei Wang","orcid":"https://orcid.org/0000-0002-3780-8316","observed_orcids":["https://orcid.org/0000-0002-3780-8316"]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4392021092","display_name":"State Key Laboratory of Tree Genetics and Breeding","ror":"https://ror.org/03a1zvg88","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210128615","https://openalex.org/I4210134523","https://openalex.org/I4392021092","https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Wang","raw_affiliation_strings":["State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing, 100083 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing, 100083 ,","institution_ids":["https://openalex.org/I31683504","https://openalex.org/I4392021092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101499936","display_name":"Zhonghai Li","orcid":"https://orcid.org/0000-0003-4913-7641","observed_orcids":["https://orcid.org/0000-0003-4913-7641"]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4392021092","display_name":"State Key Laboratory of Tree Genetics and Breeding","ror":"https://ror.org/03a1zvg88","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210128615","https://openalex.org/I4210134523","https://openalex.org/I4392021092","https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhonghai Li","raw_affiliation_strings":["State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing, 100083 ,"],"raw_orcid":"https://orcid.org/0000-0003-4913-7641","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing, 100083 ,","institution_ids":["https://openalex.org/I31683504","https://openalex.org/I4392021092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101499936"],"corresponding_institution_ids":["https://openalex.org/I31683504","https://openalex.org/I4392021092"],"apc_list":{"value":3292,"currency":"GBP","value_usd":4341},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77401522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10473","display_name":"Postharvest Quality and Shelf Life Management","score":0.05249999836087227,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leaf-senescence","display_name":"leaf senescence","score":1.0},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.996999979019165},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":1.0},{"id":"https://openalex.org/keywords/acetylation","display_name":"acetylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/methylation","display_name":"methylation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipidation","display_name":"lipid modification","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.921999990940094},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":1.0},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/wrky53","display_name":"WRKY53","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kinase-cascade","display_name":"kinase cascade","score":0.9430000185966492},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.996999979019165},{"id":"https://openalex.org/keywords/nutrient-remobilization","display_name":"nutrient remobilization","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7609000205993652},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6480000019073486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6467000246047974},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5529000163078308},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4984999895095825},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.4819999933242798},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42489999532699585},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4043999910354614},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4009999930858612},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2825999855995178},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.2736999988555908},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.2678999900817871}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/jxb/erag556","doi":"https://doi.org/10.1093/jxb/erag556","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jxb/erag556","pdf_url":null,"source":{"id":"https://openalex.org/S32610980","display_name":"Journal of Experimental Botany","issn_l":"0022-0957","issn":["0022-0957","1460-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Botany","raw_type":"journal-article"},{"id":"pmid:42960543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42960543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental botany","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3172222816","https://openalex.org/W4407334522","https://openalex.org/W4378379927","https://openalex.org/W4411190790","https://openalex.org/W2773641320","https://openalex.org/W7220732152","https://openalex.org/W4361206182","https://openalex.org/W7171456730","https://openalex.org/W4200321765","https://openalex.org/W2250574106"],"abstract_inverted_index":{"Leaf":[0],"senescence":[1,44,72,183],"is":[2],"a":[3,140,173],"highly":[4],"coordinated":[5],"developmental":[6],"program":[7],"essential":[8],"for":[9,43,144,177],"nutrient":[10],"remobilization":[11],"and":[12,19,41,64,86,95,110,119,133,155,187],"plant":[13],"fitness.":[14],"While":[15],"the":[16,33,38,50,67,71,116,131,161,178],"underlying":[17],"transcriptional":[18],"epigenetic":[20],"landscapes":[21],"have":[22],"been":[23],"extensively":[24],"mapped,":[25],"emerging":[26],"evidence":[27],"identifies":[28],"post-translational":[29],"modifications":[30],"(PTMs)":[31],"as":[32,78,83],"primary":[34],"regulatory":[35],"hubs":[36],"providing":[37],"requisite":[39],"sensitivity":[40],"precision":[42,179],"signaling.":[45],"This":[46],"review":[47],"systematically":[48],"delineates":[49],"mechanistic":[51],"contributions":[52],"of":[53,70,122,181],"diverse":[54],"PTMs-including":[55],"phosphorylation,":[56],"ubiquitination,":[57],"acetylation,":[58],"methylation,":[59],"glycosylation,":[60],"lipidation,":[61],"hydroxylation,":[62],"S-nitrosylation,":[63],"oxidative":[65],"PTMs-to":[66],"architectural":[68],"rewiring":[69],"program.":[73],"Rather":[74],"than":[75],"functioning":[76],"merely":[77],"downstream":[79],"effectors,":[80],"PTMs":[81],"operate":[82],"integrated":[84],"\"execution\"":[85],"\"decision-making\"":[87],"layers":[88],"that":[89],"bridge":[90],"environmental":[91],"inputs,":[92],"hormonal":[93],"fluxes,":[94],"metabolic":[96],"status.":[97],"By":[98,148],"dynamically":[99],"modulating":[100],"key":[101],"senescence-associated":[102],"transcription":[103],"factors":[104],"(e.g.,":[105],"ORE1,":[106],"WRKY53),":[107],"kinase":[108],"cascades,":[109],"autophagy-related":[111],"networks,":[112],"PTM":[113,166],"registries":[114],"facilitate":[115],"initiation,":[117],"amplification,":[118],"irreversible":[120],"commitment":[121],"leaf":[123],"cells":[124],"to":[125,184],"senescence.":[126],"Furthermore,":[127],"we":[128],"discuss":[129],"how":[130],"interplay":[132],"crosstalk":[134],"among":[135],"distinct":[136],"modification":[137],"types":[138],"establish":[139],"sophisticated":[141],"combinatorial":[142],"logic":[143],"sensing":[145],"physiological":[146],"thresholds.":[147],"integrating":[149],"recent":[150],"advances":[151],"in":[152],"single-cell":[153],"proteomics":[154],"spatial":[156],"omics,":[157],"this":[158],"synthesis":[159],"highlights":[160],"paradigm":[162],"shift":[163],"toward":[164],"cell-type-specific":[165],"atlases.":[167],"Ultimately,":[168],"these":[169],"molecular":[170],"insights":[171],"provide":[172],"robust":[174],"theoretical":[175],"framework":[176],"engineering":[180],"crop":[182],"enhance":[185],"resilience":[186],"yield.":[188]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-10-31T00:00:00"}