{"id":"https://openalex.org/W7224949006","doi":"https://doi.org/10.1007/s00213-026-07199-1","title":"Pharmacokinetic and abuse liability assessment of tobacco-flavored and menthol-flavored pod-based electronic nicotine delivery systems with 5% and 3% nicotine concentrations relative to combustible cigarettes","display_name":"Pharmacokinetic and abuse liability assessment of tobacco-flavored and menthol-flavored pod-based electronic nicotine delivery systems with 5% and 3% nicotine concentrations relative to combustible cigarettes","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224949006","doi":"https://doi.org/10.1007/s00213-026-07199-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42961489"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-026-07199-1","doi":"https://doi.org/10.1007/s00213-026-07199-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-026-07199-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-026-07199-1.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00213-026-07199-1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049543546","display_name":"Nicholas I. Goldenson","orcid":"https://orcid.org/0000-0002-5655-3195","observed_orcids":["https://orcid.org/0000-0002-5655-3195"]},"institutions":[{"id":"https://openalex.org/I4405267303","display_name":"JUUL Labs, Inc. (United States)","ror":"https://ror.org/023nn3g71","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267303"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas I. Goldenson","raw_affiliation_strings":["Juul Labs, Inc, Washington, 20004, USA. nicholas.goldenson@juul.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juul Labs, Inc, Washington, 20004, USA. nicholas.goldenson@juul.com","institution_ids":["https://openalex.org/I4405267303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071547167","display_name":"Douglas R. Oliveri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267303","display_name":"JUUL Labs, Inc. (United States)","ror":"https://ror.org/023nn3g71","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267303"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Oliveri","raw_affiliation_strings":["Juul Labs, Inc, Washington, 20004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juul Labs, Inc, Washington, 20004, USA","institution_ids":["https://openalex.org/I4405267303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101676571","display_name":"Qiwei Liang","orcid":"https://orcid.org/0000-0002-4422-2137","observed_orcids":["https://orcid.org/0000-0002-4422-2137"]},"institutions":[{"id":"https://openalex.org/I4405267303","display_name":"JUUL Labs, Inc. (United States)","ror":"https://ror.org/023nn3g71","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267303"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiwei Liang","raw_affiliation_strings":["Juul Labs, Inc, Washington, 20004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Juul Labs, Inc, Washington, 20004, USA","institution_ids":["https://openalex.org/I4405267303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113342270","display_name":"Saul Shiffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152626","display_name":"Pinney Associates (United States)","ror":"https://ror.org/04vh4pp56","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saul Shiffman","raw_affiliation_strings":["Pinney Associates, Inc., Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pinney Associates, Inc., Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I4387152626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049543546"],"corresponding_institution_ids":["https://openalex.org/I4405267303"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84835,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cigarettes","display_name":"electronic cigarettes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nicotine-pharmacokinetics","display_name":"nicotine pharmacokinetics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/abuse-potential","display_name":"abuse liability","score":0.9539999961853027},{"id":"https://openalex.org/keywords/menthol-flavors","display_name":"menthol flavors","score":0.6209999918937683},{"id":"https://openalex.org/keywords/tobacco-flavor","display_name":"tobacco aroma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nicotine-content","display_name":"nicotine content","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dual-use-of-e-cigarettes-and-cigarettes","display_name":"dual use of e-cigarettes and cigarettes","score":0.746999979019165},{"id":"https://openalex.org/keywords/urge-to-smoke","display_name":"smoking urges","score":0.699999988079071},{"id":"https://openalex.org/keywords/craving-reduction","display_name":"craving reduction","score":0.734000027179718},{"id":"https://openalex.org/keywords/subjective-effects","display_name":"subjective effects","score":0.628000020980835},{"id":"https://openalex.org/keywords/nicotine-delivery","display_name":"nicotine delivery","score":0.37400001287460327},{"id":"https://openalex.org/keywords/juul","display_name":"JUUL","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8815000057220459},{"id":"https://openalex.org/C3018251022","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Abuse liability","level":3,"score":0.7932000160217285},{"id":"https://openalex.org/C2780194911","wikidata":"https://www.wikidata.org/wiki/Q407418","display_name":"Menthol","level":2,"score":0.7236999869346619},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6547999978065491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6144999861717224},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6044999957084656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5340999960899353},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4885999858379364},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.41620001196861267},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.335999995470047},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C3020384764","wikidata":"https://www.wikidata.org/wiki/Q44106","display_name":"Tobacco product","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C2778887763","wikidata":"https://www.wikidata.org/wiki/Q4348342","display_name":"Nicotine gum","level":4,"score":0.27219998836517334},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2581000030040741}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00213-026-07199-1","doi":"https://doi.org/10.1007/s00213-026-07199-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-026-07199-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-026-07199-1.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:42961489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42961489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00213-026-07199-1","doi":"https://doi.org/10.1007/s00213-026-07199-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-026-07199-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-026-07199-1.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224949006.pdf","grobid_xml":"https://content.openalex.org/works/W7224949006.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1892235991","https://openalex.org/W1966331187","https://openalex.org/W1966462692","https://openalex.org/W1982606148","https://openalex.org/W2015080262","https://openalex.org/W2048270309","https://openalex.org/W2070045878","https://openalex.org/W2077620252","https://openalex.org/W2730409259","https://openalex.org/W2747050788","https://openalex.org/W2767108924","https://openalex.org/W2783256295","https://openalex.org/W2810946886","https://openalex.org/W2965542329","https://openalex.org/W2991156407","https://openalex.org/W3006262527","https://openalex.org/W3012512788","https://openalex.org/W3019448998","https://openalex.org/W3038451982","https://openalex.org/W3095944871","https://openalex.org/W3106597648","https://openalex.org/W3116044730","https://openalex.org/W3136809511","https://openalex.org/W3155518264","https://openalex.org/W3158226936","https://openalex.org/W3161231545","https://openalex.org/W3165350859","https://openalex.org/W3190082415","https://openalex.org/W3193613139","https://openalex.org/W4200197383","https://openalex.org/W4231752535","https://openalex.org/W4296894396","https://openalex.org/W4320526336","https://openalex.org/W4394832302","https://openalex.org/W4399040239","https://openalex.org/W4408865813","https://openalex.org/W7154610830","https://openalex.org/W7161628647","https://openalex.org/W7202070024"],"related_works":["https://openalex.org/W7154610830","https://openalex.org/W4393410047","https://openalex.org/W4412534178","https://openalex.org/W7168234905","https://openalex.org/W7119119614","https://openalex.org/W4388213022","https://openalex.org/W3095944871","https://openalex.org/W7202070024","https://openalex.org/W3106597648","https://openalex.org/W7168135849"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nicotine":[1],"pharmacokinetics":[2],"(PK)":[3],"and":[4,27,37,42,50,55,70,124,145,151,210,233],"subjective":[5,28],"effects":[6],"influence":[7],"the":[8],"abuse":[9,204],"liability":[10,205],"of":[11,80,130,172,207,231],"electronic":[12],"nicotine":[13,24,44,131,149,153,178,223,232],"delivery":[14,25,150],"systems":[15],"(ENDS).":[16],"This":[17],"two-arm":[18],"randomized":[19],"crossover":[20],"pharmacokinetic":[21],"study":[22,82,107,143,156,185,216],"assessed":[23],"from":[26,155,165],"responses":[29],"to":[30,47,78,176,238],"four":[31,105],"JUUL2":[32],"ENDS":[33,73,157,186,212,224],"products":[34,158,187,225],"(Virginia":[35],"Tobacco":[36,54],"Fresh":[38],"Menthol":[39,56],"flavors":[40],"[5%":[41],"3%":[43],"concentrations])":[45],"compared":[46],"combustible":[48,173],"cigarettes":[49,68,90,98,237],"NJOY":[51],"Ace":[52],"(Classic":[53],"flavors;":[57],"5%":[58,222],"nicotine)":[59],"among":[60],"adult":[61],"dual":[62],"users.":[63],"METHODS:":[64],"Adults":[65],"who":[66],"smoked":[67,88],"daily":[69],"concurrently":[71],"used":[72,111],"(dual":[74],"users)":[75],"were":[76,188,217],"assigned":[77,113],"one":[79],"two":[81],"arms":[83,144],"based":[84],"on":[85,259],"whether":[86],"they":[87,248],"nonmentholated":[89],"(Tobacco":[91],"Arm":[92,100],"[N":[93,101],"=":[94,102],"30])":[95],"or":[96,166],"mentholated":[97],"(Menthol":[99],"30]).":[103],"On":[104],"consecutive":[106],"days":[108],"participants":[109],"first":[110],"each":[112],"product":[114],"in":[115,133,214],"a":[116,134,239],"controlled":[117],"use":[118,138,146],"session":[119],"(10":[120],"standardized":[121],"3-second":[122],"puffs),":[123],"then,":[125],"after":[126],"\u2265":[127],"4":[128],"h":[129],"abstinence,":[132],"5-minute":[135],"ad":[136],"libitum":[137],"session.":[139],"RESULTS:":[140],"In":[141],"both":[142],"conditions,":[147],"peak":[148,229],"total":[152],"exposure":[154],"either":[159],"did":[160,180],"not":[161,181],"statistically":[162],"significantly":[163,168,182],"differ":[164],"was":[167],"lower":[169,218],"than":[170,194,219],"that":[171],"cigarettes;":[174],"time":[175],"maximum":[177],"concentration":[179],"differ.":[183],"All":[184],"rated":[189],"as":[190,242],"substantially":[191],"less":[192],"reinforcing":[193],"cigarettes,":[195,246],"but":[196],"similarly":[197],"effective":[198,251],"at":[199],"reducing":[200],"urge-to-smoke.":[201],"CONCLUSIONS:":[202],"The":[203,221],"profiles":[206],"all":[208],"menthol-flavored":[209],"tobacco-flavored":[211],"evaluated":[213],"this":[215],"cigarettes.":[220,254],"generally":[226],"delivered":[227],"comparable":[228],"levels":[230],"alleviated":[234],"cravings":[235],"for":[236,253],"similar":[240],"extent":[241],"participants'":[243],"usual":[244],"brand":[245],"suggesting":[247],"can":[249],"be":[250],"substitutes":[252],"CLINICAL":[255],"TRIAL":[256],"NUMBER:":[257],"ISRCTN29801527":[258],"October":[260],"25,":[261],"2024.":[262]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}