{"id":"https://openalex.org/W7224940344","doi":"https://doi.org/10.1038/s41380-026-03935-3","title":"Mitochondrial complex IV disruption is a detrimental pathology conferring ssusceptibility to alzheimer\u2019s disease","display_name":"Mitochondrial complex IV disruption is a detrimental pathology conferring ssusceptibility to alzheimer\u2019s disease","publication_year":2026,"publication_date":"2026-10-30","ids":{"openalex":"https://openalex.org/W7224940344","doi":"https://doi.org/10.1038/s41380-026-03935-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/42963367"},"language":"en","primary_location":{"id":"doi:10.1038/s41380-026-03935-3","doi":"https://doi.org/10.1038/s41380-026-03935-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41380-026-03935-3","pdf_url":"https://www.nature.com/articles/s41380-026-03935-3.pdf","source":{"id":"https://openalex.org/S71149355","display_name":"Molecular Psychiatry","issn_l":"1359-4184","issn":["1359-4184","1476-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41380-026-03935-3.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100429257","display_name":"Jing Tian","orcid":"https://orcid.org/0000-0001-6202-3441","observed_orcids":["https://orcid.org/0000-0001-6202-3441"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Tian","raw_affiliation_strings":["Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101701012","display_name":"Kun Jia","orcid":"https://orcid.org/0000-0003-4574-783X","observed_orcids":["https://orcid.org/0000-0003-4574-783X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kun Jia","raw_affiliation_strings":["Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA","Department of Immunology, Harvard Medical School, Boston, MA, USA","Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Immunology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139178919","display_name":"Yanting Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanting Chen","raw_affiliation_strings":["Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079485417","display_name":"Tienju Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tienju Wang","raw_affiliation_strings":["Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160177692","display_name":"Lan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Guo","raw_affiliation_strings":["Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050249978","display_name":"Russell Howard Swerdlow","orcid":"https://orcid.org/0000-0003-2948-7230","observed_orcids":["https://orcid.org/0000-0003-2948-7230"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell H. Swerdlow","raw_affiliation_strings":["Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":"https://orcid.org/0000-0003-2948-7230","affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014945614","display_name":"Heng Du","orcid":"https://orcid.org/0000-0002-2661-5818","observed_orcids":["https://orcid.org/0000-0002-2661-5818"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heng Du","raw_affiliation_strings":["Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA. heng.du@wfusm.edu","Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA. heng.du@wfusm.edu","Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA. heng.du@wfusm.edu"],"raw_orcid":"https://orcid.org/0000-0002-2661-5818","affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA. heng.du@wfusm.edu","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Gerontology & Geriatrics, Alzheimer's Disease Research Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA. heng.du@wfusm.edu","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Kansas, Lawrence, KS, USA. heng.du@wfusm.edu","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5014945614"],"corresponding_institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.12200000137090683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-complex-iv","display_name":"mitochondrial complex IV","score":0.9440000057220459},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7689999938011169},{"id":"https://openalex.org/keywords/alternative-oxidase","display_name":"alternative oxidase","score":0.7799999713897705},{"id":"https://openalex.org/keywords/amyloid-pathology","display_name":"amyloid pathology","score":0.7559999823570251},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cox11","display_name":"COX11","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.6899999976158142},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.4970000088214874},{"id":"https://openalex.org/keywords/proteome-wide-association-study","display_name":"proteome-wide association study","score":0.9079999923706055},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6237000226974487},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6144999861717224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5760999917984009},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5034000277519226},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5019000172615051},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4893999993801117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4839000105857849},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.4359000027179718},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.43389999866485596},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.3984000086784363},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.37779998779296875},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.337799996137619},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.3310000002384186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32910001277923584},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C2775833069","wikidata":"https://www.wikidata.org/wiki/Q6881881","display_name":"Mitochondrial myopathy","level":4,"score":0.3003000020980835},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2994000017642975},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29420000314712524},{"id":"https://openalex.org/C166252455","wikidata":"https://www.wikidata.org/wiki/Q6736610","display_name":"Trinucleotide repeat expansion","level":4,"score":0.28780001401901245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2824999988079071},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.25699999928474426}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41380-026-03935-3","doi":"https://doi.org/10.1038/s41380-026-03935-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41380-026-03935-3","pdf_url":"https://www.nature.com/articles/s41380-026-03935-3.pdf","source":{"id":"https://openalex.org/S71149355","display_name":"Molecular Psychiatry","issn_l":"1359-4184","issn":["1359-4184","1476-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Psychiatry","raw_type":"journal-article"},{"id":"pmid:42963367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42963367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular psychiatry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41380-026-03935-3","doi":"https://doi.org/10.1038/s41380-026-03935-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41380-026-03935-3","pdf_url":"https://www.nature.com/articles/s41380-026-03935-3.pdf","source":{"id":"https://openalex.org/S71149355","display_name":"Molecular Psychiatry","issn_l":"1359-4184","issn":["1359-4184","1476-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7224940344.pdf","grobid_xml":"https://content.openalex.org/works/W7224940344.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W82573178","https://openalex.org/W1968257316","https://openalex.org/W1984329960","https://openalex.org/W1985667235","https://openalex.org/W1988731658","https://openalex.org/W1991925518","https://openalex.org/W1992083637","https://openalex.org/W1995618419","https://openalex.org/W1998742630","https://openalex.org/W2000359426","https://openalex.org/W2001315565","https://openalex.org/W2001663786","https://openalex.org/W2001801014","https://openalex.org/W2003748109","https://openalex.org/W2007047564","https://openalex.org/W2007136766","https://openalex.org/W2013568483","https://openalex.org/W2023378584","https://openalex.org/W2035118435","https://openalex.org/W2048177923","https://openalex.org/W2051476652","https://openalex.org/W2052742260","https://openalex.org/W2053745263","https://openalex.org/W2064847009","https://openalex.org/W2069477808","https://openalex.org/W2071847157","https://openalex.org/W2075604126","https://openalex.org/W2080184198","https://openalex.org/W2118574111","https://openalex.org/W2134082659","https://openalex.org/W2143582172","https://openalex.org/W2149821716","https://openalex.org/W2155804262","https://openalex.org/W2159383423","https://openalex.org/W2163710163","https://openalex.org/W2227933859","https://openalex.org/W2316561841","https://openalex.org/W2337275183","https://openalex.org/W2339289295","https://openalex.org/W2345349101","https://openalex.org/W2752747237","https://openalex.org/W2770269726","https://openalex.org/W2802543878","https://openalex.org/W2809549232","https://openalex.org/W2839171862","https://openalex.org/W2901125126","https://openalex.org/W2905405688","https://openalex.org/W2906517747","https://openalex.org/W2908002252","https://openalex.org/W2968108711","https://openalex.org/W2969563383","https://openalex.org/W2970474312","https://openalex.org/W3016473409","https://openalex.org/W3029222544","https://openalex.org/W3043243920","https://openalex.org/W3083018475","https://openalex.org/W3093162562","https://openalex.org/W3106539179","https://openalex.org/W3107700988","https://openalex.org/W3112094576","https://openalex.org/W3123744360","https://openalex.org/W3126884424","https://openalex.org/W3134874816","https://openalex.org/W3137679227","https://openalex.org/W3156469684","https://openalex.org/W3193378970","https://openalex.org/W3194984287","https://openalex.org/W3197132305","https://openalex.org/W3203486197","https://openalex.org/W4292947428","https://openalex.org/W4310773007","https://openalex.org/W4311769913","https://openalex.org/W4324139030","https://openalex.org/W4362671013","https://openalex.org/W4385516413","https://openalex.org/W4388857126","https://openalex.org/W4403683695","https://openalex.org/W4404393951","https://openalex.org/W4404531706","https://openalex.org/W4406558599","https://openalex.org/W4408341147","https://openalex.org/W4411866104","https://openalex.org/W7165671328"],"related_works":["https://openalex.org/W1971884099","https://openalex.org/W7165671328","https://openalex.org/W4281724038","https://openalex.org/W4412768188","https://openalex.org/W4291777671","https://openalex.org/W4388304515","https://openalex.org/W3160242714","https://openalex.org/W2111109210","https://openalex.org/W3210587964","https://openalex.org/W2839171862"],"abstract_inverted_index":{"Mitochondrial":[0],"complex":[1],"IV":[2],"(CIV)":[3],"is":[4,187],"an":[5],"integral":[6],"part":[7],"of":[8,30,40,46,64,79,92,113,123,136,168,201,208,223,236],"the":[9,27,37,44,76,121,130,220,230],"mitochondrial":[10,22,124,194],"electron":[11],"transport":[12],"chain":[13],"(ETC)":[14],"and":[15,61,67,110,126,133,147,195,209,234],"plays":[16],"a":[17,68,89,94,103,141,153,170,188,206,210],"pivotal":[18],"role":[19,39,200],"in":[20,33,43,129,215],"maintaining":[21],"function.":[23],"In":[24,53,139],"contrast":[25],"to":[26,71,97,120,177,192,212,228],"long-standing":[28],"recognition":[29],"its":[31],"dysfunction":[32,109,125,146,186],"Alzheimer's":[34],"disease":[35],"(AD),":[36],"exact":[38],"CIV":[41,74,86,108,119,145,172,185,202,226],"deficit":[42],"pathogenesis":[45],"this":[47,54,237],"neurodegenerative":[48,238],"disorder":[49],"remains":[50],"poorly":[51],"defined.":[52],"study,":[55],"by":[56],"incorporating":[57],"clinical":[58],"resources,":[59],"mouse-":[60,132],"human-based":[62,134],"models":[63,135],"AD":[65,137,163,178,216],"risk,":[66],"genetic":[69,159],"approach":[70],"bypass":[72],"defective":[73,118],"via":[75],"ectopic":[77],"expression":[78],"alternative":[80],"oxidase":[81],"(AOX),":[82],"we":[83],"examined":[84],"whether":[85],"deficits":[87,227],"are":[88],"pathogenic":[90],"driver":[91],"or":[93],"beneficial":[95],"adaptation":[96],"AD-associated":[98,193],"pathologies.":[99],"Our":[100],"results":[101],"showed":[102],"clinicopathological":[104],"association":[105,155],"between":[106,144],"neuronal":[107,196],"pathological":[111],"characteristics":[112],"AD.":[114],"Further":[115],"experiments":[116],"linked":[117],"development":[122],"synaptic":[127],"loss":[128],"tested":[131],"risk.":[138,179],"addition,":[140],"reciprocal":[142],"relationship":[143],"amyloid":[148,213],"pathology":[149,190],"was":[150],"determined.":[151],"Lastly,":[152],"proteome-wide":[154],"study":[156],"(PWAS)":[157],"using":[158],"data":[160],"from":[161],"large-scale":[162],"cohorts":[164],"identified":[165],"that":[166,184],"downregulation":[167],"COX11,":[169],"crucial":[171],"assembly":[173],"factor,":[174],"confers":[175],"susceptibility":[176],"Collectively,":[180],"our":[181],"findings":[182],"suggest":[183],"detrimental":[189],"contributing":[191],"damage.":[197],"The":[198],"dual":[199],"dysfunction,":[203],"both":[204],"as":[205],"consequence":[207],"contributor":[211],"toxicity":[214],"pathogenesis,":[217],"further":[218],"justifies":[219],"therapeutic":[221],"potential":[222],"strategies":[224],"targeting":[225],"diversify":[229],"tools":[231],"for":[232],"prevention":[233],"treatment":[235],"disorder.":[239]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-31T00:00:00"}