{"id":"https://openalex.org/W7224945873","doi":"https://doi.org/10.64898/2026.10.25.761718","title":"Estrogen remodels large-scale cortical dynamics to promote behavioral persistence","display_name":"Estrogen remodels large-scale cortical dynamics to promote behavioral persistence","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224945873","doi":"https://doi.org/10.64898/2026.10.25.761718"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.25.761718","doi":"https://doi.org/10.64898/2026.10.25.761718","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.761718","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.25.761718.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.25.761718.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011211486","display_name":"Meenakshi M. Asokan","orcid":"https://orcid.org/0000-0002-5560-0279","observed_orcids":["https://orcid.org/0000-0002-5560-0279"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenakshi M. Asokan","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-5560-0279","affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160183582","display_name":"Alissa Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alissa Le","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093497350","display_name":"Dexter Tsin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dexter Tsin","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119713939","display_name":"Lucy Sirrs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Sirrs","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147408457","display_name":"Madeline Cramer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline Cramer","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042484127","display_name":"Stefan N. Oline","orcid":"https://orcid.org/0000-0002-7094-3800","observed_orcids":["https://orcid.org/0000-0002-7094-3800"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan N. Oline","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003176167","display_name":"Forrest Dylan Rogers","orcid":"https://orcid.org/0000-0001-7521-6904","observed_orcids":["https://orcid.org/0000-0001-7521-6904"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Forrest D. Rogers","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037726639","display_name":"Annegret L. Falkner","orcid":"https://orcid.org/0000-0001-9756-7887","observed_orcids":["https://orcid.org/0000-0001-9756-7887"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annegret L. Falkner","raw_affiliation_strings":["Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton, NJ 08540, U.S.A","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037726639"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8270000219345093},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9490000009536743},{"id":"https://openalex.org/keywords/behavioral-persistence","display_name":"behavioral persistence","score":0.6890000104904175},{"id":"https://openalex.org/keywords/social-decision-making","display_name":"social decision-making","score":0.781000018119812},{"id":"https://openalex.org/keywords/social-preferences","display_name":"social preferences","score":0.8090000152587891},{"id":"https://openalex.org/keywords/recurrent-connections","display_name":"recurrent connectivity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cortical-dynamics","display_name":"cortical dynamics","score":0.5619999766349792},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.7379999756813049},{"id":"https://openalex.org/keywords/female-mice","display_name":"female mice","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7840999960899353},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6654000282287598},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5916000008583069},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4893999993801117},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4246000051498413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42320001125335693},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.3646000027656555},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.34360000491142273},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3357999920845032},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26649999618530273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2635999917984009},{"id":"https://openalex.org/C166471694","wikidata":"https://www.wikidata.org/wiki/Q18268232","display_name":"GPER","level":5,"score":0.25839999318122864},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.25.761718","doi":"https://doi.org/10.64898/2026.10.25.761718","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.761718","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.25.761718.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.25.761718","doi":"https://doi.org/10.64898/2026.10.25.761718","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.25.761718","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/30/2026.10.25.761718.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320306279","display_name":"Jane Coffin Childs Memorial Fund for Medical Research","ror":"https://ror.org/04yhme281"},{"id":"https://openalex.org/F4320306403","display_name":"Esther A. and Joseph Klingenstein Fund","ror":"https://ror.org/01q222b25"},{"id":"https://openalex.org/F4320306489","display_name":"Charles H. Revson Foundation","ror":"https://ror.org/02c9tf451"},{"id":"https://openalex.org/F4320307384","display_name":"New York Stem Cell Foundation","ror":"https://ror.org/03n2a3p06"},{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320318390","display_name":"One Mind","ror":"https://ror.org/02prz6q96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224945873.pdf","grobid_xml":"https://content.openalex.org/works/W7224945873.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W4392272404","https://openalex.org/W4405815669","https://openalex.org/W4406447606","https://openalex.org/W4407803285","https://openalex.org/W4413875322","https://openalex.org/W4414461529","https://openalex.org/W6970065092","https://openalex.org/W7118128426","https://openalex.org/W7127159518","https://openalex.org/W7139947518","https://openalex.org/W7169786066"],"related_works":["https://openalex.org/W2989148135","https://openalex.org/W792064233","https://openalex.org/W4410759296","https://openalex.org/W4407803285","https://openalex.org/W2898613973","https://openalex.org/W7135212427","https://openalex.org/W2045035482","https://openalex.org/W2951503596","https://openalex.org/W4402046029","https://openalex.org/W1974675578"],"abstract_inverted_index":{"Sex-steroid":[0],"hormones":[1],"remodel":[2],"the":[3,112,117,142,160,172,214],"brain":[4],"on":[5,33],"slow":[6,23],"timescales":[7],"of":[8,87],"hours":[9],"to":[10,12,194,219],"days":[11],"coordinate":[13],"adaptive":[14],"behaviors":[15],"with":[16,131],"changing":[17],"bodily":[18],"physiology.":[19],"Yet":[20],"how":[21],"this":[22,77],"remodeling":[24],"reorganizes":[25],"and":[26,59,67,73,89,99,137,152,198],"constrains":[27],"neural":[28,54,74,90,124],"computations":[29,209],"that":[30,44,82,103,126,205,222],"govern":[31],"behavior":[32,72],"a":[34,188,224],"moment-to-moment":[35],"timescale":[36],"remains":[37],"poorly":[38],"understood,":[39],"particularly":[40],"in":[41,62,111,226],"cortical":[42,208],"regions":[43],"support":[45],"flexible":[46,218],"social":[47,97,154,230],"decision-making.":[48],"Here":[49],"we":[50],"combined":[51],"longitudinal":[52],"high-density":[53],"recordings,":[55],"quantitative":[56],"behavioral":[57,88,100,197],"phenotyping":[58],"estrogen-receptor":[60],"manipulation":[61],"female":[63],"mice":[64],"across":[65,156,210],"low":[66],"high":[68,83,119],"estrogen":[69,84,93,107,120,145,166,206],"states.":[70],"Tracking":[71],"dynamics":[75],"using":[76],"dense":[78],"sampling":[79],"approach":[80],"revealed":[81],"increased":[85,95,134,146,196],"signatures":[86],"persistence.":[91,200],"High":[92,165],"reversibly":[94],"male-directed":[96],"preference":[98],"persistence,":[101],"effects":[102],"were":[104,127],"abolished":[105],"by":[106],"receptor":[108],"alpha":[109],"knockdown":[110],"medial":[113],"prefrontal":[114,215],"cortex.":[115],"In":[116],"mPFC":[118],"produced":[121],"more":[122,128],"persistent":[123,220],"states":[125],"closely":[129],"aligned":[130],"ongoing":[132],"behavior,":[133],"state":[135],"discriminability,":[136],"compressed":[138],"within-state":[139],"dimensionality.":[140],"At":[141],"single-neuron":[143],"level,":[144],"tuning":[147],"selectivity,":[148],"lengthened":[149],"intrinsic":[150],"timescales,":[151,212],"stabilized":[153],"representations":[155],"days,":[157],"even":[158],"within":[159],"same":[161],"neurons":[162],"tracked":[163],"longitudinally.":[164],"also":[167],"strengthened":[168],"recurrent":[169],"connectivity":[170,177,185],"during":[171],"resting":[173],"state,":[174],"exhibiting":[175],"preferential":[176],"between":[178],"similarly":[179],"tuned":[180],"ensembles.":[181],"Finally,":[182],"incorporating":[183],"these":[184,202],"changes":[186],"into":[187],"mean-field":[189],"dynamical-systems":[190],"model":[191],"was":[192],"sufficient":[193],"reproduce":[195],"neural-state":[199],"Together,":[201],"findings":[203],"show":[204],"oscillates":[207],"multi-day":[211],"flipping":[213],"cortex":[216],"from":[217],"regimes":[221],"play":[223],"role":[225],"sustaining":[227],"potentially":[228],"costly":[229],"behaviors.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}